Denis Drygin, Amy Lin, Josh Bliesath, Caroline B Ho, Sean E O'Brien, Chris Proffitt, Mayuko Omori, Mustapha Haddach, Michael K Schwaebe, Adam Siddiqui-Jain, Nicole Streiner, Jaclyn E Quin, Elaine Sanij, Megan J Bywater, Ross D Hannan, David Ryckman, Kenna Anderes, William G Rice. Cancer Res 2011
Times Cited: 341
Times Cited: 341
Times Cited
Times Co-cited
Similarity
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J O'Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia,[...]. Nat Commun 2017
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J O'Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia,[...]. Nat Commun 2017
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Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes,[...]. Cancer Cell 2012
Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes,[...]. Cancer Cell 2012
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First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Elaine Sanij, John Lim, John Soong, Emma Link, Piers Blombery,[...]. Cancer Discov 2019
Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Elaine Sanij, John Lim, John Soong, Emma Link, Piers Blombery,[...]. Cancer Discov 2019
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Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis.
Denis Drygin, Adam Siddiqui-Jain, Sean O'Brien, Michael Schwaebe, Amy Lin, Josh Bliesath, Caroline B Ho, Chris Proffitt, Katy Trent, Jeffrey P Whitten,[...]. Cancer Res 2009
Denis Drygin, Adam Siddiqui-Jain, Sean O'Brien, Michael Schwaebe, Amy Lin, Josh Bliesath, Caroline B Ho, Chris Proffitt, Katy Trent, Jeffrey P Whitten,[...]. Cancer Res 2009
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Chemotherapeutic drugs inhibit ribosome biogenesis at various levels.
Kaspar Burger, Bastian Mühl, Thomas Harasim, Michaela Rohrmoser, Anastassia Malamoussi, Mathias Orban, Markus Kellner, Anita Gruber-Eber, Elisabeth Kremmer, Michael Hölzel,[...]. J Biol Chem 2010
Kaspar Burger, Bastian Mühl, Thomas Harasim, Michaela Rohrmoser, Anastassia Malamoussi, Mathias Orban, Markus Kellner, Anita Gruber-Eber, Elisabeth Kremmer, Michael Hölzel,[...]. J Biol Chem 2010
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The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.
Peter M Bruno, Mengrou Lu, Kady A Dennis, Haider Inam, Connor J Moore, John Sheehe, Stephen J Elledge, Michael T Hemann, Justin R Pritchard. Proc Natl Acad Sci U S A 2020
Peter M Bruno, Mengrou Lu, Kady A Dennis, Haider Inam, Connor J Moore, John Sheehe, Stephen J Elledge, Michael T Hemann, Justin R Pritchard. Proc Natl Acad Sci U S A 2020
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Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics.
Mustapha Haddach, Michael K Schwaebe, Jerome Michaux, Johnny Nagasawa, Sean E O'Brien, Jeffrey P Whitten, Fabrice Pierre, Pauline Kerdoncuff, Levan Darjania, Ryan Stansfield,[...]. ACS Med Chem Lett 2012
Mustapha Haddach, Michael K Schwaebe, Jerome Michaux, Johnny Nagasawa, Sean E O'Brien, Jeffrey P Whitten, Fabrice Pierre, Pauline Kerdoncuff, Levan Darjania, Ryan Stansfield,[...]. ACS Med Chem Lett 2012
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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova,[...]. Nat Commun 2020
Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova,[...]. Nat Commun 2020
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Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George,[...]. Oncotarget 2016
Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George,[...]. Oncotarget 2016
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Ribosome biogenesis in cancer: new players and therapeutic avenues.
Joffrey Pelletier, George Thomas, Siniša Volarević. Nat Rev Cancer 2018
Joffrey Pelletier, George Thomas, Siniša Volarević. Nat Rev Cancer 2018
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Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age.
Rita Ferreira, John S Schneekloth, Konstantin I Panov, Katherine M Hannan, Ross D Hannan. Cells 2020
Rita Ferreira, John S Schneekloth, Konstantin I Panov, Katherine M Hannan, Ross D Hannan. Cells 2020
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A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
Karita Peltonen, Laureen Colis, Hester Liu, Rishi Trivedi, Michael S Moubarek, Henna M Moore, Baoyan Bai, Michelle A Rudek, Charles J Bieberich, Marikki Laiho. Cancer Cell 2014
Karita Peltonen, Laureen Colis, Hester Liu, Rishi Trivedi, Michael S Moubarek, Henna M Moore, Baoyan Bai, Michelle A Rudek, Charles J Bieberich, Marikki Laiho. Cancer Cell 2014
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rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.
Sandeep S Negi, Patrick Brown. Oncotarget 2015
Sandeep S Negi, Patrick Brown. Oncotarget 2015
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The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.
Denis Drygin, William G Rice, Ingrid Grummt. Annu Rev Pharmacol Toxicol 2010
Denis Drygin, William G Rice, Ingrid Grummt. Annu Rev Pharmacol Toxicol 2010
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The nucleolus under stress.
Séverine Boulon, Belinda J Westman, Saskia Hutten, François-Michel Boisvert, Angus I Lamond. Mol Cell 2010
Séverine Boulon, Belinda J Westman, Saskia Hutten, François-Michel Boisvert, Angus I Lamond. Mol Cell 2010
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The multifunctional nucleolus.
François-Michel Boisvert, Silvana van Koningsbruggen, Joaquín Navascués, Angus I Lamond. Nat Rev Mol Cell Biol 2007
François-Michel Boisvert, Silvana van Koningsbruggen, Joaquín Navascués, Angus I Lamond. Nat Rev Mol Cell Biol 2007
14
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses.
Carlos P Rubbi, Jo Milner. EMBO J 2003
Carlos P Rubbi, Jo Milner. EMBO J 2003
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CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma.
Leiming Li, Yan Li, Jiansong Zhao, Shuli Fan, Liguo Wang, Xu Li. Onco Targets Ther 2016
Leiming Li, Yan Li, Jiansong Zhao, Shuli Fan, Liguo Wang, Xu Li. Onco Targets Ther 2016
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The nucleolus: an emerging target for cancer therapy.
Nadine Hein, Katherine M Hannan, Amee J George, Elaine Sanij, Ross D Hannan. Trends Mol Med 2013
Nadine Hein, Katherine M Hannan, Amee J George, Elaine Sanij, Ross D Hannan. Trends Mol Med 2013
13
Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.
Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga,[...]. Cancer Discov 2016
Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga,[...]. Cancer Discov 2016
16
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.
Peter M Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E Koch, Timothy J Eisen, Justin R Pritchard, Yves Pommier, Stephen J Lippard, Michael T Hemann. Nat Med 2017
Peter M Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E Koch, Timothy J Eisen, Justin R Pritchard, Yves Pommier, Stephen J Lippard, Michael T Hemann. Nat Med 2017
13
Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Henna M Moore, Juulia Enbäck, Pirjo Laakkonen, Anne Vaahtokari, Richard J Jones, Taija M af Hällström,[...]. PLoS One 2010
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Henna M Moore, Juulia Enbäck, Pirjo Laakkonen, Anne Vaahtokari, Richard J Jones, Taija M af Hällström,[...]. PLoS One 2010
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MYC as a regulator of ribosome biogenesis and protein synthesis.
Jan van Riggelen, Alper Yetil, Dean W Felsher. Nat Rev Cancer 2010
Jan van Riggelen, Alper Yetil, Dean W Felsher. Nat Rev Cancer 2010
12
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch,[...]. Blood 2017
Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch,[...]. Blood 2017
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Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.
Ting Wei, Saman M Najmi, Hester Liu, Karita Peltonen, Alena Kucerova, David A Schneider, Marikki Laiho. Cell Rep 2018
Ting Wei, Saman M Najmi, Hester Liu, Karita Peltonen, Alena Kucerova, David A Schneider, Marikki Laiho. Cell Rep 2018
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Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis.
Mikael S Lindström, Deana Jurada, Sladana Bursac, Ines Orsolic, Jiri Bartek, Sinisa Volarevic. Oncogene 2018
Mikael S Lindström, Deana Jurada, Sladana Bursac, Ines Orsolic, Jiri Bartek, Sinisa Volarevic. Oncogene 2018
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Targeting the nucleolus for cancer intervention.
Jaclyn E Quin, Jennifer R Devlin, Donald Cameron, Kate M Hannan, Richard B Pearson, Ross D Hannan. Biochim Biophys Acta 2014
Jaclyn E Quin, Jennifer R Devlin, Donald Cameron, Kate M Hannan, Richard B Pearson, Ross D Hannan. Biochim Biophys Acta 2014
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The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer.
Richard J Rebello, Eric Kusnadi, Donald P Cameron, Helen B Pearson, Analia Lesmana, Jennifer R Devlin, Denis Drygin, Ashlee K Clark, Laura Porter, John Pedersen,[...]. Clin Cancer Res 2016
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Nucleolar Stress: hallmarks, sensing mechanism and diseases.
Kai Yang, Jie Yang, Jing Yi. Cell Stress 2018
Kai Yang, Jie Yang, Jing Yi. Cell Stress 2018
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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.
Azadeh Arabi, Siqin Wu, Karin Ridderstråle, Holger Bierhoff, Chiounan Shiue, Karoly Fatyol, Sara Fahlén, Per Hydbring, Ola Söderberg, Ingrid Grummt,[...]. Nat Cell Biol 2005
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9
Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Zhewei Zhang, Taija Af Hällström, Henna M Moore, Paul Sirajuddin, Marikki Laiho. Mol Cancer Ther 2014
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Zhewei Zhang, Taija Af Hällström, Henna M Moore, Paul Sirajuddin, Marikki Laiho. Mol Cancer Ther 2014
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Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation.
Swagat Ray, Tatiana Panova, Gail Miller, Arsen Volkov, Andrew C G Porter, Jackie Russell, Konstantin I Panov, Joost C B M Zomerdijk. Nat Commun 2013
Swagat Ray, Tatiana Panova, Gail Miller, Arsen Volkov, Andrew C G Porter, Jackie Russell, Konstantin I Panov, Joost C B M Zomerdijk. Nat Commun 2013
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What the nucleolus says to a tumour pathologist.
Massimo Derenzini, Lorenzo Montanaro, Davide Treré. Histopathology 2009
Massimo Derenzini, Lorenzo Montanaro, Davide Treré. Histopathology 2009
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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.
Carla Grandori, Natividad Gomez-Roman, Zoe A Felton-Edkins, Celine Ngouenet, Denise A Galloway, Robert N Eisenman, Robert J White. Nat Cell Biol 2005
Carla Grandori, Natividad Gomez-Roman, Zoe A Felton-Edkins, Celine Ngouenet, Denise A Galloway, Robert N Eisenman, Robert J White. Nat Cell Biol 2005
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The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers.
Mohammed Ismael, Roger Webb, Mazhar Ajaz, Karen J Kirkby, Helen M Coley. Cancers (Basel) 2019
Mohammed Ismael, Roger Webb, Mazhar Ajaz, Karen J Kirkby, Helen M Coley. Cancers (Basel) 2019
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The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability.
Jean-Clément Mars, Michel G Tremblay, Mélissa Valere, Dany S Sibai, Marianne Sabourin-Felix, Frédéric Lessard, Tom Moss. NAR Cancer 2020
Jean-Clément Mars, Michel G Tremblay, Mélissa Valere, Dany S Sibai, Marianne Sabourin-Felix, Frédéric Lessard, Tom Moss. NAR Cancer 2020
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Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer.
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Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes.
Sarah J Goodfellow, Joost C B M Zomerdijk. Subcell Biochem 2013
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The Ribosome Biogenesis-Cancer Connection.
Marianna Penzo, Lorenzo Montanaro, Davide Treré, Massimo Derenzini. Cells 2019
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p53 and ribosome biogenesis stress: the essentials.
Lior Golomb, Sinisa Volarevic, Moshe Oren. FEBS Lett 2014
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Nucleolar reorganization in response to rDNA damage.
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Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibition.
Yaron Shav-Tal, Janna Blechman, Xavier Darzacq, Cristina Montagna, Billy T Dye, James G Patton, Robert H Singer, Dov Zipori. Mol Biol Cell 2005
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Targeting RNA polymerase I to treat MYC-driven cancer.
G Poortinga, L M Quinn, R D Hannan. Oncogene 2015
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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
Maria Barna, Aya Pusic, Ornella Zollo, Maria Costa, Nadya Kondrashov, Eduardo Rego, Pulivarthi H Rao, Davide Ruggero. Nature 2008
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Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics.
Frédéric Catez, Nicole Dalla Venezia, Virginie Marcel, Christiane Zorbas, Denis L J Lafontaine, Jean-Jacques Diaz. Biochem Pharmacol 2019
Frédéric Catez, Nicole Dalla Venezia, Virginie Marcel, Christiane Zorbas, Denis L J Lafontaine, Jean-Jacques Diaz. Biochem Pharmacol 2019
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A Genetic Map of the Response to DNA Damage in Human Cells.
Michele Olivieri, Tiffany Cho, Alejandro Álvarez-Quilón, Kejiao Li, Matthew J Schellenberg, Michal Zimmermann, Nicole Hustedt, Silvia Emma Rossi, Salomé Adam, Henrique Melo,[...]. Cell 2020
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Prevalence of quadruplexes in the human genome.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.