A citation-based method for searching scientific literature

Denis Drygin, Amy Lin, Josh Bliesath, Caroline B Ho, Sean E O'Brien, Chris Proffitt, Mayuko Omori, Mustapha Haddach, Michael K Schwaebe, Adam Siddiqui-Jain, Nicole Streiner, Jaclyn E Quin, Elaine Sanij, Megan J Bywater, Ross D Hannan, David Ryckman, Kenna Anderes, William G Rice. Cancer Res 2011
Times Cited: 341







List of co-cited articles
995 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J O'Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia,[...]. Nat Commun 2017
236
51

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes,[...]. Cancer Cell 2012
365
47

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Elaine Sanij, John Lim, John Soong, Emma Link, Piers Blombery,[...]. Cancer Discov 2019
65
50

Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis.
Denis Drygin, Adam Siddiqui-Jain, Sean O'Brien, Michael Schwaebe, Amy Lin, Josh Bliesath, Caroline B Ho, Chris Proffitt, Katy Trent, Jeffrey P Whitten,[...]. Cancer Res 2009
348
24

Chemotherapeutic drugs inhibit ribosome biogenesis at various levels.
Kaspar Burger, Bastian Mühl, Thomas Harasim, Michaela Rohrmoser, Anastassia Malamoussi, Mathias Orban, Markus Kellner, Anita Gruber-Eber, Elisabeth Kremmer, Michael Hölzel,[...]. J Biol Chem 2010
262
23

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.
Peter M Bruno, Mengrou Lu, Kady A Dennis, Haider Inam, Connor J Moore, John Sheehe, Stephen J Elledge, Michael T Hemann, Justin R Pritchard. Proc Natl Acad Sci U S A 2020
45
51

Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics.
Mustapha Haddach, Michael K Schwaebe, Jerome Michaux, Johnny Nagasawa, Sean E O'Brien, Jeffrey P Whitten, Fabrice Pierre, Pauline Kerdoncuff, Levan Darjania, Ryan Stansfield,[...]. ACS Med Chem Lett 2012
70
31

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova,[...]. Nat Commun 2020
49
42

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George,[...]. Oncotarget 2016
60
33

Ribosome biogenesis in cancer: new players and therapeutic avenues.
Joffrey Pelletier, George Thomas, Siniša Volarević. Nat Rev Cancer 2018
273
20

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age.
Rita Ferreira, John S Schneekloth, Konstantin I Panov, Katherine M Hannan, Ross D Hannan. Cells 2020
50
38

A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
Karita Peltonen, Laureen Colis, Hester Liu, Rishi Trivedi, Michael S Moubarek, Henna M Moore, Baoyan Bai, Michelle A Rudek, Charles J Bieberich, Marikki Laiho. Cancer Cell 2014
157
18


The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.
Denis Drygin, William G Rice, Ingrid Grummt. Annu Rev Pharmacol Toxicol 2010
290
15

The nucleolus under stress.
Séverine Boulon, Belinda J Westman, Saskia Hutten, François-Michel Boisvert, Angus I Lamond. Mol Cell 2010
629
15

The multifunctional nucleolus.
François-Michel Boisvert, Silvana van Koningsbruggen, Joaquín Navascués, Angus I Lamond. Nat Rev Mol Cell Biol 2007
14


CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma.
Leiming Li, Yan Li, Jiansong Zhao, Shuli Fan, Liguo Wang, Xu Li. Onco Targets Ther 2016
31
45

Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg. Cell 2011
13

The nucleolus: an emerging target for cancer therapy.
Nadine Hein, Katherine M Hannan, Amee J George, Elaine Sanij, Ross D Hannan. Trends Mol Med 2013
145
13

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.
Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga,[...]. Cancer Discov 2016
79
16

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.
Peter M Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E Koch, Timothy J Eisen, Justin R Pritchard, Yves Pommier, Stephen J Lippard, Michael T Hemann. Nat Med 2017
204
13

Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Henna M Moore, Juulia Enbäck, Pirjo Laakkonen, Anne Vaahtokari, Richard J Jones, Taija M af Hällström,[...]. PLoS One 2010
65
18

MYC as a regulator of ribosome biogenesis and protein synthesis.
Jan van Riggelen, Alper Yetil, Dean W Felsher. Nat Rev Cancer 2010
537
12

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch,[...]. Blood 2017
41
29

Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.
Ting Wei, Saman M Najmi, Hester Liu, Karita Peltonen, Alena Kucerova, David A Schneider, Marikki Laiho. Cell Rep 2018
32
37

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis.
Mikael S Lindström, Deana Jurada, Sladana Bursac, Ines Orsolic, Jiri Bartek, Sinisa Volarevic. Oncogene 2018
96
11

Targeting the nucleolus for cancer intervention.
Jaclyn E Quin, Jennifer R Devlin, Donald Cameron, Kate M Hannan, Richard B Pearson, Ross D Hannan. Biochim Biophys Acta 2014
151
11

The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer.
Richard J Rebello, Eric Kusnadi, Donald P Cameron, Helen B Pearson, Analia Lesmana, Jennifer R Devlin, Denis Drygin, Ashlee K Clark, Laura Porter, John Pedersen,[...]. Clin Cancer Res 2016
47
21

Nucleolar Stress: hallmarks, sensing mechanism and diseases.
Kai Yang, Jie Yang, Jing Yi. Cell Stress 2018
72
12

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.
Azadeh Arabi, Siqin Wu, Karin Ridderstråle, Holger Bierhoff, Chiounan Shiue, Karoly Fatyol, Sara Fahlén, Per Hydbring, Ola Söderberg, Ingrid Grummt,[...]. Nat Cell Biol 2005
337
9

Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Zhewei Zhang, Taija Af Hällström, Henna M Moore, Paul Sirajuddin, Marikki Laiho. Mol Cancer Ther 2014
41
21

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation.
Swagat Ray, Tatiana Panova, Gail Miller, Arsen Volkov, Andrew C G Porter, Jackie Russell, Konstantin I Panov, Joost C B M Zomerdijk. Nat Commun 2013
35
25

What the nucleolus says to a tumour pathologist.
Massimo Derenzini, Lorenzo Montanaro, Davide Treré. Histopathology 2009
157
9

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.
Carla Grandori, Natividad Gomez-Roman, Zoe A Felton-Edkins, Celine Ngouenet, Denise A Galloway, Robert N Eisenman, Robert J White. Nat Cell Biol 2005
455
9


Does the ribosome translate cancer?
Davide Ruggero, Pier Paolo Pandolfi. Nat Rev Cancer 2003
723
9

The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability.
Jean-Clément Mars, Michel G Tremblay, Mélissa Valere, Dany S Sibai, Marianne Sabourin-Felix, Frédéric Lessard, Tom Moss. NAR Cancer 2020
14
64

Targeting RNA-Polymerase I in Both Chemosensitive and Chemoresistant Populations in Epithelial Ovarian Cancer.
Robert Cornelison, Zachary C Dobbin, Ashwini A Katre, Dae Hoon Jeong, Yinfeng Zhang, Dongquan Chen, Yuliya Petrova, Danielle C Llaneza, Adam D Steg, Laura Parsons,[...]. Clin Cancer Res 2017
26
30

Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes.
Sarah J Goodfellow, Joost C B M Zomerdijk. Subcell Biochem 2013
90
8

The Ribosome Biogenesis-Cancer Connection.
Marianna Penzo, Lorenzo Montanaro, Davide Treré, Massimo Derenzini. Cells 2019
80
10

p53 and ribosome biogenesis stress: the essentials.
Lior Golomb, Sinisa Volarevic, Moshe Oren. FEBS Lett 2014
144
8

The nucleolus.
Thoru Pederson. Cold Spring Harb Perspect Biol 2011
223
8

Nucleolar reorganization in response to rDNA damage.
Marjolein van Sluis, Brian McStay. Curr Opin Cell Biol 2017
47
17

Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibition.
Yaron Shav-Tal, Janna Blechman, Xavier Darzacq, Cristina Montagna, Billy T Dye, James G Patton, Robert H Singer, Dov Zipori. Mol Biol Cell 2005
241
8

Targeting RNA polymerase I to treat MYC-driven cancer.
G Poortinga, L M Quinn, R D Hannan. Oncogene 2015
59
13

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
Maria Barna, Aya Pusic, Ornella Zollo, Maria Costa, Nadya Kondrashov, Eduardo Rego, Pulivarthi H Rao, Davide Ruggero. Nature 2008
291
8

Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics.
Frédéric Catez, Nicole Dalla Venezia, Virginie Marcel, Christiane Zorbas, Denis L J Lafontaine, Jean-Jacques Diaz. Biochem Pharmacol 2019
61
13

A Genetic Map of the Response to DNA Damage in Human Cells.
Michele Olivieri, Tiffany Cho, Alejandro Álvarez-Quilón, Kejiao Li, Matthew J Schellenberg, Michal Zimmermann, Nicole Hustedt, Silvia Emma Rossi, Salomé Adam, Henrique Melo,[...]. Cell 2020
123
8

Prevalence of quadruplexes in the human genome.
Julian L Huppert, Shankar Balasubramanian. Nucleic Acids Res 2005
8


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.