Ulziibat Shirendeb, Arubala P Reddy, Maria Manczak, Marcus J Calkins, Peizhong Mao, Danilo A Tagle, P Hemachandra Reddy. Hum Mol Genet 2011
Times Cited: 251
Times Cited: 251
Times Cited
Times Co-cited
Similarity
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.
Wenjun Song, Jin Chen, Alejandra Petrilli, Geraldine Liot, Eva Klinglmayr, Yue Zhou, Patrick Poquiz, Jonathan Tjong, Mahmoud A Pouladi, Michael R Hayden,[...]. Nat Med 2011
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44
Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.
Ulziibat P Shirendeb, Marcus J Calkins, Maria Manczak, Vishwanath Anekonda, Brett Dufour, Jodi L McBride, Peizhong Mao, P Hemachandra Reddy. Hum Mol Genet 2012
Ulziibat P Shirendeb, Marcus J Calkins, Maria Manczak, Vishwanath Anekonda, Brett Dufour, Jodi L McBride, Peizhong Mao, P Hemachandra Reddy. Hum Mol Genet 2012
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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease.
Jinho Kim, Jennifer P Moody, Christina K Edgerly, Olivia L Bordiuk, Kerry Cormier, Karen Smith, M Flint Beal, Robert J Ferrante. Hum Mol Genet 2010
Jinho Kim, Jennifer P Moody, Christina K Edgerly, Olivia L Bordiuk, Kerry Cormier, Karen Smith, M Flint Beal, Robert J Ferrante. Hum Mol Genet 2010
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N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
Adam L Orr, Shihua Li, Chuan-En Wang, He Li, Jianjun Wang, Juan Rong, Xingshun Xu, Pier Giorgio Mastroberardino, J Timothy Greenamyre, Xiao-Jiang Li. J Neurosci 2008
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Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release.
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Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli.
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Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.
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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
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Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Maria Manczak, Marcus J Calkins, P Hemachandra Reddy. Hum Mol Genet 2011
Maria Manczak, Marcus J Calkins, P Hemachandra Reddy. Hum Mol Genet 2011
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Mitochondrial defect in Huntington's disease caudate nucleus.
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Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons.
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Huntington's disease: from molecular pathogenesis to clinical treatment.
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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
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Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.
Xing Guo, Marie-Helene Disatnik, Marie Monbureau, Mehrdad Shamloo, Daria Mochly-Rosen, Xin Qi. J Clin Invest 2013
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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.
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Inhibition of mitochondrial protein import by mutant huntingtin.
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The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
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PINK1-induced mitophagy promotes neuroprotection in Huntington's disease.
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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
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VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Xing Guo, XiaoYan Sun, Di Hu, Ya-Juan Wang, Hisashi Fujioka, Rajan Vyas, Sudha Chakrapani, Amit Umesh Joshi, Yu Luo, Daria Mochly-Rosen,[...]. Nat Commun 2016
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Huntington disease.
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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
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Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.
P Hemachandra Reddy, Tejaswini P Reddy, Maria Manczak, Marcus J Calkins, Ulziibat Shirendeb, Peizhong Mao. Brain Res Rev 2011
P Hemachandra Reddy, Tejaswini P Reddy, Maria Manczak, Marcus J Calkins, Ulziibat Shirendeb, Peizhong Mao. Brain Res Rev 2011
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Proteomic and oxidative stress analysis in human brain samples of Huntington disease.
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Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.
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Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Marcus J Calkins, Maria Manczak, Peizhong Mao, Ulziibat Shirendeb, P Hemachandra Reddy. Hum Mol Genet 2011
Marcus J Calkins, Maria Manczak, Peizhong Mao, Ulziibat Shirendeb, P Hemachandra Reddy. Hum Mol Genet 2011
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
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Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.
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HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.
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Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage.
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Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.
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Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy.
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Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
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Huntingtin functions as a scaffold for selective macroautophagy.
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Potential function for the Huntingtin protein as a scaffold for selective autophagy.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.