Yali Hou, George E Liu, Derek M Bickhart, Maria Francesca Cardone, Kai Wang, Eui-Soo Kim, Lakshmi K Matukumalli, Mario Ventura, Jiuzhou Song, Paul M VanRaden, Tad S Sonstegard, Curt P Van Tassell. BMC Genomics 2011
Times Cited: 144
Times Cited: 144
Times Cited
Times Co-cited
Similarity
Analysis of copy number variations among diverse cattle breeds.
George E Liu, Yali Hou, Bin Zhu, Maria Francesca Cardone, Lu Jiang, Angelo Cellamare, Apratim Mitra, Leeson J Alexander, Luiz L Coutinho, Maria Elena Dell'Aquila,[...]. Genome Res 2010
George E Liu, Yali Hou, Bin Zhu, Maria Francesca Cardone, Lu Jiang, Angelo Cellamare, Apratim Mitra, Leeson J Alexander, Luiz L Coutinho, Maria Elena Dell'Aquila,[...]. Genome Res 2010
59
Copy number variation of individual cattle genomes using next-generation sequencing.
Derek M Bickhart, Yali Hou, Steven G Schroeder, Can Alkan, Maria Francesca Cardone, Lakshmi K Matukumalli, Jiuzhou Song, Robert D Schnabel, Mario Ventura, Jeremy F Taylor,[...]. Genome Res 2012
Derek M Bickhart, Yali Hou, Steven G Schroeder, Can Alkan, Maria Francesca Cardone, Lakshmi K Matukumalli, Jiuzhou Song, Robert D Schnabel, Mario Ventura, Jeremy F Taylor,[...]. Genome Res 2012
53
Global variation in copy number in the human genome.
Richard Redon, Shumpei Ishikawa, Karen R Fitch, Lars Feuk, George H Perry, T Daniel Andrews, Heike Fiegler, Michael H Shapero, Andrew R Carson, Wenwei Chen,[...]. Nature 2006
Richard Redon, Shumpei Ishikawa, Karen R Fitch, Lars Feuk, George H Perry, T Daniel Andrews, Heike Fiegler, Michael H Shapero, Andrew R Carson, Wenwei Chen,[...]. Nature 2006
51
Copy number variation in the bovine genome.
João Fadista, Bo Thomsen, Lars-Erik Holm, Christian Bendixen. BMC Genomics 2010
João Fadista, Bo Thomsen, Lars-Erik Holm, Christian Bendixen. BMC Genomics 2010
41
PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data.
Kai Wang, Mingyao Li, Dexter Hadley, Rui Liu, Joseph Glessner, Struan F A Grant, Hakon Hakonarson, Maja Bucan. Genome Res 2007
Kai Wang, Mingyao Li, Dexter Hadley, Rui Liu, Joseph Glessner, Struan F A Grant, Hakon Hakonarson, Maja Bucan. Genome Res 2007
39
Identification of copy number variations and common deletion polymorphisms in cattle.
Joon Seol Bae, Hyun Sub Cheong, Lyoung Hyo Kim, Suk NamGung, Tae Joon Park, Ji-Yong Chun, Jason Yongha Kim, Charisse Flerida A Pasaje, Jin Sol Lee, Hyoung Doo Shin. BMC Genomics 2010
Joon Seol Bae, Hyun Sub Cheong, Lyoung Hyo Kim, Suk NamGung, Tae Joon Park, Ji-Yong Chun, Jason Yongha Kim, Charisse Flerida A Pasaje, Jin Sol Lee, Hyoung Doo Shin. BMC Genomics 2010
36
Genome-wide detection of copy number variations using high-density SNP genotyping platforms in Holsteins.
Li Jiang, Jicai Jiang, Jie Yang, Xuan Liu, Jiying Wang, Haifei Wang, Xiangdong Ding, Jianfeng Liu, Qin Zhang. BMC Genomics 2013
Li Jiang, Jicai Jiang, Jie Yang, Xuan Liu, Jiying Wang, Haifei Wang, Xiangdong Ding, Jianfeng Liu, Qin Zhang. BMC Genomics 2013
59
Structural variation in the human genome.
Lars Feuk, Andrew R Carson, Stephen W Scherer. Nat Rev Genet 2006
Lars Feuk, Andrew R Carson, Stephen W Scherer. Nat Rev Genet 2006
33
Whole genome resequencing of black Angus and Holstein cattle for SNP and CNV discovery.
Paul Stothard, Jung-Woo Choi, Urmila Basu, Jennifer M Sumner-Thomson, Yan Meng, Xiaoping Liao, Stephen S Moore. BMC Genomics 2011
Paul Stothard, Jung-Woo Choi, Urmila Basu, Jennifer M Sumner-Thomson, Yan Meng, Xiaoping Liao, Stephen S Moore. BMC Genomics 2011
31
Origins and functional impact of copy number variation in the human genome.
Donald F Conrad, Dalila Pinto, Richard Redon, Lars Feuk, Omer Gokcumen, Yujun Zhang, Jan Aerts, T Daniel Andrews, Chris Barnes, Peter Campbell,[...]. Nature 2010
Donald F Conrad, Dalila Pinto, Richard Redon, Lars Feuk, Omer Gokcumen, Yujun Zhang, Jan Aerts, T Daniel Andrews, Chris Barnes, Peter Campbell,[...]. Nature 2010
31
Fine mapping of copy number variations on two cattle genome assemblies using high density SNP array.
Yali Hou, Derek M Bickhart, Miranda L Hvinden, Congjun Li, Jiuzhou Song, Didier A Boichard, Sébastien Fritz, André Eggen, Sue DeNise, George R Wiggans,[...]. BMC Genomics 2012
Yali Hou, Derek M Bickhart, Miranda L Hvinden, Congjun Li, Jiuzhou Song, Didier A Boichard, Sébastien Fritz, André Eggen, Sue DeNise, George R Wiggans,[...]. BMC Genomics 2012
51
Analysis of copy number variations in the sheep genome using 50K SNP BeadChip array.
Jiasen Liu, Li Zhang, Lingyang Xu, Hangxing Ren, Jian Lu, Xiaoning Zhang, Shifang Zhang, Xinlei Zhou, Caihong Wei, Fuping Zhao,[...]. BMC Genomics 2013
Jiasen Liu, Li Zhang, Lingyang Xu, Hangxing Ren, Jian Lu, Xiaoning Zhang, Shifang Zhang, Xinlei Zhou, Caihong Wei, Fuping Zhao,[...]. BMC Genomics 2013
54
Copy number variation in human health, disease, and evolution.
Feng Zhang, Wenli Gu, Matthew E Hurles, James R Lupski. Annu Rev Genomics Hum Genet 2009
Feng Zhang, Wenli Gu, Matthew E Hurles, James R Lupski. Annu Rev Genomics Hum Genet 2009
30
Genomic regions showing copy number variations associate with resistance or susceptibility to gastrointestinal nematodes in Angus cattle.
Yali Hou, George E Liu, Derek M Bickhart, Lakshmi K Matukumalli, Congjun Li, Jiuzhou Song, Louis C Gasbarre, Curtis P Van Tassell, Tad S Sonstegard. Funct Integr Genomics 2012
Yali Hou, George E Liu, Derek M Bickhart, Lakshmi K Matukumalli, Congjun Li, Jiuzhou Song, Louis C Gasbarre, Curtis P Van Tassell, Tad S Sonstegard. Funct Integr Genomics 2012
43
Mapping copy number variation by population-scale genome sequencing.
Ryan E Mills, Klaudia Walter, Chip Stewart, Robert E Handsaker, Ken Chen, Can Alkan, Alexej Abyzov, Seungtai Chris Yoon, Kai Ye, R Keira Cheetham,[...]. Nature 2011
Ryan E Mills, Klaudia Walter, Chip Stewart, Robert E Handsaker, Ken Chen, Can Alkan, Alexej Abyzov, Seungtai Chris Yoon, Kai Ye, R Keira Cheetham,[...]. Nature 2011
28
A comprehensive survey of copy number variation in 18 diverse pig populations and identification of candidate copy number variable genes associated with complex traits.
Congying Chen, Ruimin Qiao, Rongxing Wei, Yuanmei Guo, Huashui Ai, Junwu Ma, Jun Ren, Lusheng Huang. BMC Genomics 2012
Congying Chen, Ruimin Qiao, Rongxing Wei, Yuanmei Guo, Huashui Ai, Junwu Ma, Jun Ren, Lusheng Huang. BMC Genomics 2012
40
An initial comparative map of copy number variations in the goat (Capra hircus) genome.
Luca Fontanesi, Pier Luigi Martelli, Francesca Beretti, Valentina Riggio, Stefania Dall'Olio, Michela Colombo, Rita Casadio, Vincenzo Russo, Baldassare Portolano. BMC Genomics 2010
Luca Fontanesi, Pier Luigi Martelli, Francesca Beretti, Valentina Riggio, Stefania Dall'Olio, Michela Colombo, Rita Casadio, Vincenzo Russo, Baldassare Portolano. BMC Genomics 2010
29
A first comparative map of copy number variations in the sheep genome.
L Fontanesi, F Beretti, P L Martelli, M Colombo, S Dall'olio, M Occidente, B Portolano, R Casadio, D Matassino, V Russo. Genomics 2011
L Fontanesi, F Beretti, P L Martelli, M Colombo, S Dall'olio, M Occidente, B Portolano, R Casadio, D Matassino, V Russo. Genomics 2011
37
Genome-wide identification of copy number variations in Chinese Holstein.
Li Jiang, Jicai Jiang, Jiying Wang, Xiangdong Ding, Jianfeng Liu, Qin Zhang. PLoS One 2012
Li Jiang, Jicai Jiang, Jiying Wang, Xiangdong Ding, Jianfeng Liu, Qin Zhang. PLoS One 2012
66
A snapshot of CNVs in the pig genome.
João Fadista, Marianne Nygaard, Lars-Erik Holm, Bo Thomsen, Christian Bendixen. PLoS One 2008
João Fadista, Marianne Nygaard, Lars-Erik Holm, Bo Thomsen, Christian Bendixen. PLoS One 2008
25
Genome structural variation discovery and genotyping.
Can Alkan, Bradley P Coe, Evan E Eichler. Nat Rev Genet 2011
Can Alkan, Bradley P Coe, Evan E Eichler. Nat Rev Genet 2011
23
Genome wide CNV analysis reveals additional variants associated with milk production traits in Holsteins.
Lingyang Xu, John B Cole, Derek M Bickhart, Yali Hou, Jiuzhou Song, Paul M VanRaden, Tad S Sonstegard, Curtis P Van Tassell, George E Liu. BMC Genomics 2014
Lingyang Xu, John B Cole, Derek M Bickhart, Yali Hou, Jiuzhou Song, Paul M VanRaden, Tad S Sonstegard, Curtis P Van Tassell, George E Liu. BMC Genomics 2014
43
Evolutionary dynamics of copy number variation in pig genomes in the context of adaptation and domestication.
Yogesh Paudel, Ole Madsen, Hendrik-Jan Megens, Laurent A F Frantz, Mirte Bosse, John W M Bastiaansen, Richard P M A Crooijmans, Martien A M Groenen. BMC Genomics 2013
Yogesh Paudel, Ole Madsen, Hendrik-Jan Megens, Laurent A F Frantz, Mirte Bosse, John W M Bastiaansen, Richard P M A Crooijmans, Martien A M Groenen. BMC Genomics 2013
25
Analysis of copy loss and gain variations in Holstein cattle autosomes using BeadChip SNPs.
Eyal Seroussi, Giora Glick, Andrey Shirak, Emanuel Yakobson, Joel I Weller, Ephraim Ezra, Yoel Zeron. BMC Genomics 2010
Eyal Seroussi, Giora Glick, Andrey Shirak, Emanuel Yakobson, Joel I Weller, Ephraim Ezra, Yoel Zeron. BMC Genomics 2010
40
Large-scale copy number polymorphism in the human genome.
Jonathan Sebat, B Lakshmi, Jennifer Troge, Joan Alexander, Janet Young, Pär Lundin, Susanne Månér, Hillary Massa, Megan Walker, Maoyen Chi,[...]. Science 2004
Jonathan Sebat, B Lakshmi, Jennifer Troge, Joan Alexander, Janet Young, Pär Lundin, Susanne Månér, Hillary Massa, Megan Walker, Maoyen Chi,[...]. Science 2004
22
Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens.
Dominic Wright, Henrik Boije, Jennifer R S Meadows, Bertrand Bed'hom, David Gourichon, Agathe Vieaud, Michèle Tixier-Boichard, Carl-Johan Rubin, Freyja Imsland, Finn Hallböök,[...]. PLoS Genet 2009
Dominic Wright, Henrik Boije, Jennifer R S Meadows, Bertrand Bed'hom, David Gourichon, Agathe Vieaud, Michèle Tixier-Boichard, Carl-Johan Rubin, Freyja Imsland, Finn Hallböök,[...]. PLoS Genet 2009
21
A genome-wide detection of copy number variations using SNP genotyping arrays in swine.
Jiying Wang, Jicai Jiang, Weixuan Fu, Li Jiang, Xiangdong Ding, Jian-Feng Liu, Qin Zhang. BMC Genomics 2012
Jiying Wang, Jicai Jiang, Weixuan Fu, Li Jiang, Xiangdong Ding, Jian-Feng Liu, Qin Zhang. BMC Genomics 2012
29
Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants.
Dalila Pinto, Katayoon Darvishi, Xinghua Shi, Diana Rajan, Diane Rigler, Tom Fitzgerald, Anath C Lionel, Bhooma Thiruvahindrapuram, Jeffrey R Macdonald, Ryan Mills,[...]. Nat Biotechnol 2011
Dalila Pinto, Katayoon Darvishi, Xinghua Shi, Diana Rajan, Diane Rigler, Tom Fitzgerald, Anath C Lionel, Bhooma Thiruvahindrapuram, Jeffrey R Macdonald, Ryan Mills,[...]. Nat Biotechnol 2011
20
Global assessment of genomic variation in cattle by genome resequencing and high-throughput genotyping.
Bujie Zhan, João Fadista, Bo Thomsen, Jakob Hedegaard, Frank Panitz, Christian Bendixen. BMC Genomics 2011
Bujie Zhan, João Fadista, Bo Thomsen, Jakob Hedegaard, Frank Panitz, Christian Bendixen. BMC Genomics 2011
35
Copy number variation in the porcine genome inferred from a 60 k SNP BeadChip.
Yuliaxis Ramayo-Caldas, Anna Castelló, Romi N Pena, Estefania Alves, Anna Mercadé, Carla A Souza, Ana I Fernández, Miguel Perez-Enciso, Josep M Folch. BMC Genomics 2010
Yuliaxis Ramayo-Caldas, Anna Castelló, Romi N Pena, Estefania Alves, Anna Mercadé, Carla A Souza, Ana I Fernández, Miguel Perez-Enciso, Josep M Folch. BMC Genomics 2010
23
Relative impact of nucleotide and copy number variation on gene expression phenotypes.
Barbara E Stranger, Matthew S Forrest, Mark Dunning, Catherine E Ingle, Claude Beazley, Natalie Thorne, Richard Redon, Christine P Bird, Anna de Grassi, Charles Lee,[...]. Science 2007
Barbara E Stranger, Matthew S Forrest, Mark Dunning, Catherine E Ingle, Claude Beazley, Natalie Thorne, Richard Redon, Christine P Bird, Anna de Grassi, Charles Lee,[...]. Science 2007
19
Detection of copy number variations and their effects in Chinese bulls.
Liangzhi Zhang, Shangang Jia, Mingjuan Yang, Yao Xu, Congjun Li, Jiajie Sun, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Yang Zhou,[...]. BMC Genomics 2014
Liangzhi Zhang, Shangang Jia, Mingjuan Yang, Yao Xu, Congjun Li, Jiajie Sun, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Yang Zhou,[...]. BMC Genomics 2014
54
Massive screening of copy number population-scale variation in Bos taurus genome.
Francesco Cicconardi, Giovanni Chillemi, Anna Tramontano, Cinzia Marchitelli, Alessio Valentini, Paolo Ajmone-Marsan, Alessandro Nardone. BMC Genomics 2013
Francesco Cicconardi, Giovanni Chillemi, Anna Tramontano, Cinzia Marchitelli, Alessio Valentini, Paolo Ajmone-Marsan, Alessandro Nardone. BMC Genomics 2013
60
A whole-genome assembly of the domestic cow, Bos taurus.
Aleksey V Zimin, Arthur L Delcher, Liliana Florea, David R Kelley, Michael C Schatz, Daniela Puiu, Finnian Hanrahan, Geo Pertea, Curtis P Van Tassell, Tad S Sonstegard,[...]. Genome Biol 2009
Aleksey V Zimin, Arthur L Delcher, Liliana Florea, David R Kelley, Michael C Schatz, Daniela Puiu, Finnian Hanrahan, Geo Pertea, Curtis P Van Tassell, Tad S Sonstegard,[...]. Genome Biol 2009
18
Fast and accurate short read alignment with Burrows-Wheeler transform.
Heng Li, Richard Durbin. Bioinformatics 2009
Heng Li, Richard Durbin. Bioinformatics 2009
18
Comparing CNV detection methods for SNP arrays.
Laura Winchester, Christopher Yau, Jiannis Ragoussis. Brief Funct Genomic Proteomic 2009
Laura Winchester, Christopher Yau, Jiannis Ragoussis. Brief Funct Genomic Proteomic 2009
16
Copy number variation in the genomes of domestic animals.
A Clop, O Vidal, M Amills. Anim Genet 2012
A Clop, O Vidal, M Amills. Anim Genet 2012
20
Genome-wide copy number variation in Hanwoo, Black Angus, and Holstein cattle.
Jung-Woo Choi, Kyung-Tai Lee, Xiaoping Liao, Paul Stothard, Hyeon-Seung An, Sungmin Ahn, Seunghwan Lee, Sung-Yeoun Lee, Stephen S Moore, Tae-Hun Kim. Mamm Genome 2013
Jung-Woo Choi, Kyung-Tai Lee, Xiaoping Liao, Paul Stothard, Hyeon-Seung An, Sungmin Ahn, Seunghwan Lee, Sung-Yeoun Lee, Stephen S Moore, Tae-Hun Kim. Mamm Genome 2013
55
Copy number variation: new insights in genome diversity.
Jennifer L Freeman, George H Perry, Lars Feuk, Richard Redon, Steven A McCarroll, David M Altshuler, Hiroyuki Aburatani, Keith W Jones, Chris Tyler-Smith, Matthew E Hurles,[...]. Genome Res 2006
Jennifer L Freeman, George H Perry, Lars Feuk, Richard Redon, Steven A McCarroll, David M Altshuler, Hiroyuki Aburatani, Keith W Jones, Chris Tyler-Smith, Matthew E Hurles,[...]. Genome Res 2006
15
Development and characterization of a high density SNP genotyping assay for cattle.
Lakshmi K Matukumalli, Cynthia T Lawley, Robert D Schnabel, Jeremy F Taylor, Mark F Allan, Michael P Heaton, Jeff O'Connell, Stephen S Moore, Timothy P L Smith, Tad S Sonstegard,[...]. PLoS One 2009
Lakshmi K Matukumalli, Cynthia T Lawley, Robert D Schnabel, Jeremy F Taylor, Mark F Allan, Michael P Heaton, Jeff O'Connell, Stephen S Moore, Timothy P L Smith, Tad S Sonstegard,[...]. PLoS One 2009
15
Novel origins of copy number variation in the dog genome.
Jonas Berglund, Elisa M Nevalainen, Anna-Maja Molin, Michele Perloski, Catherine André, Michael C Zody, Ted Sharpe, Christophe Hitte, Kerstin Lindblad-Toh, Hannes Lohi,[...]. Genome Biol 2012
Jonas Berglund, Elisa M Nevalainen, Anna-Maja Molin, Michele Perloski, Catherine André, Michael C Zody, Ted Sharpe, Christophe Hitte, Kerstin Lindblad-Toh, Hannes Lohi,[...]. Genome Biol 2012
27
Population-genetic properties of differentiated copy number variations in cattle.
Lingyang Xu, Yali Hou, Derek M Bickhart, Yang Zhou, El Hamidi Abdel Hay, Jiuzhou Song, Tad S Sonstegard, Curtis P Van Tassell, George E Liu. Sci Rep 2016
Lingyang Xu, Yali Hou, Derek M Bickhart, Yang Zhou, El Hamidi Abdel Hay, Jiuzhou Song, Tad S Sonstegard, Curtis P Van Tassell, George E Liu. Sci Rep 2016
34
Detection of large-scale variation in the human genome.
A John Iafrate, Lars Feuk, Miguel N Rivera, Marc L Listewnik, Patricia K Donahoe, Ying Qi, Stephen W Scherer, Charles Lee. Nat Genet 2004
A John Iafrate, Lars Feuk, Miguel N Rivera, Marc L Listewnik, Patricia K Donahoe, Ying Qi, Stephen W Scherer, Charles Lee. Nat Genet 2004
14
A high-resolution map of segmental DNA copy number variation in the mouse genome.
Timothy A Graubert, Patrick Cahan, Deepa Edwin, Rebecca R Selzer, Todd A Richmond, Peggy S Eis, William D Shannon, Xia Li, Howard L McLeod, James M Cheverud,[...]. PLoS Genet 2007
Timothy A Graubert, Patrick Cahan, Deepa Edwin, Rebecca R Selzer, Todd A Richmond, Peggy S Eis, William D Shannon, Xia Li, Howard L McLeod, James M Cheverud,[...]. PLoS Genet 2007
14
CNVnator: an approach to discover, genotype, and characterize typical and atypical CNVs from family and population genome sequencing.
Alexej Abyzov, Alexander E Urban, Michael Snyder, Mark Gerstein. Genome Res 2011
Alexej Abyzov, Alexander E Urban, Michael Snyder, Mark Gerstein. Genome Res 2011
14
Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms.
Sharon J Diskin, Mingyao Li, Cuiping Hou, Shuzhang Yang, Joseph Glessner, Hakon Hakonarson, Maja Bucan, John M Maris, Kai Wang. Nucleic Acids Res 2008
Sharon J Diskin, Mingyao Li, Cuiping Hou, Shuzhang Yang, Joseph Glessner, Hakon Hakonarson, Maja Bucan, John M Maris, Kai Wang. Nucleic Acids Res 2008
14
Distribution and functional impact of DNA copy number variation in the rat.
Victor Guryev, Kathrin Saar, Tatjana Adamovic, Mark Verheul, Sebastiaan A A C van Heesch, Stuart Cook, Michal Pravenec, Timothy Aitman, Howard Jacob, James D Shull,[...]. Nat Genet 2008
Victor Guryev, Kathrin Saar, Tatjana Adamovic, Mark Verheul, Sebastiaan A A C van Heesch, Stuart Cook, Michal Pravenec, Timothy Aitman, Howard Jacob, James D Shull,[...]. Nat Genet 2008
14
Copy number variation and missense mutations of the agouti signaling protein (ASIP) gene in goat breeds with different coat colors.
L Fontanesi, F Beretti, V Riggio, E Gómez González, S Dall'Olio, R Davoli, V Russo, B Portolano. Cytogenet Genome Res 2009
L Fontanesi, F Beretti, V Riggio, E Gómez González, S Dall'Olio, R Davoli, V Russo, B Portolano. Cytogenet Genome Res 2009
15
Comparative Analysis of CNV Calling Algorithms: Literature Survey and a Case Study Using Bovine High-Density SNP Data.
Lingyang Xu, Yali Hou, Derek M Bickhart, Jiuzhou Song, George E Liu. Microarrays (Basel) 2013
Lingyang Xu, Yali Hou, Derek M Bickhart, Jiuzhou Song, George E Liu. Microarrays (Basel) 2013
46
Analysis of recent segmental duplications in the bovine genome.
George E Liu, Mario Ventura, Angelo Cellamare, Lin Chen, Ze Cheng, Bin Zhu, Congjun Li, Jiuzhou Song, Evan E Eichler. BMC Genomics 2009
George E Liu, Mario Ventura, Angelo Cellamare, Lin Chen, Ze Cheng, Bin Zhu, Congjun Li, Jiuzhou Song, Evan E Eichler. BMC Genomics 2009
19
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.