Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, Daming Gao, Alan Tseng, Richard S Maser, Bo Zhai, Lixin Wan, Alejandro Gutierrez, Alan W Lau, Yonghong Xiao, Amanda L Christie, Jon Aster, Jeffrey Settleman, Steven P Gygi, Andrew L Kung, Thomas Look, Keiichi I Nakayama, Ronald A DePinho, Wenyi Wei. Nature 2011
Times Cited: 474
Times Cited: 474
Times Cited
Times Co-cited
Similarity
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.
Ingrid E Wertz, Saritha Kusam, Cynthia Lam, Toru Okamoto, Wendy Sandoval, Daniel J Anderson, Elizabeth Helgason, James A Ernst, Mike Eby, Jinfeng Liu,[...]. Nature 2011
Ingrid E Wertz, Saritha Kusam, Cynthia Lam, Toru Okamoto, Wendy Sandoval, Daniel J Anderson, Elizabeth Helgason, James A Ernst, Mike Eby, Jinfeng Liu,[...]. Nature 2011
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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.
Qing Zhong, Wenhua Gao, Fenghe Du, Xiaodong Wang. Cell 2005
Qing Zhong, Wenhua Gao, Fenghe Du, Xiaodong Wang. Cell 2005
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Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.
Qingqing Ding, Xianghuo He, Jung-Mao Hsu, Weiya Xia, Chun-Te Chen, Long-Yuan Li, Dung-Fang Lee, Jaw-Ching Liu, Qing Zhong, Xiaodong Wang,[...]. Mol Cell Biol 2007
Qingqing Ding, Xianghuo He, Jung-Mao Hsu, Weiya Xia, Chun-Te Chen, Long-Yuan Li, Dung-Fang Lee, Jaw-Ching Liu, Qing Zhong, Xiaodong Wang,[...]. Mol Cell Biol 2007
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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
Markus Welcker, Bruce E Clurman. Nat Rev Cancer 2008
Markus Welcker, Bruce E Clurman. Nat Rev Cancer 2008
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Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.
Ryan J Davis, Markus Welcker, Bruce E Clurman. Cancer Cell 2014
Ryan J Davis, Markus Welcker, Bruce E Clurman. Cancer Cell 2014
18
FBXW7: a critical tumor suppressor of human cancers.
Chien-Hung Yeh, Marcia Bellon, Christophe Nicot. Mol Cancer 2018
Chien-Hung Yeh, Marcia Bellon, Christophe Nicot. Mol Cancer 2018
16
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
Masayoshi Yada, Shigetsugu Hatakeyama, Takumi Kamura, Masaaki Nishiyama, Ryosuke Tsunematsu, Hiroyuki Imaki, Noriko Ishida, Fumihiko Okumura, Keiko Nakayama, Keiichi I Nakayama. EMBO J 2004
Masayoshi Yada, Shigetsugu Hatakeyama, Takumi Kamura, Masaaki Nishiyama, Ryosuke Tsunematsu, Hiroyuki Imaki, Noriko Ishida, Fumihiko Okumura, Keiko Nakayama, Keiichi I Nakayama. EMBO J 2004
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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
Martin Schwickart, Xiaodong Huang, Jennie R Lill, Jinfeng Liu, Ronald Ferrando, Dorothy M French, Heather Maecker, Karen O'Rourke, Fernando Bazan, Jeffrey Eastham-Anderson,[...]. Nature 2010
Martin Schwickart, Xiaodong Huang, Jennie R Lill, Jinfeng Liu, Ronald Ferrando, Dorothy M French, Heather Maecker, Karen O'Rourke, Fernando Bazan, Jeffrey Eastham-Anderson,[...]. Nature 2010
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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.
Markus Welcker, Amir Orian, Jianping Jin, Jonathan E Grim, J Wade Harper, Robert N Eisenman, Bruce E Clurman. Proc Natl Acad Sci U S A 2004
Markus Welcker, Amir Orian, Jianping Jin, Jonathan E Grim, J Wade Harper, Robert N Eisenman, Bruce E Clurman. Proc Natl Acad Sci U S A 2004
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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
András Kotschy, Zoltán Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaëtane Le Toumelin-Braizat, Maïa Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled,[...]. Nature 2016
András Kotschy, Zoltán Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaëtane Le Toumelin-Braizat, Maïa Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled,[...]. Nature 2016
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Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.
M M Magiera, S Mora, B Mojsa, I Robbins, I Lassot, S Desagher. Cell Death Differ 2013
M M Magiera, S Mora, B Mojsa, I Robbins, I Lassot, S Desagher. Cell Death Differ 2013
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FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
J Tong, S Tan, F Zou, J Yu, L Zhang. Oncogene 2017
J Tong, S Tan, F Zou, J Yu, L Zhang. Oncogene 2017
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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
D M Koepp, L K Schaefer, X Ye, K Keyomarsi, C Chu, J W Harper, S J Elledge. Science 2001
D M Koepp, L K Schaefer, X Ye, K Keyomarsi, C Chu, J W Harper, S J Elledge. Science 2001
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Mcl-1 ubiquitination: unique regulation of an essential survival protein.
Barbara Mojsa, Iréna Lassot, Solange Desagher. Cells 2014
Barbara Mojsa, Iréna Lassot, Solange Desagher. Cells 2014
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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.
Ulrich Maurer, Céline Charvet, Allan S Wagman, Emmanuel Dejardin, Douglas R Green. Mol Cell 2006
Ulrich Maurer, Céline Charvet, Allan S Wagman, Emmanuel Dejardin, Douglas R Green. Mol Cell 2006
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Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors.
Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di, Guanglei Zhuang. Nat Commun 2018
Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di, Guanglei Zhuang. Nat Commun 2018
19
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.
Margaret E Harley, Lindsey A Allan, Helen S Sanderson, Paul R Clarke. EMBO J 2010
Margaret E Harley, Lindsey A Allan, Helen S Sanderson, Paul R Clarke. EMBO J 2010
12
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.
Wenyi Wei, Jianping Jin, Susanne Schlisio, J Wade Harper, William G Kaelin. Cancer Cell 2005
Wenyi Wei, Jianping Jin, Susanne Schlisio, J Wade Harper, William G Kaelin. Cancer Cell 2005
12
FBXW7/hCDC4 is a general tumor suppressor in human cancer.
Shahab Akhoondi, Dahui Sun, Natalie von der Lehr, Sophia Apostolidou, Kathleen Klotz, Alena Maljukova, Diana Cepeda, Heidi Fiegl, Dimitra Dafou, Christian Marth,[...]. Cancer Res 2007
Shahab Akhoondi, Dahui Sun, Natalie von der Lehr, Sophia Apostolidou, Kathleen Klotz, Alena Maljukova, Diana Cepeda, Heidi Fiegl, Dimitra Dafou, Christian Marth,[...]. Cancer Res 2007
12
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.
Bing Hao, Stephanie Oehlmann, Mathew E Sowa, J Wade Harper, Nikola P Pavletich. Mol Cell 2007
Bing Hao, Stephanie Oehlmann, Mathew E Sowa, J Wade Harper, Nikola P Pavletich. Mol Cell 2007
11
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Jian-Hua Mao, Il-Jin Kim, Di Wu, Joan Climent, Hio Chung Kang, Reyno DelRosario, Allan Balmain. Science 2008
Jian-Hua Mao, Il-Jin Kim, Di Wu, Joan Climent, Hio Chung Kang, Reyno DelRosario, Allan Balmain. Science 2008
11
The landscape of somatic copy-number alteration across human cancers.
Rameen Beroukhim, Craig H Mermel, Dale Porter, Guo Wei, Soumya Raychaudhuri, Jerry Donovan, Jordi Barretina, Jesse S Boehm, Jennifer Dobson, Mitsuyoshi Urashima,[...]. Nature 2010
Rameen Beroukhim, Craig H Mermel, Dale Porter, Guo Wei, Soumya Raychaudhuri, Jerry Donovan, Jordi Barretina, Jesse S Boehm, Jennifer Dobson, Mitsuyoshi Urashima,[...]. Nature 2010
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Roles of F-box proteins in cancer.
Zhiwei Wang, Pengda Liu, Hiroyuki Inuzuka, Wenyi Wei. Nat Rev Cancer 2014
Zhiwei Wang, Pengda Liu, Hiroyuki Inuzuka, Wenyi Wei. Nat Rev Cancer 2014
10
Systematic analysis and nomenclature of mammalian F-box proteins.
Jianping Jin, Timothy Cardozo, Ruth C Lovering, Stephen J Elledge, Michele Pagano, J Wade Harper. Genes Dev 2004
Jianping Jin, Timothy Cardozo, Ruth C Lovering, Stephen J Elledge, Michele Pagano, J Wade Harper. Genes Dev 2004
10
Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.
Sang-Hyun Min, Alan W Lau, Tae Ho Lee, Hiroyuki Inuzuka, Shuo Wei, Pengyu Huang, Shavali Shaik, Daniel Yenhong Lee, Greg Finn, Martin Balastik,[...]. Mol Cell 2012
Sang-Hyun Min, Alan W Lau, Tae Ho Lee, Hiroyuki Inuzuka, Shuo Wei, Pengyu Huang, Shavali Shaik, Daniel Yenhong Lee, Greg Finn, Martin Balastik,[...]. Mol Cell 2012
10
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.
Simon N Willis, Lin Chen, Grant Dewson, Andrew Wei, Edwina Naik, Jamie I Fletcher, Jerry M Adams, David C S Huang. Genes Dev 2005
Simon N Willis, Lin Chen, Grant Dewson, Andrew Wei, Edwina Naik, Jamie I Fletcher, Jerry M Adams, David C S Huang. Genes Dev 2005
10
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Sean Caenepeel, Sean P Brown, Brian Belmontes, Gordon Moody, Kathleen S Keegan, Danny Chui, Douglas A Whittington, Xin Huang, Leszek Poppe, Alan C Cheng,[...]. Cancer Discov 2018
Sean Caenepeel, Sean P Brown, Brian Belmontes, Gordon Moody, Kathleen S Keegan, Danny Chui, Douglas A Whittington, Xin Huang, Leszek Poppe, Alan C Cheng,[...]. Cancer Discov 2018
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Mcl-1; the molecular regulation of protein function.
Luke W Thomas, Connie Lam, Steven W Edwards. FEBS Lett 2010
Luke W Thomas, Connie Lam, Steven W Edwards. FEBS Lett 2010
9
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia.
Benjamin J Thompson, Silvia Buonamici, Maria Luisa Sulis, Teresa Palomero, Tomas Vilimas, Giuseppe Basso, Adolfo Ferrando, Iannis Aifantis. J Exp Med 2007
Benjamin J Thompson, Silvia Buonamici, Maria Luisa Sulis, Teresa Palomero, Tomas Vilimas, Giuseppe Basso, Adolfo Ferrando, Iannis Aifantis. J Exp Med 2007
9
Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells.
Jingshan Tong, Peng Wang, Shuai Tan, Dongshi Chen, Zaneta Nikolovska-Coleska, Fangdong Zou, Jian Yu, Lin Zhang. Cancer Res 2017
Jingshan Tong, Peng Wang, Shuai Tan, Dongshi Chen, Zaneta Nikolovska-Coleska, Fangdong Zou, Jian Yu, Lin Zhang. Cancer Res 2017
9
Targeting FBW7 as a Strategy to Overcome Resistance to Targeted Therapy in Non-Small Cell Lung Cancer.
Mingxiang Ye, Yong Zhang, Xinxin Zhang, Jianbin Zhang, Pengyu Jing, Liang Cao, Nan Li, Xia Li, Libo Yao, Jian Zhang,[...]. Cancer Res 2017
Mingxiang Ye, Yong Zhang, Xinxin Zhang, Jianbin Zhang, Pengyu Jing, Liang Cao, Nan Li, Xia Li, Libo Yao, Jian Zhang,[...]. Cancer Res 2017
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Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.
Ichiro Onoyama, Ryosuke Tsunematsu, Akinobu Matsumoto, Taichi Kimura, Ignacio Moreno de Alborán, Keiko Nakayama, Keiichi I Nakayama. J Exp Med 2007
Ichiro Onoyama, Ryosuke Tsunematsu, Akinobu Matsumoto, Taichi Kimura, Ignacio Moreno de Alborán, Keiko Nakayama, Keiichi I Nakayama. J Exp Med 2007
9
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.
Jian-Hua Mao, Jesus Perez-Losada, Di Wu, Reyno Delrosario, Ryosuke Tsunematsu, Keiichi I Nakayama, Ken Brown, Sheila Bryson, Allan Balmain. Nature 2004
Jian-Hua Mao, Jesus Perez-Losada, Di Wu, Reyno Delrosario, Ryosuke Tsunematsu, Keiichi I Nakayama, Ken Brown, Sheila Bryson, Allan Balmain. Nature 2004
9
Inactivation of hCDC4 can cause chromosomal instability.
Harith Rajagopalan, Prasad V Jallepalli, Carlo Rago, Victor E Velculescu, Kenneth W Kinzler, Bert Vogelstein, Christoph Lengauer. Nature 2004
Harith Rajagopalan, Prasad V Jallepalli, Carlo Rago, Victor E Velculescu, Kenneth W Kinzler, Bert Vogelstein, Christoph Lengauer. Nature 2004
9
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
Jennifer O'Neil, Jonathan Grim, Peter Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James Hardwick, Markus Welcker, Jules P Meijerink, Rob Pieters,[...]. J Exp Med 2007
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MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
K M Kozopas, T Yang, H L Buchan, P Zhou, R W Craig. Proc Natl Acad Sci U S A 1993
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9
MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.
Xiaowei Wu, Qingyu Luo, Pengfei Zhao, Wan Chang, Yating Wang, Tong Shu, Fang Ding, Bin Li, Zhihua Liu. Proc Natl Acad Sci U S A 2019
Xiaowei Wu, Qingyu Luo, Pengfei Zhao, Wan Chang, Yating Wang, Tong Shu, Fang Ding, Bin Li, Zhihua Liu. Proc Natl Acad Sci U S A 2019
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Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Adriana E Tron, Matthew A Belmonte, Ammar Adam, Brian M Aquila, Lawrence H Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J Embrey, Eric Gangl, Francis D Gibbons,[...]. Nat Commun 2018
Adriana E Tron, Matthew A Belmonte, Ammar Adam, Brian M Aquila, Lawrence H Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J Embrey, Eric Gangl, Francis D Gibbons,[...]. Nat Commun 2018
9
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation.
Deepak Nijhawan, Min Fang, Elie Traer, Qing Zhong, Wenhua Gao, Fenghe Du, Xiaodong Wang. Genes Dev 2003
Deepak Nijhawan, Min Fang, Elie Traer, Qing Zhong, Wenhua Gao, Fenghe Du, Xiaodong Wang. Genes Dev 2003
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The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.
Abdolrahman S Nateri, Lluís Riera-Sans, Clive Da Costa, Axel Behrens. Science 2004
Abdolrahman S Nateri, Lluís Riera-Sans, Clive Da Costa, Axel Behrens. Science 2004
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Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1.
Richard G Carroll, Emilie Hollville, Seamus J Martin. Cell Rep 2014
Richard G Carroll, Emilie Hollville, Seamus J Martin. Cell Rep 2014
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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.
H Strohmaier, C H Spruck, P Kaiser, K A Won, O Sangfelt, S I Reed. Nature 2001
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FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4.
Kuppusamy Balamurugan, Shikha Sharan, Kimberly D Klarmann, Youhong Zhang, Vincenzo Coppola, Glenn H Summers, Thierry Roger, Deborah K Morrison, Jonathan R Keller, Esta Sterneck. Nat Commun 2013
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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Peter E Czabotar, Guillaume Lessene, Andreas Strasser, Jerry M Adams. Nat Rev Mol Cell Biol 2014
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BCL-2 family proteins: changing partners in the dance towards death.
Justin Kale, Elizabeth J Osterlund, David W Andrews. Cell Death Differ 2018
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Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia.
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Fbw7 dimerization determines the specificity and robustness of substrate degradation.
Markus Welcker, Elizabeth A Larimore, Jherek Swanger, Maria T Bengoechea-Alonso, Jonathan E Grim, Johan Ericsson, Ning Zheng, Bruce E Clurman. Genes Dev 2013
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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.
Michael Certo, Victoria Del Gaizo Moore, Mari Nishino, Guo Wei, Stanley Korsmeyer, Scott A Armstrong, Anthony Letai. Cancer Cell 2006
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7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.