A Supersaxo, W R Hein, H Steffen. Pharm Res 1990
Times Cited: 233
Times Cited: 233
Times Cited
Times Co-cited
Similarity
Mechanistic determinants of biotherapeutics absorption following SC administration.
Wolfgang F Richter, Suraj G Bhansali, Marilyn E Morris. AAPS J 2012
Wolfgang F Richter, Suraj G Bhansali, Marilyn E Morris. AAPS J 2012
34
Subcutaneous drug delivery and the role of the lymphatics.
Danielle N McLennan, Christopher J H Porter, Susan A Charman. Drug Discov Today Technol 2005
Danielle N McLennan, Christopher J H Porter, Susan A Charman. Drug Discov Today Technol 2005
22
From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity.
Natalie L Trevaskis, Lisa M Kaminskas, Christopher J H Porter. Nat Rev Drug Discov 2015
Natalie L Trevaskis, Lisa M Kaminskas, Christopher J H Porter. Nat Rev Drug Discov 2015
22
Lymphatic transport and catabolism of therapeutic proteins after subcutaneous administration to rats and dogs.
Weirong Wang, Nancy Chen, Xiaolan Shen, Paul Cunningham, Scott Fauty, Kimberly Michel, Bo Wang, Xuening Hong, Christine Adreani, Christian N Nunes,[...]. Drug Metab Dispos 2012
Weirong Wang, Nancy Chen, Xiaolan Shen, Paul Cunningham, Scott Fauty, Kimberly Michel, Bo Wang, Xuening Hong, Christine Adreani, Christian N Nunes,[...]. Drug Metab Dispos 2012
35
Subcutaneous absorption of biotherapeutics: knowns and unknowns.
Wolfgang F Richter, Björn Jacobsen. Drug Metab Dispos 2014
Wolfgang F Richter, Björn Jacobsen. Drug Metab Dispos 2014
18
Lymphatic transport of proteins after subcutaneous administration.
C J Porter, S A Charman. J Pharm Sci 2000
C J Porter, S A Charman. J Pharm Sci 2000
17
Lymphatic uptake and biodistribution of liposomes after subcutaneous injection. II. Influence of liposomal size, lipid compostion and lipid dose.
C Oussoren, J Zuidema, D J Crommelin, G Storm. Biochim Biophys Acta 1997
C Oussoren, J Zuidema, D J Crommelin, G Storm. Biochim Biophys Acta 1997
16
Exploiting lymphatic transport and complement activation in nanoparticle vaccines.
Sai T Reddy, André J van der Vlies, Eleonora Simeoni, Veronique Angeli, Gwendalyn J Randolph, Conlin P O'Neil, Leslie K Lee, Melody A Swartz, Jeffrey A Hubbell. Nat Biotechnol 2007
Sai T Reddy, André J van der Vlies, Eleonora Simeoni, Veronique Angeli, Gwendalyn J Randolph, Conlin P O'Neil, Leslie K Lee, Melody A Swartz, Jeffrey A Hubbell. Nat Biotechnol 2007
16
The lymphatic system plays a major role in the intravenous and subcutaneous pharmacokinetics of trastuzumab in rats.
Annette M Dahlberg, Lisa M Kaminskas, Alanna Smith, Joseph A Nicolazzo, Christopher J H Porter, Jürgen B Bulitta, Michelle P McIntosh. Mol Pharm 2014
Annette M Dahlberg, Lisa M Kaminskas, Alanna Smith, Joseph A Nicolazzo, Christopher J H Porter, Jürgen B Bulitta, Michelle P McIntosh. Mol Pharm 2014
37
Nano-chemotherapeutics: maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers.
Gemma M Ryan, Lisa M Kaminskas, Christopher J H Porter. J Control Release 2014
Gemma M Ryan, Lisa M Kaminskas, Christopher J H Porter. J Control Release 2014
19
Lymphatic absorption of subcutaneously administered proteins: influence of different injection sites on the absorption of darbepoetin alfa using a sheep model.
Jagannath Kota, Krishna K Machavaram, Danielle N McLennan, Glenn A Edwards, Christopher J H Porter, Susan A Charman. Drug Metab Dispos 2007
Jagannath Kota, Krishna K Machavaram, Danielle N McLennan, Glenn A Edwards, Christopher J H Porter, Susan A Charman. Drug Metab Dispos 2007
24
Lymphatic absorption is the primary contributor to the systemic availability of epoetin Alfa following subcutaneous administration to sheep.
Danielle N McLennan, Christopher J H Porter, Glenn A Edwards, Steven W Martin, Anne C Heatherington, Susan A Charman. J Pharmacol Exp Ther 2005
Danielle N McLennan, Christopher J H Porter, Glenn A Edwards, Steven W Martin, Anne C Heatherington, Susan A Charman. J Pharmacol Exp Ther 2005
27
The antibody drug absorption following subcutaneous or intramuscular administration and its mathematical description by coupling physiologically based absorption process with the conventional compartment pharmacokinetic model.
Liang Zhao, Ping Ji, Zhihong Li, Partha Roy, Chandrahas G Sahajwalla. J Clin Pharmacol 2013
Liang Zhao, Ping Ji, Zhihong Li, Partha Roy, Chandrahas G Sahajwalla. J Clin Pharmacol 2013
21
Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.
Yanan Zheng, Devin B Tesar, Lisa Benincosa, Herbert Birnböck, C Andrew Boswell, Daniela Bumbaca, Kyra J Cowan, Dimitry M Danilenko, Ann L Daugherty, Paul J Fielder,[...]. MAbs 2012
Yanan Zheng, Devin B Tesar, Lisa Benincosa, Herbert Birnböck, C Andrew Boswell, Daniela Bumbaca, Kyra J Cowan, Dimitry M Danilenko, Ann L Daugherty, Paul J Fielder,[...]. MAbs 2012
16
Subcutaneous administration of biotherapeutics: current experience in animal models.
Thomas A McDonald, Monica L Zepeda, Michael J Tomlinson, Walter H Bee, Inge A Ivens. Curr Opin Mol Ther 2010
Thomas A McDonald, Monica L Zepeda, Michael J Tomlinson, Walter H Bee, Inge A Ivens. Curr Opin Mol Ther 2010
15
Lymphatic transport of proteins after s.c. injection: implications of animal model selection.
C J Porter, G A Edwards, S A Charman. Adv Drug Deliv Rev 2001
C J Porter, G A Edwards, S A Charman. Adv Drug Deliv Rev 2001
14
PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats.
Lisa M Kaminskas, Jagannath Kota, Victoria M McLeod, Brian D Kelly, Peter Karellas, Christopher Jh Porter. J Control Release 2009
Lisa M Kaminskas, Jagannath Kota, Victoria M McLeod, Brian D Kelly, Peter Karellas, Christopher Jh Porter. J Control Release 2009
11
Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site.
Hanne M Kinnunen, Randall J Mrsny. J Control Release 2014
Hanne M Kinnunen, Randall J Mrsny. J Control Release 2014
16
Subcutaneous bioavailability of golimumab at 3 different injection sites in healthy subjects.
Zhenhua Xu, Qingmin Wang, Yanli Zhuang, Bart Frederick, Hong Yan, Esther Bouman-Thio, Joseph C Marini, Monica Keen, David Snead, Hugh M Davis,[...]. J Clin Pharmacol 2010
Zhenhua Xu, Qingmin Wang, Yanli Zhuang, Bart Frederick, Hong Yan, Esther Bouman-Thio, Joseph C Marini, Monica Keen, David Snead, Hugh M Davis,[...]. J Clin Pharmacol 2010
14
Pharmacokinetic modeling of the subcutaneous absorption of therapeutic proteins.
Leonid Kagan. Drug Metab Dispos 2014
Leonid Kagan. Drug Metab Dispos 2014
29
Lymphatic absorption is a significant contributor to the subcutaneous bioavailability of insulin in a sheep model.
S A Charman, D N McLennan, G A Edwards, C J Porter. Pharm Res 2001
S A Charman, D N McLennan, G A Edwards, C J Porter. Pharm Res 2001
20
Monoclonal antibody pharmacokinetics and pharmacodynamics.
W Wang, E Q Wang, J P Balthasar. Clin Pharmacol Ther 2008
W Wang, E Q Wang, J P Balthasar. Clin Pharmacol Ther 2008
10
Recombinant human hyaluronidase (rHuPH20): an enabling platform for subcutaneous drug and fluid administration.
Gregory I Frost. Expert Opin Drug Deliv 2007
Gregory I Frost. Expert Opin Drug Deliv 2007
10
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity.
Geoffrey M Lynn, Richard Laga, Patricia A Darrah, Andrew S Ishizuka, Alexandra J Balaci, Andrés E Dulcey, Michal Pechar, Robert Pola, Michael Y Gerner, Ayako Yamamoto,[...]. Nat Biotechnol 2015
Geoffrey M Lynn, Richard Laga, Patricia A Darrah, Andrew S Ishizuka, Alexandra J Balaci, Andrés E Dulcey, Michal Pechar, Robert Pola, Michael Y Gerner, Ayako Yamamoto,[...]. Nat Biotechnol 2015
10
Fluorescence imaging of the lymph node uptake of proteins in mice after subcutaneous injection: molecular weight dependence.
Fang Wu, Suraj G Bhansali, Wing Cheung Law, Earl J Bergey, Paras N Prasad, Marilyn E Morris. Pharm Res 2012
Fang Wu, Suraj G Bhansali, Wing Cheung Law, Earl J Bergey, Paras N Prasad, Marilyn E Morris. Pharm Res 2012
31
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer.
Helge Wiig, Melody A Swartz. Physiol Rev 2012
Helge Wiig, Melody A Swartz. Physiol Rev 2012
10
The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep.
Danielle N McLennan, Christopher J H Porter, Glenn A Edwards, Anne C Heatherington, Steven W Martin, Susan A Charman. Pharm Res 2006
Danielle N McLennan, Christopher J H Porter, Glenn A Edwards, Anne C Heatherington, Steven W Martin, Susan A Charman. Pharm Res 2006
31
Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability.
Hemant Sarin. J Angiogenes Res 2010
Hemant Sarin. J Angiogenes Res 2010
9
Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice.
Rong Deng, Y Gloria Meng, Kwame Hoyte, Jeff Lutman, Yanmei Lu, Suhasini Iyer, Laura E DeForge, Frank-Peter Theil, Paul J Fielder, Saileta Prabhu. MAbs 2012
Rong Deng, Y Gloria Meng, Kwame Hoyte, Jeff Lutman, Yanmei Lu, Suhasini Iyer, Laura E DeForge, Frank-Peter Theil, Paul J Fielder, Saileta Prabhu. MAbs 2012
16
Biodegradable PLGA based nanoparticles for sustained regional lymphatic drug delivery.
Deepa A Rao, M Laird Forrest, Adam W G Alani, Glen S Kwon, Joseph R Robinson. J Pharm Sci 2010
Deepa A Rao, M Laird Forrest, Adam W G Alani, Glen S Kwon, Joseph R Robinson. J Pharm Sci 2010
9
Nanoparticles target distinct dendritic cell populations according to their size.
Vania Manolova, Anna Flace, Monika Bauer, Katrin Schwarz, Philippe Saudan, Martin F Bachmann. Eur J Immunol 2008
Vania Manolova, Anna Flace, Monika Bauer, Katrin Schwarz, Philippe Saudan, Martin F Bachmann. Eur J Immunol 2008
9
A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins.
Katherine L Gill, Iain Gardner, Linzhong Li, Masoud Jamei. AAPS J 2016
Katherine L Gill, Iain Gardner, Linzhong Li, Masoud Jamei. AAPS J 2016
21
Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities.
Beate Bittner, Wolfgang Richter, Johannes Schmidt. BioDrugs 2018
Beate Bittner, Wolfgang Richter, Johannes Schmidt. BioDrugs 2018
9
Designer vaccine nanodiscs for personalized cancer immunotherapy.
Rui Kuai, Lukasz J Ochyl, Keith S Bahjat, Anna Schwendeman, James J Moon. Nat Mater 2017
Rui Kuai, Lukasz J Ochyl, Keith S Bahjat, Anna Schwendeman, James J Moon. Nat Mater 2017
9
Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase.
O Shpilberg, C Jackisch. Br J Cancer 2013
O Shpilberg, C Jackisch. Br J Cancer 2013
10
Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges.
Yulia Vugmeyster, Xin Xu, Frank-Peter Theil, Leslie A Khawli, Michael W Leach. World J Biol Chem 2012
Yulia Vugmeyster, Xin Xu, Frank-Peter Theil, Leslie A Khawli, Michael W Leach. World J Biol Chem 2012
8
Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human.
Dhaval K Shah, Alison M Betts. J Pharmacokinet Pharmacodyn 2012
Dhaval K Shah, Alison M Betts. J Pharmacokinet Pharmacodyn 2012
8
Mechanisms of subcutaneous absorption of rituximab in rats.
Leonid Kagan, Donald E Mager. Drug Metab Dispos 2013
Leonid Kagan, Donald E Mager. Drug Metab Dispos 2013
24
Clinical pharmacokinetics of therapeutic monoclonal antibodies.
Ron J Keizer, Alwin D R Huitema, Jan H M Schellens, Jos H Beijnen. Clin Pharmacokinet 2010
Ron J Keizer, Alwin D R Huitema, Jan H M Schellens, Jos H Beijnen. Clin Pharmacokinet 2010
8
The effect of subcutaneous injection site on absorption of human growth hormone: abdomen versus thigh.
S A Beshyah, V Anyaoku, R Niththyananthan, P Sharp, D G Johnston. Clin Endocrinol (Oxf) 1991
S A Beshyah, V Anyaoku, R Niththyananthan, P Sharp, D G Johnston. Clin Endocrinol (Oxf) 1991
18
In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles.
Sai T Reddy, Annemie Rehor, Hugo G Schmoekel, Jeffrey A Hubbell, Melody A Swartz. J Control Release 2006
Sai T Reddy, Annemie Rehor, Hugo G Schmoekel, Jeffrey A Hubbell, Melody A Swartz. J Control Release 2006
8
Subcutaneous delivery of monoclonal antibodies: How do we get there?
Margarida Viola, Joana Sequeira, Raquel Seiça, Francisco Veiga, João Serra, Ana C Santos, António J Ribeiro. J Control Release 2018
Margarida Viola, Joana Sequeira, Raquel Seiça, Francisco Veiga, João Serra, Ana C Santos, António J Ribeiro. J Control Release 2018
12
Material design for lymph node drug delivery.
Alex Schudel, David M Francis, Susan N Thomas. Nat Rev Mater 2019
Alex Schudel, David M Francis, Susan N Thomas. Nat Rev Mater 2019
8
Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection.
S A Charman, A M Segrave, G A Edwards, C J Porter. J Pharm Sci 2000
S A Charman, A M Segrave, G A Edwards, C J Porter. J Pharm Sci 2000
11
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns.
Martin F Bachmann, Gary T Jennings. Nat Rev Immunol 2010
Martin F Bachmann, Gary T Jennings. Nat Rev Immunol 2010
7
Liposomes to target the lymphatics by subcutaneous administration.
C Oussoren, G Storm. Adv Drug Deliv Rev 2001
C Oussoren, G Storm. Adv Drug Deliv Rev 2001
7
PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin.
Gemma M Ryan, Lisa M Kaminskas, Jürgen B Bulitta, Michelle P McIntosh, David J Owen, Christopher J H Porter. J Control Release 2013
Gemma M Ryan, Lisa M Kaminskas, Jürgen B Bulitta, Michelle P McIntosh, David J Owen, Christopher J H Porter. J Control Release 2013
14
Pharmacokinetic model to describe the lymphatic absorption of r-metHu-leptin after subcutaneous injection to sheep.
Danielle N McLennan, Christopher J H Porter, Glenn A Edwards, Maria Brumm, Steven W Martin, Susan A Charman. Pharm Res 2003
Danielle N McLennan, Christopher J H Porter, Glenn A Edwards, Maria Brumm, Steven W Martin, Susan A Charman. Pharm Res 2003
21
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.