Gareth R Howell, Danilo G Macalinao, Gregory L Sousa, Michael Walden, Ileana Soto, Stephen C Kneeland, Jessica M Barbay, Benjamin L King, Jeffrey K Marchant, Matthew Hibbs, Beth Stevens, Ben A Barres, Abbot F Clark, Richard T Libby, Simon W M John. J Clin Invest 2011
Times Cited: 280
Times Cited: 280
Times Cited
Times Co-cited
Similarity
The classical complement cascade mediates CNS synapse elimination.
Beth Stevens, Nicola J Allen, Luis E Vazquez, Gareth R Howell, Karen S Christopherson, Navid Nouri, Kristina D Micheva, Adrienne K Mehalow, Andrew D Huberman, Benjamin Stafford,[...]. Cell 2007
Beth Stevens, Nicola J Allen, Luis E Vazquez, Gareth R Howell, Karen S Christopherson, Navid Nouri, Kristina D Micheva, Adrienne K Mehalow, Andrew D Huberman, Benjamin Stafford,[...]. Cell 2007
30
Neurotoxic reactive astrocytes are induced by activated microglia.
Shane A Liddelow, Kevin A Guttenplan, Laura E Clarke, Frederick C Bennett, Christopher J Bohlen, Lucas Schirmer, Mariko L Bennett, Alexandra E Münch, Won-Suk Chung, Todd C Peterson,[...]. Nature 2017
Shane A Liddelow, Kevin A Guttenplan, Laura E Clarke, Frederick C Bennett, Christopher J Bohlen, Lucas Schirmer, Mariko L Bennett, Alexandra E Münch, Won-Suk Chung, Todd C Peterson,[...]. Nature 2017
28
Early microglia activation in a mouse model of chronic glaucoma.
Alejandra Bosco, Michael R Steele, Monica L Vetter. J Comp Neurol 2011
Alejandra Bosco, Michael R Steele, Monica L Vetter. J Comp Neurol 2011
28
Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.
Gareth R Howell, Ileana Soto, Xianjun Zhu, Margaret Ryan, Danilo G Macalinao, Gregory L Sousa, Lura B Caddle, Katharine H MacNicoll, Jessica M Barbay, Vittorio Porciatti,[...]. J Clin Invest 2012
Gareth R Howell, Ileana Soto, Xianjun Zhu, Margaret Ryan, Danilo G Macalinao, Gregory L Sousa, Lura B Caddle, Katharine H MacNicoll, Jessica M Barbay, Vittorio Porciatti,[...]. J Clin Invest 2012
26
Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma.
Gareth R Howell, Katharine H MacNicoll, Catherine E Braine, Ileana Soto, Danilo G Macalinao, Gregory L Sousa, Simon W M John. Neurobiol Dis 2014
Gareth R Howell, Katharine H MacNicoll, Catherine E Braine, Ileana Soto, Danilo G Macalinao, Gregory L Sousa, Simon W M John. Neurobiol Dis 2014
40
The number of people with glaucoma worldwide in 2010 and 2020.
H A Quigley, A T Broman. Br J Ophthalmol 2006
H A Quigley, A T Broman. Br J Ophthalmol 2006
25
Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.
Jeffrey M Harder, Catherine E Braine, Pete A Williams, Xianjun Zhu, Katharine H MacNicoll, Gregory L Sousa, Rebecca A Buchanan, Richard S Smith, Richard T Libby, Gareth R Howell,[...]. Proc Natl Acad Sci U S A 2017
Jeffrey M Harder, Catherine E Braine, Pete A Williams, Xianjun Zhu, Katharine H MacNicoll, Gregory L Sousa, Rebecca A Buchanan, Richard S Smith, Richard T Libby, Gareth R Howell,[...]. Proc Natl Acad Sci U S A 2017
42
Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.
Pete A Williams, James R Tribble, Keating W Pepper, Stephen D Cross, B Paul Morgan, James E Morgan, Simon W M John, Gareth R Howell. Mol Neurodegener 2016
Pete A Williams, James R Tribble, Keating W Pepper, Stephen D Cross, B Paul Morgan, James E Morgan, Simon W M John, Gareth R Howell. Mol Neurodegener 2016
25
Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis.
Yih-Chung Tham, Xiang Li, Tien Y Wong, Harry A Quigley, Tin Aung, Ching-Yu Cheng. Ophthalmology 2014
Yih-Chung Tham, Xiang Li, Tien Y Wong, Harry A Quigley, Tin Aung, Ching-Yu Cheng. Ophthalmology 2014
23
Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling.
Cheng Luo, Xiangjun Yang, Angela D Kain, David W Powell, Markus H Kuehn, Gülgün Tezel. Invest Ophthalmol Vis Sci 2010
Cheng Luo, Xiangjun Yang, Angela D Kain, David W Powell, Markus H Kuehn, Gülgün Tezel. Invest Ophthalmol Vis Sci 2010
21
Oxidative stress and the regulation of complement activation in human glaucoma.
Gülgün Tezel, Xiangjun Yang, Cheng Luo, Angela D Kain, David W Powell, Markus H Kuehn, Henry J Kaplan. Invest Ophthalmol Vis Sci 2010
Gülgün Tezel, Xiangjun Yang, Cheng Luo, Angela D Kain, David W Powell, Markus H Kuehn, Henry J Kaplan. Invest Ophthalmol Vis Sci 2010
21
Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.
Alejandra Bosco, Sarah R Anderson, Kevin T Breen, Cesar O Romero, Michael R Steele, Vince A Chiodo, Sanford L Boye, William W Hauswirth, Stephen Tomlinson, Monica L Vetter. Mol Ther 2018
Alejandra Bosco, Sarah R Anderson, Kevin T Breen, Cesar O Romero, Michael R Steele, Vince A Chiodo, Sanford L Boye, William W Hauswirth, Stephen Tomlinson, Monica L Vetter. Mol Ther 2018
52
Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.
Pete A Williams, Jeffrey M Harder, Nicole E Foxworth, Kelly E Cochran, Vivek M Philip, Vittorio Porciatti, Oliver Smithies, Simon W M John. Science 2017
Pete A Williams, Jeffrey M Harder, Nicole E Foxworth, Kelly E Cochran, Vivek M Philip, Vittorio Porciatti, Oliver Smithies, Simon W M John. Science 2017
21
Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma.
Alejandra Bosco, Denise M Inman, Michael R Steele, Guangming Wu, Ileana Soto, Nicholas Marsh-Armstrong, Walter C Hubbard, David J Calkins, Philip J Horner, Monica L Vetter. Invest Ophthalmol Vis Sci 2008
Alejandra Bosco, Denise M Inman, Michael R Steele, Guangming Wu, Ileana Soto, Nicholas Marsh-Armstrong, Walter C Hubbard, David J Calkins, Philip J Horner, Monica L Vetter. Invest Ophthalmol Vis Sci 2008
20
The complex role of neuroinflammation in glaucoma.
Ileana Soto, Gareth R Howell. Cold Spring Harb Perspect Med 2014
Ileana Soto, Gareth R Howell. Cold Spring Harb Perspect Med 2014
20
Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma.
A H Neufeld. Arch Ophthalmol 1999
A H Neufeld. Arch Ophthalmol 1999
19
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.
Dorothy P Schafer, Emily K Lehrman, Amanda G Kautzman, Ryuta Koyama, Alan R Mardinly, Ryo Yamasaki, Richard M Ransohoff, Michael E Greenberg, Ben A Barres, Beth Stevens. Neuron 2012
Dorothy P Schafer, Emily K Lehrman, Amanda G Kautzman, Ryuta Koyama, Alan R Mardinly, Ryo Yamasaki, Richard M Ransohoff, Michael E Greenberg, Ben A Barres, Beth Stevens. Neuron 2012
19
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.
Gareth R Howell, Richard T Libby, Tatjana C Jakobs, Richard S Smith, F Campbell Phalan, Joseph W Barter, Jessica M Barbay, Jeffrey K Marchant, Nagaraju Mahesh, Vittorio Porciatti,[...]. J Cell Biol 2007
Gareth R Howell, Richard T Libby, Tatjana C Jakobs, Richard S Smith, F Campbell Phalan, Joseph W Barter, Jessica M Barbay, Jeffrey K Marchant, Nagaraju Mahesh, Vittorio Porciatti,[...]. J Cell Biol 2007
19
Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma.
Toru Nakazawa, Chifuyu Nakazawa, Akihisa Matsubara, Kousuke Noda, Toshio Hisatomi, Haicheng She, Norman Michaud, Ali Hafezi-Moghadam, Joan W Miller, Larry I Benowitz. J Neurosci 2006
Toru Nakazawa, Chifuyu Nakazawa, Akihisa Matsubara, Kousuke Noda, Toshio Hisatomi, Haicheng She, Norman Michaud, Ali Hafezi-Moghadam, Joan W Miller, Larry I Benowitz. J Neurosci 2006
18
Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.
Gareth R Howell, Ileana Soto, Margaret Ryan, Leah C Graham, Richard S Smith, Simon W M John. J Neuroinflammation 2013
Gareth R Howell, Ileana Soto, Margaret Ryan, Leah C Graham, Richard S Smith, Simon W M John. J Neuroinflammation 2013
30
Activated microglia in the human glaucomatous optic nerve head.
L Yuan, A H Neufeld. J Neurosci Res 2001
L Yuan, A H Neufeld. J Neurosci Res 2001
18
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John. PLoS Genet 2005
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John. PLoS Genet 2005
17
Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina.
Xiangjun Yang, Cheng Luo, Jian Cai, David W Powell, Dahai Yu, Markus H Kuehn, Gülgün Tezel. Invest Ophthalmol Vis Sci 2011
Xiangjun Yang, Cheng Luo, Jian Cai, David W Powell, Dahai Yu, Markus H Kuehn, Gülgün Tezel. Invest Ophthalmol Vis Sci 2011
16
Retinal synthesis and deposition of complement components induced by ocular hypertension.
Markus H Kuehn, Chan Y Kim, Jelena Ostojic, Micheal Bellin, Wallace L M Alward, Edwin M Stone, Donald S Sakaguchi, Sinisa D Grozdanic, Young H Kwon. Exp Eye Res 2006
Markus H Kuehn, Chan Y Kim, Jelena Ostojic, Micheal Bellin, Wallace L M Alward, Edwin M Stone, Donald S Sakaguchi, Sinisa D Grozdanic, Young H Kwon. Exp Eye Res 2006
16
Neuroinflammation in glaucoma: A new opportunity.
Pete A Williams, Nick Marsh-Armstrong, Gareth R Howell. Exp Eye Res 2017
Pete A Williams, Nick Marsh-Armstrong, Gareth R Howell. Exp Eye Res 2017
16
Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.
Pete A Williams, Catherine E Braine, Krishnakumar Kizhatil, Nicole E Foxworth, Nicholas G Tolman, Jeffrey M Harder, Rebecca A Scott, Gregory L Sousa, Alyssa Panitch, Gareth R Howell,[...]. Mol Neurodegener 2019
Pete A Williams, Catherine E Braine, Krishnakumar Kizhatil, Nicole E Foxworth, Nicholas G Tolman, Jeffrey M Harder, Rebecca A Scott, Gregory L Sousa, Alyssa Panitch, Gareth R Howell,[...]. Mol Neurodegener 2019
57
Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury.
Andreas Ebneter, Robert J Casson, John P M Wood, Glyn Chidlow. Invest Ophthalmol Vis Sci 2010
Andreas Ebneter, Robert J Casson, John P M Wood, Glyn Chidlow. Invest Ophthalmol Vis Sci 2010
14
Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma.
Alejandra Bosco, Cesar O Romero, Kevin T Breen, Alexis A Chagovetz, Michael R Steele, Balamurali K Ambati, Monica L Vetter. Dis Model Mech 2015
Alejandra Bosco, Cesar O Romero, Kevin T Breen, Alexis A Chagovetz, Michael R Steele, Balamurali K Ambati, Monica L Vetter. Dis Model Mech 2015
18
TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes.
G Tezel, L Y Li, R V Patil, M B Wax. Invest Ophthalmol Vis Sci 2001
G Tezel, L Y Li, R V Patil, M B Wax. Invest Ophthalmol Vis Sci 2001
14
Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma.
Michael R Steele, Denise M Inman, David J Calkins, Philip J Horner, Monica L Vetter. Invest Ophthalmol Vis Sci 2006
Michael R Steele, Denise M Inman, David J Calkins, Philip J Horner, Monica L Vetter. Invest Ophthalmol Vis Sci 2006
14
Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes.
Kalliopi Stasi, Dalia Nagel, Xiaoyan Yang, Rong-Fang Wang, Lizhen Ren, Steven M Podos, Thom Mittag, John Danias. Invest Ophthalmol Vis Sci 2006
Kalliopi Stasi, Dalia Nagel, Xiaoyan Yang, Rong-Fang Wang, Lizhen Ren, Steven M Podos, Thom Mittag, John Danias. Invest Ophthalmol Vis Sci 2006
14
Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.
Richard T Libby, Michael G Anderson, Iok-Hou Pang, Zachary H Robinson, Olga V Savinova, I Mihai Cosma, Amy Snow, Lawriston A Wilson, Richard S Smith, Abbot F Clark,[...]. Vis Neurosci 2005
Richard T Libby, Michael G Anderson, Iok-Hou Pang, Zachary H Robinson, Olga V Savinova, I Mihai Cosma, Amy Snow, Lawriston A Wilson, Richard S Smith, Abbot F Clark,[...]. Vis Neurosci 2005
14
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
Soyon Hong, Victoria F Beja-Glasser, Bianca M Nfonoyim, Arnaud Frouin, Shaomin Li, Saranya Ramakrishnan, Katherine M Merry, Qiaoqiao Shi, Arnon Rosenthal, Ben A Barres,[...]. Science 2016
Soyon Hong, Victoria F Beja-Glasser, Bianca M Nfonoyim, Arnaud Frouin, Shaomin Li, Saranya Ramakrishnan, Katherine M Merry, Qiaoqiao Shi, Arnon Rosenthal, Ben A Barres,[...]. Science 2016
14
Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data.
Gareth R Howell, David O Walton, Benjamin L King, Richard T Libby, Simon W M John. BMC Genomics 2011
Gareth R Howell, David O Walton, Benjamin L King, Richard T Libby, Simon W M John. BMC Genomics 2011
39
Early reduction of microglia activation by irradiation in a model of chronic glaucoma.
Alejandra Bosco, Samuel D Crish, Michael R Steele, Cesar O Romero, Denise M Inman, Philip J Horner, David J Calkins, Monica L Vetter. PLoS One 2012
Alejandra Bosco, Samuel D Crish, Michael R Steele, Cesar O Romero, Denise M Inman, Philip J Horner, David J Calkins, Monica L Vetter. PLoS One 2012
13
Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma.
Huihui Chen, Kin-Sang Cho, T H Khanh Vu, Ching-Hung Shen, Mandeep Kaur, Guochun Chen, Rose Mathew, M Lisa McHam, Ahad Fazelat, Kameran Lashkari,[...]. Nat Commun 2018
Huihui Chen, Kin-Sang Cho, T H Khanh Vu, Ching-Hung Shen, Mandeep Kaur, Guochun Chen, Rose Mathew, M Lisa McHam, Ahad Fazelat, Kameran Lashkari,[...]. Nat Commun 2018
13
Neuroinflammation and microglia in glaucoma: time for a paradigm shift.
Xin Wei, Kin-Sang Cho, Eric F Thee, Martine J Jager, Dong Feng Chen. J Neurosci Res 2019
Xin Wei, Kin-Sang Cho, Eric F Thee, Martine J Jager, Dong Feng Chen. J Neurosci Res 2019
22
Etanercept, a widely used inhibitor of tumor necrosis factor-α (TNF-α), prevents retinal ganglion cell loss in a rat model of glaucoma.
Miin Roh, Yan Zhang, Yusuke Murakami, Aristomenis Thanos, Sung Chul Lee, Demetrios G Vavvas, Larry I Benowitz, Joan W Miller. PLoS One 2012
Miin Roh, Yan Zhang, Yusuke Murakami, Aristomenis Thanos, Sung Chul Lee, Demetrios G Vavvas, Larry I Benowitz, Joan W Miller. PLoS One 2012
12
Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure.
Farid Ahmed, Kevin M Brown, Dietrich A Stephan, John C Morrison, Elaine C Johnson, Stanislav I Tomarev. Invest Ophthalmol Vis Sci 2004
Farid Ahmed, Kevin M Brown, Dietrich A Stephan, John C Morrison, Elaine C Johnson, Stanislav I Tomarev. Invest Ophthalmol Vis Sci 2004
12
Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand.
Martin B Wax, Gülgün Tezel, Junjie Yang, Guanghua Peng, Rajkumar V Patil, Neeraj Agarwal, Rebecca M Sappington, David J Calkins. J Neurosci 2008
Martin B Wax, Gülgün Tezel, Junjie Yang, Guanghua Peng, Rajkumar V Patil, Neeraj Agarwal, Rebecca M Sappington, David J Calkins. J Neurosci 2008
12
Immune regulation toward immunomodulation for neuroprotection in glaucoma.
Gülgün Tezel. Curr Opin Pharmacol 2013
Gülgün Tezel. Curr Opin Pharmacol 2013
17
Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model.
Elaine C Johnson, Lijun Jia, William O Cepurna, Thomas A Doser, John C Morrison. Invest Ophthalmol Vis Sci 2007
Elaine C Johnson, Lijun Jia, William O Cepurna, Thomas A Doser, John C Morrison. Invest Ophthalmol Vis Sci 2007
12
Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy.
Robert W Nickells, Gareth R Howell, Ileana Soto, Simon W M John. Annu Rev Neurosci 2012
Robert W Nickells, Gareth R Howell, Ileana Soto, Simon W M John. Annu Rev Neurosci 2012
11
Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma.
Purushottam Jha, Himanshu Banda, Ruslana Tytarenko, P S Bora, N S Bora. Mol Immunol 2011
Purushottam Jha, Himanshu Banda, Ruslana Tytarenko, P S Bora, N S Bora. Mol Immunol 2011
24
Distal axonopathy with structural persistence in glaucomatous neurodegeneration.
Samuel D Crish, Rebecca M Sappington, Denise M Inman, Philip J Horner, David J Calkins. Proc Natl Acad Sci U S A 2010
Samuel D Crish, Rebecca M Sappington, Denise M Inman, Philip J Horner, David J Calkins. Proc Natl Acad Sci U S A 2010
11
The pathophysiology and treatment of glaucoma: a review.
Robert N Weinreb, Tin Aung, Felipe A Medeiros. JAMA 2014
Robert N Weinreb, Tin Aung, Felipe A Medeiros. JAMA 2014
11
Critical pathogenic events underlying progression of neurodegeneration in glaucoma.
David J Calkins. Prog Retin Eye Res 2012
David J Calkins. Prog Retin Eye Res 2012
11
The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve.
Juan Qu, Tatjana C Jakobs. PLoS One 2013
Juan Qu, Tatjana C Jakobs. PLoS One 2013
14
Glia-neuron interactions in the mammalian retina.
Elena Vecino, F David Rodriguez, Noelia Ruzafa, Xandra Pereiro, Sansar C Sharma. Prog Retin Eye Res 2016
Elena Vecino, F David Rodriguez, Noelia Ruzafa, Xandra Pereiro, Sansar C Sharma. Prog Retin Eye Res 2016
11
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.