Haitao Wen, Denis Gris, Yu Lei, Sushmita Jha, Lu Zhang, Max Tze-Han Huang, Willie June Brickey, Jenny P-Y Ting. Nat Immunol 2011
Times Cited: 1133
Times Cited: 1133
Times Cited
Times Co-cited
Similarity
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance.
Bolormaa Vandanmagsar, Yun-Hee Youm, Anthony Ravussin, Jose E Galgani, Krisztian Stadler, Randall L Mynatt, Eric Ravussin, Jacqueline M Stephens, Vishwa Deep Dixit. Nat Med 2011
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A role for mitochondria in NLRP3 inflammasome activation.
Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jürg Tschopp. Nature 2011
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
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The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
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Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
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Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
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Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes.
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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
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Mechanism and Regulation of NLRP3 Inflammasome Activation.
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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
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Gout-associated uric acid crystals activate the NALP3 inflammasome.
Fabio Martinon, Virginie Pétrilli, Annick Mayor, Aubry Tardivel, Jürg Tschopp. Nature 2006
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Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
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Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors.
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Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.
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K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
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Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Yiqing Yan, Wei Jiang, Lei Liu, Xiaqiong Wang, Chen Ding, Zhigang Tian, Rongbin Zhou. Cell 2015
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Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity.
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NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation.
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NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
Yuan He, Melody Y Zeng, Dahai Yang, Benny Motro, Gabriel Núñez. Nature 2016
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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
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Obesity is associated with macrophage accumulation in adipose tissue.
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NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
Auvro R Mridha, Alexander Wree, Avril A B Robertson, Matthew M Yeh, Casey D Johnson, Derrick M Van Rooyen, Fahrettin Haczeyni, Narci C-H Teoh, Christopher Savard, George N Ioannou,[...]. J Hepatol 2017
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The inflammasome NLRs in immunity, inflammation, and associated diseases.
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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
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Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.
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Activation and regulation of the inflammasomes.
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Cryopyrin activates the inflammasome in response to toxins and ATP.
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Metabolic endotoxemia initiates obesity and insulin resistance.
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
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NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.
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Inflammasomes in health and disease.
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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.
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Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.
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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
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Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.
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Non-canonical inflammasome activation targets caspase-11.
Nobuhiko Kayagaki, Søren Warming, Mohamed Lamkanfi, Lieselotte Vande Walle, Salina Louie, Jennifer Dong, Kim Newton, Yan Qu, Jinfeng Liu, Sherry Heldens,[...]. Nature 2011
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NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
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7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.