Ernest M Wright, Donald D F Loo, Bruce A Hirayama. Physiol Rev 2011
Times Cited: 631
Times Cited: 631
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Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.
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Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.
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Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.
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22
Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes.
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Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.
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Localizations of Na(+)-D-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart.
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14
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.
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14
Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus.
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David Z I Cherney, Bruce A Perkins, Nima Soleymanlou, Maria Maione, Vesta Lai, Alana Lee, Nora M Fagan, Hans J Woerle, Odd Erik Johansen, Uli C Broedl,[...]. Circulation 2014
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Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.
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The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing.
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Pia V Röder, Kerstin E Geillinger, Tamara S Zietek, Bernard Thorens, Hermann Koepsell, Hannelore Daniel. PLoS One 2014
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SGLT2 mediates glucose reabsorption in the early proximal tubule.
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Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion.
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The SLC2 (GLUT) family of membrane transporters.
Mike Mueckler, Bernard Thorens. Mol Aspects Med 2013
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Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members.
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Jian Chen, Sandy Williams, Samantha Ho, Howard Loraine, Deborah Hagan, Jean M Whaley, John N Feder. Diabetes Ther 2010
10
Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes.
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Hassan Rahmoune, Paul W Thompson, Joanna M Ward, Chari D Smith, Guizhu Hong, John Brown. Diabetes 2005
10
Regional distribution of SGLT activity in rat brain in vivo.
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18
Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.
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Chiara Ghezzi, Donald D F Loo, Ernest M Wright. Diabetologia 2018
14
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients.
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Ele Ferrannini, Elza Muscelli, Silvia Frascerra, Simona Baldi, Andrea Mari, Tim Heise, Uli C Broedl, Hans-Juergen Woerle. J Clin Invest 2014
8
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.
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8
SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
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8
Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production.
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Aurora Merovci, Carolina Solis-Herrera, Giuseppe Daniele, Roy Eldor, Teresa Vanessa Fiorentino, Devjit Tripathy, Juan Xiong, Zandra Perez, Luke Norton, Muhammad A Abdul-Ghani,[...]. J Clin Invest 2014
8
The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer.
Hermann Koepsell. Pharmacol Ther 2017
Hermann Koepsell. Pharmacol Ther 2017
20
Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice.
Monica Sala-Rabanal, Bruce A Hirayama, Chiara Ghezzi, Jie Liu, Sung-Cheng Huang, Vladimir Kepe, Hermann Koepsell, Amy Yu, David R Powell, Bernard Thorens,[...]. J Physiol 2016
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Functional expression of SGLTs in rat brain.
Amy S Yu, Bruce A Hirayama, Gerald Timbol, Jie Liu, Ernest Basarah, Vladimir Kepe, Nagichettiar Satyamurthy, Sung-Cheng Huang, Ernest M Wright, Jorge R Barrio. Am J Physiol Cell Physiol 2010
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The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.
Y Kanai, W S Lee, G You, D Brown, M A Hediger. J Clin Invest 1994
Y Kanai, W S Lee, G You, D Brown, M A Hediger. J Clin Invest 1994
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Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences.
Linda A Gallo, Ernest M Wright, Volker Vallon. Diab Vasc Dis Res 2015
Linda A Gallo, Ernest M Wright, Volker Vallon. Diab Vasc Dis Res 2015
7
Phlorizin: a review.
Joel R L Ehrenkranz, Norman G Lewis, C Ronald Kahn, Jesse Roth. Diabetes Metab Res Rev 2005
Joel R L Ehrenkranz, Norman G Lewis, C Ronald Kahn, Jesse Roth. Diabetes Metab Res Rev 2005
7
Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia.
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Timo Rieg, Takahiro Masuda, Maria Gerasimova, Eric Mayoux, Kenneth Platt, David R Powell, Scott C Thomson, Hermann Koepsell, Volker Vallon. Am J Physiol Renal Physiol 2014
7
Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.
Charles S Hummel, Chuan Lu, Donald D F Loo, Bruce A Hirayama, Andrew A Voss, Ernest M Wright. Am J Physiol Cell Physiol 2011
Charles S Hummel, Chuan Lu, Donald D F Loo, Bruce A Hirayama, Andrew A Voss, Ernest M Wright. Am J Physiol Cell Physiol 2011
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Expression cloning and cDNA sequencing of the Na+/glucose co-transporter.
M A Hediger, M J Coady, T S Ikeda, E M Wright. Nature 1987
M A Hediger, M J Coady, T S Ikeda, E M Wright. Nature 1987
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Revised immunolocalization of the Na+-D-glucose cotransporter SGLT1 in rat organs with an improved antibody.
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Daniela Balen, Marija Ljubojevic, Davorka Breljak, Hrvoje Brzica, Vilim Zlender, Hermann Koepsell, Ivan Sabolic. Am J Physiol Cell Physiol 2008
7
SGLT2 Protein Expression Is Increased in Human Diabetic Nephropathy: SGLT2 PROTEIN INHIBITION DECREASES RENAL LIPID ACCUMULATION, INFLAMMATION, AND THE DEVELOPMENT OF NEPHROPATHY IN DIABETIC MICE.
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SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.
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Volker Vallon, Maria Gerasimova, Michael A Rose, Takahiro Masuda, Joseph Satriano, Eric Mayoux, Hermann Koepsell, Scott C Thomson, Timo Rieg. Am J Physiol Renal Physiol 2014
7
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer.
Maria L Macheda, Suzanne Rogers, James D Best. J Cell Physiol 2005
Maria L Macheda, Suzanne Rogers, James D Best. J Cell Physiol 2005
7
GLUT2 is a high affinity glucosamine transporter.
Marc Uldry, Mark Ibberson, Masaya Hosokawa, Bernard Thorens. FEBS Lett 2002
Marc Uldry, Mark Ibberson, Masaya Hosokawa, Bernard Thorens. FEBS Lett 2002
7
Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits.
Antonius Baartscheer, Cees A Schumacher, Rob C I Wüst, Jan W T Fiolet, Ger J M Stienen, Ruben Coronel, Coert J Zuurbier. Diabetologia 2017
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2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD.
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Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes.
Muhammad A Abdul-Ghani, Luke Norton, Ralph A Defronzo. Endocr Rev 2011
Muhammad A Abdul-Ghani, Luke Norton, Ralph A Defronzo. Endocr Rev 2011
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Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences.
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Novel and Unexpected Functions of SGLTs.
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Ernest M Wright, Chiara Ghezzi, Donald D F Loo. Physiology (Bethesda) 2017
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Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
L Rossetti, D Smith, G I Shulman, D Papachristou, R A DeFronzo. J Clin Invest 1987
L Rossetti, D Smith, G I Shulman, D Papachristou, R A DeFronzo. J Clin Invest 1987
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Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
Wei Meng, Bruce A Ellsworth, Alexandra A Nirschl, Peggy J McCann, Manorama Patel, Ravindar N Girotra, Gang Wu, Philip M Sher, Eamonn P Morrison, Scott A Biller,[...]. J Med Chem 2008
Wei Meng, Bruce A Ellsworth, Alexandra A Nirschl, Peggy J McCann, Manorama Patel, Ravindar N Girotra, Gang Wu, Philip M Sher, Eamonn P Morrison, Scott A Biller,[...]. J Med Chem 2008
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Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis.
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The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport.
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Salem Faham, Akira Watanabe, Gabriel Mercado Besserer, Duilio Cascio, Alexandre Specht, Bruce A Hirayama, Ernest M Wright, Jeff Abramson. Science 2008
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Functional expression of sodium-glucose transporters in cancer.
Claudio Scafoglio, Bruce A Hirayama, Vladimir Kepe, Jie Liu, Chiara Ghezzi, Nagichettiar Satyamurthy, Neda A Moatamed, Jiaoti Huang, Hermann Koepsell, Jorge R Barrio,[...]. Proc Natl Acad Sci U S A 2015
Claudio Scafoglio, Bruce A Hirayama, Vladimir Kepe, Jie Liu, Chiara Ghezzi, Nagichettiar Satyamurthy, Neda A Moatamed, Jiaoti Huang, Hermann Koepsell, Jorge R Barrio,[...]. Proc Natl Acad Sci U S A 2015
6
SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis.
Brendon L Neuen, Tamara Young, Hiddo J L Heerspink, Bruce Neal, Vlado Perkovic, Laurent Billot, Kenneth W Mahaffey, David M Charytan, David C Wheeler, Clare Arnott,[...]. Lancet Diabetes Endocrinol 2019
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GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters.
Dong Deng, Nieng Yan. Protein Sci 2016
Dong Deng, Nieng Yan. Protein Sci 2016
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Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation.
Laween Uthman, Antonius Baartscheer, Boris Bleijlevens, Cees A Schumacher, Jan W T Fiolet, Anneke Koeman, Milena Jancev, Markus W Hollmann, Nina C Weber, Ruben Coronel,[...]. Diabetologia 2018
Laween Uthman, Antonius Baartscheer, Boris Bleijlevens, Cees A Schumacher, Jan W T Fiolet, Anneke Koeman, Milena Jancev, Markus W Hollmann, Nina C Weber, Ruben Coronel,[...]. Diabetologia 2018
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.