Patricia N Sidharta, Paul L M van Giersbergen, Atef Halabi, Jasper Dingemanse. Eur J Clin Pharmacol 2011
Times Cited: 86
Times Cited: 86
Times Cited
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Similarity
Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist.
Marc Iglarz, Christoph Binkert, Keith Morrison, Walter Fischli, John Gatfield, Alexander Treiber, Thomas Weller, Martin H Bolli, Christoph Boss, Stephan Buchmann,[...]. J Pharmacol Exp Ther 2008
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Macitentan and morbidity and mortality in pulmonary arterial hypertension.
Tomás Pulido, Igor Adzerikho, Richard N Channick, Marion Delcroix, Nazzareno Galiè, Hossein-Ardeschir Ghofrani, Pavel Jansa, Zhi-Cheng Jing, Franck-Olivier Le Brun, Sanjay Mehta,[...]. N Engl J Med 2013
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Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells.
John Gatfield, Celia Mueller Grandjean, Thomas Sasse, Martine Clozel, Oliver Nayler. PLoS One 2012
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The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
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Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans.
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of macitentan, an endothelin receptor antagonist, in an ascending multiple-dose study in healthy subjects.
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Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist.
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Bosentan therapy for pulmonary arterial hypertension.
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Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study.
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Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
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The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions.
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Investigation of the effects of ketoconazole on the pharmacokinetics of macitentan, a novel dual endothelin receptor antagonist, in healthy subjects.
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Jacob Atsmon, Jasper Dingemanse, Dimitri Shaikevich, Inna Volokhov, Patricia N Sidharta. Clin Pharmacokinet 2013
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Comparison of the dissolution and pharmacokinetic profiles of two galenical formulations of the endothelin receptor antagonist macitentan.
Oliver Kummer, Manuel Haschke, Felix Hammann, Michael Bodmer, Shirin Bruderer, Yann Regnault, Jasper Dingemanse, Stephan Krähenbühl. Eur J Pharm Sci 2009
Oliver Kummer, Manuel Haschke, Felix Hammann, Michael Bodmer, Shirin Bruderer, Yann Regnault, Jasper Dingemanse, Stephan Krähenbühl. Eur J Pharm Sci 2009
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Sildenafil citrate therapy for pulmonary arterial hypertension.
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Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2.
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A novel potent vasoconstrictor peptide produced by vascular endothelial cells.
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Pharmacokinetics of macitentan in caucasian and Japanese subjects: the influence of ethnicity and sex.
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Interaction profile of macitentan, a new non-selective endothelin-1 receptor antagonist, in vitro.
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Efficacy, safety and clinical pharmacology of macitentan in comparison to other endothelin receptor antagonists in the treatment of pulmonary arterial hypertension.
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Treatment of pulmonary arterial hypertension.
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Ambrisentan therapy for pulmonary arterial hypertension.
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Pharmacokinetics of the novel dual endothelin receptor antagonist macitentan in subjects with hepatic or renal impairment.
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A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension.
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Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT).
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Inhaled iloprost for severe pulmonary hypertension.
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Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial.
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Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial.
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Macitentan does not interfere with hepatic bile salt transport.
Alexander Treiber, Päivi Äänismaa, Ruben de Kanter, Stephane Delahaye, Marianne Treher, Patrick Hess, Patricia Sidharta. J Pharmacol Exp Ther 2014
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Macitentan, a tissue-targeting endothelin receptor antagonist for the potential oral treatment of pulmonary arterial hypertension and idiopathic pulmonary fibrosis.
Shahzad G Raja. Curr Opin Investig Drugs 2010
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Long-term ambrisentan therapy for the treatment of pulmonary arterial hypertension.
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An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension.
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Results of European post-marketing surveillance of bosentan in pulmonary hypertension.
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Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study.
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Sitaxsentan therapy for pulmonary arterial hypertension.
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Guidelines for the diagnosis and treatment of pulmonary hypertension.
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Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.
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Updated clinical classification of pulmonary hypertension.
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Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study.
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First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension.
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Liver toxicity of sitaxentan in pulmonary arterial hypertension.
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Mutual pharmacokinetic interactions between steady-state bosentan and sildenafil.
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Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial.
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Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension.
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The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.