M Fernanda Amary, Krisztian Bacsi, Francesca Maggiani, Stephen Damato, Dina Halai, Fitim Berisha, Robin Pollock, Paul O'Donnell, Anita Grigoriadis, Tim Diss, Malihe Eskandarpour, Nadège Presneau, Pancras Cw Hogendoorn, Andrew Futreal, Roberto Tirabosco, Adrienne M Flanagan. J Pathol 2011
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Similarity
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Lenny Dang, David W White, Stefan Gross, Bryson D Bennett, Mark A Bittinger, Edward M Driggers, Valeria R Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C Keenan,[...]. Nature 2009
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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
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IDH1 and IDH2 mutations in gliomas.
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An integrated genomic analysis of human glioblastoma multiforme.
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Recurring mutations found by sequencing an acute myeloid leukemia genome.
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Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
Twinkal C Pansuriya, Ronald van Eijk, Pio d'Adamo, Maayke A J H van Ruler, Marieke L Kuijjer, Jan Oosting, Anne-Marie Cleton-Jansen, Jolieke G van Oosterwijk, Sofie L J Verbeke, Daniëlle Meijer,[...]. Nat Genet 2011
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Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.
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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
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IDH mutation impairs histone demethylation and results in a block to cell differentiation.
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Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.
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Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.
Courtney D DiNardo, Eytan M Stein, Stéphane de Botton, Gail J Roboz, Jessica K Altman, Alice S Mims, Ronan Swords, Robert H Collins, Gabriel N Mannis, Daniel A Pollyea,[...]. N Engl J Med 2018
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Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma.
Guo Gord Zhu, Khedoudja Nafa, Narasimhan Agaram, Ahmet Zehir, Ryma Benayed, Justyna Sadowska, Laetitia Borsu, Ciara Kelly, William D Tap, Nicola Fabbri,[...]. Clin Cancer Res 2020
Guo Gord Zhu, Khedoudja Nafa, Narasimhan Agaram, Ahmet Zehir, Ryma Benayed, Justyna Sadowska, Laetitia Borsu, Ciara Kelly, William D Tap, Nicola Fabbri,[...]. Clin Cancer Res 2020
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Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma.
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Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.
M Fernanda Amary, Stephen Damato, Dina Halai, Malihe Eskandarpour, Fitim Berisha, Fiona Bonar, Stan McCarthy, Valeria R Fantin, Kimberly S Straley, Samira Lobo,[...]. Nat Genet 2011
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IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma.
Iwona Lugowska, Pawel Teterycz, Michal Mikula, Maria Kulecka, Anna Kluska, Aneta Balabas, Magdalena Piatkowska, Michal Wagrodzki, Andrzej Pienkowski, Piotr Rutkowski,[...]. J Cancer 2018
Iwona Lugowska, Pawel Teterycz, Michal Mikula, Maria Kulecka, Anna Kluska, Aneta Balabas, Magdalena Piatkowska, Michal Wagrodzki, Andrzej Pienkowski, Piotr Rutkowski,[...]. J Cancer 2018
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Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma.
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Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.
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IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas.
Arjen H G Cleven, Johnny Suijker, Georgios Agrogiannis, Inge H Briaire-de Bruijn, Norma Frizzell, Attje S Hoekstra, Pauline M Wijers-Koster, Anne-Marie Cleton-Jansen, Judith V M G Bovée. Clin Sarcoma Res 2017
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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
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Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression.
Rémy Nicolle, Mira Ayadi, Anne Gomez-Brouchet, Lucile Armenoult, Guillaume Banneau, Nabila Elarouci, Matthias Tallegas, Anne-Valérie Decouvelaere, Sébastien Aubert, Françoise Rédini,[...]. Nat Commun 2019
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IDH mutation status in a series of 88 head and neck chondrosarcomas: different profile between tumors of the skull base and tumors involving the facial skeleton and the laryngotracheal tract.
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Dedifferentiated chondrosarcoma: prognostic factors and outcome from a European group.
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Robert J Grimer, Georg Gosheger, Antonie Taminiau, David Biau, Zdenek Matejovsky, Yehuda Kollender, Mikel San-Julian, Franco Gherlinzoni, Cristina Ferrari. Eur J Cancer 2007
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Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
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Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells.
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Mutant IDH is sufficient to initiate enchondromatosis in mice.
Makoto Hirata, Masato Sasaki, Rob A Cairns, Satoshi Inoue, Vijitha Puviindran, Wanda Y Li, Bryan E Snow, Lisa D Jones, Qingxia Wei, Shingo Sato,[...]. Proc Natl Acad Sci U S A 2015
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Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines.
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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.
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Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study.
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IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
Guido Marcucci, Kati Maharry, Yue-Zhong Wu, Michael D Radmacher, Krzysztof Mrózek, Dean Margeson, Kelsi B Holland, Susan P Whitman, Heiko Becker, Sebastian Schwind,[...]. J Clin Oncol 2010
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Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.
Tri Dung Tiet, Sevan Hopyan, Puviindran Nadesan, Nalan Gokgoz, Raymond Poon, Alvin C Lin, Taiqiang Yan, Irene L Andrulis, Benjamin A Alman, Jay S Wunder. Am J Pathol 2006
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Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database.
Angela Ylenia Giuffrida, Jorge E Burgueno, Leonidas G Koniaris, Juan C Gutierrez, Robert Duncan, Sean P Scully. J Bone Joint Surg Am 2009
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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.
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Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.
Kensuke Tateishi, Hiroaki Wakimoto, A John Iafrate, Shota Tanaka, Franziska Loebel, Nina Lelic, Dmitri Wiederschain, Olivier Bedel, Gejing Deng, Bailin Zhang,[...]. Cancer Cell 2015
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Diagnostic utility of IDH1/2 mutations to distinguish dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma of bone.
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Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations.
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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Supriya K Saha, Christine A Parachoniak, Krishna S Ghanta, Julien Fitamant, Kenneth N Ross, Mortada S Najem, Sushma Gurumurthy, Esra A Akbay, Daniela Sia, Helena Cornella,[...]. Nature 2014
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Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo.
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Ivosidenib in Isocitrate Dehydrogenase 1-Mutated Advanced Glioma.
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Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.
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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
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Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.
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Genetic characterization of mesenchymal, clear cell, and dedifferentiated chondrosarcoma.
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From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation.
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Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas.
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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
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Cartilage tumours and bone development: molecular pathology and possible therapeutic targets.
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Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.