A citation-based method for searching scientific literature

Alexander Varshavsky. Protein Sci 2011
Times Cited: 431







List of co-cited articles
827 articles co-cited >1



Times Cited
  Times     Co-cited
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N-degron and C-degron pathways of protein degradation.
Alexander Varshavsky. Proc Natl Acad Sci U S A 2019
194
42


N-terminal acetylation of cellular proteins creates specific degradation signals.
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Science 2010
427
26

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes.
Shun-Jia Chen, Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky. Science 2017
101
24

The N-end rule pathway.
Takafumi Tasaki, Shashikanth M Sriram, Kyong Soo Park, Yong Tae Kwon. Annu Rev Biochem 2012
244
19

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.
Richard T Timms, Zhiqian Zhang, David Y Rhee, J Wade Harper, Itay Koren, Stephen J Elledge. Science 2019
62
27

Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
Anna Shemorry, Cheol-Sang Hwang, Alexander Varshavsky. Mol Cell 2013
193
17

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.
Woo Suk Choi, Byung-Cheon Jeong, Yoo Jin Joo, Myeong-Ryeol Lee, Joon Kim, Michael J Eck, Hyun Kyu Song. Nat Struct Mol Biol 2010
96
17

The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators.
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T Takahashi, Alexander Varshavsky. Nature 2005
221
16

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Cheng Dong, Heng Zhang, Li Li, Wolfram Tempel, Peter Loppnau, Jinrong Min. Nat Chem Biol 2018
42
38

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.
Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Proc Natl Acad Sci U S A 2012
97
16

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
Takafumi Tasaki, Lubbertus C F Mulder, Akihiro Iwamatsu, Min Jae Lee, Ilia V Davydov, Alexander Varshavsky, Mark Muesing, Yong Tae Kwon. Mol Cell Biol 2005
228
16

Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
Christopher S Brower, Konstantin I Piatkov, Alexander Varshavsky. Mol Cell 2013
77
19

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions.
Daniel J Gibbs, Jaume Bacardit, Andreas Bachmair, Michael J Holdsworth. Trends Cell Biol 2014
132
14

Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway.
Jeong-Mok Kim, Ok-Hee Seok, Shinyeong Ju, Ji-Eun Heo, Jeonghun Yeom, Da-Som Kim, Joo-Yeon Yoo, Alexander Varshavsky, Cheolju Lee, Cheol-Sang Hwang. Science 2018
42
33

An essential role of N-terminal arginylation in cardiovascular development.
Yong Tae Kwon, Anna S Kashina, Ilia V Davydov, Rong-Gui Hu, Jee Young An, Jai Wha Seo, Fangyong Du, Alexander Varshavsky. Science 2002
242
14

Structural basis of substrate recognition and specificity in the N-end rule pathway.
Edna Matta-Camacho, Guennadi Kozlov, Flora F Li, Kalle Gehring. Nat Struct Mol Biol 2010
73
17

First Things First: Vital Protein Marks by N-Terminal Acetyltransferases.
Henriette Aksnes, Adrian Drazic, Michaël Marie, Thomas Arnesen. Trends Biochem Sci 2016
132
12

The degradation signal in a short-lived protein.
A Bachmair, A Varshavsky. Cell 1989
354
12

Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.
Konstantin I Piatkov, Jang-Hyun Oh, Yuan Liu, Alexander Varshavsky. Proc Natl Acad Sci U S A 2014
57
21

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.
Itay Koren, Richard T Timms, Tomasz Kula, Qikai Xu, Mamie Z Li, Stephen J Elledge. Cell 2018
91
12

C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.
Hsiu-Chuan Lin, Chi-Wei Yeh, Yen-Fu Chen, Ting-Ting Lee, Pei-Yun Hsieh, Domnita V Rusnac, Sung-Ya Lin, Stephen J Elledge, Ning Zheng, Hsueh-Chi S Yen. Mol Cell 2018
56
19


The N-end rule pathway: emerging functions and molecular principles of substrate recognition.
Shashikanth M Sriram, Bo Yeon Kim, Yong Tae Kwon. Nat Rev Mol Cell Biol 2011
129
11

Gid10 as an alternative N-recognin of the Pro/N-degron pathway.
Artem Melnykov, Shun-Jia Chen, Alexander Varshavsky. Proc Natl Acad Sci U S A 2019
19
52

The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Konstantin I Piatkov, Luca Colnaghi, Miklos Békés, Alexander Varshavsky, Tony T Huang. Mol Cell 2012
49
20

The N-end rule pathway: from recognition by N-recognins, to destruction by AAA+proteases.
D A Dougan, D Micevski, K N Truscott. Biochim Biophys Acta 2012
83
12

N-terminal degradation activates the NLRP1B inflammasome.
Ashley J Chui, Marian C Okondo, Sahana D Rao, Kuo Gai, Andrew R Griswold, Darren C Johnson, Daniel P Ball, Cornelius Y Taabazuing, Elizabeth L Orth, Brooke A Vittimberga,[...]. Science 2019
127
10

The N-end rule in bacteria.
J W Tobias, T E Shrader, G Rocap, A Varshavsky. Science 1991
417
10

The N-terminal methionine of cellular proteins as a degradation signal.
Heon-Ki Kim, Ryu-Ryun Kim, Jang-Hyun Oh, Hanna Cho, Alexander Varshavsky, Cheol-Sang Hwang. Cell 2014
113
10

Ubiquitin Ligases: Structure, Function, and Regulation.
Ning Zheng, Nitzan Shabek. Annu Rev Biochem 2017
522
10

In vivo aspects of protein folding and quality control.
David Balchin, Manajit Hayer-Hartl, F Ulrich Hartl. Science 2016
668
10


RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, Jee Young An, Sadao Kimura, Ilia V Davydov, Yong Tae Kwon. Proc Natl Acad Sci U S A 2005
180
10

The substrate recognition domains of the N-end rule pathway.
Takafumi Tasaki, Adriana Zakrzewska, Drew D Dudgeon, Yonghua Jiang, John S Lazo, Yong Tae Kwon. J Biol Chem 2009
89
10

PINK1 is degraded through the N-end rule pathway.
Koji Yamano, Richard J Youle. Autophagy 2013
361
9

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly.
Shuai Qiao, Christine R Langlois, Jakub Chrustowicz, Dawafuti Sherpa, Ozge Karayel, Fynn M Hansen, Viola Beier, Susanne von Gronau, Daniel Bollschweiler, Tillman Schäfer,[...]. Mol Cell 2020
25
36

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization.
Francesco Licausi, Monika Kosmacz, Daan A Weits, Beatrice Giuntoli, Federico M Giorgi, Laurentius A C J Voesenek, Pierdomenico Perata, Joost T van Dongen. Nature 2011
388
8

Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants.
Daniel J Gibbs, Seung Cho Lee, Nurulhikma Md Isa, Silvia Gramuglia, Takeshi Fukao, George W Bassel, Cristina Sousa Correia, Françoise Corbineau, Frederica L Theodoulou, Julia Bailey-Serres,[...]. Nature 2011
368
8

Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase.
Domniţa-Valeria Rusnac, Hsiu-Chuan Lin, Daniele Canzani, Karena X Tien, Thomas R Hinds, Ashley F Tsue, Matthew F Bush, Hsueh-Chi S Yen, Ning Zheng. Mol Cell 2018
30
26

Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases.
Qing Xiao, Feiran Zhang, Benjamin A Nacev, Jun O Liu, Dehua Pei. Biochemistry 2010
106
8

Discovery of cellular regulation by protein degradation.
Alexander Varshavsky. J Biol Chem 2008
72
11

Structure and Function of the 26S Proteasome.
Jared A M Bard, Ellen A Goodall, Eric R Greene, Erik Jonsson, Ken C Dong, Andreas Martin. Annu Rev Biochem 2018
279
8

Understanding the Pro/N-end rule pathway.
David A Dougan, Alexander Varshavsky. Nat Chem Biol 2018
12
66

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.
Norma Masson, Thomas P Keeley, Beatrice Giuntoli, Mark D White, Mikel Lavilla Puerta, Pierdomenico Perata, Richard J Hopkinson, Emily Flashman, Francesco Licausi, Peter J Ratcliffe. Science 2019
74
10

N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.
Young Dong Yoo, Su Ran Mun, Chang Hoon Ji, Ki Woon Sung, Keum Young Kang, Ah Jung Heo, Su Hyun Lee, Jee Young An, Joonsung Hwang, Xiang-Qun Xie,[...]. Proc Natl Acad Sci U S A 2018
30
26

ClpS is an essential component of the N-end rule pathway in Escherichia coli.
A Erbse, R Schmidt, T Bornemann, J Schneider-Mergener, A Mogk, R Zahn, D A Dougan, B Bukau. Nature 2006
168
8

The plant N-degron pathways of ubiquitin-mediated proteolysis.
Michael John Holdsworth, Jorge Vicente, Gunjan Sharma, Mohamad Abbas, Agata Zubrycka. J Integr Plant Biol 2020
25
32

Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.
F-Nora Vögtle, Stefanie Wortelkamp, René P Zahedi, Dorothea Becker, Claudia Leidhold, Kris Gevaert, Josef Kellermann, Wolfgang Voos, Albert Sickmann, Nikolaus Pfanner,[...]. Cell 2009
334
8

Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway.
Daan A Weits, Beatrice Giuntoli, Monika Kosmacz, Sandro Parlanti, Hans-Michael Hubberten, Heike Riegler, Rainer Hoefgen, Pierdomenico Perata, Joost T van Dongen, Francesco Licausi. Nat Commun 2014
182
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.