Richard Possemato, Kevin M Marks, Yoav D Shaul, Michael E Pacold, Dohoon Kim, Kıvanç Birsoy, Shalini Sethumadhavan, Hin-Koon Woo, Hyun G Jang, Abhishek K Jha, Walter W Chen, Francesca G Barrett, Nicolas Stransky, Zhi-Yang Tsun, Glenn S Cowley, Jordi Barretina, Nada Y Kalaany, Peggy P Hsu, Kathleen Ottina, Albert M Chan, Bingbing Yuan, Levi A Garraway, David E Root, Mari Mino-Kenudson, Elena F Brachtel, Edward M Driggers, David M Sabatini. Nature 2011
Times Cited: 1014
Times Cited: 1014
Times Cited
Times Co-cited
Similarity
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Jason W Locasale, Alexandra R Grassian, Tamar Melman, Costas A Lyssiotis, Katherine R Mattaini, Adam J Bass, Gregory Heffron, Christian M Metallo, Taru Muranen, Hadar Sharfi,[...]. Nat Genet 2011
Jason W Locasale, Alexandra R Grassian, Tamar Melman, Costas A Lyssiotis, Katherine R Mattaini, Adam J Bass, Gregory Heffron, Christian M Metallo, Taru Muranen, Hadar Sharfi,[...]. Nat Genet 2011
40
Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
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21
Serine, glycine and one-carbon units: cancer metabolism in full circle.
Jason W Locasale. Nat Rev Cancer 2013
Jason W Locasale. Nat Rev Cancer 2013
20
20
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Michael E Pacold, Kyle R Brimacombe, Sze Ham Chan, Jason M Rohde, Caroline A Lewis, Lotteke J Y M Swier, Richard Possemato, Walter W Chen, Lucas B Sullivan, Brian P Fiske,[...]. Nat Chem Biol 2016
Michael E Pacold, Kyle R Brimacombe, Sze Ham Chan, Jason M Rohde, Caroline A Lewis, Lotteke J Y M Swier, Richard Possemato, Walter W Chen, Lucas B Sullivan, Brian P Fiske,[...]. Nat Chem Biol 2016
20
The Emerging Hallmarks of Cancer Metabolism.
Natalya N Pavlova, Craig B Thompson. Cell Metab 2016
Natalya N Pavlova, Craig B Thompson. Cell Metab 2016
19
The importance of serine metabolism in cancer.
Katherine R Mattaini, Mark R Sullivan, Matthew G Vander Heiden. J Cell Biol 2016
Katherine R Mattaini, Mark R Sullivan, Matthew G Vander Heiden. J Cell Biol 2016
18
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.
Oliver D K Maddocks, Celia R Berkers, Susan M Mason, Liang Zheng, Karen Blyth, Eyal Gottlieb, Karen H Vousden. Nature 2013
Oliver D K Maddocks, Celia R Berkers, Susan M Mason, Liang Zheng, Karen Blyth, Eyal Gottlieb, Karen H Vousden. Nature 2013
17
NRF2 regulates serine biosynthesis in non-small cell lung cancer.
Gina M DeNicola, Pei-Hsuan Chen, Edouard Mullarky, Jessica A Sudderth, Zeping Hu, David Wu, Hao Tang, Yang Xie, John M Asara, Kenneth E Huffman,[...]. Nat Genet 2015
Gina M DeNicola, Pei-Hsuan Chen, Edouard Mullarky, Jessica A Sudderth, Zeping Hu, David Wu, Hao Tang, Yang Xie, John M Asara, Kenneth E Huffman,[...]. Nat Genet 2015
16
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.
Christiaan F Labuschagne, Niels J F van den Broek, Gillian M Mackay, Karen H Vousden, Oliver D K Maddocks. Cell Rep 2014
Christiaan F Labuschagne, Niels J F van den Broek, Gillian M Mackay, Karen H Vousden, Oliver D K Maddocks. Cell Rep 2014
15
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Edouard Mullarky, Natasha C Lucki, Reza Beheshti Zavareh, Justin L Anglin, Ana P Gomes, Brandon N Nicolay, Jenny C Y Wong, Stefan Christen, Hidenori Takahashi, Pradeep K Singh,[...]. Proc Natl Acad Sci U S A 2016
Edouard Mullarky, Natasha C Lucki, Reza Beheshti Zavareh, Justin L Anglin, Ana P Gomes, Brandon N Nicolay, Jenny C Y Wong, Stefan Christen, Hidenori Takahashi, Pradeep K Singh,[...]. Proc Natl Acad Sci U S A 2016
15
Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
Oliver D K Maddocks, Dimitris Athineos, Eric C Cheung, Pearl Lee, Tong Zhang, Niels J F van den Broek, Gillian M Mackay, Christiaan F Labuschagne, David Gay, Flore Kruiswijk,[...]. Nature 2017
Oliver D K Maddocks, Dimitris Athineos, Eric C Cheung, Pearl Lee, Tong Zhang, Niels J F van den Broek, Gillian M Mackay, Christiaan F Labuschagne, David Gay, Flore Kruiswijk,[...]. Nature 2017
15
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.
David R Wise, Ralph J DeBerardinis, Anthony Mancuso, Nabil Sayed, Xiao-Yong Zhang, Harla K Pfeiffer, Ilana Nissim, Evgueni Daikhin, Marc Yudkoff, Steven B McMahon,[...]. Proc Natl Acad Sci U S A 2008
David R Wise, Ralph J DeBerardinis, Anthony Mancuso, Nabil Sayed, Xiao-Yong Zhang, Harla K Pfeiffer, Ilana Nissim, Evgueni Daikhin, Marc Yudkoff, Steven B McMahon,[...]. Proc Natl Acad Sci U S A 2008
14
Understanding the Intersections between Metabolism and Cancer Biology.
Matthew G Vander Heiden, Ralph J DeBerardinis. Cell 2017
Matthew G Vander Heiden, Ralph J DeBerardinis. Cell 2017
14
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J Liang, Alba Luengo, Shawn M Davidson, Ahmed Ali, Gino B Ferraro,[...]. Cancer Discov 2020
Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J Liang, Alba Luengo, Shawn M Davidson, Ahmed Ali, Gino B Ferraro,[...]. Cancer Discov 2020
21
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Mohit Jain, Roland Nilsson, Sonia Sharma, Nikhil Madhusudhan, Toshimori Kitami, Amanda L Souza, Ran Kafri, Marc W Kirschner, Clary B Clish, Vamsi K Mootha. Science 2012
Mohit Jain, Roland Nilsson, Sonia Sharma, Nikhil Madhusudhan, Toshimori Kitami, Amanda L Souza, Ran Kafri, Marc W Kirschner, Clary B Clish, Vamsi K Mootha. Science 2012
13
Serine and glycine metabolism in cancer.
Ivano Amelio, Francesca Cutruzzolá, Alexey Antonov, Massimiliano Agostini, Gerry Melino. Trends Biochem Sci 2014
Ivano Amelio, Francesca Cutruzzolá, Alexey Antonov, Massimiliano Agostini, Gerry Melino. Trends Biochem Sci 2014
13
Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting.
Mark R Sullivan, Katherine R Mattaini, Emily A Dennstedt, Anna A Nguyen, Sharanya Sivanand, Montana F Reilly, Katrina Meeth, Alexander Muir, Alicia M Darnell, Marcus W Bosenberg,[...]. Cell Metab 2019
Mark R Sullivan, Katherine R Mattaini, Emily A Dennstedt, Anna A Nguyen, Sharanya Sivanand, Montana F Reilly, Katrina Meeth, Alexander Muir, Alicia M Darnell, Marcus W Bosenberg,[...]. Cell Metab 2019
12
Targeting Metabolism for Cancer Therapy.
Alba Luengo, Dan Y Gui, Matthew G Vander Heiden. Cell Chem Biol 2017
Alba Luengo, Dan Y Gui, Matthew G Vander Heiden. Cell Chem Biol 2017
11
11
Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.
Oliver D K Maddocks, Christiaan F Labuschagne, Peter D Adams, Karen H Vousden. Mol Cell 2016
Oliver D K Maddocks, Christiaan F Labuschagne, Peter D Adams, Karen H Vousden. Mol Cell 2016
11
11
PHGDH amplification and altered glucose metabolism in human melanoma.
Edouard Mullarky, Katherine R Mattaini, Matthew G Vander Heiden, Lewis C Cantley, Jason W Locasale. Pigment Cell Melanoma Res 2011
Edouard Mullarky, Katherine R Mattaini, Matthew G Vander Heiden, Lewis C Cantley, Jason W Locasale. Pigment Cell Melanoma Res 2011
11
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Linchong Sun, Libing Song, Qianfen Wan, Gongwei Wu, Xinghua Li, Yinghui Wang, Jin Wang, Zhaoji Liu, Xiuying Zhong, Xiaoping He,[...]. Cell Res 2015
Linchong Sun, Libing Song, Qianfen Wan, Gongwei Wu, Xinghua Li, Yinghui Wang, Jin Wang, Zhaoji Liu, Xiuying Zhong, Xiaoping He,[...]. Cell Res 2015
10
From Krebs to clinic: glutamine metabolism to cancer therapy.
Brian J Altman, Zachary E Stine, Chi V Dang. Nat Rev Cancer 2016
Brian J Altman, Zachary E Stine, Chi V Dang. Nat Rev Cancer 2016
10
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.
Debangshu Samanta, Youngrok Park, Shaida A Andrabi, Laura M Shelton, Daniele M Gilkes, Gregg L Semenza. Cancer Res 2016
Debangshu Samanta, Youngrok Park, Shaida A Andrabi, Laura M Shelton, Daniele M Gilkes, Gregg L Semenza. Cancer Res 2016
10
Regulation of cancer cell metabolism.
Rob A Cairns, Isaac S Harris, Tak W Mak. Nat Rev Cancer 2011
Rob A Cairns, Isaac S Harris, Tak W Mak. Nat Rev Cancer 2011
10
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
Christian M Metallo, Paulo A Gameiro, Eric L Bell, Katherine R Mattaini, Juanjuan Yang, Karsten Hiller, Christopher M Jewell, Zachary R Johnson, Darrell J Irvine, Leonard Guarente,[...]. Nature 2011
Christian M Metallo, Paulo A Gameiro, Eric L Bell, Katherine R Mattaini, Juanjuan Yang, Karsten Hiller, Christopher M Jewell, Zachary R Johnson, Darrell J Irvine, Leonard Guarente,[...]. Nature 2011
9
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis.
Sirkku Pollari, Sanna-Maria Käkönen, Henrik Edgren, Maija Wolf, Pekka Kohonen, Henri Sara, Theresa Guise, Matthias Nees, Olli Kallioniemi. Breast Cancer Res Treat 2011
Sirkku Pollari, Sanna-Maria Käkönen, Henrik Edgren, Maija Wolf, Pekka Kohonen, Henri Sara, Theresa Guise, Matthias Nees, Olli Kallioniemi. Breast Cancer Res Treat 2011
9
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.
Ping Gao, Irina Tchernyshyov, Tsung-Cheng Chang, Yun-Sil Lee, Kayoko Kita, Takafumi Ochi, Karen I Zeller, Angelo M De Marzo, Jennifer E Van Eyk, Joshua T Mendell,[...]. Nature 2009
Ping Gao, Irina Tchernyshyov, Tsung-Cheng Chang, Yun-Sil Lee, Kayoko Kita, Takafumi Ochi, Karen I Zeller, Angelo M De Marzo, Jennifer E Van Eyk, Joshua T Mendell,[...]. Nature 2009
9
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.
Sophia Y Lunt, Matthew G Vander Heiden. Annu Rev Cell Dev Biol 2011
Sophia Y Lunt, Matthew G Vander Heiden. Annu Rev Cell Dev Biol 2011
9
Lactate Metabolism in Human Lung Tumors.
Brandon Faubert, Kevin Y Li, Ling Cai, Christopher T Hensley, Jiyeon Kim, Lauren G Zacharias, Chendong Yang, Quyen N Do, Sarah Doucette, Daniel Burguete,[...]. Cell 2017
Brandon Faubert, Kevin Y Li, Ling Cai, Christopher T Hensley, Jiyeon Kim, Lauren G Zacharias, Chendong Yang, Quyen N Do, Sarah Doucette, Daniel Burguete,[...]. Cell 2017
9
Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.
Qian Wang, Maria V Liberti, Pei Liu, Xiaobing Deng, Ying Liu, Jason W Locasale, Luhua Lai. Cell Chem Biol 2017
Qian Wang, Maria V Liberti, Pei Liu, Xiaobing Deng, Ying Liu, Jason W Locasale, Luhua Lai. Cell Chem Biol 2017
12
Metabolic reprogramming and cancer progression.
Brandon Faubert, Ashley Solmonson, Ralph J DeBerardinis. Science 2020
Brandon Faubert, Ashley Solmonson, Ralph J DeBerardinis. Science 2020
9
One-Carbon Metabolism in Health and Disease.
Gregory S Ducker, Joshua D Rabinowitz. Cell Metab 2017
Gregory S Ducker, Joshua D Rabinowitz. Cell Metab 2017
8
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression.
Chih-Hao Chang, Jing Qiu, David O'Sullivan, Michael D Buck, Takuro Noguchi, Jonathan D Curtis, Qiongyu Chen, Mariel Gindin, Matthew M Gubin, Gerritje J W van der Windt,[...]. Cell 2015
Chih-Hao Chang, Jing Qiu, David O'Sullivan, Michael D Buck, Takuro Noguchi, Jonathan D Curtis, Qiongyu Chen, Mariel Gindin, Matthew M Gubin, Gerritje J W van der Windt,[...]. Cell 2015
8
Metabolic Heterogeneity in Human Lung Tumors.
Christopher T Hensley, Brandon Faubert, Qing Yuan, Naama Lev-Cohain, Eunsook Jin, Jiyeon Kim, Lei Jiang, Bookyung Ko, Rachael Skelton, Laurin Loudat,[...]. Cell 2016
Christopher T Hensley, Brandon Faubert, Qing Yuan, Naama Lev-Cohain, Eunsook Jin, Jiyeon Kim, Lei Jiang, Bookyung Ko, Rachael Skelton, Laurin Loudat,[...]. Cell 2016
8
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.
Shawn M Davidson, Thales Papagiannakopoulos, Benjamin A Olenchock, Julia E Heyman, Mark A Keibler, Alba Luengo, Matthew R Bauer, Abhishek K Jha, James P O'Brien, Kerry A Pierce,[...]. Cell Metab 2016
Shawn M Davidson, Thales Papagiannakopoulos, Benjamin A Olenchock, Julia E Heyman, Mark A Keibler, Alba Luengo, Matthew R Bauer, Abhishek K Jha, James P O'Brien, Kerry A Pierce,[...]. Cell Metab 2016
8
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.
Jiangbin Ye, Anthony Mancuso, Xuemei Tong, Patrick S Ward, Jing Fan, Joshua D Rabinowitz, Craig B Thompson. Proc Natl Acad Sci U S A 2012
Jiangbin Ye, Anthony Mancuso, Xuemei Tong, Patrick S Ward, Jing Fan, Joshua D Rabinowitz, Craig B Thompson. Proc Natl Acad Sci U S A 2012
8
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Cristovão M Sousa, Douglas E Biancur, Xiaoxu Wang, Christopher J Halbrook, Mara H Sherman, Li Zhang, Daniel Kremer, Rosa F Hwang, Agnes K Witkiewicz, Haoqiang Ying,[...]. Nature 2016
Cristovão M Sousa, Douglas E Biancur, Xiaoxu Wang, Christopher J Halbrook, Mara H Sherman, Li Zhang, Daniel Kremer, Rosa F Hwang, Agnes K Witkiewicz, Haoqiang Ying,[...]. Nature 2016
8
Serine catabolism regulates mitochondrial redox control during hypoxia.
Jiangbin Ye, Jing Fan, Sriram Venneti, Ying-Wooi Wan, Bruce R Pawel, Ji Zhang, Lydia W S Finley, Chao Lu, Tullia Lindsten, Justin R Cross,[...]. Cancer Discov 2014
Jiangbin Ye, Jing Fan, Sriram Venneti, Ying-Wooi Wan, Bruce R Pawel, Ji Zhang, Lydia W S Finley, Chao Lu, Tullia Lindsten, Justin R Cross,[...]. Cancer Discov 2014
8
Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.
Michael A Reid, Annamarie E Allen, Shiyu Liu, Maria V Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu,[...]. Nat Commun 2018
Michael A Reid, Annamarie E Allen, Shiyu Liu, Maria V Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu,[...]. Nat Commun 2018
10
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
Cosimo Commisso, Shawn M Davidson, Rengin G Soydaner-Azeloglu, Seth J Parker, Jurre J Kamphorst, Sean Hackett, Elda Grabocka, Michel Nofal, Jeffrey A Drebin, Craig B Thompson,[...]. Nature 2013
Cosimo Commisso, Shawn M Davidson, Rengin G Soydaner-Azeloglu, Seth J Parker, Jurre J Kamphorst, Sean Hackett, Elda Grabocka, Michel Nofal, Jeffrey A Drebin, Craig B Thompson,[...]. Nature 2013
8
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
Jaekyoung Son, Costas A Lyssiotis, Haoqiang Ying, Xiaoxu Wang, Sujun Hua, Matteo Ligorio, Rushika M Perera, Cristina R Ferrone, Edouard Mullarky, Ng Shyh-Chang,[...]. Nature 2013
Jaekyoung Son, Costas A Lyssiotis, Haoqiang Ying, Xiaoxu Wang, Sujun Hua, Matteo Ligorio, Rushika M Perera, Cristina R Ferrone, Edouard Mullarky, Ng Shyh-Chang,[...]. Nature 2013
8
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Mylène Tajan, Marc Hennequart, Eric C Cheung, Fabio Zani, Andreas K Hock, Nathalie Legrave, Oliver D K Maddocks, Rachel A Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet,[...]. Nat Commun 2021
Mylène Tajan, Marc Hennequart, Eric C Cheung, Fabio Zani, Andreas K Hock, Nathalie Legrave, Oliver D K Maddocks, Rachel A Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet,[...]. Nat Commun 2021
30
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.
Javier A Menendez, Ruth Lupu. Nat Rev Cancer 2007
Javier A Menendez, Ruth Lupu. Nat Rev Cancer 2007
8
Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non-Small Cell Lung Cancer Cells.
Kayleigh C Ross, Andrew J Andrews, Christopher D Marion, Timothy J Yen, Vikram Bhattacharjee. Mol Cancer Ther 2017
Kayleigh C Ross, Andrew J Andrews, Christopher D Marion, Timothy J Yen, Vikram Bhattacharjee. Mol Cancer Ther 2017
18
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.
Ralph J DeBerardinis, Anthony Mancuso, Evgueni Daikhin, Ilana Nissim, Marc Yudkoff, Suzanne Wehrli, Craig B Thompson. Proc Natl Acad Sci U S A 2007
Ralph J DeBerardinis, Anthony Mancuso, Evgueni Daikhin, Ilana Nissim, Marc Yudkoff, Suzanne Wehrli, Craig B Thompson. Proc Natl Acad Sci U S A 2007
7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.