A citation-based method for searching scientific literature

Douglas J Sheffler, Karen J Gregory, Jerri M Rook, P Jeffrey Conn. Adv Pharmacol 2011
Times Cited: 41







List of co-cited articles
380 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
29

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
P Jeffrey Conn, Arthur Christopoulos, Craig W Lindsley. Nat Rev Drug Discov 2009
746
26

Pharmacology and functions of metabotropic glutamate receptors.
P J Conn, J P Pin. Annu Rev Pharmacol Toxicol 1997
21

Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.
Karen J Gregory, Elizabeth N Dong, Jens Meiler, P Jeffrey Conn. Neuropharmacology 2011
88
21

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.
Michael R Wood, Corey R Hopkins, John T Brogan, P Jeffrey Conn, Craig W Lindsley. Biochemistry 2011
126
19

The metabotropic glutamate receptors: structure and functions.
J P Pin, R Duvoisin. Neuropharmacology 1995
19

Metabotropic glutamate receptors: from the workbench to the bedside.
F Nicoletti, J Bockaert, G L Collingridge, P J Conn, F Ferraguti, D D Schoepp, J T Wroblewski, J P Pin. Neuropharmacology 2011
399
19

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
Huixian Wu, Chong Wang, Karen J Gregory, Gye Won Han, Hyekyung P Cho, Yan Xia, Colleen M Niswender, Vsevolod Katritch, Jens Meiler, Vadim Cherezov,[...]. Science 2014
350
19

Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Søren G F Rasmussen, Brian T DeVree, Yaozhong Zou, Andrew C Kruse, Ka Young Chung, Tong Sun Kobilka, Foon Sun Thian, Pil Seok Chae, Els Pardon, Diane Calinski,[...]. Nature 2011
17

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Andrew S Doré, Krzysztof Okrasa, Jayesh C Patel, Maria Serrano-Vega, Kirstie Bennett, Robert M Cooke, James C Errey, Ali Jazayeri, Samir Khan, Ben Tehan,[...]. Nature 2014
279
17

Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators.
L Lundström, C Bissantz, J Beck, J G Wettstein, T J Woltering, J Wichmann, S Gatti. Br J Pharmacol 2011
37
16

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.
Bruce J Melancon, Corey R Hopkins, Michael R Wood, Kyle A Emmitte, Colleen M Niswender, Arthur Christopoulos, P Jeffrey Conn, Craig W Lindsley. J Med Chem 2012
161
14

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.
P Jeffrey Conn, Craig W Lindsley, Carrie K Jones. Trends Pharmacol Sci 2009
264
14

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
N Kunishima, Y Shimada, Y Tsuji, T Sato, M Yamamoto, T Kumasaka, S Nakanishi, H Jingami, K Morikawa. Nature 2000
925
14

Dimers and beyond: The functional puzzles of class C GPCRs.
Julie Kniazeff, Laurent Prézeau, Philippe Rondard, Jean-Philippe Pin, Cyril Goudet. Pharmacol Ther 2011
157
14

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.
Li Xue, Xavier Rovira, Pauline Scholler, Han Zhao, Jianfeng Liu, Jean-Philippe Pin, Philippe Rondard. Nat Chem Biol 2015
115
14

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
Julie A O'Brien, Wei Lemaire, Tsing-Bau Chen, Raymond S L Chang, Marlene A Jacobson, Sookhee N Ha, Craig W Lindsley, Hervé J Schaffhauser, Cyrille Sur, Douglas J Pettibone,[...]. Mol Pharmacol 2003
186
12

Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.
Pari Malherbe, Nicole Kratochwil, Marie-Thérèse Zenner, Jenny Piussi, Catherine Diener, Claudia Kratzeisen, Christophe Fischer, Richard H P Porter. Mol Pharmacol 2003
126
12

Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.
Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Hyekyung P Cho, Emily Days, Y Zhou, Alice L Rodriguez, Hilde Lavreysen, Shaun R Stauffer, Colleen M Niswender,[...]. Mol Pharmacol 2012
99
12

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Søren G F Rasmussen, Hee-Jung Choi, Daniel M Rosenbaum, Tong Sun Kobilka, Foon Sun Thian, Patricia C Edwards, Manfred Burghammer, Venkata R P Ratnala, Ruslan Sanishvili, Robert F Fischetti,[...]. Nature 2007
12

Crystal structure of rhodopsin: A G protein-coupled receptor.
K Palczewski, T Kumasaka, T Hori, C A Behnke, H Motoshima, B A Fox, I Le Trong, D C Teller, T Okada, R E Stenkamp,[...]. Science 2000
12

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Vadim Cherezov, Daniel M Rosenbaum, Michael A Hanson, Søren G F Rasmussen, Foon Sun Thian, Tong Sun Kobilka, Hee-Jung Choi, Peter Kuhn, William I Weis, Brian K Kobilka,[...]. Science 2007
12

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.
Sandeep T Patil, Lu Zhang, Ferenc Martenyi, Stephen L Lowe, Kimberley A Jackson, Boris V Andreev, Alla S Avedisova, Leonid M Bardenstein, Issak Y Gurovich, Margarita A Morozova,[...]. Nat Med 2007
780
12

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.
Alice L Rodriguez, Mark D Grier, Carrie K Jones, Elizabeth J Herman, Alexander S Kane, Randy L Smith, Richard Williams, Ya Zhou, Joy E Marlo, Emily L Days,[...]. Mol Pharmacol 2010
141
12

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.
Jean-Philippe Pin, Thierry Galvez, Laurent Prézeau. Pharmacol Ther 2003
443
12

ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities.
Feng Liu, Steve Grauer, Cody Kelley, Rachel Navarra, Radka Graf, Guoming Zhang, Peter J Atkinson, Michael Popiolek, Caitlin Wantuch, Xavier Khawaja,[...]. J Pharmacol Exp Ther 2008
160
12

Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators.
Stephan Schann, Stanislas Mayer, Christel Franchet, Mélanie Frauli, Edith Steinberg, Mireille Thomas, Luc Baron, Pascal Neuville. J Med Chem 2010
37
13

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
Shen Yin, Meredith J Noetzel, Kari A Johnson, Rocio Zamorano, Nidhi Jalan-Sakrikar, Karen J Gregory, P Jeffrey Conn, Colleen M Niswender. J Neurosci 2014
80
12

Development of allosteric modulators of GPCRs for treatment of CNS disorders.
Hilary Highfield Nickols, P Jeffrey Conn. Neurobiol Dis 2014
146
12


Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.
Karen J Gregory, Elizabeth D Nguyen, Chrysa Malosh, Jeffrey L Mendenhall, Jessica Z Zic, Brittney S Bates, Meredith J Noetzel, Emma F Squire, Eric M Turner, Jerri M Rook,[...]. ACS Chem Neurosci 2014
39
12

Metabotropic glutamate receptors and striatal synaptic plasticity: implications for neurological diseases.
Paolo Gubellini, Antonio Pisani, Diego Centonze, Giorgio Bernardi, Paolo Calabresi. Prog Neurobiol 2004
117
9

A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.
Daniella Rylander, Hanna Iderberg, Qin Li, Andrzej Dekundy, Jinlan Zhang, Hao Li, Ren Baishen, Wojciech Danysz, Erwan Bezard, M Angela Cenci. Neurobiol Dis 2010
124
9


Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.
Aashish Manglik, Andrew C Kruse, Tong Sun Kobilka, Foon Sun Thian, Jesper M Mathiesen, Roger K Sunahara, Leonardo Pardo, William I Weis, Brian K Kobilka, Sébastien Granier. Nature 2012
902
9

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
F Gasparini, K Lingenhöhl, N Stoehr, P J Flor, M Heinrich, I Vranesic, M Biollaz, H Allgeier, R Heckendorn, S Urwyler,[...]. Neuropharmacology 1999
644
9


A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
Gene G Kinney, Julie A O'Brien, Wei Lemaire, Maryann Burno, Denise J Bickel, Michelle K Clements, Tsing-Bau Chen, David D Wisnoski, Craig W Lindsley, Philip R Tiller,[...]. J Pharmacol Exp Ther 2005
244
9

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain.
C Romano, M A Sesma, C T McDonald, K O'Malley, A N Van den Pol, J W Olney. J Comp Neurol 1995
559
9


Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.
Driss El Moustaine, Sébastien Granier, Etienne Doumazane, Pauline Scholler, Rita Rahmeh, Patrick Bron, Bernard Mouillac, Jean-Louis Banères, Philippe Rondard, Jean-Philippe Pin. Proc Natl Acad Sci U S A 2012
119
9

Structures of the extracellular regions of the group II/III metabotropic glutamate receptors.
Takanori Muto, Daisuke Tsuchiya, Kosuke Morikawa, Hisato Jingami. Proc Natl Acad Sci U S A 2007
260
9

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.
Gary Tresadern, Jose María Cid, Gregor J Macdonald, Juan Antonio Vega, Ana Isabel de Lucas, Aránzazu García, Encarnación Matesanz, María Lourdes Linares, Daniel Oehlrich, Hilde Lavreysen,[...]. Bioorg Med Chem Lett 2010
49
9

Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.
Douglas J Sheffler, Anthony B Pinkerton, Russell Dahl, Athina Markou, Nicholas D P Cosford. ACS Chem Neurosci 2011
35
11

Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells.
Nuria Cabello, Jorge Gandía, Daniela C G Bertarelli, Masahiko Watanabe, Carme Lluís, Rafael Franco, Sergi Ferré, Rafael Luján, Francisco Ciruela. J Neurochem 2009
197
9

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.
J C Tu, B Xiao, S Naisbitt, J P Yuan, R S Petralia, P Brakeman, A Doan, V K Aakalu, A A Lanahan, M Sheng,[...]. Neuron 1999
802
9

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.
Karen J Gregory, Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Shaun R Stauffer, Alice L Rodriguez, Kyle A Emmitte, Ya Zhou, Aspen C Chun, Andrew S Felts,[...]. Mol Pharmacol 2012
67
9


A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.
Etienne Doumazane, Pauline Scholler, Jurriaan M Zwier, Eric Trinquet, Philippe Rondard, Jean-Philippe Pin. FASEB J 2011
195
9

Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Andrew C Kruse, Aaron M Ring, Aashish Manglik, Jianxin Hu, Kelly Hu, Katrin Eitel, Harald Hübner, Els Pardon, Celine Valant, Patrick M Sexton,[...]. Nature 2013
575
9


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.