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Times Cited: 100
Times Cited: 100
Times Cited
Times Co-cited
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Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage.
Judith Haendeler, Stefan Dröse, Nicole Büchner, Sascha Jakob, Joachim Altschmied, Christine Goy, Ioakim Spyridopoulos, Andreas M Zeiher, Ulrich Brandt, Stefanie Dimmeler. Arterioscler Thromb Vasc Biol 2009
Judith Haendeler, Stefan Dröse, Nicole Büchner, Sascha Jakob, Joachim Altschmied, Christine Goy, Ioakim Spyridopoulos, Andreas M Zeiher, Ulrich Brandt, Stefanie Dimmeler. Arterioscler Thromb Vasc Biol 2009
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Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.
Shaheda Ahmed, João F Passos, Matthew J Birket, Tina Beckmann, Sebastian Brings, Heiko Peters, Mark A Birch-Machin, Thomas von Zglinicki, Gabriele Saretzki. J Cell Sci 2008
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Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.
Janine Hertzog Santos, Joel N Meyer, Milan Skorvaga, Lois A Annab, Bennett Van Houten. Aging Cell 2004
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An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
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Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.
Judith Haendeler, Jörg Hoffmann, Ralf P Brandes, Andreas M Zeiher, Stefanie Dimmeler. Mol Cell Biol 2003
Judith Haendeler, Jörg Hoffmann, Ralf P Brandes, Andreas M Zeiher, Stefanie Dimmeler. Mol Cell Biol 2003
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hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells.
Inthrani R Indran, Manoor P Hande, Shazib Pervaiz. Cancer Res 2011
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Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis.
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Telomere dysfunction induces metabolic and mitochondrial compromise.
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Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis.
Chatchawan Singhapol, Deepali Pal, Rafal Czapiewski, Mahendar Porika, Glyn Nelson, Gabriele C Saretzki. PLoS One 2013
Chatchawan Singhapol, Deepali Pal, Rafal Czapiewski, Mahendar Porika, Glyn Nelson, Gabriele C Saretzki. PLoS One 2013
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A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction.
Olga A Kovalenko, Matthieu J Caron, Perihan Ulema, Carolina Medrano, Andrew P Thomas, Masayuki Kimura, Marcelo G Bonini, Utz Herbig, Janine H Santos. Aging Cell 2010
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Telomerase modulates Wnt signalling by association with target gene chromatin.
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TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program.
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Telomerase modulates expression of growth-controlling genes and enhances cell proliferation.
Laura L Smith, Hilary A Coller, James M Roberts. Nat Cell Biol 2003
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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.
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Specific association of human telomerase activity with immortal cells and cancer.
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Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.
Judith Haendeler, Jörg Hoffmann, J Florian Diehl, Mariuca Vasa, Ioakim Spyridopoulos, Andreas M Zeiher, Stefanie Dimmeler. Circ Res 2004
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Conditional telomerase induction causes proliferation of hair follicle stem cells.
Kavita Y Sarin, Peggie Cheung, Daniel Gilison, Eunice Lee, Ruth I Tennen, Estee Wang, Maja K Artandi, Anthony E Oro, Steven E Artandi. Nature 2005
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Extension of life-span by introduction of telomerase into normal human cells.
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Shelterin: the protein complex that shapes and safeguards human telomeres.
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Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent.
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Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins.
Paula Martínez, María A Blasco. Nat Rev Cancer 2011
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Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.
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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.
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Telomerase directly regulates NF-κB-dependent transcription.
Arkasubhra Ghosh, Gaye Saginc, Shi Chi Leow, Ekta Khattar, Eun Myong Shin, Ting Dong Yan, Marc Wong, Zhizhuo Zhang, Guoliang Li, Wing-Kin Sung,[...]. Nat Cell Biol 2012
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Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria.
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Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B.
Francesca Iannilli, Francesca Zalfa, Annette Gartner, Claudia Bagni, Carlos G Dotti. PLoS One 2013
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Extra-telomeric functions of human telomerase: cancer, mitochondria and oxidative stress.
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The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.
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The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis.
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Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis.
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Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation.
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Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase.
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Protein composition of catalytically active human telomerase from immortal cells.
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Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
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The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence.
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Separation of telomerase functions by reverse genetics.
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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.
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