Jieru E Lin, Michael Valentino, Glen Marszalowicz, Michael S Magee, Peng Li, Adam E Snook, Brian A Stoecker, Chang Chang, Scott A Waldman. Toxins (Basel) 2010
Times Cited: 25
Times Cited: 25
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Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation.
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40
Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome.
Viola Andresen, Michael Camilleri, Irene A Busciglio, April Grudell, Duane Burton, Sanna McKinzie, Amy Foxx-Orenstein, Caroline B Kurtz, Vineeta Sharma, Jeffrey M Johnston,[...]. Gastroenterology 2007
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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit.
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Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain.
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Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.
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Guanylyl cyclases and signaling by cyclic GMP.
K A Lucas, G M Pitari, S Kazerounian, I Ruiz-Stewart, J Park, S Schulz, K P Chepenik, S A Waldman. Pharmacol Rev 2000
K A Lucas, G M Pitari, S Kazerounian, I Ruiz-Stewart, J Park, S Schulz, K P Chepenik, S A Waldman. Pharmacol Rev 2000
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George F Longstreth, W Grant Thompson, William D Chey, Lesley A Houghton, Fermin Mearin, Robin C Spiller. Gastroenterology 2006
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A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.
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Michael A Valentino, Jieru E Lin, Adam E Snook, Peng Li, Gilbert W Kim, Glen Marszalowicz, Michael S Magee, Terry Hyslop, Stephanie Schulz, Scott A Waldman. J Clin Invest 2011
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Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.
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Guanylate cyclase-C receptor activation: unexpected biology.
Stuart M Brierley. Curr Opin Pharmacol 2012
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Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety.
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24
A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation.
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Satish Rao, Anthony J Lembo, Steven J Shiff, Bernard J Lavins, Mark G Currie, Xinwei D Jia, Kelvin Shi, James E MacDougall, James Z Shao, Paul Eng,[...]. Am J Gastroenterol 2012
24
Two randomized trials of linaclotide for chronic constipation.
Anthony J Lembo, Harvey A Schneier, Steven J Shiff, Caroline B Kurtz, James E MacDougall, Xinwei D Jia, James Z Shao, Bernard J Lavins, Mark G Currie, Donald A Fitch,[...]. N Engl J Med 2011
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20
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract.
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20
Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe and well-tolerated in single doses.
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20
Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation.
Robert W Busby, Marco M Kessler, Wilmin P Bartolini, Alexander P Bryant, Gerhard Hannig, Carolyn S Higgins, Robert M Solinga, Jenny V Tobin, James D Wakefield, Caroline B Kurtz,[...]. J Pharmacol Exp Ther 2013
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20
Uroguanylin and guanylin: distinct but overlapping patterns of messenger RNA expression in mouse intestine.
T L Whitaker, D P Witte, M C Scott, M B Cohen. Gastroenterology 1997
T L Whitaker, D P Witte, M C Scott, M B Cohen. Gastroenterology 1997
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Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints.
E M M Quigley, J Tack, W D Chey, S S Rao, J Fortea, M Falques, C Diaz, S J Shiff, M G Currie, J M Johnston. Aliment Pharmacol Ther 2013
E M M Quigley, J Tack, W D Chey, S S Rao, J Fortea, M Falques, C Diaz, S J Shiff, M G Currie, J M Johnston. Aliment Pharmacol Ther 2013
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A randomized placebo-controlled phase IIb trial of a3309, a bile acid transporter inhibitor, for chronic idiopathic constipation.
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16
Randomised clinical trial: The ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation--a double-blind study.
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M Simrén, A Bajor, P-G Gillberg, M Rudling, H Abrahamsson. Aliment Pharmacol Ther 2011
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Gastrointestinal pain: unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation.
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16
The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.
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12
Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer.
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Scott A Waldman, Terry Hyslop, Stephanie Schulz, Alan Barkun, Karl Nielsen, Janis Haaf, Christine Bonaccorso, Yanyan Li, David S Weinberg. JAMA 2009
12
Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor.
Stephen L Carrithers, Cobern E Ott, Michael J Hill, Brett R Johnson, Weiyan Cai, Jason J Chang, Rajesh G Shah, Congmei Sun, Elizabeth A Mann, Manasses C Fonteles,[...]. Kidney Int 2004
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Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity.
Peng Li, Stephanie Schulz, Alessandro Bombonati, Juan P Palazzo, Terry M Hyslop, Yihuan Xu, Amy A Baran, Linda D Siracusa, Giovanni M Pitari, Scott A Waldman. Gastroenterology 2007
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12
Guanylyl cyclase is a heat-stable enterotoxin receptor.
S Schulz, C K Green, P S Yuen, D L Garbers. Cell 1990
S Schulz, C K Green, P S Yuen, D L Garbers. Cell 1990
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Opossum colonic mucosa contains uroguanylin and guanylin peptides.
F K Hamra, W J Krause, S L Eber, R H Freeman, C E Smith, M G Currie, L R Forte. Am J Physiol 1996
F K Hamra, W J Krause, S L Eber, R H Freeman, C E Smith, M G Currie, L R Forte. Am J Physiol 1996
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Characterization of human uroguanylin: a member of the guanylin peptide family.
T Kita, C E Smith, K F Fok, K L Duffin, W M Moore, P J Karabatsos, J F Kachur, F K Hamra, N V Pidhorodeckyj, L R Forte. Am J Physiol 1994
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Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics.
Leonard Ralph Forte. Pharmacol Ther 2004
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Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer.
B Cagir, A Gelmann, J Park, T Fava, A Tankelevitch, E W Bittner, E J Weaver, J P Palazzo, D Weinberg, R D Fry,[...]. Ann Intern Med 1999
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F K Hamra, S L Eber, D T Chin, M G Currie, L R Forte. Proc Natl Acad Sci U S A 1997
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Uroguanylin is expressed by enterochromaffin cells in the rat gastrointestinal tract.
A Perkins, M F Goy, Z Li. Gastroenterology 1997
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Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases.
Lincoln R Potter. Pharmacol Ther 2011
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Transmembrane guanylate cyclase in intestinal pathophysiology.
Kris A Steinbrecher, Mitchell B Cohen. Curr Opin Gastroenterol 2011
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Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior.
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Familial diarrhea syndrome caused by an activating GUCY2C mutation.
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E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actions.
Ralph A Giannella, Elizabeth A Mann. Trans Am Clin Climatol Assoc 2003
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Linaclotide - a secretagogue and antihyperalgesic agent - what next?
A E Bharucha, D R Linden. Neurogastroenterol Motil 2010
A E Bharucha, D R Linden. Neurogastroenterol Motil 2010
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Cure and curse: E. coli heat-stable enterotoxin and its receptor guanylyl cyclase C.
Philipp R Weiglmeier, Paul Rösch, Hanna Berkner. Toxins (Basel) 2010
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The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis.
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Glenn F King, Margaret C Hardy. Annu Rev Entomol 2013
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Prucalopride: safety, efficacy and potential applications.
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Rebecca M Lovell, Alexander C Ford. Clin Gastroenterol Hepatol 2012
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Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.
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Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.
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Elobixibat for the treatment of constipation.
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Isolation, sequencing, and structure-activity relationships of cyclotides.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.