Otilia Postea, Martin Biel. Nat Rev Drug Discov 2011
Times Cited: 140
Times Cited: 140
Times Cited
Times Co-cited
Similarity
Hyperpolarization-activated cation channels: from genes to function.
Martin Biel, Christian Wahl-Schott, Stylianos Michalakis, Xiangang Zong. Physiol Rev 2009
Martin Biel, Christian Wahl-Schott, Stylianos Michalakis, Xiangang Zong. Physiol Rev 2009
40
HCN2 ion channels play a central role in inflammatory and neuropathic pain.
Edward C Emery, Gareth T Young, Esther M Berrocoso, Lubin Chen, Peter A McNaughton. Science 2011
Edward C Emery, Gareth T Young, Esther M Berrocoso, Lubin Chen, Peter A McNaughton. Science 2011
26
Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain.
Takuya Notomi, Ryuichi Shigemoto. J Comp Neurol 2004
Takuya Notomi, Ryuichi Shigemoto. J Comp Neurol 2004
21
Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels.
Gareth T Young, Edward C Emery, Elizabeth R Mooney, Christoforos Tsantoulas, Peter A McNaughton. Pain 2014
Gareth T Young, Edward C Emery, Elizabeth R Mooney, Christoforos Tsantoulas, Peter A McNaughton. Pain 2014
26
Hyperpolarization-activated cation currents: from molecules to physiological function.
Richard B Robinson, Steven A Siegelbaum. Annu Rev Physiol 2003
Richard B Robinson, Steven A Siegelbaum. Annu Rev Physiol 2003
17
HCN2 ion channels: an emerging role as the pacemakers of pain.
Edward C Emery, Gareth T Young, Peter A McNaughton. Trends Pharmacol Sci 2012
Edward C Emery, Gareth T Young, Peter A McNaughton. Trends Pharmacol Sci 2012
22
A family of hyperpolarization-activated mammalian cation channels.
A Ludwig, X Zong, M Jeglitsch, F Hofmann, M Biel. Nature 1998
A Ludwig, X Zong, M Jeglitsch, F Hofmann, M Biel. Nature 1998
16
Role of the hyperpolarization-activated current Ih in somatosensory neurons.
Aliakmal Momin, Hervé Cadiou, Adrian Mason, Peter A McNaughton. J Physiol 2008
Aliakmal Momin, Hervé Cadiou, Adrian Mason, Peter A McNaughton. J Physiol 2008
16
Neurophysiology of HCN channels: from cellular functions to multiple regulations.
Chao He, Fang Chen, Bo Li, Zhian Hu. Prog Neurobiol 2014
Chao He, Fang Chen, Bo Li, Zhian Hu. Prog Neurobiol 2014
16
Molecular mechanism of cAMP modulation of HCN pacemaker channels.
B J Wainger, M DeGennaro, B Santoro, S A Siegelbaum, G R Tibbs. Nature 2001
B J Wainger, M DeGennaro, B Santoro, S A Siegelbaum, G R Tibbs. Nature 2001
15
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2.
Andreas Ludwig, Thomas Budde, Juliane Stieber, Sven Moosmang, Christian Wahl, Knut Holthoff, Anke Langebartels, Carsten Wotjak, Thomas Munsch, Xiangang Zong,[...]. EMBO J 2003
Andreas Ludwig, Thomas Budde, Juliane Stieber, Sven Moosmang, Christian Wahl, Knut Holthoff, Anke Langebartels, Carsten Wotjak, Thomas Munsch, Xiangang Zong,[...]. EMBO J 2003
14
Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.
Sandra R Chaplan, Hong-Qing Guo, Doo Hyun Lee, Lin Luo, Changlu Liu, Chester Kuei, Alexander A Velumian, Matthew P Butler, Sean M Brown, Adrienne E Dubin. J Neurosci 2003
Sandra R Chaplan, Hong-Qing Guo, Doo Hyun Lee, Lin Luo, Changlu Liu, Chester Kuei, Alexander A Velumian, Matthew P Butler, Sean M Brown, Adrienne E Dubin. J Neurosci 2003
14
HCN channels: structure, cellular regulation and physiological function.
C Wahl-Schott, M Biel. Cell Mol Life Sci 2009
C Wahl-Schott, M Biel. Cell Mol Life Sci 2009
14
Dysfunctional HCN ion channels in neurological diseases.
Jacopo C DiFrancesco, Dario DiFrancesco. Front Cell Neurosci 2015
Jacopo C DiFrancesco, Dario DiFrancesco. Front Cell Neurosci 2015
18
A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons.
Matthew F Nolan, Gaël Malleret, Josh T Dudman, Derek L Buhl, Bina Santoro, Emma Gibbs, Svetlana Vronskaya, György Buzsáki, Steven A Siegelbaum, Eric R Kandel,[...]. Cell 2004
Matthew F Nolan, Gaël Malleret, Josh T Dudman, Derek L Buhl, Bina Santoro, Emma Gibbs, Svetlana Vronskaya, György Buzsáki, Steven A Siegelbaum, Eric R Kandel,[...]. Cell 2004
12
Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers.
Michele Melchiorre, Martina Del Lungo, Luca Guandalini, Elisabetta Martini, Silvia Dei, Dina Manetti, Serena Scapecchi, Elisabetta Teodori, Laura Sartiani, Alessandro Mugelli,[...]. J Med Chem 2010
Michele Melchiorre, Martina Del Lungo, Luca Guandalini, Elisabetta Martini, Silvia Dei, Dina Manetti, Serena Scapecchi, Elisabetta Teodori, Laura Sartiani, Alessandro Mugelli,[...]. J Med Chem 2010
44
The Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels.
Laura Sartiani, Guido Mannaioni, Alessio Masi, Maria Novella Romanelli, Elisabetta Cerbai. Pharmacol Rev 2017
Laura Sartiani, Guido Mannaioni, Alessio Masi, Maria Novella Romanelli, Elisabetta Cerbai. Pharmacol Rev 2017
22
Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites.
Nicholas P Poolos, Michele Migliore, Daniel Johnston. Nat Neurosci 2002
Nicholas P Poolos, Michele Migliore, Daniel Johnston. Nat Neurosci 2002
11
Structural basis for modulation and agonist specificity of HCN pacemaker channels.
William N Zagotta, Nelson B Olivier, Kevin D Black, Edgar C Young, Rich Olson, Eric Gouaux. Nature 2003
William N Zagotta, Nelson B Olivier, Kevin D Black, Edgar C Young, Rich Olson, Eric Gouaux. Nature 2003
11
TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.
Bina Santoro, Rebecca A Piskorowski, Phillip Pian, Lei Hu, Haiying Liu, Steven A Siegelbaum. Neuron 2009
Bina Santoro, Rebecca A Piskorowski, Phillip Pian, Lei Hu, Haiying Liu, Steven A Siegelbaum. Neuron 2009
10
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.
Karl Swedberg, Michel Komajda, Michael Böhm, Jeffrey S Borer, Ian Ford, Ariane Dubost-Brama, Guy Lerebours, Luigi Tavazzi. Lancet 2010
Karl Swedberg, Michel Komajda, Michael Böhm, Jeffrey S Borer, Ian Ford, Ariane Dubost-Brama, Guy Lerebours, Luigi Tavazzi. Lancet 2010
10
Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial.
Kim Fox, Ian Ford, P Gabriel Steg, Michal Tendera, Roberto Ferrari. Lancet 2008
Kim Fox, Ian Ford, P Gabriel Steg, Michal Tendera, Roberto Ferrari. Lancet 2008
10
Bradycardic and proarrhythmic properties of sinus node inhibitors.
Juliane Stieber, Karen Wieland, Georg Stöckl, Andreas Ludwig, Franz Hofmann. Mol Pharmacol 2006
Juliane Stieber, Karen Wieland, Georg Stöckl, Andreas Ludwig, Franz Hofmann. Mol Pharmacol 2006
12
Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide.
S Chen, J Wang, S A Siegelbaum. J Gen Physiol 2001
S Chen, J Wang, S A Siegelbaum. J Gen Physiol 2001
10
Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.
D DiFrancesco, P Tortora. Nature 1991
D DiFrancesco, P Tortora. Nature 1991
9
HCN channels in behavior and neurological disease: too hyper or not active enough?
Alan S Lewis, Dane M Chetkovich. Mol Cell Neurosci 2011
Alan S Lewis, Dane M Chetkovich. Mol Cell Neurosci 2011
15
Ivabradine in stable coronary artery disease without clinical heart failure.
Kim Fox, Ian Ford, Philippe Gabriel Steg, Jean-Claude Tardif, Michal Tendera, Roberto Ferrari. N Engl J Med 2014
Kim Fox, Ian Ford, Philippe Gabriel Steg, Jean-Claude Tardif, Michal Tendera, Roberto Ferrari. N Engl J Med 2014
9
Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat.
Yu-Qiu Jiang, Guo-Gang Xing, Sheng-Lan Wang, Hui-Yin Tu, Ye-Nan Chi, Jie Li, Feng-Yu Liu, Ji-Sheng Han, You Wan. Pain 2008
Yu-Qiu Jiang, Guo-Gang Xing, Sheng-Lan Wang, Hui-Yin Tu, Ye-Nan Chi, Jie Li, Feng-Yu Liu, Ji-Sheng Han, You Wan. Pain 2008
10
Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors.
Chung Sub Kim, Payne Y Chang, Daniel Johnston. Neuron 2012
Chung Sub Kim, Payne Y Chang, Daniel Johnston. Neuron 2012
9
Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.
B Santoro, D T Liu, H Yao, D Bartsch, E R Kandel, S A Siegelbaum, G R Tibbs. Cell 1998
B Santoro, D T Liu, H Yao, D Bartsch, E R Kandel, S A Siegelbaum, G R Tibbs. Cell 1998
9
Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels.
Lan Cheng, Krista Kinard, Ramkumar Rajamani, Michael C Sanguinetti. J Pharmacol Exp Ther 2007
Lan Cheng, Krista Kinard, Ramkumar Rajamani, Michael C Sanguinetti. J Pharmacol Exp Ther 2007
23
Molecular identification of a hyperpolarization-activated channel in sea urchin sperm.
R Gauss, R Seifert, U B Kaupp. Nature 1998
R Gauss, R Seifert, U B Kaupp. Nature 1998
9
Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.
B Santoro, S Chen, A Luthi, P Pavlidis, G P Shumyatsky, G R Tibbs, S A Siegelbaum. J Neurosci 2000
B Santoro, S Chen, A Luthi, P Pavlidis, G P Shumyatsky, G R Tibbs, S A Siegelbaum. J Neurosci 2000
8
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.
Juliette Descoeur, Vanessa Pereira, Anne Pizzoccaro, Amaury Francois, Bing Ling, Violette Maffre, Brigitte Couette, Jérôme Busserolles, Christine Courteix, Jacques Noel,[...]. EMBO Mol Med 2011
Juliette Descoeur, Vanessa Pereira, Anne Pizzoccaro, Amaury Francois, Bing Ling, Violette Maffre, Brigitte Couette, Jérôme Busserolles, Christine Courteix, Jacques Noel,[...]. EMBO Mol Med 2011
8
CNG and HCN channels: two peas, one pod.
Kimberley B Craven, William N Zagotta. Annu Rev Physiol 2006
Kimberley B Craven, William N Zagotta. Annu Rev Physiol 2006
8
Queer current and pacemaker: the hyperpolarization-activated cation current in neurons.
H C Pape. Annu Rev Physiol 1996
H C Pape. Annu Rev Physiol 1996
8
Spinal hyperpolarization-activated cyclic nucleotide-gated cation channels at primary afferent terminals contribute to chronic pain.
Keiko Takasu, Hideki Ono, Mitsuo Tanabe. Pain 2010
Keiko Takasu, Hideki Ono, Mitsuo Tanabe. Pain 2010
16
Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?
Xing Wu, Liping Liao, Xiangming Liu, Fang Luo, Tianming Yang, Chenhong Li. Channels (Austin) 2012
Xing Wu, Liping Liao, Xiangming Liu, Fang Luo, Tianming Yang, Chenhong Li. Channels (Austin) 2012
14
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
S Moosmang, J Stieber, X Zong, M Biel, F Hofmann, A Ludwig. Eur J Biochem 2001
S Moosmang, J Stieber, X Zong, M Biel, F Hofmann, A Ludwig. Eur J Biochem 2001
8
Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites.
Andrea Lörincz, Takuya Notomi, Gábor Tamás, Ryuichi Shigemoto, Zoltan Nusser. Nat Neurosci 2002
Andrea Lörincz, Takuya Notomi, Gábor Tamás, Ryuichi Shigemoto, Zoltan Nusser. Nat Neurosci 2002
8
HCN channels--modulators of cardiac and neuronal excitability.
Stefan Herrmann, Sabine Schnorr, Andreas Ludwig. Int J Mol Sci 2015
Stefan Herrmann, Sabine Schnorr, Andreas Ludwig. Int J Mol Sci 2015
23
Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.
Alan S Lewis, Sachin P Vaidya, Cory A Blaiss, Zhiqiang Liu, Travis R Stoub, Darrin H Brager, Xiangdong Chen, Roland A Bender, Chad M Estep, Andrey B Popov,[...]. J Neurosci 2011
Alan S Lewis, Sachin P Vaidya, Cory A Blaiss, Zhiqiang Liu, Travis R Stoub, Darrin H Brager, Xiangdong Chen, Roland A Bender, Chad M Estep, Andrey B Popov,[...]. J Neurosci 2011
8
Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine.
Annalisa Bucchi, Mirko Baruscotti, Dario DiFrancesco. J Gen Physiol 2002
Annalisa Bucchi, Mirko Baruscotti, Dario DiFrancesco. J Gen Physiol 2002
8
Identification of the molecular site of ivabradine binding to HCN4 channels.
Annalisa Bucchi, Mirko Baruscotti, Marco Nardini, Andrea Barbuti, Stefano Micheloni, Martino Bolognesi, Dario DiFrancesco. PLoS One 2013
Annalisa Bucchi, Mirko Baruscotti, Marco Nardini, Andrea Barbuti, Stefano Micheloni, Martino Bolognesi, Dario DiFrancesco. PLoS One 2013
20
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.
A Bucchi, A Tognati, R Milanesi, M Baruscotti, D DiFrancesco. J Physiol 2006
A Bucchi, A Tognati, R Milanesi, M Baruscotti, D DiFrancesco. J Physiol 2006
8
Physiology and pharmacology of the cardiac pacemaker ("funny") current.
Mirko Baruscotti, Annalisa Bucchi, Dario Difrancesco. Pharmacol Ther 2005
Mirko Baruscotti, Annalisa Bucchi, Dario Difrancesco. Pharmacol Ther 2005
8
Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue.
Martina Del Lungo, Michele Melchiorre, Luca Guandalini, Laura Sartiani, Alessandro Mugelli, Istvan Koncz, Tamas Szel, Andras Varro, Maria Novella Romanelli, Elisabetta Cerbai. Br J Pharmacol 2012
Martina Del Lungo, Michele Melchiorre, Luca Guandalini, Laura Sartiani, Alessandro Mugelli, Istvan Koncz, Tamas Szel, Andras Varro, Maria Novella Romanelli, Elisabetta Cerbai. Br J Pharmacol 2012
25
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal.
Nicholas P Franks. Nat Rev Neurosci 2008
Nicholas P Franks. Nat Rev Neurosci 2008
7
Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.
Mirko Baruscotti, Annalisa Bucchi, Carlo Viscomi, Giacomo Mandelli, Giacomo Consalez, Tomaso Gnecchi-Rusconi, Nicola Montano, Karina Rabello Casali, Stefano Micheloni, Andrea Barbuti,[...]. Proc Natl Acad Sci U S A 2011
Mirko Baruscotti, Annalisa Bucchi, Carlo Viscomi, Giacomo Mandelli, Giacomo Consalez, Tomaso Gnecchi-Rusconi, Nicola Montano, Karina Rabello Casali, Stefano Micheloni, Andrea Barbuti,[...]. Proc Natl Acad Sci U S A 2011
7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.