Benoit Viollet, Bruno Guigas, Nieves Sanz Garcia, Jocelyne Leclerc, Marc Foretz, Fabrizio Andreelli. Clin Sci (Lond) 2012
Times Cited: 1001
Times Cited: 1001
Times Cited
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Role of AMP-activated protein kinase in mechanism of metformin action.
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
19
The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
18
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
9
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
M R Owen, E Doran, A P Halestrap. Biochem J 2000
M R Owen, E Doran, A P Halestrap. Biochem J 2000
9
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
M Y El-Mir, V Nogueira, E Fontaine, N Avéret, M Rigoulet, X Leverve. J Biol Chem 2000
M Y El-Mir, V Nogueira, E Fontaine, N Avéret, M Rigoulet, X Leverve. J Biol Chem 2000
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Clinical pharmacokinetics of metformin.
Garry G Graham, Jeroen Punt, Manit Arora, Richard O Day, Matthew P Doogue, Janna K Duong, Timothy J Furlong, Jerry R Greenfield, Louise C Greenup, Carl M Kirkpatrick,[...]. Clin Pharmacokinet 2011
Garry G Graham, Jeroen Punt, Manit Arora, Richard O Day, Matthew P Doogue, Janna K Duong, Timothy J Furlong, Jerry R Greenfield, Louise C Greenup, Carl M Kirkpatrick,[...]. Clin Pharmacokinet 2011
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Metformin and reduced risk of cancer in diabetic patients.
Josie M M Evans, Louise A Donnelly, Alistair M Emslie-Smith, Dario R Alessi, Andrew D Morris. BMJ 2005
Josie M M Evans, Louise A Donnelly, Alistair M Emslie-Smith, Dario R Alessi, Andrew D Morris. BMJ 2005
8
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.
Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet. J Clin Invest 2010
Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet. J Clin Invest 2010
8
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.
Hannah R Bridges, Andrew J Y Jones, Michael N Pollak, Judy Hirst. Biochem J 2014
Hannah R Bridges, Andrew J Y Jones, Michael N Pollak, Judy Hirst. Biochem J 2014
8
Metformin: from mechanisms of action to therapies.
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
8
Metformin: a review of its potential indications.
Yi-Wei Wang, Si-Jia He, Xiao Feng, Jin Cheng, Yun-Tao Luo, Ling Tian, Qian Huang. Drug Des Devel Ther 2017
Yi-Wei Wang, Si-Jia He, Xiao Feng, Jin Cheng, Yun-Tao Luo, Ling Tian, Qian Huang. Drug Des Devel Ther 2017
7
AMPK: a nutrient and energy sensor that maintains energy homeostasis.
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
7
Metformin and the gastrointestinal tract.
Laura J McCreight, Clifford J Bailey, Ewan R Pearson. Diabetologia 2016
Laura J McCreight, Clifford J Bailey, Ewan R Pearson. Diabetologia 2016
6
Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity.
Roberto Romero, Offer Erez, Maik Hüttemann, Eli Maymon, Bogdan Panaitescu, Agustin Conde-Agudelo, Percy Pacora, Bo Hyun Yoon, Lawrence I Grossman. Am J Obstet Gynecol 2017
Roberto Romero, Offer Erez, Maik Hüttemann, Eli Maymon, Bogdan Panaitescu, Agustin Conde-Agudelo, Percy Pacora, Bo Hyun Yoon, Lawrence I Grossman. Am J Obstet Gynecol 2017
6
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.
Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix,[...]. Nat Med 2017
Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix,[...]. Nat Med 2017
6
Metformin--mode of action and clinical implications for diabetes and cancer.
Ida Pernicova, Márta Korbonits. Nat Rev Endocrinol 2014
Ida Pernicova, Márta Korbonits. Nat Rev Endocrinol 2014
6
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Adem Kalender, Anand Selvaraj, So Young Kim, Pawan Gulati, Sophie Brûlé, Benoit Viollet, Bruce E Kemp, Nabeel Bardeesy, Patrick Dennis, John J Schlager,[...]. Cell Metab 2010
Adem Kalender, Anand Selvaraj, So Young Kim, Pawan Gulati, Sophie Brûlé, Benoit Viollet, Bruce E Kemp, Nabeel Bardeesy, Patrick Dennis, John J Schlager,[...]. Cell Metab 2010
6
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
Yan Shu, Steven A Sheardown, Chaline Brown, Ryan P Owen, Shuzhong Zhang, Richard A Castro, Alexandra G Ianculescu, Lin Yue, Joan C Lo, Esteban G Burchard,[...]. J Clin Invest 2007
Yan Shu, Steven A Sheardown, Chaline Brown, Ryan P Owen, Shuzhong Zhang, Richard A Castro, Alexandra G Ianculescu, Lin Yue, Joan C Lo, Esteban G Burchard,[...]. J Clin Invest 2007
6
Cellular and Molecular Mechanisms of Metformin Action.
Traci E LaMoia, Gerald I Shulman. Endocr Rev 2021
Traci E LaMoia, Gerald I Shulman. Endocr Rev 2021
11
Metformin in cancer prevention and therapy.
Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski. Ann Transl Med 2014
Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski. Ann Transl Med 2014
5
AMPK: guardian of metabolism and mitochondrial homeostasis.
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
5
Role of Mitochondria in the Mechanism(s) of Action of Metformin.
Guillaume Vial, Dominique Detaille, Bruno Guigas. Front Endocrinol (Lausanne) 2019
Guillaume Vial, Dominique Detaille, Bruno Guigas. Front Endocrinol (Lausanne) 2019
5
5
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.
I Ben Sahra, K Laurent, A Loubat, S Giorgetti-Peraldi, P Colosetti, P Auberger, J F Tanti, Y Le Marchand-Brustel, F Bost. Oncogene 2008
I Ben Sahra, K Laurent, A Loubat, S Giorgetti-Peraldi, P Colosetti, P Auberger, J F Tanti, Y Le Marchand-Brustel, F Bost. Oncogene 2008
5
Metformin: an old but still the best treatment for type 2 diabetes.
Lilian Beatriz Aguayo Rojas, Marilia Brito Gomes. Diabetol Metab Syndr 2013
Lilian Beatriz Aguayo Rojas, Marilia Brito Gomes. Diabetol Metab Syndr 2013
5
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.
Russell A Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoit Viollet, Morris J Birnbaum. Nature 2013
Russell A Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoit Viollet, Morris J Birnbaum. Nature 2013
5
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review.
A Natali, E Ferrannini. Diabetologia 2006
A Natali, E Ferrannini. Diabetologia 2006
5
Metformin: Mechanisms in Human Obesity and Weight Loss.
Armen Yerevanian, Alexander A Soukas. Curr Obes Rep 2019
Armen Yerevanian, Alexander A Soukas. Curr Obes Rep 2019
7
An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice.
Na-Ri Shin, June-Chul Lee, Hae-Youn Lee, Min-Soo Kim, Tae Woong Whon, Myung-Shik Lee, Jin-Woo Bae. Gut 2014
Na-Ri Shin, June-Chul Lee, Hae-Youn Lee, Min-Soo Kim, Tae Woong Whon, Myung-Shik Lee, Jin-Woo Bae. Gut 2014
5
Metformin activates AMP kinase through inhibition of AMP deaminase.
Jiangyong Ouyang, Rahulkumar A Parakhia, Raymond S Ochs. J Biol Chem 2011
Jiangyong Ouyang, Rahulkumar A Parakhia, Raymond S Ochs. J Biol Chem 2011
5
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, João-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp,[...]. Nat Med 2018
Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, João-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp,[...]. Nat Med 2018
5
Benefits of Metformin in Attenuating the Hallmarks of Aging.
Ameya S Kulkarni, Sriram Gubbi, Nir Barzilai. Cell Metab 2020
Ameya S Kulkarni, Sriram Gubbi, Nir Barzilai. Cell Metab 2020
5
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.
Isaam Ben Sahra, Claire Regazzetti, Guillaume Robert, Kathiane Laurent, Yannick Le Marchand-Brustel, Patrick Auberger, Jean-François Tanti, Sophie Giorgetti-Peraldi, Frédéric Bost. Cancer Res 2011
Isaam Ben Sahra, Claire Regazzetti, Guillaume Robert, Kathiane Laurent, Yannick Le Marchand-Brustel, Patrick Auberger, Jean-François Tanti, Sophie Giorgetti-Peraldi, Frédéric Bost. Cancer Res 2011
5
Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice.
Wang Zhang, Ji-Hao Xu, Tao Yu, Qi-Kui Chen. Biomed Pharmacother 2019
Wang Zhang, Ji-Hao Xu, Tao Yu, Qi-Kui Chen. Biomed Pharmacother 2019
7
Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation.
Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez,[...]. Front Endocrinol (Lausanne) 2018
Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez,[...]. Front Endocrinol (Lausanne) 2018
8
An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress.
D Bonnefont-Rousselot, B Raji, S Walrand, M Gardès-Albert, D Jore, A Legrand, J Peynet, M P Vasson. Metabolism 2003
D Bonnefont-Rousselot, B Raji, S Walrand, M Gardès-Albert, D Jore, A Legrand, J Peynet, M P Vasson. Metabolism 2003
4
Metformin reduces endogenous reactive oxygen species and associated DNA damage.
Carolyn Algire, Olga Moiseeva, Xavier Deschênes-Simard, Lilian Amrein, Luca Petruccelli, Elena Birman, Benoit Viollet, Gerardo Ferbeyre, Michael N Pollak. Cancer Prev Res (Phila) 2012
Carolyn Algire, Olga Moiseeva, Xavier Deschênes-Simard, Lilian Amrein, Luca Petruccelli, Elena Birman, Benoit Viollet, Gerardo Ferbeyre, Michael N Pollak. Cancer Prev Res (Phila) 2012
4
Immune-mediated antitumor effect by type 2 diabetes drug, metformin.
Shingo Eikawa, Mikako Nishida, Shusaku Mizukami, Chihiro Yamazaki, Eiichi Nakayama, Heiichiro Udono. Proc Natl Acad Sci U S A 2015
Shingo Eikawa, Mikako Nishida, Shusaku Mizukami, Chihiro Yamazaki, Eiichi Nakayama, Heiichiro Udono. Proc Natl Acad Sci U S A 2015
4
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
Jong-Ho Cha, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Seung-Oe Lim, Chia-Wei Li, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee,[...]. Mol Cell 2018
Jong-Ho Cha, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Seung-Oe Lim, Chia-Wei Li, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee,[...]. Mol Cell 2018
4
Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects.
Muhamad Noor Alfarizal Kamarudin, Md Moklesur Rahman Sarker, Jin-Rong Zhou, Ishwar Parhar. J Exp Clin Cancer Res 2019
Muhamad Noor Alfarizal Kamarudin, Md Moklesur Rahman Sarker, Jin-Rong Zhou, Ishwar Parhar. J Exp Clin Cancer Res 2019
7
Metformin and gut microbiota: their interactions and their impact on diabetes.
Natalia G Vallianou, Theodora Stratigou, Stylianos Tsagarakis. Hormones (Athens) 2019
Natalia G Vallianou, Theodora Stratigou, Stylianos Tsagarakis. Hormones (Athens) 2019
11
Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis.
Zhi-Jiang Zhang, Zhi-Jie Zheng, Haidong Kan, Yiqing Song, Wei Cui, Genming Zhao, Kevin E Kip. Diabetes Care 2011
Zhi-Jiang Zhang, Zhi-Jie Zheng, Haidong Kan, Yiqing Song, Wei Cui, Genming Zhao, Kevin E Kip. Diabetes Care 2011
4
Investigating metformin for cancer prevention and treatment: the end of the beginning.
Michael N Pollak. Cancer Discov 2012
Michael N Pollak. Cancer Discov 2012
4
Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid-Producing Microbiota in the Gut.
Jacobo de la Cuesta-Zuluaga, Noel T Mueller, Vanessa Corrales-Agudelo, Eliana P Velásquez-Mejía, Jenny A Carmona, José M Abad, Juan S Escobar. Diabetes Care 2017
Jacobo de la Cuesta-Zuluaga, Noel T Mueller, Vanessa Corrales-Agudelo, Eliana P Velásquez-Mejía, Jenny A Carmona, José M Abad, Juan S Escobar. Diabetes Care 2017
4
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.
Heather A Hirsch, Dimitrios Iliopoulos, Philip N Tsichlis, Kevin Struhl. Cancer Res 2009
Heather A Hirsch, Dimitrios Iliopoulos, Philip N Tsichlis, Kevin Struhl. Cancer Res 2009
4
Anticancer activity of metformin: a systematic review of the literature.
Mohamad Aljofan, Dieter Riethmacher. Future Sci OA 2019
Mohamad Aljofan, Dieter Riethmacher. Future Sci OA 2019
8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.