A citation-based method for searching scientific literature

Brian Keith, Randall S Johnson, M Celeste Simon. Nat Rev Cancer 2011
Times Cited: 1124







List of co-cited articles
738 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
P H Maxwell, M S Wiesener, G W Chang, S C Clifford, E C Vaux, M E Cockman, C C Wykoff, C W Pugh, E R Maher, P J Ratcliffe. Nature 1999
12

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
G L Wang, B H Jiang, E A Rue, G L Semenza. Proc Natl Acad Sci U S A 1995
12

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression.
Luana Schito, Gregg L Semenza. Trends Cancer 2016
460
11

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond.
Pearl Lee, Navdeep S Chandel, M Celeste Simon. Nat Rev Mol Cell Biol 2020
250
11

Targeting HIF-1 for cancer therapy.
Gregg L Semenza. Nat Rev Cancer 2003
10

Hypoxia-inducible factors and the response to hypoxic stress.
Amar J Majmundar, Waihay J Wong, M Celeste Simon. Mol Cell 2010
9

Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg. Cell 2011
8

Targeting renal cell carcinoma with a HIF-2 antagonist.
Wenfang Chen, Haley Hill, Alana Christie, Min Soo Kim, Eboni Holloman, Andrea Pavia-Jimenez, Farrah Homayoun, Yuanqing Ma, Nirav Patel, Paul Yell,[...]. Nature 2016
387
8

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Cheng-Jun Hu, Li-Yi Wang, Lewis A Chodosh, Brian Keith, M Celeste Simon. Mol Cell Biol 2003
961
8

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
Raju R Raval, Kah Weng Lau, Maxine G B Tran, Heidi M Sowter, Stefano J Mandriota, Ji-Liang Li, Christopher W Pugh, Patrick H Maxwell, Adrian L Harris, Peter J Ratcliffe. Mol Cell Biol 2005
705
8

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, J M Asara, W S Lane, W G Kaelin. Science 2001
8

Passing the baton: the HIF switch.
Mei Yee Koh, Garth Powis. Trends Biochem Sci 2012
295
8


Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein.
M Ohh, C W Park, M Ivan, M A Hoffman, T Y Kim, L E Huang, N Pavletich, V Chau, W G Kaelin. Nat Cell Biol 2000
7

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene.
Chuan Shen, Rameen Beroukhim, Steven E Schumacher, Jing Zhou, Michelle Chang, Sabina Signoretti, William G Kaelin. Cancer Discov 2011
273
7


Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.
Linda Holmquist-Mengelbier, Erik Fredlund, Tobias Löfstedt, Rosa Noguera, Samuel Navarro, Helén Nilsson, Alexander Pietras, Johan Vallon-Christersson, Ake Borg, Katarina Gradin,[...]. Cancer Cell 2006
498
7

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
P Jaakkola, D R Mole, Y M Tian, M I Wilson, J Gielbert, S J Gaskell, A von Kriegsheim, H F Hebestreit, M Mukherji, C J Schofield,[...]. Science 2001
7

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.
Zhizhong Li, Shideng Bao, Qiulian Wu, Hui Wang, Christine Eyler, Sith Sathornsumetee, Qing Shi, Yiting Cao, Justin Lathia, Roger E McLendon,[...]. Cancer Cell 2009
899
7


Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience.
Neil S Sanghani, Volker H Haase. Adv Chronic Kidney Dis 2019
83
7

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
Rebecca J Appelhoff, Ya-Min Tian, Raju R Raval, Helen Turley, Adrian L Harris, Christopher W Pugh, Peter J Ratcliffe, Jonathan M Gleadle. J Biol Chem 2004
762
6

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
6



Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
J A Forsythe, B H Jiang, N V Iyer, F Agani, S W Leung, R D Koos, G L Semenza. Mol Cell Biol 1996
6


Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang,[...]. Cell 2012
6

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Yilong Zou, Michael J Palte, Amy A Deik, Haoxin Li, John K Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Kost-Alimova, Vlado Dančík,[...]. Nat Commun 2019
219
6

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Brent R Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I Bush, Marcus Conrad, Scott J Dixon, Simone Fulda, Sergio Gascón, Stavroula K Hatzios, Valerian E Kagan,[...]. Cell 2017
6

HIF-1α pathway: role, regulation and intervention for cancer therapy.
Georgina N Masoud, Wei Li. Acta Pharm Sin B 2015
868
6


HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.
Edurne Berra, Emmanuel Benizri, Amandine Ginouvès, Véronique Volmat, Danièle Roux, Jacques Pouysségur. EMBO J 2003
5

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.
Robert D Guzy, Beatrice Hoyos, Emmanuel Robin, Hong Chen, Liping Liu, Kyle D Mansfield, M Celeste Simon, Ulrich Hammerling, Paul T Schumacker. Cell Metab 2005
5

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.
Weinan Du, Luchang Zhang, Adina Brett-Morris, Brittany Aguila, Janos Kerner, Charles L Hoppel, Michelle Puchowicz, Dolors Serra, Laura Herrero, Brian I Rini,[...]. Nat Commun 2017
161
5

The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy.
Barbara Muz, Pilar de la Puente, Feda Azab, Abdel Kareem Azab. Hypoxia (Auckl) 2015
764
5


Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Eric V Dang, Joseph Barbi, Huang-Yu Yang, Dilini Jinasena, Hong Yu, Ying Zheng, Zachary Bordman, Juan Fu, Young Kim, Hung-Rong Yen,[...]. Cell 2011
974
5



Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
M E Cockman, N Masson, D R Mole, P Jaakkola, G W Chang, S C Clifford, E R Maher, C W Pugh, P J Ratcliffe, P H Maxwell. J Biol Chem 2000
845
5

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.
David Lando, Daniel J Peet, Jeffrey J Gorman, Dean A Whelan, Murray L Whitelaw, Richard K Bruick. Genes Dev 2002
5

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer.
Caroline Wigerup, Sven Påhlman, Daniel Bexell. Pharmacol Ther 2016
345
5

Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors.
Michael L Nickerson, Erich Jaeger, Yangu Shi, Jeffrey A Durocher, Sunil Mahurkar, David Zaridze, Vsevolod Matveev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko,[...]. Clin Cancer Res 2008
383
5

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Jose Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth, Yulia Y Tyurina, Vladimir A Tyurin, Victoria J Hammond, Nadja Herbach, Michaela Aichler, Axel Walch, Elke Eggenhofer,[...]. Nat Cell Biol 2014
5

Regulation of ferroptotic cancer cell death by GPX4.
Wan Seok Yang, Rohitha SriRamaratnam, Matthew E Welsch, Kenichi Shimada, Rachid Skouta, Vasanthi S Viswanathan, Jaime H Cheah, Paul A Clemons, Alykhan F Shamji, Clary B Clish,[...]. Cell 2014
5

Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11.
Xueting Lang, Michael D Green, Weimin Wang, Jiali Yu, Jae Eun Choi, Long Jiang, Peng Liao, Jiajia Zhou, Qiang Zhang, Ania Dow,[...]. Cancer Discov 2019
267
5




Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.