Liming Sun, Huayi Wang, Zhigao Wang, Sudan He, She Chen, Daohong Liao, Lai Wang, Jiacong Yan, Weilong Liu, Xiaoguang Lei, Xiaodong Wang. Cell 2012
Times Cited: 1410
Times Cited: 1410
Times Cited
Times Co-cited
Similarity
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.
Huayi Wang, Liming Sun, Lijing Su, Josep Rizo, Lei Liu, Li-Feng Wang, Fu-Sheng Wang, Xiaodong Wang. Mol Cell 2014
Huayi Wang, Liming Sun, Lijing Su, Josep Rizo, Lei Liu, Li-Feng Wang, Fu-Sheng Wang, Xiaodong Wang. Mol Cell 2014
40
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.
Sudan He, Lai Wang, Lin Miao, Tao Wang, Fenghe Du, Liping Zhao, Xiaodong Wang. Cell 2009
Sudan He, Lai Wang, Lin Miao, Tao Wang, Fenghe Du, Liping Zhao, Xiaodong Wang. Cell 2009
36
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
Young Sik Cho, Sreerupa Challa, David Moquin, Ryan Genga, Tathagat Dutta Ray, Melissa Guildford, Francis Ka-Ming Chan. Cell 2009
Young Sik Cho, Sreerupa Challa, David Moquin, Ryan Genga, Tathagat Dutta Ray, Melissa Guildford, Francis Ka-Ming Chan. Cell 2009
33
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Zhenyu Cai, Siriporn Jitkaew, Jie Zhao, Hsueh-Cheng Chiang, Swati Choksi, Jie Liu, Yvona Ward, Ling-Gang Wu, Zheng-Gang Liu. Nat Cell Biol 2014
Zhenyu Cai, Siriporn Jitkaew, Jie Zhao, Hsueh-Cheng Chiang, Swati Choksi, Jie Liu, Yvona Ward, Ling-Gang Wu, Zheng-Gang Liu. Nat Cell Biol 2014
30
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.
Duan-Wu Zhang, Jing Shao, Juan Lin, Na Zhang, Bao-Ju Lu, Sheng-Cai Lin, Meng-Qiu Dong, Jiahuai Han. Science 2009
Duan-Wu Zhang, Jing Shao, Juan Lin, Na Zhang, Bao-Ju Lu, Sheng-Cai Lin, Meng-Qiu Dong, Jiahuai Han. Science 2009
30
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death.
Xin Chen, Wenjuan Li, Junming Ren, Deli Huang, Wan-Ting He, Yunlong Song, Chao Yang, Wanyun Li, Xinru Zheng, Pengda Chen,[...]. Cell Res 2014
Xin Chen, Wenjuan Li, Junming Ren, Deli Huang, Wan-Ting He, Yunlong Song, Chao Yang, Wanyun Li, Xinru Zheng, Pengda Chen,[...]. Cell Res 2014
29
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Alexei Degterev, Zhihong Huang, Michael Boyce, Yaqiao Li, Prakash Jagtap, Noboru Mizushima, Gregory D Cuny, Timothy J Mitchison, Michael A Moskowitz, Junying Yuan. Nat Chem Biol 2005
Alexei Degterev, Zhihong Huang, Michael Boyce, Yaqiao Li, Prakash Jagtap, Noboru Mizushima, Gregory D Cuny, Timothy J Mitchison, Michael A Moskowitz, Junying Yuan. Nat Chem Biol 2005
27
Identification of RIP1 kinase as a specific cellular target of necrostatins.
Alexei Degterev, Junichi Hitomi, Megan Germscheid, Irene L Ch'en, Olga Korkina, Xin Teng, Derek Abbott, Gregory D Cuny, Chengye Yuan, Gerhard Wagner,[...]. Nat Chem Biol 2008
Alexei Degterev, Junichi Hitomi, Megan Germscheid, Irene L Ch'en, Olga Korkina, Xin Teng, Derek Abbott, Gregory D Cuny, Chengye Yuan, Gerhard Wagner,[...]. Nat Chem Biol 2008
26
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb,[...]. Immunity 2013
James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb,[...]. Immunity 2013
26
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.
Jie Zhao, Siriporn Jitkaew, Zhenyu Cai, Swati Choksi, Qiuning Li, Ji Luo, Zheng-Gang Liu. Proc Natl Acad Sci U S A 2012
Jie Zhao, Siriporn Jitkaew, Zhenyu Cai, Swati Choksi, Qiuning Li, Ji Luo, Zheng-Gang Liu. Proc Natl Acad Sci U S A 2012
26
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews,[...]. Cell Death Differ 2018
Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews,[...]. Cell Death Differ 2018
23
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
21
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.
Yves Dondelinger, Wim Declercq, Sylvie Montessuit, Ria Roelandt, Amanda Goncalves, Inge Bruggeman, Paco Hulpiau, Kathrin Weber, Clark A Sehon, Robert W Marquis,[...]. Cell Rep 2014
Yves Dondelinger, Wim Declercq, Sylvie Montessuit, Ria Roelandt, Amanda Goncalves, Inge Bruggeman, Paco Hulpiau, Kathrin Weber, Clark A Sehon, Robert W Marquis,[...]. Cell Rep 2014
20
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
Joanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, Samuel N Young, Sukhdeep K Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick C J Dobson, Andrew I Webb,[...]. Proc Natl Acad Sci U S A 2014
Joanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, Samuel N Young, Sukhdeep K Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick C J Dobson, Andrew I Webb,[...]. Proc Natl Acad Sci U S A 2014
20
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
N Holler, R Zaru, O Micheau, M Thome, A Attinger, S Valitutti, J L Bodmer, P Schneider, B Seed, J Tschopp. Nat Immunol 2000
N Holler, R Zaru, O Micheau, M Thome, A Attinger, S Valitutti, J L Bodmer, P Schneider, B Seed, J Tschopp. Nat Immunol 2000
19
19
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
William J Kaiser, Haripriya Sridharan, Chunzi Huang, Pratyusha Mandal, Jason W Upton, Peter J Gough, Clark A Sehon, Robert W Marquis, John Bertin, Edward S Mocarski. J Biol Chem 2013
William J Kaiser, Haripriya Sridharan, Chunzi Huang, Pratyusha Mandal, Jason W Upton, Peter J Gough, Clark A Sehon, Robert W Marquis, John Bertin, Edward S Mocarski. J Biol Chem 2013
19
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang, Feng Shao. Nature 2017
Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang, Feng Shao. Nature 2017
16
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis.
Jixi Li, Thomas McQuade, Ansgar B Siemer, Johanna Napetschnig, Kenta Moriwaki, Yu-Shan Hsiao, Ermelinda Damko, David Moquin, Thomas Walz, Ann McDermott,[...]. Cell 2012
Jixi Li, Thomas McQuade, Ansgar B Siemer, Johanna Napetschnig, Kenta Moriwaki, Yu-Shan Hsiao, Ermelinda Damko, David Moquin, Thomas Walz, Ann McDermott,[...]. Cell 2012
16
DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.
Jason W Upton, William J Kaiser, Edward S Mocarski. Cell Host Microbe 2012
Jason W Upton, William J Kaiser, Edward S Mocarski. Cell Host Microbe 2012
16
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Christopher P Dillon, Ricardo Weinlich, Diego A Rodriguez, James G Cripps, Giovanni Quarato, Prajwal Gurung, Katherine C Verbist, Taylor L Brewer, Fabien Llambi, Yi-Nan Gong,[...]. Cell 2014
Christopher P Dillon, Ricardo Weinlich, Diego A Rodriguez, James G Cripps, Giovanni Quarato, Prajwal Gurung, Katherine C Verbist, Taylor L Brewer, Fabien Llambi, Yi-Nan Gong,[...]. Cell 2014
15
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.
James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton,[...]. Cell 2014
James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton,[...]. Cell 2014
15
Necroptosis: the release of damage-associated molecular patterns and its physiological relevance.
Agnieszka Kaczmarek, Peter Vandenabeele, Dmitri V Krysko. Immunity 2013
Agnieszka Kaczmarek, Peter Vandenabeele, Dmitri V Krysko. Immunity 2013
15
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
Andre L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon,[...]. Nat Commun 2020
Andre L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon,[...]. Nat Commun 2020
22
Molecular mechanisms of necroptosis: an ordered cellular explosion.
Peter Vandenabeele, Lorenzo Galluzzi, Tom Vanden Berghe, Guido Kroemer. Nat Rev Mol Cell Biol 2010
Peter Vandenabeele, Lorenzo Galluzzi, Tom Vanden Berghe, Guido Kroemer. Nat Rev Mol Cell Biol 2010
14
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.
Kim Newton, Katherine E Wickliffe, Debra L Dugger, Allie Maltzman, Merone Roose-Girma, Monika Dohse, László Kőműves, Joshua D Webster, Vishva M Dixit. Nature 2019
Kim Newton, Katherine E Wickliffe, Debra L Dugger, Allie Maltzman, Merone Roose-Girma, Monika Dohse, László Kőműves, Joshua D Webster, Vishva M Dixit. Nature 2019
14
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death.
Jianjin Shi, Wenqing Gao, Feng Shao. Trends Biochem Sci 2017
Jianjin Shi, Wenqing Gao, Feng Shao. Trends Biochem Sci 2017
14
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Pratyusha Mandal, Scott B Berger, Sirika Pillay, Kenta Moriwaki, Chunzi Huang, Hongyan Guo, John D Lich, Joshua Finger, Viera Kasparcova, Bart Votta,[...]. Mol Cell 2014
Pratyusha Mandal, Scott B Berger, Sirika Pillay, Kenta Moriwaki, Chunzi Huang, Hongyan Guo, John D Lich, Joshua Finger, Viera Kasparcova, Bart Votta,[...]. Mol Cell 2014
14
Pore-forming activity and structural autoinhibition of the gasdermin family.
Jingjin Ding, Kun Wang, Wang Liu, Yang She, Qi Sun, Jianjin Shi, Hanzi Sun, Da-Cheng Wang, Feng Shao. Nature 2016
Jingjin Ding, Kun Wang, Wang Liu, Yang She, Qi Sun, Jianjin Shi, Hanzi Sun, Da-Cheng Wang, Feng Shao. Nature 2016
14
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
J F Kerr, A H Wyllie, A R Currie. Br J Cancer 1972
J F Kerr, A H Wyllie, A R Currie. Br J Cancer 1972
13
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome.
Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu,[...]. Nat Commun 2017
Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu,[...]. Nat Commun 2017
13
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Nobuhiko Kayagaki, Irma B Stowe, Bettina L Lee, Karen O'Rourke, Keith Anderson, Søren Warming, Trinna Cuellar, Benjamin Haley, Merone Roose-Girma, Qui T Phung,[...]. Nature 2015
Nobuhiko Kayagaki, Irma B Stowe, Bettina L Lee, Karen O'Rourke, Keith Anderson, Søren Warming, Trinna Cuellar, Benjamin Haley, Merone Roose-Girma, Qui T Phung,[...]. Nature 2015
13
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
Tom Vanden Berghe, Andreas Linkermann, Sandrine Jouan-Lanhouet, Henning Walczak, Peter Vandenabeele. Nat Rev Mol Cell Biol 2014
Tom Vanden Berghe, Andreas Linkermann, Sandrine Jouan-Lanhouet, Henning Walczak, Peter Vandenabeele. Nat Rev Mol Cell Biol 2014
13
Inflammatory caspases are innate immune receptors for intracellular LPS.
Jianjin Shi, Yue Zhao, Yupeng Wang, Wenqing Gao, Jingjin Ding, Peng Li, Liyan Hu, Feng Shao. Nature 2014
Jianjin Shi, Yue Zhao, Yupeng Wang, Wenqing Gao, Jingjin Ding, Peng Li, Liyan Hu, Feng Shao. Nature 2014
12
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.
Olivier Micheau, Jürg Tschopp. Cell 2003
Olivier Micheau, Jürg Tschopp. Cell 2003
12
Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Kim Newton, Debra L Dugger, Katherine E Wickliffe, Neeraj Kapoor, M Cristina de Almagro, Domagoj Vucic, Laszlo Komuves, Ronald E Ferrando, Dorothy M French, Joshua Webster,[...]. Science 2014
Kim Newton, Debra L Dugger, Katherine E Wickliffe, Neeraj Kapoor, M Cristina de Almagro, Domagoj Vucic, Laszlo Komuves, Ronald E Ferrando, Dorothy M French, Joshua Webster,[...]. Science 2014
12
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Andrew Oberst, Christopher P Dillon, Ricardo Weinlich, Laura L McCormick, Patrick Fitzgerald, Cristina Pop, Razq Hakem, Guy S Salvesen, Douglas R Green. Nature 2011
Andrew Oberst, Christopher P Dillon, Ricardo Weinlich, Laura L McCormick, Patrick Fitzgerald, Cristina Pop, Razq Hakem, Guy S Salvesen, Douglas R Green. Nature 2011
12
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway.
Sudan He, Yuqiong Liang, Feng Shao, Xiaodong Wang. Proc Natl Acad Sci U S A 2011
Sudan He, Yuqiong Liang, Feng Shao, Xiaodong Wang. Proc Natl Acad Sci U S A 2011
12
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.
Stephanie A Conos, Kaiwen W Chen, Dominic De Nardo, Hideki Hara, Lachlan Whitehead, Gabriel Núñez, Seth L Masters, James M Murphy, Kate Schroder, David L Vaux,[...]. Proc Natl Acad Sci U S A 2017
Stephanie A Conos, Kaiwen W Chen, Dominic De Nardo, Hideki Hara, Lachlan Whitehead, Gabriel Núñez, Seth L Masters, James M Murphy, Kate Schroder, David L Vaux,[...]. Proc Natl Acad Sci U S A 2017
12
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
Yi-Nan Gong, Cliff Guy, Hannes Olauson, Jan Ulrich Becker, Mao Yang, Patrick Fitzgerald, Andreas Linkermann, Douglas R Green. Cell 2017
Yi-Nan Gong, Cliff Guy, Hannes Olauson, Jan Ulrich Becker, Mao Yang, Patrick Fitzgerald, Andreas Linkermann, Douglas R Green. Cell 2017
12
Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang,[...]. Cell 2012
Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang,[...]. Cell 2012
12
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, Joka Pipercevic, Rosalie Heilig, Henning Stahlberg, Christopher J Farady, Daniel J Müller, Petr Broz, Sebastian Hiller. EMBO J 2016
Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, Joka Pipercevic, Rosalie Heilig, Henning Stahlberg, Christopher J Farady, Daniel J Müller, Petr Broz, Sebastian Hiller. EMBO J 2016
12
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
12
Pyroptosis versus necroptosis: similarities, differences, and crosstalk.
Daniel Frank, James E Vince. Cell Death Differ 2019
Daniel Frank, James E Vince. Cell Death Differ 2019
12
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
Kate E Lawlor, Nufail Khan, Alison Mildenhall, Motti Gerlic, Ben A Croker, Akshay A D'Cruz, Cathrine Hall, Sukhdeep Kaur Spall, Holly Anderton, Seth L Masters,[...]. Nat Commun 2015
Kate E Lawlor, Nufail Khan, Alison Mildenhall, Motti Gerlic, Ben A Croker, Akshay A D'Cruz, Cathrine Hall, Sukhdeep Kaur Spall, Holly Anderton, Seth L Masters,[...]. Nat Commun 2015
11
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis.
Jianfeng Wu, Zhe Huang, Junming Ren, Zhirong Zhang, Peng He, Yangxin Li, Jianhui Ma, Wanze Chen, Yingying Zhang, Xiaojuan Zhou,[...]. Cell Res 2013
Jianfeng Wu, Zhe Huang, Junming Ren, Zhirong Zhang, Peng He, Yangxin Li, Jianhui Ma, Wanze Chen, Yingying Zhang, Xiaojuan Zhou,[...]. Cell Res 2013
11
TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL.
Ayaz Najafov, Adnan K Mookhtiar, Hoang Son Luu, Alban Ordureau, Heling Pan, Palak P Amin, Ying Li, Qingxian Lu, Junying Yuan. Mol Cell 2019
Ayaz Najafov, Adnan K Mookhtiar, Hoang Son Luu, Alban Ordureau, Heling Pan, Palak P Amin, Ying Li, Qingxian Lu, Junying Yuan. Mol Cell 2019
23
MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.
Seongmin Yoon, Andrew Kovalenko, Konstantin Bogdanov, David Wallach. Immunity 2017
Seongmin Yoon, Andrew Kovalenko, Konstantin Bogdanov, David Wallach. Immunity 2017
11
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.