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Times Co-cited
Similarity
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Lenny Dang, David W White, Stefan Gross, Bryson D Bennett, Mark A Bittinger, Edward M Driggers, Valeria R Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C Keenan,[...]. Nature 2009
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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
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IDH mutation impairs histone demethylation and results in a block to cell differentiation.
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IDH1 and IDH2 mutations in gliomas.
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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
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An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.
Dan Rohle, Janeta Popovici-Muller, Nicolaos Palaskas, Sevin Turcan, Christian Grommes, Carl Campos, Jennifer Tsoi, Owen Clark, Barbara Oldrini, Evangelia Komisopoulou,[...]. Science 2013
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An integrated genomic analysis of human glioblastoma multiforme.
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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
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(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.
Julie-Aurore Losman, Ryan E Looper, Peppi Koivunen, Sungwoo Lee, Rebekka K Schneider, Christine McMahon, Glenn S Cowley, David E Root, Benjamin L Ebert, William G Kaelin. Science 2013
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Hypoxia Induces Production of L-2-Hydroxyglutarate.
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.
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Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours.
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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
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Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.
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Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas.
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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
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Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
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Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents.
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Mutant IDH1 regulates the tumor-associated immune system in gliomas.
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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
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Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.
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Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.
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Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.
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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.
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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
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Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.
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The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.
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Lactate dehydrogenase A silencing in IDH mutant gliomas.
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Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair.
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Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.