Kimberly A Fernandes, Jeffrey M Harder, Laura B Fornarola, Robert S Freeman, Abbot F Clark, Iok-Hou Pang, Simon W M John, Richard T Libby. Neurobiol Dis 2012
Times Cited: 99
Times Cited: 99
Times Cited
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Similarity
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.
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Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John. PLoS Genet 2005
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John. PLoS Genet 2005
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Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.
Derek S Welsbie, Zhiyong Yang, Yan Ge, Katherine L Mitchell, Xinrong Zhou, Scott E Martin, Cynthia A Berlinicke, Laszlo Hackler, John Fuller, Jie Fu,[...]. Proc Natl Acad Sci U S A 2013
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JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells.
Kimberly A Fernandes, Jeffrey M Harder, Jessica Kim, Richard T Libby. Exp Eye Res 2013
Kimberly A Fernandes, Jeffrey M Harder, Jessica Kim, Richard T Libby. Exp Eye Res 2013
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Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.
Gareth R Howell, Richard T Libby, Tatjana C Jakobs, Richard S Smith, F Campbell Phalan, Joseph W Barter, Jessica M Barbay, Jeffrey K Marchant, Nagaraju Mahesh, Vittorio Porciatti,[...]. J Cell Biol 2007
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DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity.
Arundhati Sengupta Ghosh, Bei Wang, Christine D Pozniak, Mark Chen, Ryan J Watts, Joseph W Lewcock. J Cell Biol 2011
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A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.
Bradley R Miller, Craig Press, Richard W Daniels, Yo Sasaki, Jeffrey Milbrandt, Aaron DiAntonio. Nat Neurosci 2009
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Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.
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BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina.
Jeffrey M Harder, Richard T Libby. Mol Neurodegener 2011
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The transcription factor c-jun is activated in retinal ganglion cells in experimental rat glaucoma.
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Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma.
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DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury.
Kimberly A Fernandes, Jeffrey M Harder, Simon W John, Peter Shrager, Richard T Libby. Neurobiol Dis 2014
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Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric.
Cassandra L Schlamp, Yan Li, Joel A Dietz, Katherine T Janssen, Robert W Nickells. BMC Neurosci 2006
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The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
Bogdan Beirowski, Elisabetta Babetto, Michael P Coleman, Keith R Martin. Eur J Neurosci 2008
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Bax-dependent and independent pathways of retinal ganglion cell death induced by different damaging stimuli.
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Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.
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Pathological axonal death through a MAPK cascade that triggers a local energy deficit.
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Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice.
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Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve.
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Expression of phosphorylated c-Jun N-terminal protein kinase (JNK) in experimental glaucoma in rats.
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Glaucoma: thinking in new ways-a rôle for autonomous axonal self-destruction and other compartmentalised processes?
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Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis.
Heather R Pelzel, Cassandra L Schlamp, Robert W Nickells. BMC Neurosci 2010
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The molecular basis of retinal ganglion cell death in glaucoma.
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Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration.
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Experimental induction of retinal ganglion cell death in adult mice.
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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.
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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.
Sarah Huntwork-Rodriguez, Bei Wang, Trent Watkins, Arundhati Sengupta Ghosh, Christine D Pozniak, Daisy Bustos, Kim Newton, Donald S Kirkpatrick, Joseph W Lewcock. J Cell Biol 2013
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Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling.
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JUN is important for ocular hypertension-induced retinal ganglion cell degeneration.
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Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms.
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The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice.
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Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury.
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BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells.
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Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.
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Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.
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