A citation-based method for searching scientific literature

D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
Times Cited: 2424







List of co-cited articles
353 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


AMPK: guardian of metabolism and mitochondrial homeostasis.
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
916
14

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
11

AMPK: Sensing Glucose as well as Cellular Energy Status.
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
349
10

AMPK in Health and Disease.
Gregory R Steinberg, Bruce E Kemp. Physiol Rev 2009
10



mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
7

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
6

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.
Morgan D Fullerton, Sandra Galic, Katarina Marcinko, Sarah Sikkema, Thomas Pulinilkunnil, Zhi-Ping Chen, Hayley M O'Neill, Rebecca J Ford, Rengasamy Palanivel, Matthew O'Brien,[...]. Nat Med 2013
434
6

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs.
D Grahame Hardie, Bethany E Schaffer, Anne Brunet. Trends Cell Biol 2016
436
6

The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
675
6

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.
Angela Woods, Kristina Dickerson, Richard Heath, Seung-Pyo Hong, Milica Momcilovic, Stephen R Johnstone, Marian Carlson, David Carling. Cell Metab 2005
989
6


Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.
Chen-Song Zhang, Simon A Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu,[...]. Nature 2017
249
5

AMPK signalling in health and disease.
David Carling. Curr Opin Cell Biol 2017
241
5


Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer's model mice.
Helena R Zimmermann, Wenzhong Yang, Nicole P Kasica, Xueyan Zhou, Xin Wang, Brenna C Beckelman, Jingyun Lee, Cristina M Furdui, C Dirk Keene, Tao Ma. J Clin Invest 2020
19
26

AMPK activators: mechanisms of action and physiological activities.
Joungmok Kim, Goowon Yang, Yeji Kim, Jin Kim, Joohun Ha. Exp Mol Med 2016
281
5

Metformin: from mechanisms of action to therapies.
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
611
5

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
Sibylle Jäger, Christoph Handschin, Julie St-Pierre, Bruce M Spiegelman. Proc Natl Acad Sci U S A 2007
5

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Barbara B Kahn, Thierry Alquier, David Carling, D Grahame Hardie. Cell Metab 2005
5

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Emily C Cokorinos, Jake Delmore, Allan R Reyes, Bina Albuquerque, Rasmus Kjøbsted, Nicolas O Jørgensen, Jean-Luc Tran, Aditi Jatkar, Katherine Cialdea, Ryan M Esquejo,[...]. Cell Metab 2017
123
5

Role of AMP-activated protein kinase in mechanism of metformin action.
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
5

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
Simon A Hawley, David A Pan, Kirsty J Mustard, Louise Ross, Jenny Bain, Arthur M Edelman, Bruno G Frenguelli, D Grahame Hardie. Cell Metab 2005
5

Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg. Cell 2011
5


mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
4

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
M Y El-Mir, V Nogueira, E Fontaine, N Avéret, M Rigoulet, X Leverve. J Biol Chem 2000
933
4

Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.
Erin Quan Toyama, Sébastien Herzig, Julien Courchet, Tommy L Lewis, Oliver C Losón, Kristina Hellberg, Nathan P Young, Hsiuchen Chen, Franck Polleux, David C Chan,[...]. Science 2016
511
4

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.
Yue Zong, Chen-Song Zhang, Mengqi Li, Wen Wang, Zhichao Wang, Simon A Hawley, Teng Ma, Jin-Wei Feng, Xiao Tian, Qu Qi,[...]. Cell Res 2019
46
8

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Daniel F Egan, David B Shackelford, Maria M Mihaylova, Sara Gelino, Rebecca A Kohnz, William Mair, Debbie S Vasquez, Aashish Joshi, Dana M Gwinn, Rebecca Taylor,[...]. Science 2011
4

AMPK inhibition in health and disease.
Benoit Viollet, Sandrine Horman, Jocelyne Leclerc, Louise Lantier, Marc Foretz, Marc Billaud, Shailendra Giri, Fabrizio Andreelli. Crit Rev Biochem Mol Biol 2010
266
4

AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue.
Lingyan Wu, Lina Zhang, Bohan Li, Haowen Jiang, Yanan Duan, Zhifu Xie, Lin Shuai, Jia Li, Jingya Li. Front Physiol 2018
94
4

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.
Robert W Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Effie Tozzo, Xiaodong Yang, Marc M Kurtz, Maria Trujillo, Dinko Gonzalez Trotter,[...]. Science 2017
138
4


AMP-activated protein kinase: the current landscape for drug development.
Gregory R Steinberg, David Carling. Nat Rev Drug Discov 2019
154
4

The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
4

Fundamentals of cancer metabolism.
Ralph J DeBerardinis, Navdeep S Chandel. Sci Adv 2016
4

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
Angela Woods, Stephen R Johnstone, Kristina Dickerson, Fiona C Leiper, Lee G D Fryer, Dietbert Neumann, Uwe Schlattner, Theo Wallimann, Marian Carlson, David Carling. Curr Biol 2003
4

AMPK and SIRT1: a long-standing partnership?
Neil B Ruderman, X Julia Xu, Lauren Nelson, José M Cacicedo, Asish K Saha, Fan Lan, Yasuo Ido. Am J Physiol Endocrinol Metab 2010
514
4

Structure of mammalian AMPK and its regulation by ADP.
Bing Xiao, Matthew J Sanders, Elizabeth Underwood, Richard Heath, Faith V Mayer, David Carmena, Chun Jing, Philip A Walker, John F Eccleston, Lesley F Haire,[...]. Nature 2011
569
4

Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
690
4

On the origin of cancer cells.
O WARBURG. Science 1956
4

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration.
Pazit Polak, Nadine Cybulski, Jerome N Feige, Johan Auwerx, Markus A Rüegg, Michael N Hall. Cell Metab 2008
356
3

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
886
3


5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments.
Keith R Laderoute, Khalid Amin, Joy M Calaoagan, Merrill Knapp, Theresamai Le, Juan Orduna, Marc Foretz, Benoit Viollet. Mol Cell Biol 2006
344
3

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.
Brenna C Beckelman, Wenzhong Yang, Nicole P Kasica, Helena R Zimmermann, Xueyan Zhou, C Dirk Keene, Alexey G Ryazanov, Tao Ma. J Clin Invest 2019
27
11

Metabolic regulation of neuronal plasticity by the energy sensor AMPK.
Wyatt B Potter, Kenneth J O'Riordan, David Barnett, Susan M K Osting, Matthew Wagoner, Corinna Burger, Avtar Roopra. PLoS One 2010
122
3

Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke.
Jun Li, Zhiyuan Zeng, Benoit Viollet, Gabriele V Ronnett, Louise D McCullough. Stroke 2007
181
3


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.