A citation-based method for searching scientific literature

Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima, David A Guertin, David M Sabatini, Joseph A Baur. Science 2012
Times Cited: 718







List of co-cited articles
1263 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
29

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
24

mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
23

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
19

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
16

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
16

A novel rapamycin analog is highly selective for mTORC1 in vivo.
Katherine H Schreiber, Sebastian I Arriola Apelo, Deyang Yu, Jacqueline A Brinkman, Michael C Velarde, Faizan A Syed, Chen-Yu Liao, Emma L Baar, Kathryn A Carbajal, Dawn S Sherman,[...]. Nat Commun 2019
47
31

mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
388
15

The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
14

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani,[...]. Science 2009
758
14

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.
Sebastian I Arriola Apelo, Joshua C Neuman, Emma L Baar, Faizan A Syed, Nicole E Cummings, Harpreet K Brar, Cassidy P Pumper, Michelle E Kimple, Dudley W Lamming. Aging Cell 2016
95
14

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Pankaj Kapahi, Brian M Zid, Tony Harper, Daniel Koslover, Viveca Sapin, Seymour Benzer. Curr Biol 2004
877
13


Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith,[...]. Elife 2016
147
13

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Matt Kaeberlein, R Wilson Powers, Kristan K Steffen, Eric A Westman, Di Hu, Nick Dang, Emily O Kerr, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. Science 2005
900
12


TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Stacey Robida-Stubbs, Kira Glover-Cutter, Dudley W Lamming, Masaki Mizunuma, Sri Devi Narasimhan, Elke Neumann-Haefelin, David M Sabatini, T Keith Blackwell. Cell Metab 2012
346
12

Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
670
12

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
12

Duration of rapamycin treatment has differential effects on metabolism in mice.
Yimin Fang, Reyhan Westbrook, Cristal Hill, Ravneet K Boparai, Oge Arum, Adam Spong, Feiya Wang, Martin A Javors, Jie Chen, Liou Y Sun,[...]. Cell Metab 2013
125
11

Rapamycin slows aging in mice.
John E Wilkinson, Lisa Burmeister, Susan V Brooks, Chi-Chao Chan, Sabrina Friedline, David E Harrison, James F Hejtmancik, Nancy Nadon, Randy Strong, Lauren K Wood,[...]. Aging Cell 2012
392
11

Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue.
Vanessa P Houde, Sophie Brûlé, William T Festuccia, Pierre-Gilles Blanchard, Kerstin Bellmann, Yves Deshaies, André Marette. Diabetes 2010
302
11

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R Allegrini, Sara C Kozma, Johan Auwerx,[...]. Nature 2004
11

A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
Sarah J Mahoney, Sridhar Narayan, Lisa Molz, Lauren A Berstler, Seong A Kang, George P Vlasuk, Eddine Saiah. Nat Commun 2018
35
31

mTOR is a key modulator of ageing and age-related disease.
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
931
11

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
11

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
11

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Richard A Miller, David E Harrison, C M Astle, Joseph A Baur, Angela Rodriguez Boyd, Rafael de Cabo, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, James F Nelson,[...]. J Gerontol A Biol Sci Med Sci 2011
577
10

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
446
10

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
10

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.
Randy Strong, Richard A Miller, Adam Antebi, Clinton M Astle, Molly Bogue, Martin S Denzel, Elizabeth Fernandez, Kevin Flurkey, Karyn L Hamilton, Dudley W Lamming,[...]. Aging Cell 2016
136
9

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice.
Sebastian I Arriola Apelo, Cassidy P Pumper, Emma L Baar, Nicole E Cummings, Dudley W Lamming. J Gerontol A Biol Sci Med Sci 2016
62
14

Rapamycin: one drug, many effects.
Jing Li, Sang Gyun Kim, John Blenis. Cell Metab 2014
514
9

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
Peggy P Hsu, Seong A Kang, Jonathan Rameseder, Yi Zhang, Kathleen A Ottina, Daniel Lim, Timothy R Peterson, Yongmun Choi, Nathanael S Gray, Michael B Yaffe,[...]. Science 2011
723
9

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Yonghao Yu, Sang-Oh Yoon, George Poulogiannis, Qian Yang, Xiaoju Max Ma, Judit Villén, Neil Kubica, Gregory R Hoffman, Lewis C Cantley, Steven P Gygi,[...]. Science 2011
583
9

TORC1 inhibition enhances immune function and reduces infections in the elderly.
Joan B Mannick, Melody Morris, Hans-Ulrich P Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn,[...]. Sci Transl Med 2018
158
9

mTOR inhibition improves immune function in the elderly.
Joan B Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M Valiante, Jens Praestgaard, Baisong Huang, Michael A Lonetto, Holden T Maecker, John Kovarik, Simon Carson,[...]. Sci Transl Med 2014
353
9

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.
Ivana Bjedov, Janne M Toivonen, Fiona Kerr, Cathy Slack, Jake Jacobson, Andrea Foley, Linda Partridge. Cell Metab 2010
609
9

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.
Richard A Miller, David E Harrison, Clinton M Astle, Elizabeth Fernandez, Kevin Flurkey, Melissa Han, Martin A Javors, Xinna Li, Nancy L Nadon, James F Nelson,[...]. Aging Cell 2014
293
9

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Kenta Hara, Yoshiko Maruki, Xiaomeng Long, Ken-ichi Yoshino, Noriko Oshiro, Sujuti Hidayat, Chiharu Tokunaga, Joseph Avruch, Kazuyoshi Yonezawa. Cell 2002
9

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Estela Jacinto, Valeria Facchinetti, Dou Liu, Nelyn Soto, Shiniu Wei, Sung Yun Jung, Qiaojia Huang, Jun Qin, Bing Su. Cell 2006
9

Extension of chronological life span in yeast by decreased TOR pathway signaling.
R Wilson Powers, Matt Kaeberlein, Seth D Caldwell, Brian K Kennedy, Stanley Fields. Genes Dev 2006
643
8

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.
Sebastian I Arriola Apelo, Dudley W Lamming. J Gerontol A Biol Sci Med Sci 2016
90
8

AKT/PKB Signaling: Navigating the Network.
Brendan D Manning, Alex Toker. Cell 2017
8

Rapamycin extends murine lifespan but has limited effects on aging.
Frauke Neff, Diana Flores-Dominguez, Devon P Ryan, Marion Horsch, Susanne Schröder, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Lillian Garrett,[...]. J Clin Invest 2013
231
8

Rapamycin extends life and health in C57BL/6 mice.
Yiqiang Zhang, Alex Bokov, John Gelfond, Vanessa Soto, Yuji Ikeno, Gene Hubbard, Vivian Diaz, Lauren Sloane, Keith Maslin, Stephen Treaster,[...]. J Gerontol A Biol Sci Med Sci 2014
181
8

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.
C Florian Bentzinger, Klaas Romanino, Dimitri Cloëtta, Shuo Lin, Joseph B Mascarenhas, Filippo Oliveri, Jinyu Xia, Emilio Casanova, Céline F Costa, Marijke Brink,[...]. Cell Metab 2008
438
8

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
Laura S Harrington, Greg M Findlay, Alex Gray, Tatiana Tolkacheva, Simon Wigfield, Heike Rebholz, Jill Barnett, Nick R Leslie, Susan Cheng, Peter R Shepherd,[...]. J Cell Biol 2004
818
8

AMPK directly activates mTORC2 to promote cell survival during acute energetic stress.
Dubek Kazyken, Brian Magnuson, Cagri Bodur, Hugo A Acosta-Jaquez, Deqiang Zhang, Xin Tong, Tammy M Barnes, Gabrielle K Steinl, Nicole E Patterson, Christopher H Altheim,[...]. Sci Signal 2019
62
12

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Liron Bar-Peled, Lynne Chantranupong, Andrew D Cherniack, Walter W Chen, Kathleen A Ottina, Brian C Grabiner, Eric D Spear, Scott L Carter, Matthew Meyerson, David M Sabatini. Science 2013
569
8


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.