A citation-based method for searching scientific literature

Mathieu Laplante, David M Sabatini. Cell 2012
Times Cited: 5243







List of co-cited articles
576 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
12

mTOR: from growth signal integration to cancer, diabetes and ageing.
Roberto Zoncu, Alejo Efeyan, David M Sabatini. Nat Rev Mol Cell Biol 2011
9

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
8

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
823
7

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
6

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R Allegrini, Sara C Kozma, Johan Auwerx,[...]. Nature 2004
6

TOR signaling in growth and metabolism.
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
6

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
6


AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
5

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
886
5

Molecular mechanisms of mTOR-mediated translational control.
Xiaoju Max Ma, John Blenis. Nat Rev Mol Cell Biol 2009
5

Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Mitsugu Shimobayashi, Michael N Hall. Nat Rev Mol Cell Biol 2014
668
5

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
5

Regulation of immune responses by mTOR.
Jonathan D Powell, Kristen N Pollizzi, Emily B Heikamp, Maureen R Horton. Annu Rev Immunol 2012
496
5

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
Jingxiang Huang, Brendan D Manning. Biochem J 2008
785
5

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Shuyu Wang, Zhi-Yang Tsun, Rachel L Wolfson, Kuang Shen, Gregory A Wyant, Molly E Plovanich, Elizabeth D Yuan, Tony D Jones, Lynne Chantranupong, William Comb,[...]. Science 2015
465
5


mTOR signaling at a glance.
Mathieu Laplante, David M Sabatini. J Cell Sci 2009
5

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
5

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
4

The TSC-mTOR pathway regulates macrophage polarization.
Vanessa Byles, Anthony J Covarrubias, Issam Ben-Sahra, Dudley W Lamming, David M Sabatini, Brendan D Manning, Tiffany Horng. Nat Commun 2013
297
4

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
727
4

Autophagy: renovation of cells and tissues.
Noboru Mizushima, Masaaki Komatsu. Cell 2011
4

mTOR is a key modulator of ageing and age-related disease.
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
940
4

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy.
Giulia Milan, Vanina Romanello, Francesca Pescatore, Andrea Armani, Ji-Hye Paik, Laura Frasson, Anke Seydel, Jinghui Zhao, Reimar Abraham, Alfred L Goldberg,[...]. Nat Commun 2015
312
4

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
Marco Sandri, Claudia Sandri, Alex Gilbert, Carsten Skurk, Elisa Calabria, Anne Picard, Kenneth Walsh, Stefano Schiaffino, Stewart H Lecker, Alfred L Goldberg. Cell 2004
4

Sarcopenia: Aging-Related Loss of Muscle Mass and Function.
Lars Larsson, Hans Degens, Meishan Li, Leonardo Salviati, Young Il Lee, Wesley Thompson, James L Kirkland, Marco Sandri. Physiol Rev 2019
259
4

Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy.
Perrine Castets, Shuo Lin, Nathalie Rion, Sabrina Di Fulvio, Klaas Romanino, Maitea Guridi, Stephan Frank, Lionel A Tintignac, Michael Sinnreich, Markus A Rüegg. Cell Metab 2013
148
4

Mechanism and medical implications of mammalian autophagy.
Ivan Dikic, Zvulun Elazar. Nat Rev Mol Cell Biol 2018
893
4

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
452
4

AKT/PKB Signaling: Navigating the Network.
Brendan D Manning, Alex Toker. Cell 2017
4

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
4

Defining the role of mTOR in cancer.
David A Guertin, David M Sabatini. Cancer Cell 2007
4

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.
Nao Hosokawa, Taichi Hara, Takeshi Kaizuka, Chieko Kishi, Akito Takamura, Yutaka Miura, Shun-ichiro Iemura, Tohru Natsume, Kenji Takehana, Naoyuki Yamada,[...]. Mol Biol Cell 2009
4


Rheb binds and regulates the mTOR kinase.
Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Kazuyoshi Yonezawa, Joseph Avruch. Curr Biol 2005
666
4

A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
E J Brown, M W Albers, T B Shin, K Ichikawa, C T Keith, W S Lane, S L Schreiber. Nature 1994
4


Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg. Cell 2011
4

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
4

mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
411
4

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Manuele Rebsamen, Lorena Pochini, Taras Stasyk, Mariana E G de Araújo, Michele Galluccio, Richard K Kandasamy, Berend Snijder, Astrid Fauster, Elena L Rudashevskaya, Manuela Bruckner,[...]. Nature 2015
385
4

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
Roberto Zoncu, Liron Bar-Peled, Alejo Efeyan, Shuyu Wang, Yasemin Sancak, David M Sabatini. Science 2011
4


Molecular neurobiology of mTOR.
Katarzyna Switon, Katarzyna Kotulska, Aleksandra Janusz-Kaminska, Justyna Zmorzynska, Jacek Jaworski. Neuroscience 2017
162
4

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Kim. Nat Cell Biol 2007
820
4

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Yasemin Sancak, Carson C Thoreen, Timothy R Peterson, Robert A Lindquist, Seong A Kang, Eric Spooner, Steven A Carr, David M Sabatini. Mol Cell 2007
868
4


Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway.
Xing Zhang, Yan Luo, Chunqing Wang, Xiaofeng Ding, Xin Yang, Dandan Wu, Floyd Silva, Zijiang Yang, Qin Zhou, Lu Wang,[...]. Cell Rep 2018
29
10


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.