A citation-based method for searching scientific literature

Stacey Robida-Stubbs, Kira Glover-Cutter, Dudley W Lamming, Masaki Mizunuma, Sri Devi Narasimhan, Elke Neumann-Haefelin, David M Sabatini, T Keith Blackwell. Cell Metab 2012
Times Cited: 347







List of co-cited articles
1622 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
46

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.
Ivana Bjedov, Janne M Toivonen, Fiona Kerr, Cathy Slack, Jake Jacobson, Andrea Foley, Linda Partridge. Cell Metab 2010
611
38

The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
28

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
727
22

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Pankaj Kapahi, Brian M Zid, Tony Harper, Daniel Koslover, Viveca Sapin, Seymour Benzer. Curr Biol 2004
880
21

Extension of chronological life span in yeast by decreased TOR pathway signaling.
R Wilson Powers, Matt Kaeberlein, Seth D Caldwell, Brian K Kennedy, Stanley Fields. Genes Dev 2006
650
21

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Matt Kaeberlein, R Wilson Powers, Kristan K Steffen, Eric A Westman, Di Hu, Nick Dang, Emily O Kerr, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. Science 2005
907
19

Genetics: influence of TOR kinase on lifespan in C. elegans.
Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L Kovacs, László Orosz, Fritz Müller. Nature 2003
723
19

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
19


Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.
Malene Hansen, Stefan Taubert, Douglas Crawford, Nataliya Libina, Seung-Jae Lee, Cynthia Kenyon. Aging Cell 2007
558
18

The genetics of ageing.
Cynthia J Kenyon. Nature 2010
18

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani,[...]. Science 2009
760
18

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Richard A Miller, David E Harrison, C M Astle, Joseph A Baur, Angela Rodriguez Boyd, Rafael de Cabo, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, James F Nelson,[...]. J Gerontol A Biol Sci Med Sci 2011
581
17

mTOR is a key modulator of ageing and age-related disease.
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
940
17

A C. elegans mutant that lives twice as long as wild type.
C Kenyon, J Chang, E Gensch, A Rudner, R Tabtiang. Nature 1993
16

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.
T Keith Blackwell, Michael J Steinbaugh, John M Hourihan, Collin Y Ewald, Meltem Isik. Free Radic Biol Med 2015
222
16

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.
Coleen T Murphy, Steven A McCarroll, Cornelia I Bargmann, Andrew Fraser, Ravi S Kamath, Julie Ahringer, Hao Li, Cynthia Kenyon. Nature 2003
15


Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
Jennifer M A Tullet, Maren Hertweck, Jae Hyung An, Joseph Baker, Ji Yun Hwang, Shu Liu, Riva P Oliveira, Ralf Baumeister, T Keith Blackwell. Cell 2008
567
15

mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
14

Rapamycin slows aging in mice.
John E Wilkinson, Lisa Burmeister, Susan V Brooks, Chi-Chao Chan, Sabrina Friedline, David E Harrison, James F Hejtmancik, Nancy Nadon, Randy Strong, Lauren K Wood,[...]. Aging Cell 2012
394
14

Extending healthy life span--from yeast to humans.
Luigi Fontana, Linda Partridge, Valter D Longo. Science 2010
14

mTOR inhibition improves immune function in the elderly.
Joan B Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M Valiante, Jens Praestgaard, Baisong Huang, Michael A Lonetto, Holden T Maecker, John Kovarik, Simon Carson,[...]. Sci Transl Med 2014
357
14

Two neurons mediate diet-restriction-induced longevity in C. elegans.
Nicholas A Bishop, Leonard Guarente. Nature 2007
458
13


Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
505
12

Metformin as a Tool to Target Aging.
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
426
12

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
Eric L Greer, Dara Dowlatshahi, Max R Banko, Judit Villen, Kimmi Hoang, Daniel Blanchard, Steven P Gygi, Anne Brunet. Curr Biol 2007
507
12

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
12

Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
690
12

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice.
Sebastian I Arriola Apelo, Cassidy P Pumper, Emma L Baar, Nicole E Cummings, Dudley W Lamming. J Gerontol A Biol Sci Med Sci 2016
62
19

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.
Alexander A Soukas, Elizabeth A Kane, Christopher E Carr, Justine A Melo, Gary Ruvkun. Genes Dev 2009
271
12

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith,[...]. Elife 2016
152
12

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.
Louis R Lapierre, C Daniel De Magalhaes Filho, Philip R McQuary, Chu-Chiao Chu, Orane Visvikis, Jessica T Chang, Sara Gelino, Binnan Ong, Andrew E Davis, Javier E Irazoqui,[...]. Nat Commun 2013
242
11

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
Malene Hansen, Abha Chandra, Laura L Mitic, Brian Onken, Monica Driscoll, Cynthia Kenyon. PLoS Genet 2008
476
11

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.
J Julie Wu, Jie Liu, Edmund B Chen, Jennifer J Wang, Liu Cao, Nisha Narayan, Marie M Fergusson, Ilsa I Rovira, Michele Allen, Danielle A Springer,[...]. Cell Rep 2013
189
11

TORC1 inhibition enhances immune function and reduces infections in the elderly.
Joan B Mannick, Melody Morris, Hans-Ulrich P Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn,[...]. Sci Transl Med 2018
162
11

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.
Richard A Miller, David E Harrison, Clinton M Astle, Elizabeth Fernandez, Kevin Flurkey, Melissa Han, Martin A Javors, Xinna Li, Nancy L Nadon, James F Nelson,[...]. Aging Cell 2014
294
11


The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
10

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.
Laurent Mouchiroud, Riekelt H Houtkooper, Norman Moullan, Elena Katsyuba, Dongryeol Ryu, Carles Cantó, Adrienne Mottis, Young-Suk Jo, Mohan Viswanathan, Kristina Schoonjans,[...]. Cell 2013
631
10

Regulation of aging and age-related disease by DAF-16 and heat-shock factor.
Ao-Lin Hsu, Coleen T Murphy, Cynthia Kenyon. Science 2003
991
9


PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
Siler H Panowski, Suzanne Wolff, Hugo Aguilaniu, Jenni Durieux, Andrew Dillin. Nature 2007
383
9

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence.
Michael J Steinbaugh, Sri Devi Narasimhan, Stacey Robida-Stubbs, Lorenza E Moronetti Mazzeo, Jonathan M Dreyfuss, John M Hourihan, Prashant Raghavan, Theresa N Operaña, Reza Esmaillie, T Keith Blackwell. Elife 2015
107
9


Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.
Patricia Spilman, Natalia Podlutskaya, Matthew J Hart, Jayanta Debnath, Olivia Gorostiza, Dale Bredesen, Arlan Richardson, Randy Strong, Veronica Galvan. PLoS One 2010
657
9

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.
Sebastian I Arriola Apelo, Joshua C Neuman, Emma L Baar, Faizan A Syed, Nicole E Cummings, Harpreet K Brar, Cassidy P Pumper, Michelle E Kimple, Dudley W Lamming. Aging Cell 2016
96
9

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.
Chong Chen, Yu Liu, Yang Liu, Pan Zheng. Sci Signal 2009
407
9


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.