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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
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Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.
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Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
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Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.
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The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.
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Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.
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Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.
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The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.
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Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications.
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Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location.
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EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
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Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations.
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Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression.
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Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.
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Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation.
Kosuke Funato, Tamara Major, Peter W Lewis, C David Allis, Viviane Tabar. Science 2014
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Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma.
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Characteristics of H3 K27M-mutant gliomas in adults.
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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.
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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.
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cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant.
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Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma.
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H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.
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Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.
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H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.
Manav Pathania, Nicolas De Jay, Nicola Maestro, Ashot S Harutyunyan, Justyna Nitarska, Pirasteh Pahlavan, Stephen Henderson, Leonie G Mikael, Angela Richard-Londt, Ying Zhang,[...]. Cancer Cell 2017
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Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma.
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DNA methylation-based classification of central nervous system tumours.
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Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.
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H3F3A K27M mutations in thalamic gliomas from young adult patients.
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Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG.
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Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.
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Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas.
Christopher W Mount, Robbie G Majzner, Shree Sundaresh, Evan P Arnold, Meena Kadapakkam, Samuel Haile, Louai Labanieh, Esther Hulleman, Pamelyn J Woo, Skyler P Rietberg,[...]. Nat Med 2018
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The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.
David N Louis, Arie Perry, Pieter Wesseling, Daniel J Brat, Ian A Cree, Dominique Figarella-Branger, Cynthia Hawkins, H K Ng, Stefan M Pfister, Guido Reifenberger,[...]. Neuro Oncol 2021
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Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation.
M S Aboian, D A Solomon, E Felton, M C Mabray, J E Villanueva-Meyer, S Mueller, S Cha. AJNR Am J Neuroradiol 2017
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Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.
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Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
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cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading.
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Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.
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Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets.
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Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma.
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Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma.
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The somatic genomic landscape of glioblastoma.
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Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models.
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Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.
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Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
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Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.