Tsuyoshi Hirota, Jae Wook Lee, Peter C St John, Mariko Sawa, Keiko Iwaisako, Takako Noguchi, Pagkapol Y Pongsawakul, Tim Sonntag, David K Welsh, David A Brenner, Francis J Doyle, Peter G Schultz, Steve A Kay. Science 2012
Times Cited: 286
Times Cited: 286
Times Cited
Times Co-cited
Similarity
Transcriptional architecture of the mammalian circadian clock.
Joseph S Takahashi. Nat Rev Genet 2017
Joseph S Takahashi. Nat Rev Genet 2017
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A circadian gene expression atlas in mammals: implications for biology and medicine.
Ray Zhang, Nicholas F Lahens, Heather I Ballance, Michael E Hughes, John B Hogenesch. Proc Natl Acad Sci U S A 2014
Ray Zhang, Nicholas F Lahens, Heather I Ballance, Michael E Hughes, John B Hogenesch. Proc Natl Acad Sci U S A 2014
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Transcriptional architecture and chromatin landscape of the core circadian clock in mammals.
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The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome.
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High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.
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Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.
Katja A Lamia, Stephanie J Papp, Ruth T Yu, Grant D Barish, N Henriette Uhlenhaut, Johan W Jonker, Michael Downes, Ronald M Evans. Nature 2011
Katja A Lamia, Stephanie J Papp, Ruth T Yu, Grant D Barish, N Henriette Uhlenhaut, Johan W Jonker, Michael Downes, Ronald M Evans. Nature 2011
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Zheng Chen, Seung-Hee Yoo, Joseph S Takahashi. Annu Rev Pharmacol Toxicol 2018
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Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.
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Isoform-selective regulation of mammalian cryptochromes.
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A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta.
Tsuyoshi Hirota, Warren G Lewis, Andrew C Liu, Jae Wook Lee, Peter G Schultz, Steve A Kay. Proc Natl Acad Sci U S A 2008
Tsuyoshi Hirota, Warren G Lewis, Andrew C Liu, Jae Wook Lee, Peter G Schultz, Steve A Kay. Proc Natl Acad Sci U S A 2008
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Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.
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The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.
Nicolas Preitner, Francesca Damiola, Luis Lopez-Molina, Joszef Zakany, Denis Duboule, Urs Albrecht, Ueli Schibler. Cell 2002
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Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase.
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SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket.
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Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression.
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Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.
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PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues.
Seung-Hee Yoo, Shin Yamazaki, Phillip L Lowrey, Kazuhiro Shimomura, Caroline H Ko, Ethan D Buhr, Sandra M Siepka, Hee-Kyung Hong, Won Jun Oh, Ook Joon Yoo,[...]. Proc Natl Acad Sci U S A 2004
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SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.
Luca Busino, Florian Bassermann, Alessio Maiolica, Choogon Lee, Patrick M Nolan, Sofia I H Godinho, Giulio F Draetta, Michele Pagano. Science 2007
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The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period.
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A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells.
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Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.
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Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.
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mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.
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Diurnal transcriptome atlas of a primate across major neural and peripheral tissues.
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17
C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.
Tsuyoshi Oshima, Iori Yamanaka, Anupriya Kumar, Junichiro Yamaguchi, Taeko Nishiwaki-Ohkawa, Kei Muto, Rika Kawamura, Tsuyoshi Hirota, Kazuhiro Yagita, Stephan Irle,[...]. Angew Chem Int Ed Engl 2015
Tsuyoshi Oshima, Iori Yamanaka, Anupriya Kumar, Junichiro Yamaguchi, Taeko Nishiwaki-Ohkawa, Kei Muto, Rika Kawamura, Tsuyoshi Hirota, Kazuhiro Yagita, Stephan Irle,[...]. Angew Chem Int Ed Engl 2015
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Role of the CLOCK protein in the mammalian circadian mechanism.
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GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
Daniel Grant, Lei Yin, Jon L Collins, Derek J Parks, Lisa A Orband-Miller, G Bruce Wisely, Shree Joshi, Mitchell A Lazar, Timothy M Willson, William J Zuercher. ACS Chem Biol 2010
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Identification and validation of cryptochrome inhibitors that modulate the molecular circadian clock.
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Sung Kook Chun, Jaebong Jang, Sooyoung Chung, Hwayoung Yun, Nam-Jung Kim, Jong-Wha Jung, Gi Hoon Son, Young-Ger Suh, Kyungjin Kim. ACS Chem Biol 2014
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Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.
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CRY2 and FBXL3 Cooperatively Degrade c-MYC.
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Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock.
Jae Wook Lee, Tsuyoshi Hirota, Anupriya Kumar, Nam-Jung Kim, Stephan Irle, Steve A Kay. ChemMedChem 2015
Jae Wook Lee, Tsuyoshi Hirota, Anupriya Kumar, Nam-Jung Kim, Stephan Irle, Steve A Kay. ChemMedChem 2015
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Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening.
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Zheng Chen, Seung-Hee Yoo, Yong-Sung Park, Keon-Hee Kim, Shuguang Wei, Ethan Buhr, Zeng-You Ye, Hui-Lin Pan, Joseph S Takahashi. Proc Natl Acad Sci U S A 2012
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Molecular architecture of the mammalian circadian clock.
Carrie L Partch, Carla B Green, Joseph S Takahashi. Trends Cell Biol 2014
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Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.
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SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
Gad Asher, David Gatfield, Markus Stratmann, Hans Reinke, Charna Dibner, Florian Kreppel, Raul Mostoslavsky, Frederick W Alt, Ueli Schibler. Cell 2008
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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
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Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus.
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Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
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14
Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.
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An evolutionary hotspot defines functional differences between CRYPTOCHROMES.
Clark Rosensweig, Kimberly A Reynolds, Peng Gao, Isara Laothamatas, Yongli Shan, Rama Ranganathan, Joseph S Takahashi, Carla B Green. Nat Commun 2018
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CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.
Yasushi Isojima, Masato Nakajima, Hideki Ukai, Hiroshi Fujishima, Rikuhiro G Yamada, Koh-hei Masumoto, Reiko Kiuchi, Mayumi Ishida, Maki Ukai-Tadenuma, Yoichi Minami,[...]. Proc Natl Acad Sci U S A 2009
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14
The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.
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Coordinated transcription of key pathways in the mouse by the circadian clock.
Satchidananda Panda, Marina P Antoch, Brooke H Miller, Andrew I Su, Andrew B Schook, Marty Straume, Peter G Schultz, Steve A Kay, Joseph S Takahashi, John B Hogenesch. Cell 2002
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FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.
Arisa Hirano, Kanae Yumimoto, Ryosuke Tsunematsu, Masaki Matsumoto, Masaaki Oyama, Hiroko Kozuka-Hata, Tomoki Nakagawa, Darin Lanjakornsiripan, Keiichi I Nakayama, Yoshitaka Fukada. Cell 2013
Arisa Hirano, Kanae Yumimoto, Ryosuke Tsunematsu, Masaki Matsumoto, Masaaki Oyama, Hiroko Kozuka-Hata, Tomoki Nakagawa, Darin Lanjakornsiripan, Keiichi I Nakayama, Yoshitaka Fukada. Cell 2013
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AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation.
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Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.
Alicia K Michael, Jennifer L Fribourgh, Yogarany Chelliah, Colby R Sandate, Greg L Hura, Dina Schneidman-Duhovny, Sarvind M Tripathi, Joseph S Takahashi, Carrie L Partch. Proc Natl Acad Sci U S A 2017
Alicia K Michael, Jennifer L Fribourgh, Yogarany Chelliah, Colby R Sandate, Greg L Hura, Dina Schneidman-Duhovny, Sarvind M Tripathi, Joseph S Takahashi, Carrie L Partch. Proc Natl Acad Sci U S A 2017
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Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.
Shannon N Nangle, Clark Rosensweig, Nobuya Koike, Hajime Tei, Joseph S Takahashi, Carla B Green, Ning Zheng. Elife 2014
Shannon N Nangle, Clark Rosensweig, Nobuya Koike, Hajime Tei, Joseph S Takahashi, Carla B Green, Ning Zheng. Elife 2014
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A genome-wide RNAi screen for modifiers of the circadian clock in human cells.
Eric E Zhang, Andrew C Liu, Tsuyoshi Hirota, Loren J Miraglia, Genevieve Welch, Pagkapol Y Pongsawakul, Xianzhong Liu, Ann Atwood, Jon W Huss, Jeff Janes,[...]. Cell 2009
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Optimized chemical probes for REV-ERBα.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.