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Novel mutations target distinct subgroups of medulloblastoma.
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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
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The whole-genome landscape of medulloblastoma subtypes.
Paul A Northcott, Ivo Buchhalter, A Sorana Morrissy, Volker Hovestadt, Joachim Weischenfeldt, Tobias Ehrenberger, Susanne Gröbner, Maia Segura-Wang, Thomas Zichner, Vasilisa A Rudneva,[...]. Nature 2017
Paul A Northcott, Ivo Buchhalter, A Sorana Morrissy, Volker Hovestadt, Joachim Weischenfeldt, Tobias Ehrenberger, Susanne Gröbner, Maia Segura-Wang, Thomas Zichner, Vasilisa A Rudneva,[...]. Nature 2017
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Molecular subgroups of medulloblastoma: the current consensus.
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Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
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Intertumoral Heterogeneity within Medulloblastoma Subgroups.
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
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Medulloblastoma comprises four distinct molecular variants.
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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
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Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.
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Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
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Medulloblastomics: the end of the beginning.
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Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
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Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.
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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.
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The genetic landscape of the childhood cancer medulloblastoma.
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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
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Resolving medulloblastoma cellular architecture by single-cell genomics.
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Subtypes of medulloblastoma have distinct developmental origins.
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Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.
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DNA methylation-based classification of central nervous system tumours.
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Active medulloblastoma enhancers reveal subgroup-specific cellular origins.
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Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial.
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Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes.
Tanvi Sharma, Edward C Schwalbe, Daniel Williamson, Martin Sill, Volker Hovestadt, Martin Mynarek, Stefan Rutkowski, Giles W Robinson, Amar Gajjar, Florence Cavalli,[...]. Acta Neuropathol 2019
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Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups.
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Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.
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Sebastian M Waszak, Paul A Northcott, Ivo Buchhalter, Giles W Robinson, Christian Sutter, Susanne Groebner, Kerstin B Grund, Laurence Brugières, David T W Jones, Kristian W Pajtler,[...]. Lancet Oncol 2018
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Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.
Tobias Rausch, David T W Jones, Marc Zapatka, Adrian M Stütz, Thomas Zichner, Joachim Weischenfeldt, Natalie Jäger, Marc Remke, David Shih, Paul A Northcott,[...]. Cell 2012
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Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
David T W Jones, Barbara Hutter, Natalie Jäger, Andrey Korshunov, Marcel Kool, Hans-Jörg Warnatz, Thomas Zichner, Sally R Lambert, Marina Ryzhova, Dong Anh Khuong Quang,[...]. Nat Genet 2013
David T W Jones, Barbara Hutter, Natalie Jäger, Andrey Korshunov, Marcel Kool, Hans-Jörg Warnatz, Thomas Zichner, Sally R Lambert, Marina Ryzhova, Dong Anh Khuong Quang,[...]. Nat Genet 2013
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Cytogenetic prognostication within medulloblastoma subgroups.
David J H Shih, Paul A Northcott, Marc Remke, Andrey Korshunov, Vijay Ramaswamy, Marcel Kool, Betty Luu, Yuan Yao, Xin Wang, Adrian M Dubuc,[...]. J Clin Oncol 2014
David J H Shih, Paul A Northcott, Marc Remke, Andrey Korshunov, Vijay Ramaswamy, Marcel Kool, Betty Luu, Yuan Yao, Xin Wang, Adrian M Dubuc,[...]. J Clin Oncol 2014
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Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis.
Vijay Ramaswamy, Marc Remke, Eric Bouffet, Claudia C Faria, Sebastien Perreault, Yoon-Jae Cho, David J Shih, Betty Luu, Adrian M Dubuc, Paul A Northcott,[...]. Lancet Oncol 2013
Vijay Ramaswamy, Marc Remke, Eric Bouffet, Claudia C Faria, Sebastien Perreault, Yoon-Jae Cho, David J Shih, Betty Luu, Adrian M Dubuc, Paul A Northcott,[...]. Lancet Oncol 2013
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Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.
Steven C Clifford, Meryl E Lusher, Janet C Lindsey, Jacqueline A Langdon, Richard J Gilbertson, Debbie Straughton, David W Ellison. Cell Cycle 2006
Steven C Clifford, Meryl E Lusher, Janet C Lindsey, Jacqueline A Langdon, Richard J Gilbertson, Debbie Straughton, David W Ellison. Cell Cycle 2006
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BET bromodomain inhibition of MYC-amplified medulloblastoma.
Pratiti Bandopadhayay, Guillaume Bergthold, Brian Nguyen, Simone Schubert, Sharareh Gholamin, Yujie Tang, Sara Bolin, Steven E Schumacher, Rhamy Zeid, Sabran Masoud,[...]. Clin Cancer Res 2014
Pratiti Bandopadhayay, Guillaume Bergthold, Brian Nguyen, Simone Schubert, Sharareh Gholamin, Yujie Tang, Sara Bolin, Steven E Schumacher, Rhamy Zeid, Sabran Masoud,[...]. Clin Cancer Res 2014
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Divergent clonal selection dominates medulloblastoma at recurrence.
A Sorana Morrissy, Livia Garzia, David J H Shih, Scott Zuyderduyn, Xi Huang, Patryk Skowron, Marc Remke, Florence M G Cavalli, Vijay Ramaswamy, Patricia E Lindsay,[...]. Nature 2016
A Sorana Morrissy, Livia Garzia, David J H Shih, Scott Zuyderduyn, Xi Huang, Patryk Skowron, Marc Remke, Florence M G Cavalli, Vijay Ramaswamy, Patricia E Lindsay,[...]. Nature 2016
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Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct.
Paul A Northcott, Thomas Hielscher, Adrian Dubuc, Stephen Mack, David Shih, Marc Remke, Hani Al-Halabi, Steffen Albrecht, Nada Jabado, Charles G Eberhart,[...]. Acta Neuropathol 2011
Paul A Northcott, Thomas Hielscher, Adrian Dubuc, Stephen Mack, David Shih, Marc Remke, Hani Al-Halabi, Steffen Albrecht, Nada Jabado, Charles G Eberhart,[...]. Acta Neuropathol 2011
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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma.
Yanxin Pei, Kun-Wei Liu, Jun Wang, Alexandra Garancher, Ran Tao, Lourdes A Esparza, Donna L Maier, Yoko T Udaka, Najiba Murad, Sorana Morrissy,[...]. Cancer Cell 2016
Yanxin Pei, Kun-Wei Liu, Jun Wang, Alexandra Garancher, Ran Tao, Lourdes A Esparza, Donna L Maier, Yoko T Udaka, Najiba Murad, Sorana Morrissy,[...]. Cancer Cell 2016
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Medulloblastoma.
Paul A Northcott, Giles W Robinson, Christian P Kratz, Donald J Mabbott, Scott L Pomeroy, Steven C Clifford, Stefan Rutkowski, David W Ellison, David Malkin, Michael D Taylor,[...]. Nat Rev Dis Primers 2019
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New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.
Dominik Sturm, Brent A Orr, Umut H Toprak, Volker Hovestadt, David T W Jones, David Capper, Martin Sill, Ivo Buchhalter, Paul A Northcott, Irina Leis,[...]. Cell 2016
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A mouse model of the most aggressive subgroup of human medulloblastoma.
Daisuke Kawauchi, Giles Robinson, Tamar Uziel, Paul Gibson, Jerold Rehg, Cuilan Gao, David Finkelstein, Chunxu Qu, Stanley Pounds, David W Ellison,[...]. Cancer Cell 2012
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Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.
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CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015.
Quinn T Ostrom, Haley Gittleman, Gabrielle Truitt, Alexander Boscia, Carol Kruchko, Jill S Barnholtz-Sloan. Neuro Oncol 2018
Quinn T Ostrom, Haley Gittleman, Gabrielle Truitt, Alexander Boscia, Carol Kruchko, Jill S Barnholtz-Sloan. Neuro Oncol 2018
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Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.
Volker Hovestadt, David T W Jones, Simone Picelli, Wei Wang, Marcel Kool, Paul A Northcott, Marc Sultan, Katharina Stachurski, Marina Ryzhova, Hans-Jörg Warnatz,[...]. Nature 2014
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Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.
Roger J Packer, Amar Gajjar, Gilbert Vezina, Lucy Rorke-Adams, Peter C Burger, Patricia L Robertson, Lisa Bayer, Deborah LaFond, Bernadine R Donahue, MaryAnne H Marymont,[...]. J Clin Oncol 2006
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Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Ulrich Schüller, Vivi M Heine, Junhao Mao, Alvin T Kho, Allison K Dillon, Young-Goo Han, Emmanuelle Huillard, Tao Sun, Azra H Ligon, Ying Qian,[...]. Cancer Cell 2008
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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
Jeremy Schwartzentruber, Andrey Korshunov, Xiao-Yang Liu, David T W Jones, Elke Pfaff, Karine Jacob, Dominik Sturm, Adam M Fontebasso, Dong-Anh Khuong Quang, Martje Tönjes,[...]. Nature 2012
Jeremy Schwartzentruber, Andrey Korshunov, Xiao-Yang Liu, David T W Jones, Elke Pfaff, Karine Jacob, Dominik Sturm, Adam M Fontebasso, Dong-Anh Khuong Quang, Martje Tönjes,[...]. Nature 2012
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Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
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Adult medulloblastoma comprises three major molecular variants.
Marc Remke, Thomas Hielscher, Paul A Northcott, Hendrik Witt, Marina Ryzhova, Andrea Wittmann, Axel Benner, Andreas von Deimling, Wolfram Scheurlen, Arie Perry,[...]. J Clin Oncol 2011
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Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study.
Amar Gajjar, Clinton F Stewart, David W Ellison, Sue Kaste, Larry E Kun, Roger J Packer, Stewart Goldman, Murali Chintagumpala, Dana Wallace, Naoko Takebe,[...]. Clin Cancer Res 2013
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Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor.
Giles W Robinson, Sue C Kaste, Wassim Chemaitilly, Daniel C Bowers, Stephen Laughton, Amy Smith, Nicholas G Gottardo, Sonia Partap, Anne Bendel, Karen D Wright,[...]. Oncotarget 2017
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.