Rosario Rizzuto, Diego De Stefani, Anna Raffaello, Cristina Mammucari. Nat Rev Mol Cell Biol 2012
Times Cited: 1003
Times Cited: 1003
Times Cited
Times Co-cited
Similarity
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.
Joshua M Baughman, Fabiana Perocchi, Hany S Girgis, Molly Plovanich, Casey A Belcher-Timme, Yasemin Sancak, X Robert Bao, Laura Strittmatter, Olga Goldberger, Roman L Bogorad,[...]. Nature 2011
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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.
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NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.
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MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.
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Enjoy the Trip: Calcium in Mitochondria Back and Forth.
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Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex.
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Minrui Fan, Jinru Zhang, Chen-Wei Tsai, Benjamin J Orlando, Madison Rodriguez, Yan Xu, Maofu Liao, Ming-Feng Tsai, Liang Feng. Nature 2020
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ER tubules mark sites of mitochondrial division.
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EMRE is an essential component of the mitochondrial calcium uniporter complex.
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The mitochondrial calcium uniporter is a highly selective ion channel.
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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses.
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The machineries, regulation and cellular functions of mitochondrial calcium.
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Structural and functional features and significance of the physical linkage between ER and mitochondria.
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The molecular era of the mitochondrial calcium uniporter.
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The multifaceted contributions of mitochondria to cellular metabolism.
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The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.
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Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.
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Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria.
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MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.
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MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.
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Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.
Zhiwei Dong, Santhanam Shanmughapriya, Dhanendra Tomar, Naveed Siddiqui, Solomon Lynch, Neeharika Nemani, Sarah L Breves, Xueqian Zhang, Aparna Tripathi, Palaniappan Palaniappan,[...]. Mol Cell 2017
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Autophagosomes form at ER-mitochondria contact sites.
Maho Hamasaki, Nobumichi Furuta, Atsushi Matsuda, Akiko Nezu, Akitsugu Yamamoto, Naonobu Fujita, Hiroko Oomori, Takeshi Noda, Tokuko Haraguchi, Yasushi Hiraoka,[...]. Nature 2013
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Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Pooja Jadiya, Devin W Kolmetzky, Dhanendra Tomar, Antonio Di Meco, Alyssa A Lombardi, Jonathan P Lambert, Timothy S Luongo, Marthe H Ludtmann, Domenico Praticò, John W Elrod. Nat Commun 2019
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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.
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Mitochondria at the neuronal presynapse in health and disease.
Michael J Devine, Josef T Kittler. Nat Rev Neurosci 2018
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Here, there, and everywhere: The importance of ER membrane contact sites.
Haoxi Wu, Pedro Carvalho, Gia K Voeltz. Science 2018
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MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond.
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High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter.
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The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.
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MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.
Fabiana Perocchi, Vishal M Gohil, Hany S Girgis, X Robert Bao, Janet E McCombs, Amy E Palmer, Vamsi K Mootha. Nature 2010
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MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.
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MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.
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The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease.
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria.
Olga Martins de Brito, Luca Scorrano. Nature 2008
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Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.
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Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
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Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria.
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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
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Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models.
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PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.