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Times Cited: 25
Times Cited: 25
Times Cited
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Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
Titia de Lange. Genes Dev 2005
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Alternative lengthening of telomeres pathway: recombination-mediated telomere maintenance mechanism in human cells.
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A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.
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Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection.
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Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.
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Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.
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Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas.
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Telomere length measurement-caveats and a critical assessment of the available technologies and tools.
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Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.
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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.
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Treatment Options for Medulloblastoma and CNS Primitive Neuroectodermal Tumor (PNET).
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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
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Altered telomeres in tumors with ATRX and DAXX mutations.
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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
Patrick J Killela, Zachary J Reitman, Yuchen Jiao, Chetan Bettegowda, Nishant Agrawal, Luis A Diaz, Allan H Friedman, Henry Friedman, Gary L Gallia, Beppino C Giovanella,[...]. Proc Natl Acad Sci U S A 2013
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Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin.
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8
TERT promoter mutations in familial and sporadic melanoma.
Susanne Horn, Adina Figl, P Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki,[...]. Science 2013
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Molecular diagnostics in paediatric glial tumours.
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Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency.
Oliver E Bechter, Ying Zou, Jerry W Shay, Woodring E Wright. EMBO Rep 2003
Oliver E Bechter, Ying Zou, Jerry W Shay, Woodring E Wright. EMBO Rep 2003
8
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.
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8
8
Antitumor mechanism of antisense cantide targeting human telomerase reverse transcriptase.
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Inhibition of tumor growth and metastasis with antisense oligonucleotides (Cantide) targeting hTERT in an in situ human hepatocellular carcinoma model.
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Telomerase: structure, functions, and activity regulation.
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The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel.
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Combined effects of Cantide and chemotherapeutic drugs on inhibition of tumor cells' growth in vitro and in vivo.
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The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth.
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Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria.
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Specific features of telomerase RNA from Hansenula polymorpha.
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Oxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cells.
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Chimeric antigen receptor T cells for sustained remissions in leukemia.
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