Arkasubhra Ghosh, Gaye Saginc, Shi Chi Leow, Ekta Khattar, Eun Myong Shin, Ting Dong Yan, Marc Wong, Zhizhuo Zhang, Guoliang Li, Wing-Kin Sung, Jianbiao Zhou, Wee Joo Chng, Shang Li, Edison Liu, Vinay Tergaonkar. Nat Cell Biol 2012
Times Cited: 199
Times Cited: 199
Times Cited
Times Co-cited
Similarity
Telomerase modulates Wnt signalling by association with target gene chromatin.
Jae-Il Park, Andrew S Venteicher, Ji Yeon Hong, Jinkuk Choi, Sohee Jun, Marina Shkreli, Woody Chang, Zhaojing Meng, Peggie Cheung, Hong Ji,[...]. Nature 2009
Jae-Il Park, Andrew S Venteicher, Ji Yeon Hong, Jinkuk Choi, Sohee Jun, Marina Shkreli, Woody Chang, Zhaojing Meng, Peggie Cheung, Hong Ji,[...]. Nature 2009
36
Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription.
Deqiang Ding, Peng Xi, Junzhi Zhou, Miao Wang, Yu-Sheng Cong. FASEB J 2013
Deqiang Ding, Peng Xi, Junzhi Zhou, Miao Wang, Yu-Sheng Cong. FASEB J 2013
27
Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.
Cheryl M Koh, Ekta Khattar, Shi Chi Leow, Chia Yi Liu, Julius Muller, Wei Xia Ang, Yinghui Li, Guido Franzoso, Shang Li, Ernesto Guccione,[...]. J Clin Invest 2015
Cheryl M Koh, Ekta Khattar, Shi Chi Leow, Chia Yi Liu, Julius Muller, Wei Xia Ang, Yinghui Li, Guido Franzoso, Shang Li, Ernesto Guccione,[...]. J Clin Invest 2015
22
Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
Titia de Lange. Genes Dev 2005
18
Specific association of human telomerase activity with immortal cells and cancer.
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
17
17
Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage.
Judith Haendeler, Stefan Dröse, Nicole Büchner, Sascha Jakob, Joachim Altschmied, Christine Goy, Ioakim Spyridopoulos, Andreas M Zeiher, Ulrich Brandt, Stefanie Dimmeler. Arterioscler Thromb Vasc Biol 2009
Judith Haendeler, Stefan Dröse, Nicole Büchner, Sascha Jakob, Joachim Altschmied, Christine Goy, Ioakim Spyridopoulos, Andreas M Zeiher, Ulrich Brandt, Stefanie Dimmeler. Arterioscler Thromb Vasc Biol 2009
17
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.
Shaheda Ahmed, João F Passos, Matthew J Birket, Tina Beckmann, Sebastian Brings, Heiko Peters, Mark A Birch-Machin, Thomas von Zglinicki, Gabriele Saretzki. J Cell Sci 2008
Shaheda Ahmed, João F Passos, Matthew J Birket, Tina Beckmann, Sebastian Brings, Heiko Peters, Mark A Birch-Machin, Thomas von Zglinicki, Gabriele Saretzki. J Cell Sci 2008
17
Human telomerase and its regulation.
Yu-Sheng Cong, Woodring E Wright, Jerry W Shay. Microbiol Mol Biol Rev 2002
Yu-Sheng Cong, Woodring E Wright, Jerry W Shay. Microbiol Mol Biol Rev 2002
17
Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells.
Z Liu, Q Li, K Li, L Chen, W Li, M Hou, T Liu, J Yang, C Lindvall, M Björkholm,[...]. Oncogene 2013
Z Liu, Q Li, K Li, L Chen, W Li, M Hou, T Liu, J Yang, C Lindvall, M Björkholm,[...]. Oncogene 2013
16
TERT promoter mutations in familial and sporadic melanoma.
Susanne Horn, Adina Figl, P Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki,[...]. Science 2013
Susanne Horn, Adina Figl, P Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki,[...]. Science 2013
16
Noncanonical functions of telomerase: implications in telomerase-targeted cancer therapies.
Yinghui Li, Vinay Tergaonkar. Cancer Res 2014
Yinghui Li, Vinay Tergaonkar. Cancer Res 2014
16
Telomeres shorten during ageing of human fibroblasts.
C B Harley, A B Futcher, C W Greider. Nature 1990
C B Harley, A B Futcher, C W Greider. Nature 1990
15
Highly recurrent TERT promoter mutations in human melanoma.
Franklin W Huang, Eran Hodis, Mary Jue Xu, Gregory V Kryukov, Lynda Chin, Levi A Garraway. Science 2013
Franklin W Huang, Eran Hodis, Mary Jue Xu, Gregory V Kryukov, Lynda Chin, Levi A Garraway. Science 2013
15
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins.
Paula Martínez, María A Blasco. Nat Rev Cancer 2011
Paula Martínez, María A Blasco. Nat Rev Cancer 2011
14
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
Masaharu Akiyama, Teru Hideshima, Toshiaki Hayashi, Yu-Tzu Tai, Constantine S Mitsiades, Nicholas Mitsiades, Dharminder Chauhan, Paul Richardson, Nikhil C Munshi, Kenneth C Anderson. Cancer Res 2003
Masaharu Akiyama, Teru Hideshima, Toshiaki Hayashi, Yu-Tzu Tai, Constantine S Mitsiades, Nicholas Mitsiades, Dharminder Chauhan, Paul Richardson, Nikhil C Munshi, Kenneth C Anderson. Cancer Res 2003
13
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation.
Laura L Smith, Hilary A Coller, James M Roberts. Nat Cell Biol 2003
Laura L Smith, Hilary A Coller, James M Roberts. Nat Cell Biol 2003
12
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program.
Jinkuk Choi, Lucinda K Southworth, Kavita Y Sarin, Andrew S Venteicher, Wenxiu Ma, Woody Chang, Peggie Cheung, Sohee Jun, Maja K Artandi, Naman Shah,[...]. PLoS Genet 2008
Jinkuk Choi, Lucinda K Southworth, Kavita Y Sarin, Andrew S Venteicher, Wenxiu Ma, Woody Chang, Peggie Cheung, Sohee Jun, Maja K Artandi, Naman Shah,[...]. PLoS Genet 2008
12
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.
Kenkichi Masutomi, Richard Possemato, Judy M Y Wong, Jennifer L Currier, Zuzana Tothova, Judith B Manola, Shridar Ganesan, Peter M Lansdorp, Kathleen Collins, William C Hahn. Proc Natl Acad Sci U S A 2005
Kenkichi Masutomi, Richard Possemato, Judy M Y Wong, Jennifer L Currier, Zuzana Tothova, Judith B Manola, Shridar Ganesan, Peter M Lansdorp, Kathleen Collins, William C Hahn. Proc Natl Acad Sci U S A 2005
12
Direct activation of TERT transcription by c-MYC.
K J Wu, C Grandori, M Amacker, N Simon-Vermot, A Polack, J Lingner, R Dalla-Favera. Nat Genet 1999
K J Wu, C Grandori, M Amacker, N Simon-Vermot, A Polack, J Lingner, R Dalla-Favera. Nat Genet 1999
12
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
Mohammad A Jafri, Shakeel A Ansari, Mohammed H Alqahtani, Jerry W Shay. Genome Med 2016
Mohammad A Jafri, Shakeel A Ansari, Mohammed H Alqahtani, Jerry W Shay. Genome Med 2016
12
Frequency of TERT promoter mutations in human cancers.
João Vinagre, Ana Almeida, Helena Pópulo, Rui Batista, Joana Lyra, Vasco Pinto, Ricardo Coelho, Ricardo Celestino, Hugo Prazeres, Luis Lima,[...]. Nat Commun 2013
João Vinagre, Ana Almeida, Helena Pópulo, Rui Batista, Joana Lyra, Vasco Pinto, Ricardo Coelho, Ricardo Celestino, Hugo Prazeres, Luis Lima,[...]. Nat Commun 2013
11
Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis.
Chatchawan Singhapol, Deepali Pal, Rafal Czapiewski, Mahendar Porika, Glyn Nelson, Gabriele C Saretzki. PLoS One 2013
Chatchawan Singhapol, Deepali Pal, Rafal Czapiewski, Mahendar Porika, Glyn Nelson, Gabriele C Saretzki. PLoS One 2013
12
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
C W Greider, E H Blackburn. Nature 1989
C W Greider, E H Blackburn. Nature 1989
11
Telomerase activity in human germline and embryonic tissues and cells.
W E Wright, M A Piatyszek, W E Rainey, W Byrd, J W Shay. Dev Genet 1996
W E Wright, M A Piatyszek, W E Rainey, W Byrd, J W Shay. Dev Genet 1996
11
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
Katrin Hoffmeyer, Angelo Raggioli, Stefan Rudloff, Roman Anton, Andreas Hierholzer, Ignacio Del Valle, Kerstin Hein, Riana Vogt, Rolf Kemler. Science 2012
Katrin Hoffmeyer, Angelo Raggioli, Stefan Rudloff, Roman Anton, Andreas Hierholzer, Ignacio Del Valle, Kerstin Hein, Riana Vogt, Rolf Kemler. Science 2012
11
Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression.
Ekta Khattar, Pavanish Kumar, Chia Yi Liu, Semih Can Akıncılar, Anandhkumar Raju, Manikandan Lakshmanan, Julien Jean Pierre Maury, Yu Qiang, Shang Li, Ern Yu Tan,[...]. J Clin Invest 2016
Ekta Khattar, Pavanish Kumar, Chia Yi Liu, Semih Can Akıncılar, Anandhkumar Raju, Manikandan Lakshmanan, Julien Jean Pierre Maury, Yu Qiang, Shang Li, Ern Yu Tan,[...]. J Clin Invest 2016
14
Reverse transcriptase motifs in the catalytic subunit of telomerase.
J Lingner, T R Hughes, A Shevchenko, M Mann, V Lundblad, T R Cech. Science 1997
J Lingner, T R Hughes, A Shevchenko, M Mann, V Lundblad, T R Cech. Science 1997
11
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene.
Muhammad Khairul Ramlee, Jing Wang, Wei Xun Toh, Shang Li. Genes (Basel) 2016
Muhammad Khairul Ramlee, Jing Wang, Wei Xun Toh, Shang Li. Genes (Basel) 2016
16
Telomerase: central regulator of all of the hallmarks of cancer.
Kee Chung Low, Vinay Tergaonkar. Trends Biochem Sci 2013
Kee Chung Low, Vinay Tergaonkar. Trends Biochem Sci 2013
10
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT.
S L Weinrich, R Pruzan, L Ma, M Ouellette, V M Tesmer, S E Holt, A G Bodnar, S Lichtsteiner, N W Kim, J B Trager,[...]. Nat Genet 1997
S L Weinrich, R Pruzan, L Ma, M Ouellette, V M Tesmer, S E Holt, A G Bodnar, S Lichtsteiner, N W Kim, J B Trager,[...]. Nat Genet 1997
10
10
hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells.
Inthrani R Indran, Manoor P Hande, Shazib Pervaiz. Cancer Res 2011
Inthrani R Indran, Manoor P Hande, Shazib Pervaiz. Cancer Res 2011
10
Extension of life-span by introduction of telomerase into normal human cells.
A G Bodnar, M Ouellette, M Frolkis, S E Holt, C P Chiu, G B Morin, C B Harley, J W Shay, S Lichtsteiner, W E Wright. Science 1998
A G Bodnar, M Ouellette, M Frolkis, S E Holt, C P Chiu, G B Morin, C B Harley, J W Shay, S Lichtsteiner, W E Wright. Science 1998
10
TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism.
P Sivaramakrishna Rachakonda, Ismail Hosen, Petra J de Verdier, Mahdi Fallah, Barbara Heidenreich, Charlotta Ryk, N Peter Wiklund, Gunnar Steineck, Dirk Schadendorf, Kari Hemminki,[...]. Proc Natl Acad Sci U S A 2013
P Sivaramakrishna Rachakonda, Ismail Hosen, Petra J de Verdier, Mahdi Fallah, Barbara Heidenreich, Charlotta Ryk, N Peter Wiklund, Gunnar Steineck, Dirk Schadendorf, Kari Hemminki,[...]. Proc Natl Acad Sci U S A 2013
9
Cancer-associated TERT promoter mutations abrogate telomerase silencing.
Kunitoshi Chiba, Joshua Z Johnson, Jacob M Vogan, Tina Wagner, John M Boyle, Dirk Hockemeyer. Elife 2015
Kunitoshi Chiba, Joshua Z Johnson, Jacob M Vogan, Tina Wagner, John M Boyle, Dirk Hockemeyer. Elife 2015
9
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
Patrick J Killela, Zachary J Reitman, Yuchen Jiao, Chetan Bettegowda, Nishant Agrawal, Luis A Diaz, Allan H Friedman, Henry Friedman, Gary L Gallia, Beppino C Giovanella,[...]. Proc Natl Acad Sci U S A 2013
Patrick J Killela, Zachary J Reitman, Yuchen Jiao, Chetan Bettegowda, Nishant Agrawal, Luis A Diaz, Allan H Friedman, Henry Friedman, Gary L Gallia, Beppino C Giovanella,[...]. Proc Natl Acad Sci U S A 2013
9
Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.
Robert J A Bell, H Tomas Rube, Alex Kreig, Andrew Mancini, Shaun D Fouse, Raman P Nagarajan, Serah Choi, Chibo Hong, Daniel He, Melike Pekmezci,[...]. Science 2015
Robert J A Bell, H Tomas Rube, Alex Kreig, Andrew Mancini, Shaun D Fouse, Raman P Nagarajan, Serah Choi, Chibo Hong, Daniel He, Melike Pekmezci,[...]. Science 2015
9
NF-kappa B regulates transcription of the mouse telomerase catalytic subunit.
L Yin, A K Hubbard, C Giardina. J Biol Chem 2000
L Yin, A K Hubbard, C Giardina. J Biol Chem 2000
10
Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.
Janine Hertzog Santos, Joel N Meyer, Milan Skorvaga, Lois A Annab, Bennett Van Houten. Aging Cell 2004
Janine Hertzog Santos, Joel N Meyer, Milan Skorvaga, Lois A Annab, Bennett Van Houten. Aging Cell 2004
9
Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.
Yinghui Li, Qi-Ling Zhou, Wenjie Sun, Prashant Chandrasekharan, Hui Shan Cheng, Zhe Ying, Manikandan Lakshmanan, Anandhkumar Raju, Daniel G Tenen, Shi-Yuan Cheng,[...]. Nat Cell Biol 2015
Yinghui Li, Qi-Ling Zhou, Wenjie Sun, Prashant Chandrasekharan, Hui Shan Cheng, Zhe Ying, Manikandan Lakshmanan, Anandhkumar Raju, Daniel G Tenen, Shi-Yuan Cheng,[...]. Nat Cell Biol 2015
9
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Jean Charles Nault, Maxime Mallet, Camilla Pilati, Julien Calderaro, Paulette Bioulac-Sage, Christophe Laurent, Alexis Laurent, Daniel Cherqui, Charles Balabaud, Jessica Zucman-Rossi. Nat Commun 2013
Jean Charles Nault, Maxime Mallet, Camilla Pilati, Julien Calderaro, Paulette Bioulac-Sage, Christophe Laurent, Alexis Laurent, Daniel Cherqui, Charles Balabaud, Jessica Zucman-Rossi. Nat Commun 2013
9
Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer.
Yong Zhang, LingLing Toh, Peishan Lau, Xueying Wang. J Biol Chem 2012
Yong Zhang, LingLing Toh, Peishan Lau, Xueying Wang. J Biol Chem 2012
9
New prospects for targeting telomerase beyond the telomere.
Greg M Arndt, Karen L MacKenzie. Nat Rev Cancer 2016
Greg M Arndt, Karen L MacKenzie. Nat Rev Cancer 2016
15
Systematic analysis of telomere length and somatic alterations in 31 cancer types.
Floris P Barthel, Wei Wei, Ming Tang, Emmanuel Martinez-Ledesma, Xin Hu, Samirkumar B Amin, Kadir C Akdemir, Sahil Seth, Xingzhi Song, Qianghu Wang,[...]. Nat Genet 2017
Floris P Barthel, Wei Wei, Ming Tang, Emmanuel Martinez-Ledesma, Xin Hu, Samirkumar B Amin, Kadir C Akdemir, Sahil Seth, Xingzhi Song, Qianghu Wang,[...]. Nat Genet 2017
9
The RNA component of human telomerase.
J Feng, W D Funk, S S Wang, S L Weinrich, A A Avilion, C P Chiu, R R Adams, E Chang, R C Allsopp, J Yu. Science 1995
J Feng, W D Funk, S S Wang, S L Weinrich, A A Avilion, C P Chiu, R R Adams, E Chang, R C Allsopp, J Yu. Science 1995
9
hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor.
Ning Liu, Deqiang Ding, Wanyu Hao, Fan Yang, Xiaoying Wu, Miao Wang, Xiaoling Xu, Zhenyu Ju, Jun-Ping Liu, Zhangfa Song,[...]. Nucleic Acids Res 2016
Ning Liu, Deqiang Ding, Wanyu Hao, Fan Yang, Xiaoying Wu, Miao Wang, Xiaoling Xu, Zhenyu Ju, Jun-Ping Liu, Zhangfa Song,[...]. Nucleic Acids Res 2016
23
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.