A citation-based method for searching scientific literature

Jiaxi Wu, Lijun Sun, Xiang Chen, Fenghe Du, Heping Shi, Chuo Chen, Zhijian J Chen. Science 2013
Times Cited: 1160







List of co-cited articles
922 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
78


cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Andrea Ablasser, Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte, Ingo Röhl, Karl-Peter Hopfner, Janos Ludwig, Veit Hornung. Nature 2013
799
30


Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Siqi Liu, Xin Cai, Jiaxi Wu, Qian Cong, Xiang Chen, Tuo Li, Fenghe Du, Junyao Ren, You-Tong Wu, Nick V Grishin,[...]. Science 2015
790
24

Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Pu Gao, Manuel Ascano, Yang Wu, Winfried Barchet, Barbara L Gaffney, Thomas Zillinger, Artem A Serganov, Yizhou Liu, Roger A Jones, Gunther Hartmann,[...]. Cell 2013
542
24

Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.
Xu Zhang, Heping Shi, Jiaxi Wu, Xuewu Zhang, Lijun Sun, Chuo Chen, Zhijian J Chen. Mol Cell 2013
553
24

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Xiang Gui, Hui Yang, Tuo Li, Xiaojun Tan, Peiqing Shi, Minghao Li, Fenghe Du, Zhijian J Chen. Nature 2019
328
22


The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
Bo Zhong, Yan Yang, Shu Li, Yan-Yi Wang, Ying Li, Feici Diao, Caoqi Lei, Xiao He, Lu Zhang, Po Tien,[...]. Immunity 2008
911
20

cGAS surveillance of micronuclei links genome instability to innate immunity.
Karen J Mackenzie, Paula Carroll, Carol-Anne Martin, Olga Murina, Adeline Fluteau, Daniel J Simpson, Nelly Olova, Hannah Sutcliffe, Jacqueline K Rainger, Andrea Leitch,[...]. Nature 2017
677
20

STING is a direct innate immune sensor of cyclic di-GMP.
Dara L Burdette, Kathryn M Monroe, Katia Sotelo-Troha, Jeff S Iwig, Barbara Eckert, Mamoru Hyodo, Yoshihiro Hayakawa, Russell E Vance. Nature 2011
897
20

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects.
Xiao-Dong Li, Jiaxi Wu, Daxing Gao, Hua Wang, Lijun Sun, Zhijian J Chen. Science 2013
636
19

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.
Qi Chen, Lijun Sun, Zhijian J Chen. Nat Immunol 2016
822
19


cGAS is essential for cellular senescence.
Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, Zhijian J Chen. Proc Natl Acad Sci U S A 2017
420
18

Structural mechanism of cytosolic DNA sensing by cGAS.
Filiz Civril, Tobias Deimling, Carina C de Oliveira Mann, Andrea Ablasser, Manuela Moldt, Gregor Witte, Veit Hornung, Karl-Peter Hopfner. Nature 2013
393
18

Activated STING in a vascular and pulmonary syndrome.
Y Liu, A A Jesus, B Marrero, D Yang, S E Ramsey, G A Montealegre Sanchez, K Tenbrock, H Wittkowski, O Y Jones, H S Kuehn,[...]. N Engl J Med 2014
697
17

Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
Xin Li, Chang Shu, Guanghui Yi, Catherine T Chaton, Catherine L Shelton, Jiasheng Diao, Xiaobing Zuo, C Cheng Kao, Andrew B Herr, Pingwei Li. Immunity 2013
295
17

Structural basis of STING binding with and phosphorylation by TBK1.
Conggang Zhang, Guijun Shang, Xiang Gui, Xuewu Zhang, Xiao-Chen Bai, Zhijian J Chen. Nature 2019
228
17

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser. Nat Cell Biol 2017
444
16

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.
Daxing Gao, Jiaxi Wu, You-Tong Wu, Fenghe Du, Chukwuemika Aroh, Nan Yan, Lijun Sun, Zhijian J Chen. Science 2013
645
15

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease.
Nicole Dobbs, Nikolay Burnaevskiy, Didi Chen, Vijay K Gonugunta, Neal M Alto, Nan Yan. Cell Host Microbe 2015
255
15

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop.
Xu Zhang, Jiaxi Wu, Fenghe Du, Hui Xu, Lijun Sun, Zhe Chen, Chad A Brautigam, Xuewu Zhang, Zhijian J Chen. Cell Rep 2014
231
14

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Christian Zierhut, Norihiro Yamaguchi, Maria Paredes, Ji-Dung Luo, Thomas Carroll, Hironori Funabiki. Cell 2019
157
14

DNA sensing by the cGAS-STING pathway in health and disease.
Mona Motwani, Scott Pesiridis, Katherine A Fitzgerald. Nat Rev Genet 2019
359
14

Targeting STING with covalent small-molecule inhibitors.
Simone M Haag, Muhammet F Gulen, Luc Reymond, Antoine Gibelin, Laurence Abrami, Alexiane Decout, Michael Heymann, F Gisou van der Goot, Gerardo Turcatti, Rayk Behrendt,[...]. Nature 2018
279
14

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Guijun Shang, Conggang Zhang, Zhijian J Chen, Xiao-Chen Bai, Xuewu Zhang. Nature 2019
183
14

Molecular mechanisms and cellular functions of cGAS-STING signalling.
Karl-Peter Hopfner, Veit Hornung. Nat Rev Mol Cell Biol 2020
252
14

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Daxing Gao, Tuo Li, Xiao-Dong Li, Xiang Chen, Quan-Zhen Li, Mary Wight-Carter, Zhijian J Chen. Proc Natl Acad Sci U S A 2015
339
14

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu, Haiping Zhang, Xiangyang Wu, Dapeng Ma, Juehui Wu, Lin Wang, Yan Jiang, Yiyan Fei, Chenggang Zhu, Rong Tan,[...]. Nature 2018
247
13

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.
Elie J Diner, Dara L Burdette, Stephen C Wilson, Kathryn M Monroe, Colleen A Kellenberger, Mamoru Hyodo, Yoshihiro Hayakawa, Ming C Hammond, Russell E Vance. Cell Rep 2013
441
13


cGAS in action: Expanding roles in immunity and inflammation.
Andrea Ablasser, Zhijian J Chen. Science 2019
283
13

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
Liufu Deng, Hua Liang, Meng Xu, Xuanming Yang, Byron Burnette, Ainhoa Arina, Xiao-Dong Li, Helena Mauceri, Michael Beckett, Thomas Darga,[...]. Immunity 2014
953
13

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.
Leticia Corrales, Laura Hix Glickman, Sarah M McWhirter, David B Kanne, Kelsey E Sivick, George E Katibah, Seng-Ryong Woo, Edward Lemmens, Tamara Banda, Justin J Leong,[...]. Cell Rep 2015
658
13

Tight nuclear tethering of cGAS is essential for preventing autoreactivity.
Hannah E Volkman, Stephanie Cambier, Elizabeth E Gray, Daniel B Stetson. Elife 2019
104
12

STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Sabrina L Ergun, Daniel Fernandez, Thomas M Weiss, Lingyin Li. Cell 2019
91
13

The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling.
Xin Cai, Yu-Hsin Chiu, Zhijian J Chen. Mol Cell 2014
532
12

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Liudmila Andreeva, Björn Hiller, Dirk Kostrewa, Charlotte Lässig, Carina C de Oliveira Mann, David Jan Drexler, Andreas Maiser, Moritz Gaidt, Heinrich Leonhardt, Veit Hornung,[...]. Nature 2017
204
12

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.
Wenxiang Sun, Yang Li, Lu Chen, Huihui Chen, Fuping You, Xiang Zhou, Yi Zhou, Zhonghe Zhai, Danying Chen, Zhengfan Jiang. Proc Natl Acad Sci U S A 2009
490
12

Pattern recognition receptors and inflammation.
Osamu Takeuchi, Shizuo Akira. Cell 2010
12

STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Seng-Ryong Woo, Mercedes B Fuertes, Leticia Corrales, Stefani Spranger, Michael J Furdyna, Michael Y K Leung, Ryan Duggan, Ying Wang, Glen N Barber, Katherine A Fitzgerald,[...]. Immunity 2014
833
12

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.
Matteo Gentili, Xavier Lahaye, Francesca Nadalin, Guilherme P F Nader, Emilia Puig Lombardi, Solène Herve, Nilushi S De Silva, Derek C Rookhuizen, Elina Zueva, Christel Goudot,[...]. Cell Rep 2019
89
12

Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Shane M Harding, Joseph L Benci, Jerome Irianto, Dennis E Discher, Andy J Minn, Roger A Greenberg. Nature 2017
633
11

Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
Hui Jiang, Xiaoyu Xue, Swarupa Panda, Ajinkya Kawale, Richard M Hooy, Fengshan Liang, Jungsan Sohn, Patrick Sung, Nelson O Gekara. EMBO J 2019
99
11

Mitochondrial DNA stress primes the antiviral innate immune response.
A Phillip West, William Khoury-Hanold, Matthew Staron, Michal C Tal, Cristiana M Pineda, Sabine M Lang, Megan Bestwick, Brett A Duguay, Nuno Raimundo, Donna A MacDuff,[...]. Nature 2015
810
11

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Wen Zhou, Aaron T Whiteley, Carina C de Oliveira Mann, Benjamin R Morehouse, Radosław P Nowak, Eric S Fischer, Nathanael S Gray, John J Mekalanos, Philip J Kranzusch. Cell 2018
127
11

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Katherine A Fitzgerald, Sarah M McWhirter, Kerrie L Faia, Daniel C Rowe, Eicke Latz, Douglas T Golenbock, Anthony J Coyle, Sha-Mei Liao, Tom Maniatis. Nat Immunol 2003
11

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response.
Assaf Marcus, Amy J Mao, Monisha Lensink-Vasan, LeeAnn Wang, Russell E Vance, David H Raulet. Immunity 2018
184
11


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.