Cong Ma, Lijing Su, Alpay B Seven, Yibin Xu, Josep Rizo. Science 2013
Times Cited: 247
Times Cited: 247
Times Cited
Times Co-cited
Similarity
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
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Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution.
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Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex.
Cong Ma, Wei Li, Yibin Xu, Josep Rizo. Nat Struct Mol Biol 2011
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Neurotransmitter release: the last millisecond in the life of a synaptic vesicle.
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A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly.
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Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.
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Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.
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A conformational switch in syntaxin during exocytosis: role of munc18.
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Molecular machines governing exocytosis of synaptic vesicles.
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Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.
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Synaptic assembly of the brain in the absence of neurotransmitter secretion.
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Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
Ewa Sitarska, Junjie Xu, Seungmee Park, Xiaoxia Liu, Bradley Quade, Karolina Stepien, Kyoko Sugita, Chad A Brautigam, Shuzo Sugita, Josep Rizo. Elife 2017
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Functional synergy between the Munc13 C-terminal C1 and C2 domains.
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The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.
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The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?
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Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis.
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Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
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An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.
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Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.
Enqi He, Keimpe Wierda, Rhode van Westen, Jurjen H Broeke, Ruud F Toonen, L Niels Cornelisse, Matthijs Verhage. Nat Commun 2017
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The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.
Cordelia Imig, Sang-Won Min, Stefanie Krinner, Marife Arancillo, Christian Rosenmund, Thomas C Südhof, JeongSeop Rhee, Nils Brose, Benjamin H Cooper. Neuron 2014
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UNC-13 is required for synaptic vesicle fusion in C. elegans.
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Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.
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Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
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A minimal domain responsible for Munc13 activity.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.