Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating, Melinda Ruiz, Richard Mushlin, William Alosio, Kristi McConnell, David Connor, Carol Murphy, Steve Oakeshott, Mei Kwan, Jose Beltran, Afshin Ghavami, Dani Brunner, Larry C Park, Sylvie Ramboz, David Howland. PLoS One 2012
Times Cited: 230
Times Cited: 230
Times Cited
Times Co-cited
Similarity
48
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
45
Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.
Taneli Heikkinen, Kimmo Lehtimäki, Nina Vartiainen, Jukka Puoliväli, Susan J Hendricks, Jack R Glaser, Amyaouch Bradaia, Kristian Wadel, Chrystelle Touller, Outi Kontkanen,[...]. PLoS One 2012
Taneli Heikkinen, Kimmo Lehtimäki, Nina Vartiainen, Jukka Puoliväli, Susan J Hendricks, Jack R Glaser, Amyaouch Bradaia, Kristian Wadel, Chrystelle Touller, Outi Kontkanen,[...]. PLoS One 2012
42
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.
Michelle Gray, Dyna I Shirasaki, Carlos Cepeda, Véronique M André, Brian Wilburn, Xiao-Hong Lu, Jifang Tao, Irene Yamazaki, Shi-Hua Li, Yi E Sun,[...]. J Neurosci 2008
Michelle Gray, Dyna I Shirasaki, Carlos Cepeda, Véronique M André, Brian Wilburn, Xiao-Hong Lu, Jifang Tao, Irene Yamazaki, Shi-Hua Li, Yi E Sun,[...]. J Neurosci 2008
24
Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.
Liliana B Menalled, Jessica D Sison, Ioannis Dragatsis, Scott Zeitlin, Marie-Françoise Chesselet. J Comp Neurol 2003
Liliana B Menalled, Jessica D Sison, Ioannis Dragatsis, Scott Zeitlin, Marie-Françoise Chesselet. J Comp Neurol 2003
23
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.
Peter Langfelder, Jeffrey P Cantle, Doxa Chatzopoulou, Nan Wang, Fuying Gao, Ismael Al-Ramahi, Xiao-Hong Lu, Eliana Marisa Ramos, Karla El-Zein, Yining Zhao,[...]. Nat Neurosci 2016
Peter Langfelder, Jeffrey P Cantle, Doxa Chatzopoulou, Nan Wang, Fuying Gao, Ismael Al-Ramahi, Xiao-Hong Lu, Eliana Marisa Ramos, Karla El-Zein, Yining Zhao,[...]. Nat Neurosci 2016
22
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
19
Huntington disease.
Gillian P Bates, Ray Dorsey, James F Gusella, Michael R Hayden, Chris Kay, Blair R Leavitt, Martha Nance, Christopher A Ross, Rachael I Scahill, Ronald Wetzel,[...]. Nat Rev Dis Primers 2015
Gillian P Bates, Ray Dorsey, James F Gusella, Michael R Hayden, Chris Kay, Blair R Leavitt, Martha Nance, Christopher A Ross, Rachael I Scahill, Ronald Wetzel,[...]. Nat Rev Dis Primers 2015
19
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Elizabeth J Slow, Jeremy van Raamsdonk, Daniel Rogers, Sarah H Coleman, Rona K Graham, Yu Deng, Rosemary Oh, Nagat Bissada, Sazzad M Hossain, Yu-Zhou Yang,[...]. Hum Mol Genet 2003
Elizabeth J Slow, Jeremy van Raamsdonk, Daniel Rogers, Sarah H Coleman, Rona K Graham, Yu Deng, Rosemary Oh, Nagat Bissada, Sazzad M Hossain, Yu-Zhou Yang,[...]. Hum Mol Genet 2003
18
Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study.
Nikisha Carty, Nadège Berson, Karsten Tillack, Christina Thiede, Diana Scholz, Karsten Kottig, Yalda Sedaghat, Christina Gabrysiak, George Yohrling, Heinz von der Kammer,[...]. PLoS One 2015
Nikisha Carty, Nadège Berson, Karsten Tillack, Christina Thiede, Diana Scholz, Karsten Kottig, Yalda Sedaghat, Christina Gabrysiak, George Yohrling, Heinz von der Kammer,[...]. PLoS One 2015
45
Neuropathological classification of Huntington's disease.
J P Vonsattel, R H Myers, T J Stevens, R J Ferrante, E D Bird, E P Richardson. J Neuropathol Exp Neurol 1985
J P Vonsattel, R H Myers, T J Stevens, R J Ferrante, E D Bird, E P Richardson. J Neuropathol Exp Neurol 1985
16
Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease.
Tim Indersmitten, Conny H Tran, Carlos Cepeda, Michael S Levine. J Neurophysiol 2015
Tim Indersmitten, Conny H Tran, Carlos Cepeda, Michael S Levine. J Neurophysiol 2015
32
Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.
Liliana Menalled, Bassem F El-Khodor, Monica Patry, Mayte Suárez-Fariñas, Samantha J Orenstein, Benjamin Zahasky, Christina Leahy, Vanessa Wheeler, X William Yang, Marcy MacDonald,[...]. Neurobiol Dis 2009
Liliana Menalled, Bassem F El-Khodor, Monica Patry, Mayte Suárez-Fariñas, Samantha J Orenstein, Benjamin Zahasky, Christina Leahy, Vanessa Wheeler, X William Yang, Marcy MacDonald,[...]. Neurobiol Dis 2009
15
Targeting Huntingtin Expression in Patients with Huntington's Disease.
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
15
The corticostriatal pathway in Huntington's disease.
Carlos Cepeda, Nanping Wu, Véronique M André, Damian M Cummings, Michael S Levine. Prog Neurobiol 2007
Carlos Cepeda, Nanping Wu, Véronique M André, Damian M Cummings, Michael S Levine. Prog Neurobiol 2007
14
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
13
Huntington's disease: from molecular pathogenesis to clinical treatment.
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
13
13
Molecular mechanisms and potential therapeutical targets in Huntington's disease.
Chiara Zuccato, Marta Valenza, Elena Cattaneo. Physiol Rev 2010
Chiara Zuccato, Marta Valenza, Elena Cattaneo. Physiol Rev 2010
12
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease.
Bryan Zeitler, Steven Froelich, Kimberly Marlen, David A Shivak, Qi Yu, Davis Li, Jocelynn R Pearl, Jeffrey C Miller, Lei Zhang, David E Paschon,[...]. Nat Med 2019
Bryan Zeitler, Steven Froelich, Kimberly Marlen, David A Shivak, Qi Yu, Davis Li, Jocelynn R Pearl, Jeffrey C Miller, Lei Zhang, David E Paschon,[...]. Nat Med 2019
18
Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.
Gaynor A Smith, Emily M Rocha, Jesse R McLean, Melissa A Hayes, Sarah C Izen, Ole Isacson, Penelope J Hallett. Hum Mol Genet 2014
Gaynor A Smith, Emily M Rocha, Jesse R McLean, Melissa A Hayes, Sarah C Izen, Ole Isacson, Penelope J Hallett. Hum Mol Genet 2014
20
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.
Nan Wang, Michelle Gray, Xiao-Hong Lu, Jeffrey P Cantle, Sandra M Holley, Erin Greiner, Xiaofeng Gu, Dyna Shirasaki, Carlos Cepeda, Yuqing Li,[...]. Nat Med 2014
Nan Wang, Michelle Gray, Xiao-Hong Lu, Jeffrey P Cantle, Sandra M Holley, Erin Greiner, Xiaofeng Gu, Dyna Shirasaki, Carlos Cepeda, Yuqing Li,[...]. Nat Med 2014
12
Neurological abnormalities in a knock-in mouse model of Huntington's disease.
C H Lin, S Tallaksen-Greene, W M Chien, J A Cearley, W S Jackson, A B Crouse, S Ren, X J Li, R L Albin, P J Detloff. Hum Mol Genet 2001
C H Lin, S Tallaksen-Greene, W M Chien, J A Cearley, W S Jackson, A B Crouse, S Ren, X J Li, R L Albin, P J Detloff. Hum Mol Genet 2001
12
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
12
Meso scale discovery-based assays for the detection of aggregated huntingtin.
Wolfgang Reindl, Barbara Baldo, Jana Schulz, Isabell Janack, Ilka Lindner, Markus Kleinschmidt, Yalda Sedaghat, Christina Thiede, Karsten Tillack, Christina Schmidt,[...]. PLoS One 2019
Wolfgang Reindl, Barbara Baldo, Jana Schulz, Isabell Janack, Ilka Lindner, Markus Kleinschmidt, Yalda Sedaghat, Christina Thiede, Karsten Tillack, Christina Schmidt,[...]. PLoS One 2019
60
Disrupted striatal neuron inputs and outputs in Huntington's disease.
Anton Reiner, Yun-Ping Deng. CNS Neurosci Ther 2018
Anton Reiner, Yun-Ping Deng. CNS Neurosci Ther 2018
27
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.
Edward J Wild, Roberto Boggio, Douglas Langbehn, Nicola Robertson, Salman Haider, James R C Miller, Henrik Zetterberg, Blair R Leavitt, Rainer Kuhn, Sarah J Tabrizi,[...]. J Clin Invest 2015
Edward J Wild, Roberto Boggio, Douglas Langbehn, Nicola Robertson, Salman Haider, James R C Miller, Henrik Zetterberg, Blair R Leavitt, Rainer Kuhn, Sarah J Tabrizi,[...]. J Clin Invest 2015
11
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.
G Schilling, M W Becher, A H Sharp, H A Jinnah, K Duan, J A Kotzuk, H H Slunt, T Ratovitski, J K Cooper, N A Jenkins,[...]. Hum Mol Genet 1999
G Schilling, M W Becher, A H Sharp, H A Jinnah, K Duan, J A Kotzuk, H H Slunt, T Ratovitski, J K Cooper, N A Jenkins,[...]. Hum Mol Genet 1999
11
Corticostriatal synaptic adaptations in Huntington's disease.
Joshua L Plotkin, D James Surmeier. Curr Opin Neurobiol 2015
Joshua L Plotkin, D James Surmeier. Curr Opin Neurobiol 2015
15
Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's Disease.
Qi Peng, Bin Wu, Mali Jiang, Jing Jin, Zhipeng Hou, Jennifer Zheng, Jiangyang Zhang, Wenzhen Duan. PLoS One 2016
Qi Peng, Bin Wu, Mali Jiang, Jing Jin, Zhipeng Hou, Jennifer Zheng, Jiangyang Zhang, Wenzhen Duan. PLoS One 2016
36
Differential loss of striatal projection neurons in Huntington disease.
A Reiner, R L Albin, K D Anderson, C J D'Amato, J B Penney, A B Young. Proc Natl Acad Sci U S A 1988
A Reiner, R L Albin, K D Anderson, C J D'Amato, J B Penney, A B Young. Proc Natl Acad Sci U S A 1988
10
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.
Jennifer Bradford, Ji-Yeon Shin, Meredith Roberts, Chuan-En Wang, Xiao-Jiang Li, Shihua Li. Proc Natl Acad Sci U S A 2009
Jennifer Bradford, Ji-Yeon Shin, Meredith Roberts, Chuan-En Wang, Xiao-Jiang Li, Shihua Li. Proc Natl Acad Sci U S A 2009
10
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.
C A Gutekunst, S H Li, H Yi, J S Mulroy, S Kuemmerle, R Jones, D Rye, R J Ferrante, S M Hersch, X J Li. J Neurosci 1999
C A Gutekunst, S H Li, H Yi, J S Mulroy, S Kuemmerle, R Jones, D Rye, R J Ferrante, S M Hersch, X J Li. J Neurosci 1999
10
Quantification assays for total and polyglutamine-expanded huntingtin proteins.
Douglas Macdonald, Michela A Tessari, Ivette Boogaard, Melanie Smith, Kristiina Pulli, Agnieszka Szynol, Faywell Albertus, Marieke B A C Lamers, Sipke Dijkstra, Daniel Kordt,[...]. PLoS One 2014
Douglas Macdonald, Michela A Tessari, Ivette Boogaard, Melanie Smith, Kristiina Pulli, Agnieszka Szynol, Faywell Albertus, Marieke B A C Lamers, Sipke Dijkstra, Daniel Kordt,[...]. PLoS One 2014
28
An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.
Amber L Southwell, Amy Smith-Dijak, Chris Kay, Marja Sepers, Erika B Villanueva, Matthew P Parsons, Yuanyun Xie, Lisa Anderson, Boguslaw Felczak, Sabine Waltl,[...]. Hum Mol Genet 2016
Amber L Southwell, Amy Smith-Dijak, Chris Kay, Marja Sepers, Erika B Villanueva, Matthew P Parsons, Yuanyun Xie, Lisa Anderson, Boguslaw Felczak, Sabine Waltl,[...]. Hum Mol Genet 2016
30
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
C Zuccato, A Ciammola, D Rigamonti, B R Leavitt, D Goffredo, L Conti, M E MacDonald, R M Friedlander, V Silani, M R Hayden,[...]. Science 2001
C Zuccato, A Ciammola, D Rigamonti, B R Leavitt, D Goffredo, L Conti, M E MacDonald, R M Friedlander, V Silani, M R Hayden,[...]. Science 2001
10
Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.
Nicholas R Franich, Miriam A Hickey, Chunni Zhu, Georgina F Osborne, Nadira Ali, Tiffany Chu, Nicholas H Bove, Vincent Lemesre, Renata P Lerner, Scott O Zeitlin,[...]. J Neurosci Res 2019
Nicholas R Franich, Miriam A Hickey, Chunni Zhu, Georgina F Osborne, Nadira Ali, Tiffany Chu, Nicholas H Bove, Vincent Lemesre, Renata P Lerner, Scott O Zeitlin,[...]. J Neurosci Res 2019
55
Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice.
Y P Deng, T Wong, C Bricker-Anthony, B Deng, A Reiner. Neurobiol Dis 2013
Y P Deng, T Wong, C Bricker-Anthony, B Deng, A Reiner. Neurobiol Dis 2013
12
Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.
Baljit S Khakh, Vahri Beaumont, Roger Cachope, Ignacio Munoz-Sanjuan, Steven A Goldman, Rosemarie Grantyn. Trends Neurosci 2017
Baljit S Khakh, Vahri Beaumont, Roger Cachope, Ignacio Munoz-Sanjuan, Steven A Goldman, Rosemarie Grantyn. Trends Neurosci 2017
10
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease.
A Yamamoto, J J Lucas, R Hen. Cell 2000
A Yamamoto, J J Lucas, R Hen. Cell 2000
9
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.
E Scherzinger, R Lurz, M Turmaine, L Mangiarini, B Hollenbach, R Hasenbank, G P Bates, S W Davies, H Lehrach, E E Wanker. Cell 1997
E Scherzinger, R Lurz, M Turmaine, L Mangiarini, B Hollenbach, R Hasenbank, G P Bates, S W Davies, H Lehrach, E E Wanker. Cell 1997
9
Huntington disease: natural history, biomarkers and prospects for therapeutics.
Christopher A Ross, Elizabeth H Aylward, Edward J Wild, Douglas R Langbehn, Jeffrey D Long, John H Warner, Rachael I Scahill, Blair R Leavitt, Julie C Stout, Jane S Paulsen,[...]. Nat Rev Neurol 2014
Christopher A Ross, Elizabeth H Aylward, Edward J Wild, Douglas R Langbehn, Jeffrey D Long, John H Warner, Rachael I Scahill, Blair R Leavitt, Julie C Stout, Jane S Paulsen,[...]. Nat Rev Neurol 2014
9
Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease.
Damian M Cummings, Véronique M André, Besim O Uzgil, Steven M Gee, Yvette E Fisher, Carlos Cepeda, Michael S Levine. J Neurosci 2009
Damian M Cummings, Véronique M André, Besim O Uzgil, Steven M Gee, Yvette E Fisher, Carlos Cepeda, Michael S Levine. J Neurosci 2009
9
Network organization of the huntingtin proteomic interactome in mammalian brain.
Dyna I Shirasaki, Erin R Greiner, Ismael Al-Ramahi, Michelle Gray, Pinmanee Boontheung, Daniel H Geschwind, Juan Botas, Giovanni Coppola, Steve Horvath, Joseph A Loo,[...]. Neuron 2012
Dyna I Shirasaki, Erin R Greiner, Ismael Al-Ramahi, Michelle Gray, Pinmanee Boontheung, Daniel H Geschwind, Juan Botas, Giovanni Coppola, Steve Horvath, Joseph A Loo,[...]. Neuron 2012
9
Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models.
Carlos Cepeda, Laurie Galvan, Sandra M Holley, Shilpa P Rao, Véronique M André, Elian P Botelho, Jane Y Chen, Joseph B Watson, Karl Deisseroth, Michael S Levine. J Neurosci 2013
Carlos Cepeda, Laurie Galvan, Sandra M Holley, Shilpa P Rao, Véronique M André, Elian P Botelho, Jane Y Chen, Joseph B Watson, Karl Deisseroth, Michael S Levine. J Neurosci 2013
11
Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.
L A Raymond, V M André, C Cepeda, C M Gladding, A J Milnerwood, M S Levine. Neuroscience 2011
L A Raymond, V M André, C Cepeda, C M Gladding, A J Milnerwood, M S Levine. Neuroscience 2011
9
The Neuropathology of Huntington's Disease.
Henry J Waldvogel, Eric H Kim, Lynette J Tippett, Jean-Paul G Vonsattel, Richard L M Faull. Curr Top Behav Neurosci 2015
Henry J Waldvogel, Eric H Kim, Lynette J Tippett, Jean-Paul G Vonsattel, Richard L M Faull. Curr Top Behav Neurosci 2015
11
Regional and cellular gene expression changes in human Huntington's disease brain.
Angela Hodges, Andrew D Strand, Aaron K Aragaki, Alexandre Kuhn, Thierry Sengstag, Gareth Hughes, Lyn A Elliston, Cathy Hartog, Darlene R Goldstein, Doris Thu,[...]. Hum Mol Genet 2006
Angela Hodges, Andrew D Strand, Aaron K Aragaki, Alexandre Kuhn, Thierry Sengstag, Gareth Hughes, Lyn A Elliston, Cathy Hartog, Darlene R Goldstein, Doris Thu,[...]. Hum Mol Genet 2006
9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.