Le Cong, F Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, Patrick D Hsu, Xuebing Wu, Wenyan Jiang, Luciano A Marraffini, Feng Zhang. Science 2013
Times Cited: 8412
Times Cited: 8412
Times Cited
Times Co-cited
Similarity
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier. Science 2012
Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier. Science 2012
50
RNA-guided human genome engineering via Cas9.
Prashant Mali, Luhan Yang, Kevin M Esvelt, John Aach, Marc Guell, James E DiCarlo, Julie E Norville, George M Church. Science 2013
Prashant Mali, Luhan Yang, Kevin M Esvelt, John Aach, Marc Guell, James E DiCarlo, Julie E Norville, George M Church. Science 2013
44
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.
Bernd Zetsche, Jonathan S Gootenberg, Omar O Abudayyeh, Ian M Slaymaker, Kira S Makarova, Patrick Essletzbichler, Sara E Volz, Julia Joung, John van der Oost, Aviv Regev,[...]. Cell 2015
Bernd Zetsche, Jonathan S Gootenberg, Omar O Abudayyeh, Ian M Slaymaker, Kira S Makarova, Patrick Essletzbichler, Sara E Volz, Julia Joung, John van der Oost, Aviv Regev,[...]. Cell 2015
18
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.
Nicole M Gaudelli, Alexis C Komor, Holly A Rees, Michael S Packer, Ahmed H Badran, David I Bryson, David R Liu. Nature 2017
Nicole M Gaudelli, Alexis C Komor, Holly A Rees, Michael S Packer, Ahmed H Badran, David I Bryson, David R Liu. Nature 2017
16
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage.
Alexis C Komor, Yongjoo B Kim, Michael S Packer, John A Zuris, David R Liu. Nature 2016
Alexis C Komor, Yongjoo B Kim, Michael S Packer, John A Zuris, David R Liu. Nature 2016
16
Search-and-replace genome editing without double-strand breaks or donor DNA.
Andrew V Anzalone, Peyton B Randolph, Jessie R Davis, Alexander A Sousa, Luke W Koblan, Jonathan M Levy, Peter J Chen, Christopher Wilson, Gregory A Newby, Aditya Raguram,[...]. Nature 2019
Andrew V Anzalone, Peyton B Randolph, Jessie R Davis, Alexander A Sousa, Luke W Koblan, Jonathan M Levy, Peter J Chen, Christopher Wilson, Gregory A Newby, Aditya Raguram,[...]. Nature 2019
14
Rationally engineered Cas9 nucleases with improved specificity.
Ian M Slaymaker, Linyi Gao, Bernd Zetsche, David A Scott, Winston X Yan, Feng Zhang. Science 2016
Ian M Slaymaker, Linyi Gao, Bernd Zetsche, David A Scott, Winston X Yan, Feng Zhang. Science 2016
13
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.
Benjamin P Kleinstiver, Vikram Pattanayak, Michelle S Prew, Shengdar Q Tsai, Nhu T Nguyen, Zongli Zheng, J Keith Joung. Nature 2016
Benjamin P Kleinstiver, Vikram Pattanayak, Michelle S Prew, Shengdar Q Tsai, Nhu T Nguyen, Zongli Zheng, J Keith Joung. Nature 2016
13
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria.
Giedrius Gasiunas, Rodolphe Barrangou, Philippe Horvath, Virginijus Siksnys. Proc Natl Acad Sci U S A 2012
Giedrius Gasiunas, Rodolphe Barrangou, Philippe Horvath, Virginijus Siksnys. Proc Natl Acad Sci U S A 2012
13
Genome-scale CRISPR-Cas9 knockout screening in human cells.
Ophir Shalem, Neville E Sanjana, Ella Hartenian, Xi Shi, David A Scott, Tarjei Mikkelson, Dirk Heckl, Benjamin L Ebert, David E Root, John G Doench,[...]. Science 2014
Ophir Shalem, Neville E Sanjana, Ella Hartenian, Xi Shi, David A Scott, Tarjei Mikkelson, Dirk Heckl, Benjamin L Ebert, David E Root, John G Doench,[...]. Science 2014
12
Crystal structure of Cas9 in complex with guide RNA and target DNA.
Hiroshi Nishimasu, F Ann Ran, Patrick D Hsu, Silvana Konermann, Soraya I Shehata, Naoshi Dohmae, Ryuichiro Ishitani, Feng Zhang, Osamu Nureki. Cell 2014
Hiroshi Nishimasu, F Ann Ran, Patrick D Hsu, Silvana Konermann, Soraya I Shehata, Naoshi Dohmae, Ryuichiro Ishitani, Feng Zhang, Osamu Nureki. Cell 2014
12
CRISPR provides acquired resistance against viruses in prokaryotes.
Rodolphe Barrangou, Christophe Fremaux, Hélène Deveau, Melissa Richards, Patrick Boyaval, Sylvain Moineau, Dennis A Romero, Philippe Horvath. Science 2007
Rodolphe Barrangou, Christophe Fremaux, Hélène Deveau, Melissa Richards, Patrick Boyaval, Sylvain Moineau, Dennis A Romero, Philippe Horvath. Science 2007
12
In vivo genome editing using Staphylococcus aureus Cas9.
F Ann Ran, Le Cong, Winston X Yan, David A Scott, Jonathan S Gootenberg, Andrea J Kriz, Bernd Zetsche, Ophir Shalem, Xuebing Wu, Kira S Makarova,[...]. Nature 2015
F Ann Ran, Le Cong, Winston X Yan, David A Scott, Jonathan S Gootenberg, Andrea J Kriz, Bernd Zetsche, Ophir Shalem, Xuebing Wu, Kira S Makarova,[...]. Nature 2015
11
RNA targeting with CRISPR-Cas13.
Omar O Abudayyeh, Jonathan S Gootenberg, Patrick Essletzbichler, Shuo Han, Julia Joung, Joseph J Belanto, Vanessa Verdine, David B T Cox, Max J Kellner, Aviv Regev,[...]. Nature 2017
Omar O Abudayyeh, Jonathan S Gootenberg, Patrick Essletzbichler, Shuo Han, Julia Joung, Joseph J Belanto, Vanessa Verdine, David B T Cox, Max J Kellner, Aviv Regev,[...]. Nature 2017
11
Development and applications of CRISPR-Cas9 for genome engineering.
Patrick D Hsu, Eric S Lander, Feng Zhang. Cell 2014
Patrick D Hsu, Eric S Lander, Feng Zhang. Cell 2014
11
RNA-programmed genome editing in human cells.
Martin Jinek, Alexandra East, Aaron Cheng, Steven Lin, Enbo Ma, Jennifer Doudna. Elife 2013
Martin Jinek, Alexandra East, Aaron Cheng, Steven Lin, Enbo Ma, Jennifer Doudna. Elife 2013
11
DNA targeting specificity of RNA-guided Cas9 nucleases.
Patrick D Hsu, David A Scott, Joshua A Weinstein, F Ann Ran, Silvana Konermann, Vineeta Agarwala, Yinqing Li, Eli J Fine, Xuebing Wu, Ophir Shalem,[...]. Nat Biotechnol 2013
Patrick D Hsu, David A Scott, Joshua A Weinstein, F Ann Ran, Silvana Konermann, Vineeta Agarwala, Yinqing Li, Eli J Fine, Xuebing Wu, Ophir Shalem,[...]. Nat Biotechnol 2013
11
Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product.
Y Ishino, H Shinagawa, K Makino, M Amemura, A Nakata. J Bacteriol 1987
Y Ishino, H Shinagawa, K Makino, M Amemura, A Nakata. J Bacteriol 1987
10
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.
Luke A Gilbert, Matthew H Larson, Leonardo Morsut, Zairan Liu, Gloria A Brar, Sandra E Torres, Noam Stern-Ginossar, Onn Brandman, Evan H Whitehead, Jennifer A Doudna,[...]. Cell 2013
Luke A Gilbert, Matthew H Larson, Leonardo Morsut, Zairan Liu, Gloria A Brar, Sandra E Torres, Noam Stern-Ginossar, Onn Brandman, Evan H Whitehead, Jennifer A Doudna,[...]. Cell 2013
10
Genome editing. The new frontier of genome engineering with CRISPR-Cas9.
Jennifer A Doudna, Emmanuelle Charpentier. Science 2014
Jennifer A Doudna, Emmanuelle Charpentier. Science 2014
10
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.
Michael Kosicki, Kärt Tomberg, Allan Bradley. Nat Biotechnol 2018
Michael Kosicki, Kärt Tomberg, Allan Bradley. Nat Biotechnol 2018
9
Small CRISPR RNAs guide antiviral defense in prokaryotes.
Stan J J Brouns, Matthijs M Jore, Magnus Lundgren, Edze R Westra, Rik J H Slijkhuis, Ambrosius P L Snijders, Mark J Dickman, Kira S Makarova, Eugene V Koonin, John van der Oost. Science 2008
Stan J J Brouns, Matthijs M Jore, Magnus Lundgren, Edze R Westra, Rik J H Slijkhuis, Ambrosius P L Snijders, Mark J Dickman, Kira S Makarova, Eugene V Koonin, John van der Oost. Science 2008
9
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.
Yanfang Fu, Jennifer A Foden, Cyd Khayter, Morgan L Maeder, Deepak Reyon, J Keith Joung, Jeffry D Sander. Nat Biotechnol 2013
Yanfang Fu, Jennifer A Foden, Cyd Khayter, Morgan L Maeder, Deepak Reyon, J Keith Joung, Jeffry D Sander. Nat Biotechnol 2013
9
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.
Omar O Abudayyeh, Jonathan S Gootenberg, Silvana Konermann, Julia Joung, Ian M Slaymaker, David B T Cox, Sergey Shmakov, Kira S Makarova, Ekaterina Semenova, Leonid Minakhin,[...]. Science 2016
Omar O Abudayyeh, Jonathan S Gootenberg, Silvana Konermann, Julia Joung, Ian M Slaymaker, David B T Cox, Sergey Shmakov, Kira S Makarova, Ekaterina Semenova, Leonid Minakhin,[...]. Science 2016
9
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.
Lei S Qi, Matthew H Larson, Luke A Gilbert, Jennifer A Doudna, Jonathan S Weissman, Adam P Arkin, Wendell A Lim. Cell 2013
Lei S Qi, Matthew H Larson, Luke A Gilbert, Jennifer A Doudna, Jonathan S Weissman, Adam P Arkin, Wendell A Lim. Cell 2013
9
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins.
Sojung Kim, Daesik Kim, Seung Woo Cho, Jungeun Kim, Jin-Soo Kim. Genome Res 2014
Sojung Kim, Daesik Kim, Seung Woo Cho, Jungeun Kim, Jin-Soo Kim. Genome Res 2014
9
Functionally diverse type V CRISPR-Cas systems.
Winston X Yan, Pratyusha Hunnewell, Lauren E Alfonse, Jason M Carte, Elise Keston-Smith, Shanmugapriya Sothiselvam, Anthony J Garrity, Shaorong Chong, Kira S Makarova, Eugene V Koonin,[...]. Science 2019
Winston X Yan, Pratyusha Hunnewell, Lauren E Alfonse, Jason M Carte, Elise Keston-Smith, Shanmugapriya Sothiselvam, Anthony J Garrity, Shaorong Chong, Kira S Makarova, Eugene V Koonin,[...]. Science 2019
8
RNA editing with CRISPR-Cas13.
David B T Cox, Jonathan S Gootenberg, Omar O Abudayyeh, Brian Franklin, Max J Kellner, Julia Joung, Feng Zhang. Science 2017
David B T Cox, Jonathan S Gootenberg, Omar O Abudayyeh, Brian Franklin, Max J Kellner, Julia Joung, Feng Zhang. Science 2017
8
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity.
Janice S Chen, Enbo Ma, Lucas B Harrington, Maria Da Costa, Xinran Tian, Joel M Palefsky, Jennifer A Doudna. Science 2018
Janice S Chen, Enbo Ma, Lucas B Harrington, Maria Da Costa, Xinran Tian, Joel M Palefsky, Jennifer A Doudna. Science 2018
8
Nucleic acid detection with CRISPR-Cas13a/C2c2.
Jonathan S Gootenberg, Omar O Abudayyeh, Jeong Wook Lee, Patrick Essletzbichler, Aaron J Dy, Julia Joung, Vanessa Verdine, Nina Donghia, Nichole M Daringer, Catherine A Freije,[...]. Science 2017
Jonathan S Gootenberg, Omar O Abudayyeh, Jeong Wook Lee, Patrick Essletzbichler, Aaron J Dy, Julia Joung, Vanessa Verdine, Nina Donghia, Nichole M Daringer, Catherine A Freije,[...]. Science 2017
8
An updated evolutionary classification of CRISPR-Cas systems.
Kira S Makarova, Yuri I Wolf, Omer S Alkhnbashi, Fabrizio Costa, Shiraz A Shah, Sita J Saunders, Rodolphe Barrangou, Stan J J Brouns, Emmanuelle Charpentier, Daniel H Haft,[...]. Nat Rev Microbiol 2015
Kira S Makarova, Yuri I Wolf, Omer S Alkhnbashi, Fabrizio Costa, Shiraz A Shah, Sita J Saunders, Rodolphe Barrangou, Stan J J Brouns, Emmanuelle Charpentier, Daniel H Haft,[...]. Nat Rev Microbiol 2015
8
Off-target Effects in CRISPR/Cas9-mediated Genome Engineering.
Xiao-Hui Zhang, Louis Y Tee, Xiao-Gang Wang, Qun-Shan Huang, Shi-Hua Yang. Mol Ther Nucleic Acids 2015
Xiao-Hui Zhang, Louis Y Tee, Xiao-Gang Wang, Qun-Shan Huang, Shi-Hua Yang. Mol Ther Nucleic Acids 2015
8
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.
Baohui Chen, Luke A Gilbert, Beth A Cimini, Joerg Schnitzbauer, Wei Zhang, Gene-Wei Li, Jason Park, Elizabeth H Blackburn, Jonathan S Weissman, Lei S Qi,[...]. Cell 2013
Baohui Chen, Luke A Gilbert, Beth A Cimini, Joerg Schnitzbauer, Wei Zhang, Gene-Wei Li, Jason Park, Elizabeth H Blackburn, Jonathan S Weissman, Lei S Qi,[...]. Cell 2013
8
CRISPR/Cas, the immune system of bacteria and archaea.
Philippe Horvath, Rodolphe Barrangou. Science 2010
Philippe Horvath, Rodolphe Barrangou. Science 2010
8
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Martin Jinek, Fuguo Jiang, David W Taylor, Samuel H Sternberg, Emine Kaya, Enbo Ma, Carolin Anders, Michael Hauer, Kaihong Zhou, Steven Lin,[...]. Science 2014
Martin Jinek, Fuguo Jiang, David W Taylor, Samuel H Sternberg, Emine Kaya, Enbo Ma, Carolin Anders, Michael Hauer, Kaihong Zhou, Steven Lin,[...]. Science 2014
8
Genome engineering using the CRISPR-Cas9 system.
F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang. Nat Protoc 2013
F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang. Nat Protoc 2013
8
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.
John G Doench, Nicolo Fusi, Meagan Sullender, Mudra Hegde, Emma W Vaimberg, Katherine F Donovan, Ian Smith, Zuzana Tothova, Craig Wilen, Robert Orchard,[...]. Nat Biotechnol 2016
John G Doench, Nicolo Fusi, Meagan Sullender, Mudra Hegde, Emma W Vaimberg, Katherine F Donovan, Ian Smith, Zuzana Tothova, Craig Wilen, Robert Orchard,[...]. Nat Biotechnol 2016
8
Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.
Kira S Makarova, Yuri I Wolf, Jaime Iranzo, Sergey A Shmakov, Omer S Alkhnbashi, Stan J J Brouns, Emmanuelle Charpentier, David Cheng, Daniel H Haft, Philippe Horvath,[...]. Nat Rev Microbiol 2020
Kira S Makarova, Yuri I Wolf, Jaime Iranzo, Sergey A Shmakov, Omer S Alkhnbashi, Stan J J Brouns, Emmanuelle Charpentier, David Cheng, Daniel H Haft, Philippe Horvath,[...]. Nat Rev Microbiol 2020
7
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors.
Silvana Konermann, Peter Lotfy, Nicholas J Brideau, Jennifer Oki, Maxim N Shokhirev, Patrick D Hsu. Cell 2018
Silvana Konermann, Peter Lotfy, Nicholas J Brideau, Jennifer Oki, Maxim N Shokhirev, Patrick D Hsu. Cell 2018
7
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.
F Ann Ran, Patrick D Hsu, Chie-Yu Lin, Jonathan S Gootenberg, Silvana Konermann, Alexandro E Trevino, David A Scott, Azusa Inoue, Shogo Matoba, Yi Zhang,[...]. Cell 2013
F Ann Ran, Patrick D Hsu, Chie-Yu Lin, Jonathan S Gootenberg, Silvana Konermann, Alexandro E Trevino, David A Scott, Azusa Inoue, Shogo Matoba, Yi Zhang,[...]. Cell 2013
7
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements.
Francisco J M Mojica, César Díez-Villaseñor, Jesús García-Martínez, Elena Soria. J Mol Evol 2005
Francisco J M Mojica, César Díez-Villaseñor, Jesús García-Martínez, Elena Soria. J Mol Evol 2005
7
Genetic screens in human cells using the CRISPR-Cas9 system.
Tim Wang, Jenny J Wei, David M Sabatini, Eric S Lander. Science 2014
Tim Wang, Jenny J Wei, David M Sabatini, Eric S Lander. Science 2014
7
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.
Yanfang Fu, Jeffry D Sander, Deepak Reyon, Vincent M Cascio, J Keith Joung. Nat Biotechnol 2014
Yanfang Fu, Jeffry D Sander, Deepak Reyon, Vincent M Cascio, J Keith Joung. Nat Biotechnol 2014
7
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.
Johnny H Hu, Shannon M Miller, Maarten H Geurts, Weixin Tang, Liwei Chen, Ning Sun, Christina M Zeina, Xue Gao, Holly A Rees, Zhi Lin,[...]. Nature 2018
Johnny H Hu, Shannon M Miller, Maarten H Geurts, Weixin Tang, Liwei Chen, Ning Sun, Christina M Zeina, Xue Gao, Holly A Rees, Zhi Lin,[...]. Nature 2018
7
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
Janice S Chen, Yavuz S Dagdas, Benjamin P Kleinstiver, Moira M Welch, Alexander A Sousa, Lucas B Harrington, Samuel H Sternberg, J Keith Joung, Ahmet Yildiz, Jennifer A Doudna. Nature 2017
Janice S Chen, Yavuz S Dagdas, Benjamin P Kleinstiver, Moira M Welch, Alexander A Sousa, Lucas B Harrington, Samuel H Sternberg, J Keith Joung, Ahmet Yildiz, Jennifer A Doudna. Nature 2017
7
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni.
Eunji Kim, Taeyoung Koo, Sung Wook Park, Daesik Kim, Kyoungmi Kim, Hee-Yeon Cho, Dong Woo Song, Kyu Jun Lee, Min Hee Jung, Seokjoong Kim,[...]. Nat Commun 2017
Eunji Kim, Taeyoung Koo, Sung Wook Park, Daesik Kim, Kyoungmi Kim, Hee-Yeon Cho, Dong Woo Song, Kyu Jun Lee, Min Hee Jung, Seokjoong Kim,[...]. Nat Commun 2017
7
7
Base editing: precision chemistry on the genome and transcriptome of living cells.
Holly A Rees, David R Liu. Nat Rev Genet 2018
Holly A Rees, David R Liu. Nat Rev Genet 2018
6
Identification of preexisting adaptive immunity to Cas9 proteins in humans.
Carsten T Charlesworth, Priyanka S Deshpande, Daniel P Dever, Joab Camarena, Viktor T Lemgart, M Kyle Cromer, Christopher A Vakulskas, Michael A Collingwood, Liyang Zhang, Nicole M Bode,[...]. Nat Med 2019
Carsten T Charlesworth, Priyanka S Deshpande, Daniel P Dever, Joab Camarena, Viktor T Lemgart, M Kyle Cromer, Christopher A Vakulskas, Michael A Collingwood, Liyang Zhang, Nicole M Bode,[...]. Nat Med 2019
6
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III.
Elitza Deltcheva, Krzysztof Chylinski, Cynthia M Sharma, Karine Gonzales, Yanjie Chao, Zaid A Pirzada, Maria R Eckert, Jörg Vogel, Emmanuelle Charpentier. Nature 2011
Elitza Deltcheva, Krzysztof Chylinski, Cynthia M Sharma, Karine Gonzales, Yanjie Chao, Zaid A Pirzada, Maria R Eckert, Jörg Vogel, Emmanuelle Charpentier. Nature 2011
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.