Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.
Gaia Codolo, Nicoletta Plotegher, Tommaso Pozzobon, Marco Brucale, Isabella Tessari, Luigi Bubacco, Marina de Bernard. PLoS One 2013
Times Cited: 320
Times Cited: 320
Times Cited
Times Co-cited
Similarity
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.
Richard Gordon, Eduardo A Albornoz, Daniel C Christie, Monica R Langley, Vinod Kumar, Susanna Mantovani, Avril A B Robertson, Mark S Butler, Dominic B Rowe, Luke A O'Neill,[...]. Sci Transl Med 2018
Richard Gordon, Eduardo A Albornoz, Daniel C Christie, Monica R Langley, Vinod Kumar, Susanna Mantovani, Avril A B Robertson, Mark S Butler, Dominic B Rowe, Luke A O'Neill,[...]. Sci Transl Med 2018
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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng,[...]. Nature 2013
Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng,[...]. Nature 2013
36
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Annett Halle, Veit Hornung, Gabor C Petzold, Cameron R Stewart, Brian G Monks, Thomas Reinheckel, Katherine A Fitzgerald, Eicke Latz, Kathryn J Moore, Douglas T Golenbock. Nat Immunol 2008
Annett Halle, Veit Hornung, Gabor C Petzold, Cameron R Stewart, Brian G Monks, Thomas Reinheckel, Katherine A Fitzgerald, Eicke Latz, Kathryn J Moore, Douglas T Golenbock. Nat Immunol 2008
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Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Yiqing Yan, Wei Jiang, Lei Liu, Xiaqiong Wang, Chen Ding, Zhigang Tian, Rongbin Zhou. Cell 2015
Yiqing Yan, Wei Jiang, Lei Liu, Xiaqiong Wang, Chen Ding, Zhigang Tian, Rongbin Zhou. Cell 2015
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MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration.
Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Yu. Cell Death Differ 2019
Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Yu. Cell Death Differ 2019
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MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease.
Yan Zhou, Ming Lu, Ren-Hong Du, Chen Qiao, Chun-Yi Jiang, Ke-Zhong Zhang, Jian-Hua Ding, Gang Hu. Mol Neurodegener 2016
Yan Zhou, Ming Lu, Ren-Hong Du, Chen Qiao, Chun-Yi Jiang, Ke-Zhong Zhang, Jian-Hua Ding, Gang Hu. Mol Neurodegener 2016
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Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.
Nikhil Panicker, Souvarish Sarkar, Dilshan S Harischandra, Matthew Neal, Tae-In Kam, Huajun Jin, Hariharan Saminathan, Monica Langley, Adhithiya Charli, Manikandan Samidurai,[...]. J Exp Med 2019
Nikhil Panicker, Souvarish Sarkar, Dilshan S Harischandra, Matthew Neal, Tae-In Kam, Huajun Jin, Hariharan Saminathan, Monica Langley, Adhithiya Charli, Manikandan Samidurai,[...]. J Exp Med 2019
24
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia.
Changyoun Kim, Dong-Hwan Ho, Ji-Eun Suk, Sungyong You, Sarah Michael, Junghee Kang, Sung Joong Lee, Eliezer Masliah, Daehee Hwang, He-Jin Lee,[...]. Nat Commun 2013
Changyoun Kim, Dong-Hwan Ho, Ji-Eun Suk, Sungyong You, Sarah Michael, Junghee Kang, Sung Joong Lee, Eliezer Masliah, Daehee Hwang, He-Jin Lee,[...]. Nat Commun 2013
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Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.
Wei Wang, Linh T T Nguyen, Christopher Burlak, Fariba Chegini, Feng Guo, Tim Chataway, Shulin Ju, Oriana S Fisher, David W Miller, Debajyoti Datta,[...]. Proc Natl Acad Sci U S A 2016
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The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson's Disease in Rats.
Zhijuan Mao, Chanchan Liu, Suqiong Ji, Qingmei Yang, Hongxiang Ye, Haiyan Han, Zheng Xue. Neurochem Res 2017
Zhijuan Mao, Chanchan Liu, Suqiong Ji, Qingmei Yang, Hongxiang Ye, Haiyan Han, Zheng Xue. Neurochem Res 2017
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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
Fabio Martinon, Kimberly Burns, Jürg Tschopp. Mol Cell 2002
Fabio Martinon, Kimberly Burns, Jürg Tschopp. Mol Cell 2002
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Inflammasomes: mechanism of action, role in disease, and therapeutics.
Haitao Guo, Justin B Callaway, Jenny P-Y Ting. Nat Med 2015
Haitao Guo, Justin B Callaway, Jenny P-Y Ting. Nat Med 2015
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Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.
Carmen Venegas, Sathish Kumar, Bernardo S Franklin, Tobias Dierkes, Rebecca Brinkschulte, Dario Tejera, Ana Vieira-Saecker, Stephanie Schwartz, Francesco Santarelli, Markus P Kummer,[...]. Nature 2017
Carmen Venegas, Sathish Kumar, Bernardo S Franklin, Tobias Dierkes, Rebecca Brinkschulte, Dario Tejera, Ana Vieira-Saecker, Stephanie Schwartz, Francesco Santarelli, Markus P Kummer,[...]. Nature 2017
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
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Rebecca C Coll, Avril A B Robertson, Jae Jin Chae, Sarah C Higgins, Raúl Muñoz-Planillo, Marco C Inserra, Irina Vetter, Lara S Dungan, Brian G Monks, Andrea Stutz,[...]. Nat Med 2015
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Inflammasome signalling in brain function and neurodegenerative disease.
Michael T Heneka, Róisín M McManus, Eicke Latz. Nat Rev Neurosci 2018
Michael T Heneka, Róisín M McManus, Eicke Latz. Nat Rev Neurosci 2018
16
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease.
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Neurotoxic reactive astrocytes are induced by activated microglia.
Shane A Liddelow, Kevin A Guttenplan, Laura E Clarke, Frederick C Bennett, Christopher J Bohlen, Lucas Schirmer, Mariko L Bennett, Alexandra E Münch, Won-Suk Chung, Todd C Peterson,[...]. Nature 2017
Shane A Liddelow, Kevin A Guttenplan, Laura E Clarke, Frederick C Bennett, Christopher J Bohlen, Lucas Schirmer, Mariko L Bennett, Alexandra E Münch, Won-Suk Chung, Todd C Peterson,[...]. Nature 2017
16
Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease.
Zheng Fan, Yu-Ting Pan, Zhi-Yuan Zhang, Hui Yang, Shu-Yue Yu, Yan Zheng, Jing-Hong Ma, Xiao-Min Wang. J Neuroinflammation 2020
Zheng Fan, Yu-Ting Pan, Zhi-Yuan Zhang, Hui Yang, Shu-Yue Yu, Yan Zheng, Jing-Hong Ma, Xiao-Min Wang. J Neuroinflammation 2020
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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease.
Alexander Gerhard, Nicola Pavese, Gary Hotton, Federico Turkheimer, Meltem Es, Alexander Hammers, Karla Eggert, Wolfgang Oertel, Richard B Banati, David J Brooks. Neurobiol Dis 2006
Alexander Gerhard, Nicola Pavese, Gary Hotton, Federico Turkheimer, Meltem Es, Alexander Hammers, Karla Eggert, Wolfgang Oertel, Richard B Banati, David J Brooks. Neurobiol Dis 2006
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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains.
P L McGeer, S Itagaki, B E Boyes, E G McGeer. Neurology 1988
P L McGeer, S Itagaki, B E Boyes, E G McGeer. Neurology 1988
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Mechanism and Regulation of NLRP3 Inflammasome Activation.
Yuan He, Hideki Hara, Gabriel Núñez. Trends Biochem Sci 2016
Yuan He, Hideki Hara, Gabriel Núñez. Trends Biochem Sci 2016
14
Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.
Lisa Fellner, Regina Irschick, Kathrin Schanda, Markus Reindl, Lars Klimaschewski, Werner Poewe, Gregor K Wenning, Nadia Stefanova. Glia 2013
Lisa Fellner, Regina Irschick, Kathrin Schanda, Markus Reindl, Lars Klimaschewski, Werner Poewe, Gregor K Wenning, Nadia Stefanova. Glia 2013
14
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.
Marina Saresella, Francesca La Rosa, Federica Piancone, Martina Zoppis, Ivana Marventano, Elena Calabrese, Veronica Rainone, Raffaello Nemni, Roberta Mancuso, Mario Clerici. Mol Neurodegener 2016
Marina Saresella, Francesca La Rosa, Federica Piancone, Martina Zoppis, Ivana Marventano, Elena Calabrese, Veronica Rainone, Raffaello Nemni, Roberta Mancuso, Mario Clerici. Mol Neurodegener 2016
14
The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
14
NLRP3 inflammasome activation drives tau pathology.
Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne V Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín M McManus, Dario Tejera,[...]. Nature 2019
Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne V Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín M McManus, Dario Tejera,[...]. Nature 2019
14
NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients.
Sonja Johann, Marius Heitzer, Mithila Kanagaratnam, Anand Goswami, Tania Rizo, Joachim Weis, Dirk Troost, Cordian Beyer. Glia 2015
Sonja Johann, Marius Heitzer, Mithila Kanagaratnam, Anand Goswami, Tania Rizo, Joachim Weis, Dirk Troost, Cordian Beyer. Glia 2015
13
Inflammasomes in the CNS.
John G Walsh, Daniel A Muruve, Christopher Power. Nat Rev Neurosci 2014
John G Walsh, Daniel A Muruve, Christopher Power. Nat Rev Neurosci 2014
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A role for mitochondria in NLRP3 inflammasome activation.
Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jürg Tschopp. Nature 2011
Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jürg Tschopp. Nature 2011
13
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.
Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam,[...]. NPJ Parkinsons Dis 2017
Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker, Adhithiya Charli, Bharathi N Palanisamy, Dharmin Rokad, Huajun Jin, Vellareddy Anantharam,[...]. NPJ Parkinsons Dis 2017
13
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.
C Dempsey, A Rubio Araiz, K J Bryson, O Finucane, C Larkin, E L Mills, A A B Robertson, M A Cooper, L A J O'Neill, M A Lynch. Brain Behav Immun 2017
C Dempsey, A Rubio Araiz, K J Bryson, O Finucane, C Larkin, E L Mills, A A B Robertson, M A Cooper, L A J O'Neill, M A Lynch. Brain Behav Immun 2017
13
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains.
Kazuhiro Imamura, Nozomi Hishikawa, Makoto Sawada, Toshiharu Nagatsu, Mari Yoshida, Yoshio Hashizume. Acta Neuropathol 2003
Kazuhiro Imamura, Nozomi Hishikawa, Makoto Sawada, Toshiharu Nagatsu, Mari Yoshida, Yoshio Hashizume. Acta Neuropathol 2003
13
Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients.
M Mogi, M Harada, T Kondo, P Riederer, H Inagaki, M Minami, T Nagatsu. Neurosci Lett 1994
M Mogi, M Harada, T Kondo, P Riederer, H Inagaki, M Minami, T Nagatsu. Neurosci Lett 1994
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Mechanisms underlying inflammation in neurodegeneration.
Christopher K Glass, Kaoru Saijo, Beate Winner, Maria Carolina Marchetto, Fred H Gage. Cell 2010
Christopher K Glass, Kaoru Saijo, Beate Winner, Maria Carolina Marchetto, Fred H Gage. Cell 2010
12
Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease.
Adelin Gustot, José Ignacio Gallea, Rabia Sarroukh, María Soledad Celej, Jean-Marie Ruysschaert, Vincent Raussens. Biochem J 2015
Adelin Gustot, José Ignacio Gallea, Rabia Sarroukh, María Soledad Celej, Jean-Marie Ruysschaert, Vincent Raussens. Biochem J 2015
12
Alpha-synuclein in Lewy bodies.
M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert. Nature 1997
M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert. Nature 1997
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Inflammasomes: mechanism of assembly, regulation and signalling.
Petr Broz, Vishva M Dixit. Nat Rev Immunol 2016
Petr Broz, Vishva M Dixit. Nat Rev Immunol 2016
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The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation.
Nathan Kelley, Devon Jeltema, Yanhui Duan, Yuan He. Int J Mol Sci 2019
Nathan Kelley, Devon Jeltema, Yanhui Duan, Yuan He. Int J Mol Sci 2019
12
Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study.
Koustav Chatterjee, Akash Roy, Rebecca Banerjee, Supriyo Choudhury, Banashree Mondal, Saptak Halder, Purba Basu, Shantanu Shubham, Sanjit Dey, Hrishikesh Kumar. J Neuroimmunol 2020
Koustav Chatterjee, Akash Roy, Rebecca Banerjee, Supriyo Choudhury, Banashree Mondal, Saptak Halder, Purba Basu, Shantanu Shubham, Sanjit Dey, Hrishikesh Kumar. J Neuroimmunol 2020
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Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.
D Blum-Degen, T Müller, W Kuhn, M Gerlach, H Przuntek, P Riederer. Neurosci Lett 1995
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Staging of brain pathology related to sporadic Parkinson's disease.
Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak. Neurobiol Aging 2003
Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak. Neurobiol Aging 2003
11
Inflammasomes in neuroinflammatory and neurodegenerative diseases.
Sofie Voet, Sahana Srinivasan, Mohamed Lamkanfi, Geert van Loo. EMBO Mol Med 2019
Sofie Voet, Sahana Srinivasan, Mohamed Lamkanfi, Geert van Loo. EMBO Mol Med 2019
11
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Franz G Bauernfeind, Gabor Horvath, Andrea Stutz, Emad S Alnemri, Kelly MacDonald, David Speert, Teresa Fernandes-Alnemri, Jianghong Wu, Brian G Monks, Katherine A Fitzgerald,[...]. J Immunol 2009
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Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease: A Systematic Review and Meta-analysis.
Xiao-Yan Qin, Shu-Ping Zhang, Chang Cao, Y Peng Loh, Yong Cheng. JAMA Neurol 2016
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Neuroinflammation in Parkinson's disease: a target for neuroprotection?
Etienne C Hirsch, Stéphane Hunot. Lancet Neurol 2009
Etienne C Hirsch, Stéphane Hunot. Lancet Neurol 2009
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Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.
Stefano G Daniele, Dawn Béraud, Connor Davenport, Kui Cheng, Hang Yin, Kathleen A Maguire-Zeiss. Sci Signal 2015
Stefano G Daniele, Dawn Béraud, Connor Davenport, Kui Cheng, Hang Yin, Kathleen A Maguire-Zeiss. Sci Signal 2015
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Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo.
Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Julien Couturier, Alexandre Vanoosthuyse, Sofie Kessels, Chritica Lodder, Bert Brône, François Huaux, Jean-Noël Octave,[...]. Acta Neuropathol 2019
Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Julien Couturier, Alexandre Vanoosthuyse, Sofie Kessels, Chritica Lodder, Bert Brône, François Huaux, Jean-Noël Octave,[...]. Acta Neuropathol 2019
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Innate immune activation in neurodegenerative disease.
Michael T Heneka, Markus P Kummer, Eicke Latz. Nat Rev Immunol 2014
Michael T Heneka, Markus P Kummer, Eicke Latz. Nat Rev Immunol 2014
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10
Inflammasomes in health and disease.
Till Strowig, Jorge Henao-Mejia, Eran Elinav, Richard Flavell. Nature 2012
Till Strowig, Jorge Henao-Mejia, Eran Elinav, Richard Flavell. Nature 2012
10
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.