Jianxiong Jiang, Yi Quan, Thota Ganesh, Wendy A Pouliot, F Edward Dudek, Raymond Dingledine. Proc Natl Acad Sci U S A 2013
Times Cited: 117
Times Cited: 117
Times Cited
Times Co-cited
Similarity
Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.
Jianxiong Jiang, Thota Ganesh, Yuhong Du, Yi Quan, Geidy Serrano, Min Qui, Iris Speigel, Asheebo Rojas, Nadia Lelutiu, Raymond Dingledine. Proc Natl Acad Sci U S A 2012
Jianxiong Jiang, Thota Ganesh, Yuhong Du, Yi Quan, Geidy Serrano, Min Qui, Iris Speigel, Asheebo Rojas, Nadia Lelutiu, Raymond Dingledine. Proc Natl Acad Sci U S A 2012
47
Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus.
Jianxiong Jiang, Myung-Soon Yang, Yi Quan, Paoula Gueorguieva, Thota Ganesh, Raymond Dingledine. Neurobiol Dis 2015
Jianxiong Jiang, Myung-Soon Yang, Yi Quan, Paoula Gueorguieva, Thota Ganesh, Raymond Dingledine. Neurobiol Dis 2015
61
Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus.
G E Serrano, N Lelutiu, A Rojas, S Cochi, R Shaw, C D Makinson, D Wang, G A FitzGerald, R Dingledine. J Neurosci 2011
G E Serrano, N Lelutiu, A Rojas, S Cochi, R Shaw, C D Makinson, D Wang, G A FitzGerald, R Dingledine. J Neurosci 2011
35
Cyclooxygenase-2 in epilepsy.
Asheebo Rojas, Jianxiong Jiang, Thota Ganesh, Myung-Soon Yang, Nadia Lelutiu, Paoula Gueorguieva, Raymond Dingledine. Epilepsia 2014
Asheebo Rojas, Jianxiong Jiang, Thota Ganesh, Myung-Soon Yang, Nadia Lelutiu, Paoula Gueorguieva, Raymond Dingledine. Epilepsia 2014
35
EP2 receptor signaling pathways regulate classical activation of microglia.
Yi Quan, Jianxiong Jiang, Ray Dingledine. J Biol Chem 2013
Yi Quan, Jianxiong Jiang, Ray Dingledine. J Biol Chem 2013
40
Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus.
Asheebo Rojas, Thota Ganesh, Nadia Lelutiu, Paoula Gueorguieva, Raymond Dingledine. Neuropharmacology 2015
Asheebo Rojas, Thota Ganesh, Nadia Lelutiu, Paoula Gueorguieva, Raymond Dingledine. Neuropharmacology 2015
58
The role of inflammation in epilepsy.
Annamaria Vezzani, Jacqueline French, Tamas Bartfai, Tallie Z Baram. Nat Rev Neurol 2011
Annamaria Vezzani, Jacqueline French, Tamas Bartfai, Tallie Z Baram. Nat Rev Neurol 2011
27
Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.
Jianxiong Jiang, Ray Dingledine. Trends Pharmacol Sci 2013
Jianxiong Jiang, Ray Dingledine. Trends Pharmacol Sci 2013
25
Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia.
Jenny U Johansson, Suraj Pradhan, Ludmila A Lokteva, Nathaniel S Woodling, Novie Ko, Holden D Brown, Qian Wang, Christina Loh, Egle Cekanaviciute, Marion Buckwalter,[...]. J Neurosci 2013
Jenny U Johansson, Suraj Pradhan, Ludmila A Lokteva, Nathaniel S Woodling, Novie Ko, Holden D Brown, Qian Wang, Christina Loh, Egle Cekanaviciute, Marion Buckwalter,[...]. J Neurosci 2013
38
Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats.
Asheebo Rojas, Thota Ganesh, Zahra Manji, Theon O'neill, Raymond Dingledine. Neuropharmacology 2016
Asheebo Rojas, Thota Ganesh, Zahra Manji, Theon O'neill, Raymond Dingledine. Neuropharmacology 2016
47
Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.
Jianxiong Jiang, Thota Ganesh, Yuhong Du, Pahk Thepchatri, Asheebo Rojas, Iestyn Lewis, Serdar Kurtkaya, Lian Li, Min Qui, Geidy Serrano,[...]. Proc Natl Acad Sci U S A 2010
Jianxiong Jiang, Thota Ganesh, Yuhong Du, Pahk Thepchatri, Asheebo Rojas, Iestyn Lewis, Serdar Kurtkaya, Lian Li, Min Qui, Geidy Serrano,[...]. Proc Natl Acad Sci U S A 2010
35
Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.
Keun-Hwa Jung, Kon Chu, Soon-Tae Lee, Juhyun Kim, Dong-In Sinn, Jeong-Min Kim, Dong-Kyu Park, Jung-Ju Lee, Seung U Kim, Manho Kim,[...]. Neurobiol Dis 2006
Keun-Hwa Jung, Kon Chu, Soon-Tae Lee, Juhyun Kim, Dong-In Sinn, Jeong-Min Kim, Dong-Kyu Park, Jung-Ju Lee, Seung U Kim, Manho Kim,[...]. Neurobiol Dis 2006
22
The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy.
Nadine Polascheck, Marion Bankstahl, Wolfgang Löscher. Exp Neurol 2010
Nadine Polascheck, Marion Bankstahl, Wolfgang Löscher. Exp Neurol 2010
22
Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.
Louise McCullough, Liejun Wu, Norman Haughey, Xibin Liang, Tracey Hand, Qian Wang, Richard M Breyer, Katrin Andreasson. J Neurosci 2004
Louise McCullough, Liejun Wu, Norman Haughey, Xibin Liang, Tracey Hand, Qian Wang, Richard M Breyer, Katrin Andreasson. J Neurosci 2004
21
Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.
Jianxiong Jiang, Ray Dingledine. J Pharmacol Exp Ther 2013
Jianxiong Jiang, Ray Dingledine. J Pharmacol Exp Ther 2013
26
Emerging roles of PGE2 receptors in models of neurological disease.
Katrin Andreasson. Prostaglandins Other Lipid Mediat 2010
Katrin Andreasson. Prostaglandins Other Lipid Mediat 2010
20
Lead optimization studies of cinnamic amide EP2 antagonists.
Thota Ganesh, Jianxiong Jiang, Myung-Soon Yang, Ray Dingledine. J Med Chem 2014
Thota Ganesh, Jianxiong Jiang, Myung-Soon Yang, Ray Dingledine. J Med Chem 2014
55
Development of second generation EP2 antagonists with high selectivity.
Thota Ganesh, Jianxiong Jiang, Ray Dingledine. Eur J Med Chem 2014
Thota Ganesh, Jianxiong Jiang, Ray Dingledine. Eur J Med Chem 2014
73
Candidate drug targets for prevention or modification of epilepsy.
Nicholas H Varvel, Jianxiong Jiang, Raymond Dingledine. Annu Rev Pharmacol Toxicol 2015
Nicholas H Varvel, Jianxiong Jiang, Raymond Dingledine. Annu Rev Pharmacol Toxicol 2015
37
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
Mattia Maroso, Silvia Balosso, Teresa Ravizza, Jaron Liu, Eleonora Aronica, Anand M Iyer, Carlo Rossetti, Monica Molteni, Maura Casalgrandi, Angelo A Manfredi,[...]. Nat Med 2010
Mattia Maroso, Silvia Balosso, Teresa Ravizza, Jaron Liu, Eleonora Aronica, Anand M Iyer, Carlo Rossetti, Monica Molteni, Maura Casalgrandi, Angelo A Manfredi,[...]. Nat Med 2010
17
Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.
Xibin Liang, Qian Wang, Tracey Hand, Liejun Wu, Richard M Breyer, Thomas J Montine, Katrin Andreasson. J Neurosci 2005
Xibin Liang, Qian Wang, Tracey Hand, Liejun Wu, Richard M Breyer, Thomas J Montine, Katrin Andreasson. J Neurosci 2005
17
The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis.
Xibin Liang, Qian Wang, Ju Shi, Ludmila Lokteva, Richard M Breyer, Thomas J Montine, Katrin Andreasson. Ann Neurol 2008
Xibin Liang, Qian Wang, Ju Shi, Ludmila Lokteva, Richard M Breyer, Thomas J Montine, Katrin Andreasson. Ann Neurol 2008
17
Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy.
L Holtman, E A van Vliet, R van Schaik, C M Queiroz, E Aronica, J A Gorter. Epilepsy Res 2009
L Holtman, E A van Vliet, R van Schaik, C M Queiroz, E Aronica, J A Gorter. Epilepsy Res 2009
20
Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists.
Thota Ganesh, Jianxiong Jiang, Rangaiah Shashidharamurthy, Ray Dingledine. ACS Med Chem Lett 2013
Thota Ganesh, Jianxiong Jiang, Rangaiah Shashidharamurthy, Ray Dingledine. ACS Med Chem Lett 2013
76
The role of inflammation in epileptogenesis.
Annamaria Vezzani, Alon Friedman, Raymond J Dingledine. Neuropharmacology 2013
Annamaria Vezzani, Alon Friedman, Raymond J Dingledine. Neuropharmacology 2013
16
Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice.
Mattia Maroso, Silvia Balosso, Teresa Ravizza, Valentina Iori, Christopher Ian Wright, Jacqueline French, Annamaria Vezzani. Neurotherapeutics 2011
Mattia Maroso, Silvia Balosso, Teresa Ravizza, Valentina Iori, Christopher Ian Wright, Jacqueline French, Annamaria Vezzani. Neurotherapeutics 2011
16
EP2 Receptor Signaling Regulates Microglia Death.
Yujiao Fu, Myung-Soon Yang, Jianxiong Jiang, Thota Ganesh, Eunhye Joe, Raymond Dingledine. Mol Pharmacol 2015
Yujiao Fu, Myung-Soon Yang, Jianxiong Jiang, Thota Ganesh, Eunhye Joe, Raymond Dingledine. Mol Pharmacol 2015
53
Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models.
Jenny U Johansson, Nathaniel S Woodling, Qian Wang, Maharshi Panchal, Xibin Liang, Angel Trueba-Saiz, Holden D Brown, Siddhita D Mhatre, Taylor Loui, Katrin I Andreasson. J Clin Invest 2015
Jenny U Johansson, Nathaniel S Woodling, Qian Wang, Maharshi Panchal, Xibin Liang, Angel Trueba-Saiz, Holden D Brown, Siddhita D Mhatre, Taylor Loui, Katrin I Andreasson. J Clin Invest 2015
15
Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside.
Avijit Dey, Xu Kang, Jiange Qiu, Yifeng Du, Jianxiong Jiang. Trends Pharmacol Sci 2016
Avijit Dey, Xu Kang, Jiange Qiu, Yifeng Du, Jianxiong Jiang. Trends Pharmacol Sci 2016
15
Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury.
Jianxiong Jiang, Ying Yu, Erika Reime Kinjo, Yifeng Du, Hoang Phuong Nguyen, Ray Dingledine. Neuropharmacology 2019
Jianxiong Jiang, Ying Yu, Erika Reime Kinjo, Yifeng Du, Hoang Phuong Nguyen, Ray Dingledine. Neuropharmacology 2019
53
Interleukin-1beta contributes to the generation of experimental febrile seizures.
Celine Dubé, Annamaria Vezzani, Marga Behrens, Tamas Bartfai, Tallie Z Baram. Ann Neurol 2005
Celine Dubé, Annamaria Vezzani, Marga Behrens, Tamas Bartfai, Tallie Z Baram. Ann Neurol 2005
14
Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy.
Linda Holtman, Erwin A van Vliet, Peter M Edelbroek, Eleonora Aronica, Jan A Gorter. Epilepsy Res 2010
Linda Holtman, Erwin A van Vliet, Peter M Edelbroek, Eleonora Aronica, Jan A Gorter. Epilepsy Res 2010
22
Defining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus.
Yifeng Du, Timothy Kemper, Jiange Qiu, Jianxiong Jiang. Expert Rev Neurother 2016
Yifeng Du, Timothy Kemper, Jiange Qiu, Jianxiong Jiang. Expert Rev Neurother 2016
56
13
Neuroinflammatory targets and treatments for epilepsy validated in experimental models.
Eleonora Aronica, Sebastian Bauer, Yuri Bozzi, Matteo Caleo, Raymond Dingledine, Jan A Gorter, David C Henshall, Daniela Kaufer, Sookyong Koh, Wolfgang Löscher,[...]. Epilepsia 2017
Eleonora Aronica, Sebastian Bauer, Yuri Bozzi, Matteo Caleo, Raymond Dingledine, Jan A Gorter, David C Henshall, Daniela Kaufer, Sookyong Koh, Wolfgang Löscher,[...]. Epilepsia 2017
14
Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype.
Xu Kang, Jiange Qiu, Qianqian Li, Katherine A Bell, Yifeng Du, Da Woon Jung, Jae Yeol Lee, Jiukuan Hao, Jianxiong Jiang. Sci Rep 2017
Xu Kang, Jiange Qiu, Qianqian Li, Katherine A Bell, Yifeng Du, Da Woon Jung, Jae Yeol Lee, Jiukuan Hao, Jianxiong Jiang. Sci Rep 2017
43
Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus.
M G De Simoni, C Perego, T Ravizza, D Moneta, M Conti, F Marchesi, A De Luigi, S Garattini, A Vezzani. Eur J Neurosci 2000
M G De Simoni, C Perego, T Ravizza, D Moneta, M Conti, F Marchesi, A De Luigi, S Garattini, A Vezzani. Eur J Neurosci 2000
12
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein.
Jinghua Jin, Feng-Shiun Shie, Jun Liu, Yan Wang, Jeanne Davis, Aimee M Schantz, Kathleen S Montine, Thomas J Montine, Jing Zhang. J Neuroinflammation 2007
Jinghua Jin, Feng-Shiun Shie, Jun Liu, Yan Wang, Jeanne Davis, Aimee M Schantz, Kathleen S Montine, Thomas J Montine, Jing Zhang. J Neuroinflammation 2007
13
Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures.
Mauro Schneider Oliveira, Ana Flávia Furian, Luiz Fernando Freire Royes, Michele Rechia Fighera, Natália Gindri Fiorenza, Marcelo Castelli, Pablo Machado, Denise Bohrer, Marlei Veiga, Juliano Ferreira,[...]. Epilepsy Res 2008
Mauro Schneider Oliveira, Ana Flávia Furian, Luiz Fernando Freire Royes, Michele Rechia Fighera, Natália Gindri Fiorenza, Marcelo Castelli, Pablo Machado, Denise Bohrer, Marlei Veiga, Juliano Ferreira,[...]. Epilepsy Res 2008
17
Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene.
Jamie R Levin, Geidy Serrano, Raymond Dingledine. Epilepsia 2012
Jamie R Levin, Geidy Serrano, Raymond Dingledine. Epilepsia 2012
46
Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region.
Takako Takemiya, Michiyo Maehara, Kiyoshi Matsumura, Shin Yasuda, Hiroko Sugiura, Kanato Yamagata. Neurosci Res 2006
Takako Takemiya, Michiyo Maehara, Kiyoshi Matsumura, Shin Yasuda, Hiroko Sugiura, Kanato Yamagata. Neurosci Res 2006
13
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats.
Erwin A van Vliet, Guido Zibell, Anton Pekcec, Juli Schlichtiger, Peter M Edelbroek, Linda Holtman, Eleonora Aronica, Jan A Gorter, Heidrun Potschka. Neuropharmacology 2010
Erwin A van Vliet, Guido Zibell, Anton Pekcec, Juli Schlichtiger, Peter M Edelbroek, Linda Holtman, Eleonora Aronica, Jan A Gorter, Heidrun Potschka. Neuropharmacology 2010
12
Modification of seizure activity by electrical stimulation. II. Motor seizure.
R J Racine. Electroencephalogr Clin Neurophysiol 1972
R J Racine. Electroencephalogr Clin Neurophysiol 1972
12
Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats.
Lei Ma, Xiao-Li Cui, Ying Wang, Xiao-Wei Li, Feng Yang, Dong Wei, Wen Jiang. Brain Res 2012
Lei Ma, Xiao-Li Cui, Ying Wang, Xiao-Wei Li, Feng Yang, Dong Wei, Wen Jiang. Brain Res 2012
26
Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.
F M Noe, N Polascheck, F Frigerio, M Bankstahl, T Ravizza, S Marchini, L Beltrame, C Reschke Banderó, W Löscher, A Vezzani. Neurobiol Dis 2013
F M Noe, N Polascheck, F Frigerio, M Bankstahl, T Ravizza, S Marchini, L Beltrame, C Reschke Banderó, W Löscher, A Vezzani. Neurobiol Dis 2013
12
Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.
Karin Borges, Marla Gearing, Dayna L McDermott, Amy B Smith, Antoine G Almonte, Bruce H Wainer, Raymond Dingledine. Exp Neurol 2003
Karin Borges, Marla Gearing, Dayna L McDermott, Amy B Smith, Antoine G Almonte, Bruce H Wainer, Raymond Dingledine. Exp Neurol 2003
12
Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability.
Annamaria Vezzani, Barbara Viviani. Neuropharmacology 2015
Annamaria Vezzani, Barbara Viviani. Neuropharmacology 2015
12
The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.
Asheebo Rojas, Paoula Gueorguieva, Nadia Lelutiu, Yi Quan, Renee Shaw, Raymond Dingledine. Neurobiol Dis 2014
Asheebo Rojas, Paoula Gueorguieva, Nadia Lelutiu, Yi Quan, Renee Shaw, Raymond Dingledine. Neurobiol Dis 2014
54
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy.
Teresa Ravizza, Barbara Gagliardi, Francesco Noé, Karin Boer, Eleonora Aronica, Annamaria Vezzani. Neurobiol Dis 2008
Teresa Ravizza, Barbara Gagliardi, Francesco Noé, Karin Boer, Eleonora Aronica, Annamaria Vezzani. Neurobiol Dis 2008
11
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.