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Times Cited: 95
Times Cited: 95
Times Cited
Times Co-cited
Similarity
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
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The canonical Notch signaling pathway: unfolding the activation mechanism.
Raphael Kopan, Maria Xenia G Ilagan. Cell 2009
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Therapeutic antibody targeting of individual Notch receptors.
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Direct inhibition of the NOTCH transcription factor complex.
Raymond E Moellering, Melanie Cornejo, Tina N Davis, Cristina Del Bianco, Jon C Aster, Stephen C Blacklow, Andrew L Kung, D Gary Gilliland, Gregory L Verdine, James E Bradner. Nature 2009
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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
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TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
L W Ellisen, J Bird, D C West, A L Soreng, T C Reynolds, S D Smith, J Sklar. Cell 1991
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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.
Pedro J Real, Valeria Tosello, Teresa Palomero, Mireia Castillo, Eva Hernando, Elisa de Stanchina, Maria Luisa Sulis, Kelly Barnes, Catherine Sawai, Irene Homminga,[...]. Nat Med 2009
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Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.
Miguel Aste-Amézaga, Ningyan Zhang, Janet E Lineberger, Beth A Arnold, Timothy J Toner, Mingcheng Gu, Lingyi Huang, Salvatore Vitelli, Kim T Vo, Peter Haytko,[...]. PLoS One 2010
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Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes.
Michael J Malecki, Cheryll Sanchez-Irizarry, Jennifer L Mitchell, Gavin Histen, Mina L Xu, Jon C Aster, Stephen C Blacklow. Mol Cell Biol 2006
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Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila.
G Periz, M E Fortini. EMBO J 1999
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Leukemia-specific delivery of mutant NOTCH1 targeted therapy.
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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
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Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts.
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Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.
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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
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A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.
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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia.
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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.
Xose S Puente, Magda Pinyol, Víctor Quesada, Laura Conde, Gonzalo R Ordóñez, Neus Villamor, Georgia Escaramis, Pedro Jares, Sílvia Beà, Marcos González-Díaz,[...]. Nature 2011
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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Andrew P Weng, John M Millholland, Yumi Yashiro-Ohtani, Marie Laure Arcangeli, Arthur Lau, Carol Wai, Cristina Del Bianco, Carlos G Rodriguez, Hong Sai, John Tobias,[...]. Genes Dev 2006
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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
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Targeting thapsigargin towards tumors.
Nhu Thi Quynh Doan, Eleonora Sandholdt Paulsen, Pankaj Sehgal, Jesper Vuust Møller, Poul Nissen, Samuel R Denmeade, John T Isaacs, Craig A Dionne, Søren Brøgger Christensen. Steroids 2015
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The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling.
C De Ford, B Heidersdorf, F Haun, R Murillo, T Friedrich, C Borner, I Merfort. Cell Death Dis 2016
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Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3.
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NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.
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Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.
W S Pear, J C Aster, M L Scott, R P Hasserjian, B Soffer, J Sklar, D Baltimore. J Exp Med 1996
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Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy.
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Calcium depletion dissociates and activates heterodimeric notch receptors.
M D Rand, L M Grimm, S Artavanis-Tsakonas, V Patriub, S C Blacklow, J Sklar, J C Aster. Mol Cell Biol 2000
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The Notch signalling system: recent insights into the complexity of a conserved pathway.
K G Guruharsha, Mark W Kankel, Spyros Artavanis-Tsakonas. Nat Rev Genet 2012
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Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
Nicholas J Wang, Zachary Sanborn, Kelly L Arnett, Laura J Bayston, Wilson Liao, Charlotte M Proby, Irene M Leigh, Eric A Collisson, Patricia B Gordon, Lakshmi Jakkula,[...]. Proc Natl Acad Sci U S A 2011
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The mutational landscape of head and neck squamous cell carcinoma.
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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J Watts, Christopher Callahan, Ian Kasman,[...]. Nature 2006
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J Watts, Christopher Callahan, Ian Kasman,[...]. Nature 2006
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The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis.
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Orai1 and STIM1 are critical for breast tumor cell migration and metastasis.
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Store-independent activation of Orai1 by SPCA2 in mammary tumors.
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Structural basis for autoinhibition of Notch.
Wendy R Gordon, Didem Vardar-Ulu, Gavin Histen, Cheryll Sanchez-Irizarry, Jon C Aster, Stephen C Blacklow. Nat Struct Mol Biol 2007
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Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia.
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A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
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p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner.
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Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
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The Varied Roles of Notch in Cancer.
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Chronic DLL4 blockade induces vascular neoplasms.
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Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.
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A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.
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CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors.
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Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
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Notch signaling: cell fate control and signal integration in development.
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Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.
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8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.