Kenji Hashimoto, Berend Malchow, Peter Falkai, Andrea Schmitt. Eur Arch Psychiatry Clin Neurosci 2013
Times Cited: 162
Times Cited: 162
Times Cited
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Targeting of NMDA receptors in new treatments for schizophrenia.
Kenji Hashimoto. Expert Opin Ther Targets 2014
Kenji Hashimoto. Expert Opin Ther Targets 2014
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Antidepressant effects of ketamine in depressed patients.
R M Berman, A Cappiello, A Anand, D A Oren, G R Heninger, D S Charney, J H Krystal. Biol Psychiatry 2000
R M Berman, A Cappiello, A Anand, D A Oren, G R Heninger, D S Charney, J H Krystal. Biol Psychiatry 2000
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A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Carlos A Zarate, Jaskaran B Singh, Paul J Carlson, Nancy E Brutsche, Rezvan Ameli, David A Luckenbaugh, Dennis S Charney, Husseini K Manji. Arch Gen Psychiatry 2006
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Recent advances in the phencyclidine model of schizophrenia.
D C Javitt, S R Zukin. Am J Psychiatry 1991
D C Javitt, S R Zukin. Am J Psychiatry 1991
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Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia.
Kenji Hashimoto, Takeshi Fukushima, Eiji Shimizu, Naoya Komatsu, Hiroyuki Watanabe, Naoyuki Shinoda, Michiko Nakazato, Chikara Kumakiri, Shin-ichi Okada, Hisanori Hasegawa,[...]. Arch Gen Psychiatry 2003
Kenji Hashimoto, Takeshi Fukushima, Eiji Shimizu, Naoya Komatsu, Hiroyuki Watanabe, Naoyuki Shinoda, Michiko Nakazato, Chikara Kumakiri, Shin-ichi Okada, Hisanori Hasegawa,[...]. Arch Gen Psychiatry 2003
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Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.
Sandeep T Patil, Lu Zhang, Ferenc Martenyi, Stephen L Lowe, Kimberley A Jackson, Boris V Andreev, Alla S Avedisova, Leonid M Bardenstein, Issak Y Gurovich, Margarita A Morozova,[...]. Nat Med 2007
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Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients.
Kenji Hashimoto, Göran Engberg, Eiji Shimizu, Conny Nordin, Leif H Lindström, Masaomi Iyo. Prog Neuropsychopharmacol Biol Psychiatry 2005
Kenji Hashimoto, Göran Engberg, Eiji Shimizu, Conny Nordin, Leif H Lindström, Masaomi Iyo. Prog Neuropsychopharmacol Biol Psychiatry 2005
10
Increased levels of glutamate in brains from patients with mood disorders.
Kenji Hashimoto, Akira Sawa, Masaomi Iyo. Biol Psychiatry 2007
Kenji Hashimoto, Akira Sawa, Masaomi Iyo. Biol Psychiatry 2007
10
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.
Nanxin Li, Boyoung Lee, Rong-Jian Liu, Mounira Banasr, Jason M Dwyer, Masaaki Iwata, Xiao-Yuan Li, George Aghajanian, Ronald S Duman. Science 2010
Nanxin Li, Boyoung Lee, Rong-Jian Liu, Mounira Banasr, Jason M Dwyer, Masaaki Iwata, Xiao-Yuan Li, George Aghajanian, Ronald S Duman. Science 2010
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Emerging role of glutamate in the pathophysiology of major depressive disorder.
Kenji Hashimoto. Brain Res Rev 2009
Kenji Hashimoto. Brain Res Rev 2009
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A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia.
Inna Bendikov, Carmit Nadri, Shirly Amar, Rogerio Panizzutti, Joari De Miranda, Herman Wolosker, Galila Agam. Schizophr Res 2007
Inna Bendikov, Carmit Nadri, Shirly Amar, Rogerio Panizzutti, Joari De Miranda, Herman Wolosker, Galila Agam. Schizophr Res 2007
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R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects.
C Yang, Y Shirayama, J-c Zhang, Q Ren, W Yao, M Ma, C Dong, K Hashimoto. Transl Psychiatry 2015
C Yang, Y Shirayama, J-c Zhang, Q Ren, W Yao, M Ma, C Dong, K Hashimoto. Transl Psychiatry 2015
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Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression.
Ji-chun Zhang, Wei Yao, Chao Dong, Chun Yang, Qian Ren, Min Ma, Mei Han, Kenji Hashimoto. Psychopharmacology (Berl) 2015
Ji-chun Zhang, Wei Yao, Chao Dong, Chun Yang, Qian Ren, Min Ma, Mei Han, Kenji Hashimoto. Psychopharmacology (Berl) 2015
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Glutamate Signaling in Synaptogenesis and NMDA Receptors as Potential Therapeutic Targets for Psychiatric Disorders.
Y Ohgi, T Futamura, K Hashimoto. Curr Mol Med 2015
Y Ohgi, T Futamura, K Hashimoto. Curr Mol Med 2015
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D-serine added to antipsychotics for the treatment of schizophrenia.
G Tsai, P Yang, L C Chung, N Lange, J T Coyle. Biol Psychiatry 1998
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NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease.
Pierre Paoletti, Camilla Bellone, Qiang Zhou. Nat Rev Neurosci 2013
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Glutamate receptor ion channels: structure, regulation, and function.
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Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis.
Guochuan E Tsai, Pao-Yen Lin. Curr Pharm Des 2010
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Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond.
John H Krystal, Gerard Sanacora, Ronald S Duman. Biol Psychiatry 2013
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Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders.
Gerard Sanacora, Carlos A Zarate, John H Krystal, Husseini K Manji. Nat Rev Drug Discov 2008
Gerard Sanacora, Carlos A Zarate, John H Krystal, Husseini K Manji. Nat Rev Drug Discov 2008
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From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment.
Bita Moghaddam, Daniel Javitt. Neuropsychopharmacology 2012
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The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond.
Darrick T Balu, Joseph T Coyle. Curr Opin Pharmacol 2015
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Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats.
B Moghaddam, B W Adams. Science 1998
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7
A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.
Nancy Diazgranados, Lobna Ibrahim, Nancy E Brutsche, Andrew Newberg, Phillip Kronstein, Sami Khalife, William A Kammerer, Zenaide Quezado, David A Luckenbaugh, Giacomo Salvadore,[...]. Arch Gen Psychiatry 2010
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7
An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.
Sheldon H Preskorn, Bryan Baker, Sheela Kolluri, Frank S Menniti, Michael Krams, Jaren W Landen. J Clin Psychopharmacol 2008
Sheldon H Preskorn, Bryan Baker, Sheela Kolluri, Frank S Menniti, Michael Krams, Jaren W Landen. J Clin Psychopharmacol 2008
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Correlation between plasma levels of glutamate, alanine and serine with severity of depression.
Hideaki Mitani, Yukihiko Shirayama, Takeshi Yamada, Kazuhisa Maeda, Charles R Ashby, Ryuzou Kawahara. Prog Neuropsychopharmacol Biol Psychiatry 2006
Hideaki Mitani, Yukihiko Shirayama, Takeshi Yamada, Kazuhisa Maeda, Charles R Ashby, Ryuzou Kawahara. Prog Neuropsychopharmacol Biol Psychiatry 2006
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Antidepressant actions of ketamine: from molecular mechanisms to clinical practice.
Lisa M Monteggia, Carlos Zarate. Curr Opin Neurobiol 2015
Lisa M Monteggia, Carlos Zarate. Curr Opin Neurobiol 2015
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NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
Anita E Autry, Megumi Adachi, Elena Nosyreva, Elisa S Na, Maarten F Los, Peng-fei Cheng, Ege T Kavalali, Lisa M Monteggia. Nature 2011
Anita E Autry, Megumi Adachi, Elena Nosyreva, Elisa S Na, Maarten F Los, Peng-fei Cheng, Ege T Kavalali, Lisa M Monteggia. Nature 2011
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Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study.
Daniel Umbricht, Daniela Alberati, Meret Martin-Facklam, Edilio Borroni, Eriene A Youssef, Michael Ostland, Tanya L Wallace, Frédéric Knoflach, Ernest Dorflinger, Joseph G Wettstein,[...]. JAMA Psychiatry 2014
Daniel Umbricht, Daniela Alberati, Meret Martin-Facklam, Edilio Borroni, Eriene A Youssef, Michael Ostland, Tanya L Wallace, Frédéric Knoflach, Ernest Dorflinger, Joseph G Wettstein,[...]. JAMA Psychiatry 2014
7
Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial.
Carlos A Zarate, Nancy E Brutsche, Lobna Ibrahim, Jose Franco-Chaves, Nancy Diazgranados, Anibal Cravchik, Jessica Selter, Craig A Marquardt, Victoria Liberty, David A Luckenbaugh. Biol Psychiatry 2012
Carlos A Zarate, Nancy E Brutsche, Lobna Ibrahim, Jose Franco-Chaves, Nancy Diazgranados, Anibal Cravchik, Jessica Selter, Craig A Marquardt, Victoria Liberty, David A Luckenbaugh. Biol Psychiatry 2012
7
NMDAR inhibition-independent antidepressant actions of ketamine metabolites.
Panos Zanos, Ruin Moaddel, Patrick J Morris, Polymnia Georgiou, Jonathan Fischell, Greg I Elmer, Manickavasagom Alkondon, Peixiong Yuan, Heather J Pribut, Nagendra S Singh,[...]. Nature 2016
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A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia.
Bruce J Kinon, Lu Zhang, Brian A Millen, Olawale O Osuntokun, Judy E Williams, Sara Kollack-Walker, Kimberley Jackson, Ludmila Kryzhanovskaya, Natalia Jarkova. J Clin Psychopharmacol 2011
Bruce J Kinon, Lu Zhang, Brian A Millen, Olawale O Osuntokun, Judy E Williams, Sara Kollack-Walker, Kimberley Jackson, Ludmila Kryzhanovskaya, Natalia Jarkova. J Clin Psychopharmacol 2011
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The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity.
M L Woolley, D J Pemberton, S Bate, C Corti, D N C Jones. Psychopharmacology (Berl) 2008
M L Woolley, D J Pemberton, S Bate, C Corti, D N C Jones. Psychopharmacology (Berl) 2008
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Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
Ruggero Galici, Carrie K Jones, Kamondanai Hemstapat, Yi Nong, Nicholas G Echemendia, Lilly C Williams, Tomas de Paulis, P Jeffrey Conn. J Pharmacol Exp Ther 2006
Ruggero Galici, Carrie K Jones, Kamondanai Hemstapat, Yi Nong, Nicholas G Echemendia, Lilly C Williams, Tomas de Paulis, P Jeffrey Conn. J Pharmacol Exp Ther 2006
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Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions.
Kenji Hashimoto. Psychiatry Clin Neurosci 2010
Kenji Hashimoto. Psychiatry Clin Neurosci 2010
6
Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist.
Yukihiko Shirayama, Chun Yang, Ji-chun Zhang, Qian Ren, Wei Yao, Kenji Hashimoto. Eur Neuropsychopharmacol 2015
Yukihiko Shirayama, Chun Yang, Ji-chun Zhang, Qian Ren, Wei Yao, Kenji Hashimoto. Eur Neuropsychopharmacol 2015
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Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation.
Ji-chun Zhang, Jin Wu, Yuko Fujita, Wei Yao, Qian Ren, Chun Yang, Su-xia Li, Yukihiko Shirayama, Kenji Hashimoto. Int J Neuropsychopharmacol 2014
Ji-chun Zhang, Jin Wu, Yuko Fujita, Wei Yao, Qian Ren, Chun Yang, Su-xia Li, Yukihiko Shirayama, Kenji Hashimoto. Int J Neuropsychopharmacol 2014
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Phencyclidine/schizophrenia: one view toward the past, the other to the future.
Edward F Domino, Elliot D Luby. Schizophr Bull 2012
Edward F Domino, Elliot D Luby. Schizophr Bull 2012
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Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.
Thomas Papouin, Laurent Ladépêche, Jérôme Ruel, Silvia Sacchi, Marilyne Labasque, Marwa Hanini, Laurent Groc, Loredano Pollegioni, Jean-Pierre Mothet, Stéphane H R Oliet. Cell 2012
Thomas Papouin, Laurent Ladépêche, Jérôme Ruel, Silvia Sacchi, Marilyne Labasque, Marwa Hanini, Laurent Groc, Loredano Pollegioni, Jean-Pierre Mothet, Stéphane H R Oliet. Cell 2012
6
Behavioral and cognitive effects of the N-methyl-D-aspartate receptor co-agonist D-serine in healthy humans: initial findings.
Raz Levin, Adi Ein Dor-Abarbanel, Shany Edelman, Andrea R Durrant, Kenji Hashimoto, Daniel C Javitt, Uriel Heresco-Levy. J Psychiatr Res 2015
Raz Levin, Adi Ein Dor-Abarbanel, Shany Edelman, Andrea R Durrant, Kenji Hashimoto, Daniel C Javitt, Uriel Heresco-Levy. J Psychiatr Res 2015
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Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor.
Hsien-Yuan Lane, Ching-Hua Lin, Michael F Green, Gerhard Hellemann, Chih-Chia Huang, Po-Wei Chen, Rene Tun, Yue-Cung Chang, Guochuan E Tsai. JAMA Psychiatry 2013
Hsien-Yuan Lane, Ching-Hua Lin, Michael F Green, Gerhard Hellemann, Chih-Chia Huang, Po-Wei Chen, Rene Tun, Yue-Cung Chang, Guochuan E Tsai. JAMA Psychiatry 2013
6
D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia.
Uriel Heresco-Levy, Daniel C Javitt, Richard Ebstein, Agnes Vass, Pesach Lichtenberg, Gali Bar, Sara Catinari, Marina Ermilov. Biol Psychiatry 2005
Uriel Heresco-Levy, Daniel C Javitt, Richard Ebstein, Agnes Vass, Pesach Lichtenberg, Gali Bar, Sara Catinari, Marina Ermilov. Biol Psychiatry 2005
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Decreased levels of D-aspartate and NMDA in the prefrontal cortex and striatum of patients with schizophrenia.
Francesco Errico, Francesco Napolitano, Marta Squillace, Daniela Vitucci, Giuseppe Blasi, Andrea de Bartolomeis, Alessandro Bertolino, Antimo D'Aniello, Alessandro Usiello. J Psychiatr Res 2013
Francesco Errico, Francesco Napolitano, Marta Squillace, Daniela Vitucci, Giuseppe Blasi, Andrea de Bartolomeis, Alessandro Bertolino, Antimo D'Aniello, Alessandro Usiello. J Psychiatr Res 2013
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Signaling pathways underlying the rapid antidepressant actions of ketamine.
Ronald S Duman, Nanxin Li, Rong-Jian Liu, Vanja Duric, George Aghajanian. Neuropharmacology 2012
Ronald S Duman, Nanxin Li, Rong-Jian Liu, Vanja Duric, George Aghajanian. Neuropharmacology 2012
6
Inflammatory biomarkers as differential predictors of antidepressant response.
Kenji Hashimoto. Int J Mol Sci 2015
Kenji Hashimoto. Int J Mol Sci 2015
7
Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress.
Qian Ren, Min Ma, Tamaki Ishima, Christophe Morisseau, Jun Yang, Karen M Wagner, Ji-Chun Zhang, Chun Yang, Wei Yao, Chao Dong,[...]. Proc Natl Acad Sci U S A 2016
Qian Ren, Min Ma, Tamaki Ishima, Christophe Morisseau, Jun Yang, Karen M Wagner, Ji-Chun Zhang, Chun Yang, Wei Yao, Chao Dong,[...]. Proc Natl Acad Sci U S A 2016
6
R (-)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine.
Ji-Chun Zhang, Su-Xia Li, Kenji Hashimoto. Pharmacol Biochem Behav 2014
Ji-Chun Zhang, Su-Xia Li, Kenji Hashimoto. Pharmacol Biochem Behav 2014
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.