Stéphanie Tomé, Kevin Manley, Jodie P Simard, Greg W Clark, Meghan M Slean, Meera Swami, Peggy F Shelbourne, Elisabeth R M Tillier, Darren G Monckton, Anne Messer, Christopher E Pearson. PLoS Genet 2013
Times Cited: 83
Times Cited: 83
Times Cited
Times Co-cited
Similarity
Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Ricardo Mouro Pinto, Ella Dragileva, Andrew Kirby, Alejandro Lloret, Edith Lopez, Jason St Claire, Gagan B Panigrahi, Caixia Hou, Kim Holloway, Tammy Gillis,[...]. PLoS Genet 2013
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Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes.
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Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.
Meera Swami, Audrey E Hendricks, Tammy Gillis, Tiffany Massood, Jayalakshmi Mysore, Richard H Myers, Vanessa C Wheeler. Hum Mol Genet 2009
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Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice.
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Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion.
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Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study.
Davina J Hensman Moss, Antonio F Pardiñas, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, Peter Holmans, Lesley Jones,[...]. Lancet Neurol 2017
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Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice.
Laurent Foiry, Li Dong, Cédric Savouret, Laurence Hubert, Hein te Riele, Claudine Junien, Geneviève Gourdon. Hum Genet 2006
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Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis.
Laura Kennedy, Elizabeth Evans, Chiung-Mei Chen, Lyndsey Craven, Peter J Detloff, Margaret Ennis, Peggy F Shelbourne. Hum Mol Genet 2003
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DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases.
Conceição Bettencourt, Davina Hensman-Moss, Michael Flower, Sarah Wiethoff, Alexis Brice, Cyril Goizet, Giovanni Stevanin, Georgios Koutsis, Georgia Karadima, Marios Panas,[...]. Ann Neurol 2016
Conceição Bettencourt, Davina Hensman-Moss, Michael Flower, Sarah Wiethoff, Alexis Brice, Cyril Goizet, Giovanni Stevanin, Georgios Koutsis, Georgia Karadima, Marios Panas,[...]. Ann Neurol 2016
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Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.
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(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition.
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Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.
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OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.
Irina V Kovtun, Yuan Liu, Magnar Bjoras, Arne Klungland, Samuel H Wilson, Cynthia T McMurray. Nature 2007
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Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain.
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MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.
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The mismatch repair protein MSH2 is rate limiting for repeat expansion in a fragile X premutation mouse model.
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Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
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MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells.
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A polymorphism in the MSH3 mismatch repair gene is associated with the levels of somatic instability of the expanded CTG repeat in the blood DNA of myotonic dystrophy type 1 patients.
Fernando Morales, Melissa Vásquez, Carolina Santamaría, Patricia Cuenca, Eyleen Corrales, Darren G Monckton. DNA Repair (Amst) 2016
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Trinucleotide expansion in haploid germ cells by gap repair.
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A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes.
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Marc Ciosi, Alastair Maxwell, Sarah A Cumming, Davina J Hensman Moss, Asma M Alshammari, Michael D Flower, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Peter Holmans,[...]. EBioMedicine 2019
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Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm.
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Repeat instability as the basis for human diseases and as a potential target for therapy.
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A modifier of Huntington's disease onset at the MLH1 locus.
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A novel approach to investigate tissue-specific trinucleotide repeat instability.
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Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation.
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Trinucleotide repeats that expand in human disease form hairpin structures in vitro.
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Mutsβ generates both expansions and contractions in a mouse model of the Fragile X-associated disorders.
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FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.
Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones,[...]. Hum Mol Genet 2019
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DNA mismatch repair complex MutSβ promotes GAA·TTC repeat expansion in human cells.
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Huntington disease.
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Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues.
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Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.
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Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.
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Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells.
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Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease.
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MSH2-dependent germinal CTG repeat expansions are produced continuously in spermatogonia from DM1 transgenic mice.
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The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model.
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Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.