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Times Cited: 1099
Times Cited: 1099
Times Cited
Times Co-cited
Similarity
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Haoqiang Ying, Alec C Kimmelman, Costas A Lyssiotis, Sujun Hua, Gerald C Chu, Eliot Fletcher-Sananikone, Jason W Locasale, Jaekyoung Son, Hailei Zhang, Jonathan L Coloff,[...]. Cell 2012
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From Krebs to clinic: glutamine metabolism to cancer therapy.
Brian J Altman, Zachary E Stine, Chi V Dang. Nat Rev Cancer 2016
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David R Wise, Craig B Thompson. Trends Biochem Sci 2010
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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.
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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.
Ralph J DeBerardinis, Anthony Mancuso, Evgueni Daikhin, Ilana Nissim, Marc Yudkoff, Suzanne Wehrli, Craig B Thompson. Proc Natl Acad Sci U S A 2007
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Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
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Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.
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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids.
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Glutamine and cancer: cell biology, physiology, and clinical opportunities.
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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer.
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Otto Warburg's contributions to current concepts of cancer metabolism.
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Pancreatic cancers require autophagy for tumor growth.
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Cysteine depletion induces pancreatic tumor ferroptosis in mice.
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Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.
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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.
Kıvanç Birsoy, Tim Wang, Walter W Chen, Elizaveta Freinkman, Monther Abu-Remaileh, David M Sabatini. Cell 2015
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Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.
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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer.
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Metabolic Heterogeneity in Human Lung Tumors.
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Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.
Patrick S Ward, Craig B Thompson. Cancer Cell 2012
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A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells.
Hee Chan Yoo, Seung Joon Park, Miso Nam, Juwon Kang, Kibum Kim, Joo Hye Yeo, Joon-Ki Kim, Yunkyung Heo, Hee Seung Lee, Myeong Youl Lee,[...]. Cell Metab 2020
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Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.
Conan G Kinsey, Soledad A Camolotto, Amelie M Boespflug, Katrin P Guillen, Mona Foth, Amanda Truong, Sophia S Schuman, Jill E Shea, Michael T Seipp, Jeffrey T Yap,[...]. Nat Med 2019
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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
Kirsten L Bryant, Clint A Stalnecker, Daniel Zeitouni, Jennifer E Klomp, Sen Peng, Andrey P Tikunov, Venugopal Gunda, Mariaelena Pierobon, Andrew M Waters, Samuel D George,[...]. Nat Med 2019
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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.
David R Wise, Patrick S Ward, Jessica E S Shay, Justin R Cross, Joshua J Gruber, Uma M Sachdeva, Jesse M Platt, Raymond G DeMatteo, M Celeste Simon, Craig B Thompson. Proc Natl Acad Sci U S A 2011
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Reductive carboxylation supports growth in tumour cells with defective mitochondria.
Andrew R Mullen, William W Wheaton, Eunsook S Jin, Pei-Hsuan Chen, Lucas B Sullivan, Tzuling Cheng, Youfeng Yang, W Marston Linehan, Navdeep S Chandel, Ralph J DeBerardinis. Nature 2011
Andrew R Mullen, William W Wheaton, Eunsook S Jin, Pei-Hsuan Chen, Lucas B Sullivan, Tzuling Cheng, Youfeng Yang, W Marston Linehan, Navdeep S Chandel, Ralph J DeBerardinis. Nature 2011
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Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism.
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Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
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Glutamine Metabolism in Cancer: Understanding the Heterogeneity.
Ahmad A Cluntun, Michael J Lukey, Richard A Cerione, Jason W Locasale. Trends Cancer 2017
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α-Ketoglutarate links p53 to cell fate during tumour suppression.
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Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer.
Christopher J Halbrook, Costas A Lyssiotis. Cancer Cell 2017
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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
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Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.
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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.
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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
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Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
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Glutaminolysis: A Hallmark of Cancer Metabolism.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.