A citation-based method for searching scientific literature

Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
Times Cited: 496







List of co-cited articles
1265 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
670
34

Metformin as a Tool to Target Aging.
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
411
26

The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
21


Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.
Wouter De Haes, Lotte Frooninckx, Roel Van Assche, Arne Smolders, Geert Depuydt, Johan Billen, Bart P Braeckman, Liliane Schoofs, Liesbet Temmerman. Proc Natl Acad Sci U S A 2014
182
19

Role of AMP-activated protein kinase in mechanism of metformin action.
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
16

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.
Olga Moiseeva, Xavier Deschênes-Simard, Emmanuelle St-Germain, Sebastian Igelmann, Geneviève Huot, Alexandra E Cadar, Véronique Bourdeau, Michael N Pollak, Gerardo Ferbeyre. Aging Cell 2013
228
16

The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
652
15

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Kristoffer Forslund, Falk Hildebrand, Trine Nielsen, Gwen Falony, Emmanuelle Le Chatelier, Shinichi Sunagawa, Edi Prifti, Sara Vieira-Silva, Valborg Gudmundsdottir, Helle K Pedersen,[...]. Nature 2015
890
13

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
13

Metformin extends C. elegans lifespan through lysosomal pathway.
Jie Chen, Yuhui Ou, Yi Li, Shumei Hu, Li-Wa Shao, Ying Liu. Elife 2017
64
20

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen. Nature 2011
13


Resveratrol improves health and survival of mice on a high-calorie diet.
Joseph A Baur, Kevin J Pearson, Nathan L Price, Hamish A Jamieson, Carles Lerin, Avash Kalra, Vinayakumar V Prabhu, Joanne S Allard, Guillermo Lopez-Lluch, Kaitlyn Lewis,[...]. Nature 2006
12

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls.
C A Bannister, S E Holden, S Jenkins-Jones, C Ll Morgan, J P Halcox, G Schernthaner, J Mukherjee, C J Currie. Diabetes Obes Metab 2014
167
12

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang,[...]. Nature 2003
12

Metformin slows down aging and extends life span of female SHR mice.
Vladimir N Anisimov, Lev M Berstein, Peter A Egormin, Tatiana S Piskunova, Irina G Popovich, Mark A Zabezhinski, Margarita L Tyndyk, Maria V Yurova, Irina G Kovalenko, Tatiana E Poroshina,[...]. Cell Cycle 2008
216
12

Metformin reduces endogenous reactive oxygen species and associated DNA damage.
Carolyn Algire, Olga Moiseeva, Xavier Deschênes-Simard, Lilian Amrein, Luca Petruccelli, Elena Birman, Benoit Viollet, Gerardo Ferbeyre, Michael N Pollak. Cancer Prev Res (Phila) 2012
201
12

Metformin as Anti-Aging Therapy: Is It for Everyone?
Alexander A Soukas, Haibin Hao, Lianfeng Wu. Trends Endocrinol Metab 2019
44
25

Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults.
Ameya S Kulkarni, Erika F Brutsaert, Valentin Anghel, Kehao Zhang, Noah Bloomgarden, Michael Pollak, Jessica C Mar, Meredith Hawkins, Jill P Crandall, Nir Barzilai. Aging Cell 2018
50
22

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer.
Lianfeng Wu, Ben Zhou, Noriko Oshiro-Rapley, Man Li, Joao A Paulo, Christopher M Webster, Fan Mou, Michael C Kacergis, Michael E Talkowski, Christopher E Carr,[...]. Cell 2016
116
11

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect.
Yoshifumi Saisho. Endocr Metab Immune Disord Drug Targets 2015
209
11


Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics.
Aurian P García-González, Ashlyn D Ritter, Shaleen Shrestha, Erik C Andersen, L Safak Yilmaz, Albertha J M Walhout. Cell 2017
96
10

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.
Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix,[...]. Nat Med 2017
561
10

mTOR is a key modulator of ageing and age-related disease.
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
931
10

Extending healthy life span--from yeast to humans.
Luigi Fontana, Linda Partridge, Valter D Longo. Science 2010
10

Senolytics improve physical function and increase lifespan in old age.
Ming Xu, Tamar Pirtskhalava, Joshua N Farr, Bettina M Weigand, Allyson K Palmer, Megan M Weivoda, Christina L Inman, Mikolaj B Ogrodnik, Christine M Hachfeld, Daniel G Fraser,[...]. Nat Med 2018
572
10


Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans.
Timothy A Scott, Leonor M Quintaneiro, Povilas Norvaisas, Prudence P Lui, Matthew P Wilson, Kit-Yi Leung, Lucia Herrera-Dominguez, Sonia Sudiwala, Alberto Pessia, Peter T Clayton,[...]. Cell 2017
100
9

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
Rosina Pryor, Povilas Norvaisas, Georgios Marinos, Lena Best, Louise B Thingholm, Leonor M Quintaneiro, Wouter De Haes, Daniela Esser, Silvio Waschina, Celia Lujan,[...]. Cell 2019
81
11

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Adem Kalender, Anand Selvaraj, So Young Kim, Pawan Gulati, Sophie Brûlé, Benoit Viollet, Bruce E Kemp, Nabeel Bardeesy, Patrick Dennis, John J Schlager,[...]. Cell Metab 2010
569
9

Metformin and reduced risk of cancer in diabetic patients.
Josie M M Evans, Louise A Donnelly, Alistair M Emslie-Smith, Dario R Alessi, Andrew D Morris. BMJ 2005
9

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.
Jamie N Justice, Anoop M Nambiar, Tamar Tchkonia, Nathan K LeBrasseur, Rodolfo Pascual, Shahrukh K Hashmi, Larissa Prata, Michal M Masternak, Stephen B Kritchevsky, Nicolas Musi,[...]. EBioMedicine 2019
309
9

Folate Acts in E. coli to Accelerate C. elegans Aging Independently of Bacterial Biosynthesis.
Bhupinder Virk, Jie Jia, Claire A Maynard, Adelaide Raimundo, Jolien Lefebvre, Shane A Richards, Natalia Chetina, Yen Liang, Noel Helliwell, Marta Cipinska,[...]. Cell Rep 2016
43
18

Microbial Genetic Composition Tunes Host Longevity.
Bing Han, Priya Sivaramakrishnan, Chih-Chun J Lin, Isaiah A A Neve, Jingquan He, Li Wei Rachel Tay, Jessica N Sowa, Antons Sizovs, Guangwei Du, Jin Wang,[...]. Cell 2017
128
8

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
Vladimir N Anisimov, Lev M Berstein, Irina G Popovich, Mark A Zabezhinski, Peter A Egormin, Tatiana S Piskunova, Anna V Semenchenko, Margarita L Tyndyk, Maria N Yurova, Irina G Kovalenko,[...]. Aging (Albany NY) 2011
173
8

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Yi Zhu, Tamara Tchkonia, Tamar Pirtskhalava, Adam C Gower, Husheng Ding, Nino Giorgadze, Allyson K Palmer, Yuji Ikeno, Gene B Hubbard, Marc Lenburg,[...]. Aging Cell 2015
754
8

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
669
8

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Stacey Robida-Stubbs, Kira Glover-Cutter, Dudley W Lamming, Masaki Mizunuma, Sri Devi Narasimhan, Elke Neumann-Haefelin, David M Sabatini, T Keith Blackwell. Cell Metab 2012
346
8



Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation.
Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez,[...]. Front Endocrinol (Lausanne) 2018
53
15

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.
Amy R Cameron, Vicky L Morrison, Daniel Levin, Mohapradeep Mohan, Calum Forteath, Craig Beall, Alison D McNeilly, David J K Balfour, Terhi Savinko, Aaron K F Wong,[...]. Circ Res 2016
251
8

The senescence-associated secretory phenotype: the dark side of tumor suppression.
Jean-Philippe Coppé, Pierre-Yves Desprez, Ana Krtolica, Judith Campisi. Annu Rev Pathol 2010
8

An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice.
Na-Ri Shin, June-Chul Lee, Hae-Youn Lee, Min-Soo Kim, Tae Woong Whon, Myung-Shik Lee, Jin-Woo Bae. Gut 2014
771
7

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.
Bhupinder Virk, Gonçalo Correia, David P Dixon, Inna Feyst, Jie Jia, Nikolin Oberleitner, Zoe Briggs, Emily Hodge, Robert Edwards, John Ward,[...]. BMC Biol 2012
74
9

Cardioprotection and lifespan extension by the natural polyamine spermidine.
Tobias Eisenberg, Mahmoud Abdellatif, Sabrina Schroeder, Uwe Primessnig, Slaven Stekovic, Tobias Pendl, Alexandra Harger, Julia Schipke, Andreas Zimmermann, Albrecht Schmidt,[...]. Nat Med 2016
445
7

Low methionine ingestion by rats extends life span.
N Orentreich, J R Matias, A DeFelice, J A Zimmerman. J Nutr 1993
359
7



Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.