Dan Rohle, Janeta Popovici-Muller, Nicolaos Palaskas, Sevin Turcan, Christian Grommes, Carl Campos, Jennifer Tsoi, Owen Clark, Barbara Oldrini, Evangelia Komisopoulou, Kaiko Kunii, Alicia Pedraza, Stefanie Schalm, Lee Silverman, Alexandra Miller, Fang Wang, Hua Yang, Yue Chen, Andrew Kernytsky, Marc K Rosenblum, Wei Liu, Scott A Biller, Shinsan M Su, Cameron W Brennan, Timothy A Chan, Thomas G Graeber, Katharine E Yen, Ingo K Mellinghoff. Science 2013
Times Cited: 794
Times Cited: 794
Times Cited
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Similarity
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
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IDH mutation impairs histone demethylation and results in a block to cell differentiation.
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An integrated genomic analysis of human glioblastoma multiforme.
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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
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Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.
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Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.
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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
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Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
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Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.
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A vaccine targeting mutant IDH1 induces antitumour immunity.
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Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
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Ivosidenib in Isocitrate Dehydrogenase 1-Mutated Advanced Glioma.
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Recurring mutations found by sequencing an acute myeloid leukemia genome.
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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
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Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.
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Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
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Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.
Sevin Turcan, Armida W M Fabius, Alexandra Borodovsky, Alicia Pedraza, Cameron Brennan, Jason Huse, Agnes Viale, Gregory J Riggins, Timothy A Chan. Oncotarget 2013
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Mutant IDH1 regulates the tumor-associated immune system in gliomas.
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Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas.
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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Supriya K Saha, Christine A Parachoniak, Krishna S Ghanta, Julien Fitamant, Kenneth N Ross, Mortada S Najem, Sushma Gurumurthy, Esra A Akbay, Daniela Sia, Helena Cornella,[...]. Nature 2014
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Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
Brett E Johnson, Tali Mazor, Chibo Hong, Michael Barnes, Koki Aihara, Cory Y McLean, Shaun D Fouse, Shogo Yamamoto, Hiroki Ueda, Kenji Tatsuno,[...]. Science 2014
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Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma.
Zenon Konteatis, Erin Artin, Brandon Nicolay, Kimberly Straley, Anil K Padyana, Lei Jin, Yue Chen, Rohini Narayaraswamy, Shuilong Tong, Feng Wang,[...]. ACS Med Chem Lett 2020
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Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.
Andrew S Venteicher, Itay Tirosh, Christine Hebert, Keren Yizhak, Cyril Neftel, Mariella G Filbin, Volker Hovestadt, Leah E Escalante, McKenzie L Shaw, Christopher Rodman,[...]. Science 2017
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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers.
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IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas.
Takuya Watanabe, Sumihito Nobusawa, Paul Kleihues, Hiroko Ohgaki. Am J Pathol 2009
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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.
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A vaccine targeting mutant IDH1 in newly diagnosed glioma.
Michael Platten, Lukas Bunse, Antje Wick, Theresa Bunse, Lucian Le Cornet, Inga Harting, Felix Sahm, Khwab Sanghvi, Chin Leng Tan, Isabel Poschke,[...]. Nature 2021
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(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.
Julie-Aurore Losman, Ryan E Looper, Peppi Koivunen, Sungwoo Lee, Rebekka K Schneider, Christine McMahon, Glenn S Cowley, David E Root, Benjamin L Ebert, William G Kaelin. Science 2013
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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.
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The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.
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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
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Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair.
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New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.
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Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents.
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Longitudinal molecular trajectories of diffuse glioma in adults.
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Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.
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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.
Julie-Aurore Losman, William G Kaelin. Genes Dev 2013
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Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics.
Danielle Golub, Nishanth Iyengar, Siddhant Dogra, Taylor Wong, Devin Bready, Karen Tang, Aram S Modrek, Dimitris G Placantonakis. Front Oncol 2019
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.