A citation-based method for searching scientific literature

Alessandro Michelucci, Thekla Cordes, Jenny Ghelfi, Arnaud Pailot, Norbert Reiling, Oliver Goldmann, Tina Binz, André Wegner, Aravind Tallam, Antonio Rausell, Manuel Buttini, Carole L Linster, Eva Medina, Rudi Balling, Karsten Hiller. Proc Natl Acad Sci U S A 2013
Times Cited: 487

List of co-cited articles
789 articles co-cited >1

Times Cited
  Times     Co-cited

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana S H Costa, Maureen Higgins, Emily Hams,[...]. Nature 2018

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Vicky Lampropoulou, Alexey Sergushichev, Monika Bambouskova, Sharmila Nair, Emma E Vincent, Ekaterina Loginicheva, Luisa Cervantes-Barragan, Xiucui Ma, Stanley Ching-Cheng Huang, Takla Griss,[...]. Cell Metab 2016

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
G M Tannahill, A M Curtis, J Adamik, E M Palsson-McDermott, A F McGettrick, G Goel, C Frezza, N J Bernard, B Kelly, N H Foley,[...]. Nature 2013

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Monika Bambouskova, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Kendall Johnson, Daniel Korenfeld, Mary Elizabeth Mathyer, Hyeryun Kim, Li-Hao Huang,[...]. Nature 2018

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Abhishek K Jha, Stanley Ching-Cheng Huang, Alexey Sergushichev, Vicky Lampropoulou, Yulia Ivanova, Ekaterina Loginicheva, Karina Chmielewski, Kelly M Stewart, Juliet Ashall, Bart Everts,[...]. Immunity 2015

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.
Thekla Cordes, Martina Wallace, Alessandro Michelucci, Ajit S Divakaruni, Sean C Sapcariu, Carole Sousa, Haruhiko Koseki, Pedro Cabrales, Anne N Murphy, Karsten Hiller,[...]. J Biol Chem 2016

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Evanna L Mills, Beth Kelly, Angela Logan, Ana S H Costa, Mukund Varma, Clare E Bryant, Panagiotis Tourlomousis, J Henry M Däbritz, Eyal Gottlieb, Isabel Latorre,[...]. Cell 2016

Itaconic acid is a mammalian metabolite induced during macrophage activation.
Cheryl L Strelko, Wenyun Lu, Fay J Dufort, Thomas N Seyfried, Thomas C Chiles, Joshua D Rabinowitz, Mary F Roberts. J Am Chem Soc 2011

Itaconate: the poster child of metabolic reprogramming in macrophage function.
Luke A J O'Neill, Maxim N Artyomov. Nat Rev Immunol 2019

Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages.
Amanda Swain, Monika Bambouskova, Hyeryun Kim, Prabhakar Sairam Andhey, Dustin Duncan, Karine Auclair, Victor Chubukov, Donald M Simons, Thomas P Roddy, Kelly M Stewart,[...]. Nat Metab 2020

Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.
Sharmila Nair, Jeremy P Huynh, Vicky Lampropoulou, Ekaterina Loginicheva, Ekaterina Esaulova, Anshu P Gounder, Adrianus C M Boon, Elizabeth A Schwarzkopf, Tara R Bradstreet, Brian T Edelson,[...]. J Exp Med 2018

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
Jan Naujoks, Christoph Tabeling, Brian D Dill, Christine Hoffmann, Andrew S Brown, Mareike Kunze, Stefan Kempa, Andrea Peter, Hans-Joachim Mollenkopf, Anca Dorhoi,[...]. PLoS Pathog 2016

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.
Jorge Domínguez-Andrés, Boris Novakovic, Yang Li, Brendon P Scicluna, Mark S Gresnigt, Rob J W Arts, Marije Oosting, Simone J C F M Moorlag, Laszlo A Groh, Jelle Zwaag,[...]. Cell Metab 2019

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate.
Wei Qin, Ke Qin, Yanling Zhang, Wentong Jia, Ying Chen, Bo Cheng, Linghang Peng, Nan Chen, Yuan Liu, Wen Zhou,[...]. Nat Chem Biol 2019

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
Brian P Daniels, Sigal B Kofman, Julian R Smith, Geoffrey T Norris, Annelise G Snyder, Joseph P Kolb, Xia Gao, Jason W Locasale, Jennifer Martinez, Michael Gale,[...]. Immunity 2019

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.
Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E Corcoran, Marah C Runtsch, Chris Ling, Melanie C Ruzek, Peter F Slivka, Anne F McGettrick, Kathy Banahan,[...]. Cell Metab 2020

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite.
Thekla Cordes, Alessandro Michelucci, Karsten Hiller. Annu Rev Nutr 2015

Krebs Cycle Reborn in Macrophage Immunometabolism.
Dylan G Ryan, Luke A J O'Neill. Annu Rev Immunol 2020

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.
Shan-Ting Liao, Chao Han, Ding-Qiao Xu, Xiao-Wei Fu, Jun-Song Wang, Ling-Yi Kong. Nat Commun 2019

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming.
Pu-Ste Liu, Haiping Wang, Xiaoyun Li, Tung Chao, Tony Teav, Stefan Christen, Giusy Di Conza, Wan-Chen Cheng, Chih-Hung Chou, Magdalena Vavakova,[...]. Nat Immunol 2017

A guide to immunometabolism for immunologists.
Luke A J O'Neill, Rigel J Kishton, Jeff Rathmell. Nat Rev Immunol 2016

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.
Rob J W Arts, Boris Novakovic, Rob Ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih-Chin Cheng, Shuang-Yin Wang,[...]. Cell Metab 2016

Bacterial itaconate degradation promotes pathogenicity.
Jahminy Sasikaran, Michał Ziemski, Piotr K Zadora, Angela Fleig, Ivan A Berg. Nat Chem Biol 2014

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors.
Jonathan M Weiss, Luke C Davies, Megan Karwan, Lilia Ileva, Michelle K Ozaki, Robert Ys Cheng, Lisa A Ridnour, Christina M Annunziata, David A Wink, Daniel W McVicar. J Clin Invest 2018

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Eva M Palsson-McDermott, Anne M Curtis, Gautam Goel, Mario A R Lauterbach, Frederick J Sheedy, Laura E Gleeson, Mirjam W M van den Bosch, Susan R Quinn, Raquel Domingo-Fernandez, Daniel G W Johnston,[...]. Cell Metab 2015

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
Shih-Chin Cheng, Jessica Quintin, Robert A Cramer, Kelly M Shepardson, Sadia Saeed, Vinod Kumar, Evangelos J Giamarellos-Bourboulis, Joost H A Martens, Nagesha Appukudige Rao, Ali Aghajanirefah,[...]. Science 2014

Metabolic regulation of gene expression by histone lactylation.
Di Zhang, Zhanyun Tang, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut,[...]. Nature 2019

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Jade D Bailey, Marina Diotallevi, Thomas Nicol, Eileen McNeill, Andrew Shaw, Surawee Chuaiphichai, Ashley Hale, Anna Starr, Manasi Nandi, Elena Stylianou,[...]. Cell Rep 2019

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.
Erika M Palmieri, Marieli Gonzalez-Cotto, Walter A Baseler, Luke C Davies, Bart Ghesquière, Nunziata Maio, Christopher M Rice, Tracey A Rouault, Teresa Cassel, Richard M Higashi,[...]. Nat Commun 2020

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.
Bart Everts, Eyal Amiel, Stanley Ching-Cheng Huang, Amber M Smith, Chih-Hao Chang, Wing Y Lam, Veronika Redmann, Tori C Freitas, Julianna Blagih, Gerritje J W van der Windt,[...]. Nat Immunol 2014

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation.
Divya Vats, Lata Mukundan, Justin I Odegaard, Lina Zhang, Kristi L Smith, Christine R Morel, Roger A Wagner, David R Greaves, Peter J Murray, Ajay Chawla. Cell Metab 2006

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
A Phillip West, Igor E Brodsky, Christoph Rahner, Dong Kyun Woo, Hediye Erdjument-Bromage, Paul Tempst, Matthew C Walsh, Yongwon Choi, Gerald S Shadel, Sankar Ghosh. Nature 2011

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.
Jan Van den Bossche, Jeroen Baardman, Natasja A Otto, Saskia van der Velden, Annette E Neele, Susan M van den Berg, Rosario Luque-Martin, Hung-Jen Chen, Marieke C S Boshuizen, Mohamed Ahmed,[...]. Cell Rep 2016

Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella.
Meixin Chen, Hui Sun, Maikel Boot, Lin Shao, Shu-Jung Chang, Weiwei Wang, Tukiet T Lam, Maria Lara-Tejero, E Hesper Rego, Jorge E Galán. Science 2020

The Immunomodulatory Potential of the Metabolite Itaconate.
Alexander Hooftman, Luke A J O'Neill. Trends Immunol 2019

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
Stanley Ching-Cheng Huang, Bart Everts, Yulia Ivanova, David O'Sullivan, Marcia Nascimento, Amber M Smith, Wandy Beatty, Latisha Love-Gregory, Wing Y Lam, Christina M O'Neill,[...]. Nat Immunol 2014

The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.
Hongying Shen, Gregory C Campanello, Daniel Flicker, Zenon Grabarek, Junchi Hu, Cheng Luo, Ruma Banerjee, Vamsi K Mootha. Cell 2017

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase.
Mario A Lauterbach, Jasmin E Hanke, Magdalini Serefidou, Matthew S J Mangan, Carl-Christian Kolbe, Timo Hess, Maximilian Rothe, Romina Kaiser, Florian Hoss, Jan Gehlen,[...]. Immunity 2019

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury.
Thekla Cordes, Alfredo Lucas, Ajit S Divakaruni, Anne N Murphy, Pedro Cabrales, Christian M Metallo. Mol Metab 2020

ATP-citrate lyase is essential for macrophage inflammatory response.
Vittoria Infantino, Vito Iacobazzi, Ferdinando Palmieri, Alessio Menga. Biochem Biophys Res Commun 2013

Macrophage Immunometabolism: Where Are We (Going)?
Jan Van den Bossche, Luke A O'Neill, Deepthi Menon. Trends Immunol 2017

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Oscar R Colegio, Ngoc-Quynh Chu, Alison L Szabo, Thach Chu, Anne Marie Rhebergen, Vikram Jairam, Nika Cyrus, Carolyn E Brokowski, Stephanie C Eisenbarth, Gillian M Phillips,[...]. Nature 2014

(1)H NMR-based metabolomic profiling in mice infected with Mycobacterium tuberculosis.
Ji-Hyun Shin, Ji-Young Yang, Bo-Young Jeon, Yoo Jeong Yoon, Sang-Nae Cho, Yeon-Ho Kang, Do Hyun Ryu, Geum-Sook Hwang. J Proteome Res 2011

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage.
Beáta Németh, Judit Doczi, Dániel Csete, Gergely Kacso, Dora Ravasz, Daniel Adams, Gergely Kiss, Adam M Nagy, Gergo Horvath, Laszlo Tretter,[...]. FASEB J 2016

Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair.
Markus Ruetz, Gregory C Campanello, Meredith Purchal, Hongying Shen, Liam McDevitt, Harsha Gouda, Shoko Wakabayashi, Junhao Zhu, Eric J Rubin, Kurt Warncke,[...]. Science 2019

Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation.
Sebastián A Riquelme, Kalle Liimatta, Tania Wong Fok Lung, Blanche Fields, Danielle Ahn, David Chen, Carmen Lozano, Yolanda Sáenz, Anne-Catrin Uhlemann, Barbara C Kahl,[...]. Cell Metab 2020

An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism.
Hua Wang, Alexander A Fedorov, Elena V Fedorov, Debbie M Hunt, Angela Rodgers, Holly L Douglas, Acely Garza-Garcia, Jeffrey B Bonanno, Steven C Almo, Luiz Pedro Sório de Carvalho. Proc Natl Acad Sci U S A 2019

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes.
Ekta Lachmandas, Lily Boutens, Jacqueline M Ratter, Anneke Hijmans, Guido J Hooiveld, Leo A B Joosten, Richard J Rodenburg, Jack A M Fransen, Riekelt H Houtkooper, Reinout van Crevel,[...]. Nat Microbiol 2016

Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.