A citation-based method for searching scientific literature

James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
Times Cited: 945







List of co-cited articles
718 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
993
11


Hedgehog: functions and mechanisms.
Markku Varjosalo, Jussi Taipale. Genes Dev 2008
819
11

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors.
Tadas K Rimkus, Richard L Carpenter, Shadi Qasem, Michael Chan, Hui-Wen Lo. Cancers (Basel) 2016
321
10

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.
Eric W Humke, Karolin V Dorn, Ljiljana Milenkovic, Matthew P Scott, Rajat Rohatgi. Genes Dev 2010
303
10

Gli proteins in development and disease.
Chi-Chung Hui, Stephane Angers. Annu Rev Cell Dev Biol 2011
430
10

Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
942
10

Primary Cilia and Mammalian Hedgehog Signaling.
Fiona Bangs, Kathryn V Anderson. Cold Spring Harb Perspect Biol 2017
225
10


Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
9

Hedgehog signaling in development and cancer.
Jin Jiang, Chi-Chung Hui. Dev Cell 2008
739
9

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
Ishan Deshpande, Jiahao Liang, Danielle Hedeen, Kelsey J Roberts, Yunxiao Zhang, Betty Ha, Naomi R Latorraca, Bryan Faust, Ron O Dror, Philip A Beachy,[...]. Nature 2019
64
14

Hedgehog Signaling: From Basic Biology to Cancer Therapy.
Fujia Wu, Yu Zhang, Bo Sun, Andrew P McMahon, Yu Wang. Cell Chem Biol 2017
148
8

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.
Saikat Mukhopadhyay, Xiaohui Wen, Navneet Ratti, Alexander Loktev, Linda Rangell, Suzie J Scales, Peter K Jackson. Cell 2013
263
8

Activation of heterotrimeric G proteins by Smoothened.
Natalia A Riobo, Berangere Saucy, Cherisse Dilizio, David R Manning. Proc Natl Acad Sci U S A 2006
169
8

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
Xiaofeng Qi, Heng Liu, Bonne Thompson, Jeffrey McDonald, Cheng Zhang, Xiaochun Li. Nature 2019
67
11

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.
Benjamin R Myers, Lila Neahring, Yunxiao Zhang, Kelsey J Roberts, Philip A Beachy. Proc Natl Acad Sci U S A 2017
60
11


Biochemical mechanisms of vertebrate hedgehog signaling.
Jennifer H Kong, Christian Siebold, Rajat Rohatgi. Development 2019
76
9

Roles for Hedgehog signaling in adult organ homeostasis and repair.
Ralitsa Petrova, Alexandra L Joyner. Development 2014
197
7

Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling.
Pawel Niewiadomski, Jennifer H Kong, Robert Ahrends, Yan Ma, Eric W Humke, Sohini Khan, Mary N Teruel, Bennett G Novitch, Rajat Rohatgi. Cell Rep 2014
133
7

Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
Dereck Amakye, Zainab Jagani, Marion Dorsch. Nat Med 2013
367
7

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
Suzie J Scales, Frederic J de Sauvage. Trends Pharmacol Sci 2009
476
6

Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
740
6

Hedgehog signalling.
Raymond Teck Ho Lee, Zhonghua Zhao, Philip W Ingham. Development 2016
115
6

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist.
Shifeng Pan, Xu Wu, Jiqing Jiang, Wenqi Gao, Yongqin Wan, Dai Cheng, Dong Han, Jun Liu, Nathan P Englund, Yan Wang,[...]. ACS Med Chem Lett 2010
192
6

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, Cindy Jao, Youngchang Kim, Jing Liu, Adrian Salic. Cell 2016
187
6

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.
P Dai, H Akimaru, Y Tanaka, T Maekawa, M Nakafuku, S Ishii. J Biol Chem 1999
419
6

Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.
Kasturi Pal, Sun-Hee Hwang, Bandarigoda Somatilaka, Hemant Badgandi, Peter K Jackson, Kathryn DeFea, Saikat Mukhopadhyay. J Cell Biol 2016
74
8

The primary cilium: a signalling centre during vertebrate development.
Sarah C Goetz, Kathryn V Anderson. Nat Rev Genet 2010
6


Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.
Xu Xiao, Jing-Jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-Ping Qiu, Yue Xiong, Lian-Fang Yang, Hai-Wei Cui, Xiao-Long He,[...]. Mol Cell 2017
93
6

Mechanisms and functions of Hedgehog signalling across the metazoa.
Philip W Ingham, Yoshiro Nakano, Claudia Seger. Nat Rev Genet 2011
377
6

The Hedgehog signal transduction network.
David J Robbins, Dennis Liang Fei, Natalia A Riobo. Sci Signal 2012
254
6

Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.
Hanna Tukachinsky, Ryan P Kuzmickas, Cindy Y Jao, Jing Liu, Adrian Salic. Cell Rep 2012
124
6


Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
5

Altered neural cell fates and medulloblastoma in mouse patched mutants.
L V Goodrich, L Milenković, K M Higgins, M P Scott. Science 1997
5


A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.
Junhao Mao, Keith L Ligon, Elena Y Rakhlin, Sarah P Thayer, Roderick T Bronson, David Rowitch, Andrew P McMahon. Cancer Res 2006
204
5

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
Scott X Atwood, Kavita Y Sarin, Ramon J Whitson, Jiang R Li, Geurim Kim, Melika Rezaee, Mina S Ally, Jinah Kim, Catherine Yao, Anne Lynn S Chang,[...]. Cancer Cell 2015
238
5

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
Yujie Tang, Sharareh Gholamin, Simone Schubert, Minde I Willardson, Alex Lee, Pratiti Bandopadhayay, Guillame Bergthold, Sabran Masoud, Brian Nguyen, Nujsaubnusi Vue,[...]. Nat Med 2014
194
5


Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Matthias Lauth, Asa Bergström, Takashi Shimokawa, Rune Toftgård. Proc Natl Acad Sci U S A 2007
554
5

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.
Benjamin R Myers, Navdar Sever, Yong Chun Chong, James Kim, Jitendra D Belani, Scott Rychnovsky, J Fernando Bazan, Philip A Beachy. Dev Cell 2013
122
5

Structural Basis of Smoothened Activation in Hedgehog Signaling.
Pengxiang Huang, Sanduo Zheng, Bradley M Wierbowski, Youngchang Kim, Daniel Nedelcu, Laura Aravena, Jing Liu, Andrew C Kruse, Adrian Salic. Cell 2018
70
7

Structural basis of Smoothened regulation by its extracellular domains.
Eamon F X Byrne, Ria Sircar, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo,[...]. Nature 2016
190
5

Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
571
5

Genes and molecular pathways underpinning ciliopathies.
Jeremy F Reiter, Michel R Leroux. Nat Rev Mol Cell Biol 2017
475
5

Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy.
M Swiderska-Syn, W K Syn, G Xie, L Krüger, M V Machado, G Karaca, G A Michelotti, S S Choi, R T Premont, A M Diehl. Gut 2014
79
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.