A citation-based method for searching scientific literature

Nicholas Stephane Caron, Carly Robyn Desmond, Jianrun Xia, Ray Truant. Proc Natl Acad Sci U S A 2013
Times Cited: 85







List of co-cited articles
920 articles co-cited >1



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  Times     Co-cited
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Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Xiaofeng Gu, Erin R Greiner, Rakesh Mishra, Ravindra Kodali, Alex Osmand, Steven Finkbeiner, Joan S Steffan, Leslie Michels Thompson, Ronald Wetzel, X William Yang. Neuron 2009
213
37

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.
Randy Singh Atwal, Jianrun Xia, Deborah Pinchev, Jillian Taylor, Richard M Epand, Ray Truant. Hum Mol Genet 2007
253
36

Kinase inhibitors modulate huntingtin cell localization and toxicity.
Randy Singh Atwal, Carly R Desmond, Nicholas Caron, Tamara Maiuri, Jianrun Xia, Simonetta Sipione, Ray Truant. Nat Chem Biol 2011
116
34

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.
Ashwani K Thakur, Murali Jayaraman, Rakesh Mishra, Monika Thakur, Veronique M Chellgren, In-Ja L Byeon, Dalaver H Anjum, Ravindra Kodali, Trevor P Creamer, James F Conway,[...]. Nat Struct Mol Biol 2009
299
34

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
30

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Leslie Michels Thompson, Charity T Aiken, Linda S Kaltenbach, Namita Agrawal, Katalin Illes, Ali Khoshnan, Marta Martinez-Vincente, Montserrat Arrasate, Jacqueline Gire O'Rourke, Hasan Khashwji,[...]. J Cell Biol 2009
239
30

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation.
Stephen Tam, Christoph Spiess, William Auyeung, Lukasz Joachimiak, Bryan Chen, Michelle A Poirier, Judith Frydman. Nat Struct Mol Biol 2009
170
29

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.
Montserrat Arrasate, Siddhartha Mitra, Erik S Schweitzer, Mark R Segal, Steven Finkbeiner. Nature 2004
28

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation.
Scott L Crick, Kiersten M Ruff, Kanchan Garai, Carl Frieden, Rohit V Pappu. Proc Natl Acad Sci U S A 2013
129
28

Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.
Murali Jayaraman, Ravindra Kodali, Bankanidhi Sahoo, Ashwani K Thakur, Anand Mayasundari, Rakesh Mishra, Cynthia B Peterson, Ronald Wetzel. J Mol Biol 2012
124
27

Secondary structure of Huntingtin amino-terminal region.
Mee Whi Kim, Yogarany Chelliah, Sang Woo Kim, Zbyszek Otwinowski, Ilya Bezprozvanny. Structure 2009
178
24

Oligoproline effects on polyglutamine conformation and aggregation.
Anusri Bhattacharyya, Ashwani K Thakur, Veronique M Chellgren, Geetha Thiagarajan, Angela D Williams, Brian W Chellgren, Trevor P Creamer, Ronald Wetzel. J Mol Biol 2006
184
24

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation.
Songming Chen, Frank A Ferrone, Ronald Wetzel. Proc Natl Acad Sci U S A 2002
386
23

Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.
Charity T Aiken, Joan S Steffan, Cortnie M Guerrero, Hasan Khashwji, Tamas Lukacsovich, Danielle Simmons, Judy M Purcell, Kimia Menhaji, Ya-Zhen Zhu, Kim Green,[...]. J Biol Chem 2009
108
23

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
252
22

SUMO modification of Huntingtin and Huntington's disease pathology.
Joan S Steffan, Namita Agrawal, Judit Pallos, Erica Rockabrand, Lloyd C Trotman, Natalia Slepko, Katalin Illes, Tamas Lukacsovich, Ya-Zhen Zhu, Elena Cattaneo,[...]. Science 2004
482
22


Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.
Alba Di Pardo, Vittorio Maglione, Melanie Alpaugh, Melanie Horkey, Randy S Atwal, Jenny Sassone, Andrea Ciammola, Joan S Steffan, Karim Fouad, Ray Truant,[...]. Proc Natl Acad Sci U S A 2012
100
21

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
21

Structural features and domain organization of huntingtin fibrils.
Charles W Bugg, J Mario Isas, Torsten Fischer, Paul H Patterson, Ralf Langen. J Biol Chem 2012
55
32

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
20

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.
E Scherzinger, R Lurz, M Turmaine, L Mangiarini, B Hollenbach, R Hasenbank, G P Bates, S W Davies, H Lehrach, E E Wanker. Cell 1997
987
18

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.
Erica Rockabrand, Natalia Slepko, Antonello Pantalone, Vidya N Nukala, Aleksey Kazantsev, J Lawrence Marsh, Patrick G Sullivan, Joan S Steffan, Stefano L Sensi, Leslie Michels Thompson. Hum Mol Genet 2007
187
18

Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.
Christian Landles, Kirupa Sathasivam, Andreas Weiss, Ben Woodman, Hilary Moffitt, Steve Finkbeiner, Banghua Sun, Juliette Gafni, Lisa M Ellerby, Yvon Trottier,[...]. J Biol Chem 2010
208
18


Modulation of polyglutamine conformations and dimer formation by the N-terminus of huntingtin.
Tim E Williamson, Andreas Vitalis, Scott L Crick, Rohit V Pappu. J Mol Biol 2010
91
18

A toxic monomeric conformer of the polyglutamine protein.
Yoshitaka Nagai, Takashi Inui, H Akiko Popiel, Nobuhiro Fujikake, Kazuhiro Hasegawa, Yoshihiro Urade, Yuji Goto, Hironobu Naiki, Tatsushi Toda. Nat Struct Mol Biol 2007
230
17

The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils.
V N Sivanandam, Murali Jayaraman, Cody L Hoop, Ravindra Kodali, Ronald Wetzel, Patrick C A van der Wel. J Am Chem Soc 2011
115
17

Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure.
Gregory Darnell, Joseph P R O Orgel, Reinhard Pahl, Stephen C Meredith. J Mol Biol 2007
116
17


Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.
Rakesh Mishra, Cody L Hoop, Ravindra Kodali, Bankanidhi Sahoo, Patrick C A van der Wel, Ronald Wetzel. J Mol Biol 2012
53
26

A linear lattice model for polyglutamine in CAG-expansion diseases.
Melanie J Bennett, Kathryn E Huey-Tubman, Andrew B Herr, Anthony P West, Scott A Ross, Pamela J Bjorkman. Proc Natl Acad Sci U S A 2002
103
16

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.
E Scherzinger, A Sittler, K Schweiger, V Heiser, R Lurz, R Hasenbank, G P Bates, H Lehrach, E E Wanker. Proc Natl Acad Sci U S A 1999
514
16

Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent.
Karunakar Kar, Murali Jayaraman, Bankanidhi Sahoo, Ravindra Kodali, Ronald Wetzel. Nat Struct Mol Biol 2011
142
16

Flanking sequences profoundly alter polyglutamine toxicity in yeast.
Martin L Duennwald, Smitha Jagadish, Paul J Muchowski, Susan Lindquist. Proc Natl Acad Sci U S A 2006
211
15

Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties.
Murali Jayaraman, Rakesh Mishra, Ravindra Kodali, Ashwani K Thakur, Leonardus M I Koharudin, Angela M Gronenborn, Ronald Wetzel. Biochemistry 2012
47
27


The Biology of Huntingtin.
Frédéric Saudou, Sandrine Humbert. Neuron 2016
328
15

The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin.
Kathleen A Burke, Karlina J Kauffman, C Samuel Umbaugh, Shelli L Frey, Justin Legleiter. J Biol Chem 2013
53
22

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
Laurent R Gauthier, Bénédicte C Charrin, Maria Borrell-Pagès, Jim P Dompierre, Hélène Rangone, Fabrice P Cordelières, Jan De Mey, Marcy E MacDonald, Volkmar Lessmann, Sandrine Humbert,[...]. Cell 2004
769
14


Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions.
Astrid Lunkes, Katrin S Lindenberg, Léa Ben-Haïem, Chantal Weber, Didier Devys, G Bernhard Landwehrmeyer, Jean-Louis Mandel, Yvon Trottier. Mol Cell 2002
269
14

Membrane interactions of the amphipathic amino terminus of huntingtin.
Matthias Michalek, Evgeniy S Salnikov, Sebastiaan Werten, Burkhard Bechinger. Biochemistry 2013
60
20

Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences.
Vinal V Lakhani, Feng Ding, Nikolay V Dokholyan. PLoS Comput Biol 2010
72
16

An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1.
Zhiqiang Zheng, Aimin Li, Brandon B Holmes, Jayne C Marasa, Marc I Diamond. J Biol Chem 2013
49
24

Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions.
Scott L Crick, Murali Jayaraman, Carl Frieden, Ronald Wetzel, Rohit V Pappu. Proc Natl Acad Sci U S A 2006
197
12

Identifying polyglutamine protein species in situ that best predict neurodegeneration.
Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peters Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra,[...]. Nat Chem Biol 2011
128
12

Mechanism of cis-inhibition of polyQ fibrillation by polyP: PPII oligomers and the hydrophobic effect.
Gregory D Darnell, JohnMark Derryberry, Josh W Kurutz, Stephen C Meredith. Biophys J 2009
39
28



Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.