Ralph A Nixon. Nat Med 2013
Times Cited: 1175
Times Cited: 1175
Times Cited
Times Co-cited
Similarity
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Evandro F Fang, Yujun Hou, Konstantinos Palikaras, Bryan A Adriaanse, Jesse S Kerr, Beimeng Yang, Sofie Lautrup, Md Mahdi Hasan-Olive, Domenica Caponio, Xiuli Dan,[...]. Nat Neurosci 2019
Evandro F Fang, Yujun Hou, Konstantinos Palikaras, Bryan A Adriaanse, Jesse S Kerr, Beimeng Yang, Sofie Lautrup, Md Mahdi Hasan-Olive, Domenica Caponio, Xiuli Dan,[...]. Nat Neurosci 2019
12
Loss of autophagy in the central nervous system causes neurodegeneration in mice.
Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba, Shigeo Murata, Jun-ichi Iwata, Isei Tanida, Takashi Ueno, Masato Koike, Yasuo Uchiyama, Eiki Kominami,[...]. Nature 2006
Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba, Shigeo Murata, Jun-ichi Iwata, Isei Tanida, Takashi Ueno, Masato Koike, Yasuo Uchiyama, Eiki Kominami,[...]. Nature 2006
11
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice.
Taichi Hara, Kenji Nakamura, Makoto Matsui, Akitsugu Yamamoto, Yohko Nakahara, Rika Suzuki-Migishima, Minesuke Yokoyama, Kenji Mishima, Ichiro Saito, Hideyuki Okano,[...]. Nature 2006
Taichi Hara, Kenji Nakamura, Makoto Matsui, Akitsugu Yamamoto, Yohko Nakahara, Rika Suzuki-Migishima, Minesuke Yokoyama, Kenji Mishima, Ichiro Saito, Hideyuki Okano,[...]. Nature 2006
11
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
10
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.
Fiona Pickford, Eliezer Masliah, Markus Britschgi, Kurt Lucin, Ramya Narasimhan, Philipp A Jaeger, Scott Small, Brian Spencer, Edward Rockenstein, Beth Levine,[...]. J Clin Invest 2008
Fiona Pickford, Eliezer Masliah, Markus Britschgi, Kurt Lucin, Ramya Narasimhan, Philipp A Jaeger, Scott Small, Brian Spencer, Edward Rockenstein, Beth Levine,[...]. J Clin Invest 2008
10
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli,[...]. Autophagy 2016
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli,[...]. Autophagy 2016
9
Compromised autophagy and neurodegenerative diseases.
Fiona M Menzies, Angeleen Fleming, David C Rubinsztein. Nat Rev Neurosci 2015
Fiona M Menzies, Angeleen Fleming, David C Rubinsztein. Nat Rev Neurosci 2015
9
Autophagy fights disease through cellular self-digestion.
Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky. Nature 2008
Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky. Nature 2008
8
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
Fiona M Menzies, Angeleen Fleming, Andrea Caricasole, Carla F Bento, Stephen P Andrews, Avraham Ashkenazi, Jens Füllgrabe, Anne Jackson, Maria Jimenez Sanchez, Cansu Karabiyik,[...]. Neuron 2017
Fiona M Menzies, Angeleen Fleming, Andrea Caricasole, Carla F Bento, Stephen P Andrews, Avraham Ashkenazi, Jens Füllgrabe, Anne Jackson, Maria Jimenez Sanchez, Cansu Karabiyik,[...]. Neuron 2017
8
TFEB links autophagy to lysosomal biogenesis.
Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito, Moises Garcia Arencibia, Francesco Vetrini, Serkan Erdin, Serpil Uckac Erdin, Tuong Huynh, Diego Medina, Pasqualina Colella,[...]. Science 2011
Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito, Moises Garcia Arencibia, Francesco Vetrini, Serkan Erdin, Serpil Uckac Erdin, Tuong Huynh, Diego Medina, Pasqualina Colella,[...]. Science 2011
7
Alpha-Synuclein is degraded by both autophagy and the proteasome.
Julie L Webb, Brinda Ravikumar, Jane Atkins, Jeremy N Skepper, David C Rubinsztein. J Biol Chem 2003
Julie L Webb, Brinda Ravikumar, Jane Atkins, Jeremy N Skepper, David C Rubinsztein. J Biol Chem 2003
7
Autophagy: cellular and molecular mechanisms.
Danielle Glick, Sandra Barth, Kay F Macleod. J Pathol 2010
Danielle Glick, Sandra Barth, Kay F Macleod. J Pathol 2010
7
Mechanism and medical implications of mammalian autophagy.
Ivan Dikic, Zvulun Elazar. Nat Rev Mol Cell Biol 2018
Ivan Dikic, Zvulun Elazar. Nat Rev Mol Cell Biol 2018
6
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.
Ashley R Winslow, Chien-Wen Chen, Silvia Corrochano, Abraham Acevedo-Arozena, David E Gordon, Andrew A Peden, Maike Lichtenberg, Fiona M Menzies, Brinda Ravikumar, Sara Imarisio,[...]. J Cell Biol 2010
Ashley R Winslow, Chien-Wen Chen, Silvia Corrochano, Abraham Acevedo-Arozena, David E Gordon, Andrew A Peden, Maike Lichtenberg, Fiona M Menzies, Brinda Ravikumar, Sara Imarisio,[...]. J Cell Biol 2010
6
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.
Ralph A Nixon, Jerzy Wegiel, Asok Kumar, Wai Haung Yu, Corrinne Peterhoff, Anne Cataldo, Ana Maria Cuervo. J Neuropathol Exp Neurol 2005
Ralph A Nixon, Jerzy Wegiel, Asok Kumar, Wai Haung Yu, Corrinne Peterhoff, Anne Cataldo, Ana Maria Cuervo. J Neuropathol Exp Neurol 2005
6
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.
Barry Boland, Asok Kumar, Sooyeon Lee, Frances M Platt, Jerzy Wegiel, W Haung Yu, Ralph A Nixon. J Neurosci 2008
Barry Boland, Asok Kumar, Sooyeon Lee, Frances M Platt, Jerzy Wegiel, W Haung Yu, Ralph A Nixon. J Neurosci 2008
6
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
Ju-Hyun Lee, W Haung Yu, Asok Kumar, Sooyeon Lee, Panaiyur S Mohan, Corrinne M Peterhoff, Devin M Wolfe, Marta Martinez-Vicente, Ashish C Massey, Guy Sovak,[...]. Cell 2010
Ju-Hyun Lee, W Haung Yu, Asok Kumar, Sooyeon Lee, Panaiyur S Mohan, Corrinne M Peterhoff, Devin M Wolfe, Marta Martinez-Vicente, Ashish C Massey, Guy Sovak,[...]. Cell 2010
6
Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria.
Nadia Cummins, Andrea Tweedie, Steven Zuryn, Jesus Bertran-Gonzalez, Jürgen Götz. EMBO J 2019
Nadia Cummins, Andrea Tweedie, Steven Zuryn, Jesus Bertran-Gonzalez, Jürgen Götz. EMBO J 2019
6
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.
Geir Bjørkøy, Trond Lamark, Andreas Brech, Heidi Outzen, Maria Perander, Aud Overvatn, Harald Stenmark, Terje Johansen. J Cell Biol 2005
Geir Bjørkøy, Trond Lamark, Andreas Brech, Heidi Outzen, Maria Perander, Aud Overvatn, Harald Stenmark, Terje Johansen. J Cell Biol 2005
6
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Manuela Neumann, Deepak M Sampathu, Linda K Kwong, Adam C Truax, Matthew C Micsenyi, Thomas T Chou, Jennifer Bruce, Theresa Schuck, Murray Grossman, Christopher M Clark,[...]. Science 2006
Manuela Neumann, Deepak M Sampathu, Linda K Kwong, Adam C Truax, Matthew C Micsenyi, Thomas T Chou, Jennifer Bruce, Theresa Schuck, Murray Grossman, Christopher M Clark,[...]. Science 2006
6
Autophagy failure in Alzheimer's disease--locating the primary defect.
Ralph A Nixon, Dun-Sheng Yang. Neurobiol Dis 2011
Ralph A Nixon, Dun-Sheng Yang. Neurobiol Dis 2011
5
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Y Kabeya, N Mizushima, T Ueno, A Yamamoto, T Kirisako, T Noda, E Kominami, Y Ohsumi, T Yoshimori. EMBO J 2000
Y Kabeya, N Mizushima, T Ueno, A Yamamoto, T Kirisako, T Noda, E Kominami, Y Ohsumi, T Yoshimori. EMBO J 2000
5
Signals from the lysosome: a control centre for cellular clearance and energy metabolism.
Carmine Settembre, Alessandro Fraldi, Diego L Medina, Andrea Ballabio. Nat Rev Mol Cell Biol 2013
Carmine Settembre, Alessandro Fraldi, Diego L Medina, Andrea Ballabio. Nat Rev Mol Cell Biol 2013
5
5
Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.
Chung-Han Hsieh, Atossa Shaltouki, Ashley E Gonzalez, Alexandre Bettencourt da Cruz, Lena F Burbulla, Erica St Lawrence, Birgitt Schüle, Dimitri Krainc, Theo D Palmer, Xinnan Wang. Cell Stem Cell 2016
Chung-Han Hsieh, Atossa Shaltouki, Ashley E Gonzalez, Alexandre Bettencourt da Cruz, Lena F Burbulla, Erica St Lawrence, Birgitt Schüle, Dimitri Krainc, Theo D Palmer, Xinnan Wang. Cell Stem Cell 2016
5
The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
5
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.
Marta M Lipinski, Bin Zheng, Tao Lu, Zhenyu Yan, Bénédicte F Py, Aylwin Ng, Ramnik J Xavier, Cheng Li, Bruce A Yankner, Clemens R Scherzer,[...]. Proc Natl Acad Sci U S A 2010
Marta M Lipinski, Bin Zheng, Tao Lu, Zhenyu Yan, Bénédicte F Py, Aylwin Ng, Ramnik J Xavier, Cheng Li, Bruce A Yankner, Clemens R Scherzer,[...]. Proc Natl Acad Sci U S A 2010
5
Interplay of pathogenic forms of human tau with different autophagic pathways.
Benjamin Caballero, Yipeng Wang, Antonio Diaz, Inmaculada Tasset, Yves Robert Juste, Barbara Stiller, Eva-Maria Mandelkow, Eckhard Mandelkow, Ana Maria Cuervo. Aging Cell 2018
Benjamin Caballero, Yipeng Wang, Antonio Diaz, Inmaculada Tasset, Yves Robert Juste, Barbara Stiller, Eva-Maria Mandelkow, Eckhard Mandelkow, Ana Maria Cuervo. Aging Cell 2018
6
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
5
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
Noriyuki Matsuda, Shigeto Sato, Kahori Shiba, Kei Okatsu, Keiko Saisho, Clement A Gautier, Yu-Shin Sou, Shinji Saiki, Sumihiro Kawajiri, Fumiaki Sato,[...]. J Cell Biol 2010
Noriyuki Matsuda, Shigeto Sato, Kahori Shiba, Kei Okatsu, Keiko Saisho, Clement A Gautier, Yu-Shin Sou, Shinji Saiki, Sumihiro Kawajiri, Fumiaki Sato,[...]. J Cell Biol 2010
5
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase.
You-Tong Wu, Hui-Ling Tan, Guanghou Shui, Chantal Bauvy, Qing Huang, Markus R Wenk, Choon-Nam Ong, Patrice Codogno, Han-Ming Shen. J Biol Chem 2010
You-Tong Wu, Hui-Ling Tan, Guanghou Shui, Chantal Bauvy, Qing Huang, Markus R Wenk, Choon-Nam Ong, Patrice Codogno, Han-Ming Shen. J Biol Chem 2010
5
Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism.
Wen-Chuan Shen, Huei-Ying Li, Guang-Chao Chen, Yijuang Chern, Pang-Hsien Tu. Autophagy 2015
Wen-Chuan Shen, Huei-Ying Li, Guang-Chao Chen, Yijuang Chern, Pang-Hsien Tu. Autophagy 2015
5
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Fumika Koyano, Kei Okatsu, Hidetaka Kosako, Yasushi Tamura, Etsu Go, Mayumi Kimura, Yoko Kimura, Hikaru Tsuchiya, Hidehito Yoshihara, Takatsugu Hirokawa,[...]. Nature 2014
Fumika Koyano, Kei Okatsu, Hidetaka Kosako, Yasushi Tamura, Etsu Go, Mayumi Kimura, Yoko Kimura, Hikaru Tsuchiya, Hidehito Yoshihara, Takatsugu Hirokawa,[...]. Nature 2014
5
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.
Anne Simonsen, Robert C Cumming, Andreas Brech, Pauline Isakson, David R Schubert, Kim D Finley. Autophagy 2008
Anne Simonsen, Robert C Cumming, Andreas Brech, Pauline Isakson, David R Schubert, Kim D Finley. Autophagy 2008
5
Association Between Autophagy and Neurodegenerative Diseases.
Nobuhiro Fujikake, Minkyoung Shin, Shigeomi Shimizu. Front Neurosci 2018
Nobuhiro Fujikake, Minkyoung Shin, Shigeomi Shimizu. Front Neurosci 2018
5
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena,[...]. Autophagy 2021
Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena,[...]. Autophagy 2021
5
The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
Yvette C Wong, Erika L F Holzbaur. J Neurosci 2014
Yvette C Wong, Erika L F Holzbaur. J Neurosci 2014
5
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.
Timothy R Sampson, Justine W Debelius, Taren Thron, Stefan Janssen, Gauri G Shastri, Zehra Esra Ilhan, Collin Challis, Catherine E Schretter, Sandra Rocha, Viviana Gradinaru,[...]. Cell 2016
Timothy R Sampson, Justine W Debelius, Taren Thron, Stefan Janssen, Gauri G Shastri, Zehra Esra Ilhan, Collin Challis, Catherine E Schretter, Sandra Rocha, Viviana Gradinaru,[...]. Cell 2016
5
ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
Josephine J Wu, Ashley Cai, Jessie E Greenslade, Nicole R Higgins, Cong Fan, Nhat T T Le, Micaela Tatman, Alexandra M Whiteley, Miguel A Prado, Birger V Dieriks,[...]. Proc Natl Acad Sci U S A 2020
Josephine J Wu, Ashley Cai, Jessie E Greenslade, Nicole R Higgins, Cong Fan, Nhat T T Le, Micaela Tatman, Alexandra M Whiteley, Miguel A Prado, Birger V Dieriks,[...]. Proc Natl Acad Sci U S A 2020
18
Autophagy in immunity and inflammation.
Beth Levine, Noboru Mizushima, Herbert W Virgin. Nature 2011
Beth Levine, Noboru Mizushima, Herbert W Virgin. Nature 2011
4
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.
Sandra Maday, Karen E Wallace, Erika L F Holzbaur. J Cell Biol 2012
Sandra Maday, Karen E Wallace, Erika L F Holzbaur. J Cell Biol 2012
4
mTOR regulation of autophagy.
Chang Hwa Jung, Seung-Hyun Ro, Jing Cao, Neil Michael Otto, Do-Hyung Kim. FEBS Lett 2010
Chang Hwa Jung, Seung-Hyun Ro, Jing Cao, Neil Michael Otto, Do-Hyung Kim. FEBS Lett 2010
4
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.
Justin M Long, David M Holtzman. Cell 2019
Justin M Long, David M Holtzman. Cell 2019
4
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Maria Manczak, Marcus J Calkins, P Hemachandra Reddy. Hum Mol Genet 2011
Maria Manczak, Marcus J Calkins, P Hemachandra Reddy. Hum Mol Genet 2011
4
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
Cristina Malagelada, Zong Hao Jin, Vernice Jackson-Lewis, Serge Przedborski, Lloyd A Greene. J Neurosci 2010
Cristina Malagelada, Zong Hao Jin, Vernice Jackson-Lewis, Serge Przedborski, Lloyd A Greene. J Neurosci 2010
4
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark, Andreas Brech, Jack-Ansgar Bruun, Heidi Outzen, Aud Øvervatn, Geir Bjørkøy, Terje Johansen. J Biol Chem 2007
Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark, Andreas Brech, Jack-Ansgar Bruun, Heidi Outzen, Aud Øvervatn, Geir Bjørkøy, Terje Johansen. J Biol Chem 2007
4
Regulation of mammalian autophagy in physiology and pathophysiology.
Brinda Ravikumar, Sovan Sarkar, Janet E Davies, Marie Futter, Moises Garcia-Arencibia, Zeyn W Green-Thompson, Maria Jimenez-Sanchez, Viktor I Korolchuk, Maike Lichtenberg, Shouqing Luo,[...]. Physiol Rev 2010
Brinda Ravikumar, Sovan Sarkar, Janet E Davies, Marie Futter, Moises Garcia-Arencibia, Zeyn W Green-Thompson, Maria Jimenez-Sanchez, Viktor I Korolchuk, Maike Lichtenberg, Shouqing Luo,[...]. Physiol Rev 2010
4
Bassoon Controls Presynaptic Autophagy through Atg5.
Nathan D Okerlund, Katharina Schneider, Sergio Leal-Ortiz, Carolina Montenegro-Venegas, Sally A Kim, Loren C Garner, Clarissa L Waites, Eckart D Gundelfinger, Richard J Reimer, Craig C Garner. Neuron 2017
Nathan D Okerlund, Katharina Schneider, Sergio Leal-Ortiz, Carolina Montenegro-Venegas, Sally A Kim, Loren C Garner, Clarissa L Waites, Eckart D Gundelfinger, Richard J Reimer, Craig C Garner. Neuron 2017
4
Neuronal stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical long-term depression.
Mohammad Shehata, Hiroyuki Matsumura, Reiko Okubo-Suzuki, Noriaki Ohkawa, Kaoru Inokuchi. J Neurosci 2012
Mohammad Shehata, Hiroyuki Matsumura, Reiko Okubo-Suzuki, Noriaki Ohkawa, Kaoru Inokuchi. J Neurosci 2012
4
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.