A citation-based method for searching scientific literature

Hilary Highfield Nickols, P Jeffrey Conn. Neurobiol Dis 2014
Times Cited: 146







List of co-cited articles
1075 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
28

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
P Jeffrey Conn, Arthur Christopoulos, Craig W Lindsley. Nat Rev Drug Discov 2009
746
18

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.
P Jeffrey Conn, Craig W Lindsley, Jens Meiler, Colleen M Niswender. Nat Rev Drug Discov 2014
175
18

Metabotropic glutamate receptors: from the workbench to the bedside.
F Nicoletti, J Bockaert, G L Collingridge, P J Conn, F Ferraguti, D D Schoepp, J T Wroblewski, J P Pin. Neuropharmacology 2011
399
15

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.
Alice L Rodriguez, Mark D Grier, Carrie K Jones, Elizabeth J Herman, Alexander S Kane, Randy L Smith, Richard Williams, Ya Zhou, Joy E Marlo, Emily L Days,[...]. Mol Pharmacol 2010
141
12

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
Huixian Wu, Chong Wang, Karen J Gregory, Gye Won Han, Hyekyung P Cho, Yan Xia, Colleen M Niswender, Vsevolod Katritch, Jens Meiler, Vadim Cherezov,[...]. Science 2014
350
12

Pharmacology and functions of metabotropic glutamate receptors.
P J Conn, J P Pin. Annu Rev Pharmacol Toxicol 1997
11

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Andrew S Doré, Krzysztof Okrasa, Jayesh C Patel, Maria Serrano-Vega, Kirstie Bennett, Robert M Cooke, James C Errey, Ali Jazayeri, Samir Khan, Ben Tehan,[...]. Nature 2014
279
11

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
Shen Yin, Meredith J Noetzel, Kari A Johnson, Rocio Zamorano, Nidhi Jalan-Sakrikar, Karen J Gregory, P Jeffrey Conn, Colleen M Niswender. J Neurosci 2014
80
13

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.
Jerri M Rook, Meredith J Noetzel, Wendy A Pouliot, Thomas M Bridges, Paige N Vinson, Hyekyung P Cho, Ya Zhou, Rocco D Gogliotti, Jason T Manka, Karen J Gregory,[...]. Biol Psychiatry 2013
76
13

Emerging paradigms in GPCR allostery: implications for drug discovery.
Denise Wootten, Arthur Christopoulos, Patrick M Sexton. Nat Rev Drug Discov 2013
274
10

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.
Jerri M Rook, Zixiu Xiang, Xiaohui Lv, Ayan Ghoshal, Jonathan W Dickerson, Thomas M Bridges, Kari A Johnson, Daniel J Foster, Karen J Gregory, Paige N Vinson,[...]. Neuron 2015
81
12

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.
M J Noetzel, K J Gregory, P N Vinson, J T Manka, S R Stauffer, C W Lindsley, C M Niswender, Z Xiang, P J Conn. Mol Pharmacol 2013
64
14

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
Gene G Kinney, Julie A O'Brien, Wei Lemaire, Maryann Burno, Denise J Bickel, Michelle K Clements, Tsing-Bau Chen, David D Wisnoski, Craig W Lindsley, Philip R Tiller,[...]. J Pharmacol Exp Ther 2005
244
9

The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease.
J G Doria, J M de Souza, J N Andrade, H A Rodrigues, I M Guimaraes, T G Carvalho, C Guatimosim, T Dobransky, F M Ribeiro. Neurobiol Dis 2015
36
25

Metabotropic glutamate receptors as drug targets: what's new?
Ferdinando Nicoletti, Valeria Bruno, Richard Teke Ngomba, Roberto Gradini, Giuseppe Battaglia. Curr Opin Pharmacol 2015
68
13


Trends in GPCR drug discovery: new agents, targets and indications.
Alexander S Hauser, Misty M Attwood, Mathias Rask-Andersen, Helgi B Schiöth, David E Gloriam. Nat Rev Drug Discov 2017
840
9

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.
Michael Bubser, Thomas M Bridges, Ditte Dencker, Robert W Gould, Michael Grannan, Meredith J Noetzel, Atin Lamsal, Colleen M Niswender, J Scott Daniels, Michael S Poslusney,[...]. ACS Chem Neurosci 2014
80
10

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
Richard H P Porter, Georg Jaeschke, Will Spooren, Theresa M Ballard, Bernd Büttelmann, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Jürgen Wichmann, Eric Vieira,[...]. J Pharmacol Exp Ther 2005
229
8

Metabotropic glutamate receptors.
Francesco Ferraguti, Ryuichi Shigemoto. Cell Tissue Res 2006
352
8

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.
N C Bodick, W W Offen, A I Levey, N R Cutler, S G Gauthier, A Satlin, H E Shannon, G D Tollefson, K Rasmussen, F P Bymaster,[...]. Arch Neurol 1997
471
8

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Sophie Parmentier-Batteur, Peter H Hutson, Karsten Menzel, Jason M Uslaner, Britta A Mattson, Julie A O'Brien, Brian C Magliaro, Thomas Forest, Craig A Stump, Robert M Tynebor,[...]. Neuropharmacology 2014
66
12



Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study.
J C Pecknold, D J McClure, L Appeltauer, L Wrzesinski, T Allan. J Clin Psychopharmacol 1982
127
7


Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.
Lothar Lindemann, Richard H Porter, Sebastian H Scharf, Basil Kuennecke, Andreas Bruns, Markus von Kienlin, Anthony C Harrison, Axel Paehler, Christoph Funk, Andreas Gloge,[...]. J Pharmacol Exp Ther 2015
69
10


Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.
Katie Leach, Patrick M Sexton, Arthur Christopoulos. Trends Pharmacol Sci 2007
266
7

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders.
Chad J Swanson, Mark Bures, Michael P Johnson, Anni-Maija Linden, James A Monn, Darryle D Schoepp. Nat Rev Drug Discov 2005
457
7

Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.
Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Hyekyung P Cho, Emily Days, Y Zhou, Alice L Rodriguez, Hilde Lavreysen, Shaun R Stauffer, Colleen M Niswender,[...]. Mol Pharmacol 2012
99
7

Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7.
Colleen M Niswender, Kari A Johnson, Nicole R Miller, Jennifer E Ayala, Qingwei Luo, Richard Williams, Samir Saleh, Darren Orton, C David Weaver, P Jeffrey Conn. Mol Pharmacol 2010
64
10

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia.
Anantha Shekhar, William Z Potter, Jeffrey Lightfoot, John Lienemann, Sanjay Dubé, Craig Mallinckrodt, Frank P Bymaster, David L McKinzie, Christian C Felder. Am J Psychiatry 2008
305
7

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.
Etienne Doumazane, Pauline Scholler, Jurriaan M Zwier, Eric Trinquet, Philippe Rondard, Jean-Philippe Pin. FASEB J 2011
195
7

ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities.
Feng Liu, Steve Grauer, Cody Kelley, Rachel Navarra, Radka Graf, Guoming Zhang, Peter J Atkinson, Michael Popiolek, Caitlin Wantuch, Xavier Khawaja,[...]. J Pharmacol Exp Ther 2008
160
7

Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.
Susana Conde-Ceide, Carlos M Martínez-Viturro, Jesús Alcázar, Pedro M Garcia-Barrantes, Hilde Lavreysen, Claire Mackie, Paige N Vinson, Jerri M Rook, Thomas M Bridges, J Scott Daniels,[...]. ACS Med Chem Lett 2015
33
21


Molecular signatures of G-protein-coupled receptors.
A J Venkatakrishnan, Xavier Deupi, Guillaume Lebon, Christopher G Tate, Gebhard F Schertler, M Madan Babu. Nature 2013
918
7

VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy.
Hilary Highfield Nickols, Joannes P Yuh, Karen J Gregory, Ryan D Morrison, Brittney S Bates, Shaun R Stauffer, Kyle A Emmitte, Michael Bubser, Weimin Peng, Michael T Nedelcovych,[...]. J Pharmacol Exp Ther 2016
26
26

Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.
Robert W Gould, Russell J Amato, Michael Bubser, Max E Joffe, Michael T Nedelcovych, Analisa D Thompson, Hilary H Nickols, Johannes P Yuh, Xiaoyan Zhan, Andrew S Felts,[...]. Neuropsychopharmacology 2016
25
28

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.
Craig W Lindsley, Kyle A Emmitte, Corey R Hopkins, Thomas M Bridges, Karen J Gregory, Colleen M Niswender, P Jeffrey Conn. Chem Rev 2016
113
7

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
David M Thal, Bingfa Sun, Dan Feng, Vindhya Nawaratne, Katie Leach, Christian C Felder, Mark G Bures, David A Evans, William I Weis, Priti Bachhawat,[...]. Nature 2016
177
7

The structure and function of G-protein-coupled receptors.
Daniel M Rosenbaum, Søren G F Rasmussen, Brian K Kobilka. Nature 2009
6

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.
Robert Fredriksson, Malin C Lagerström, Lars-Gustav Lundin, Helgi B Schiöth. Mol Pharmacol 2003
6

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
F Gasparini, K Lingenhöhl, N Stoehr, P J Flor, M Heinrich, I Vranesic, M Biollaz, H Allgeier, R Heckendorn, S Urwyler,[...]. Neuropharmacology 1999
644
6

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.
Karen J Gregory, Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Shaun R Stauffer, Alice L Rodriguez, Kyle A Emmitte, Ya Zhou, Aspen C Chun, Andrew S Felts,[...]. Mol Pharmacol 2012
67
8

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.
Julie A O'Brien, Wei Lemaire, Marion Wittmann, Marlene A Jacobson, Sookhee N Ha, David D Wisnoski, Craig W Lindsley, Hervé J Schaffhauser, Blake Rowe, Cyrille Sur,[...]. J Pharmacol Exp Ther 2004
149
6


A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.
Daniella Rylander, Hanna Iderberg, Qin Li, Andrzej Dekundy, Jinlan Zhang, Hao Li, Ren Baishen, Wojciech Danysz, Erwan Bezard, M Angela Cenci. Neurobiol Dis 2010
124
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.