Naoko Takebe, Dat Nguyen, Sherry X Yang. Pharmacol Ther 2014
Times Cited: 264
Times Cited: 264
Times Cited
Times Co-cited
Similarity
The canonical Notch signaling pathway: unfolding the activation mechanism.
Raphael Kopan, Maria Xenia G Ilagan. Cell 2009
Raphael Kopan, Maria Xenia G Ilagan. Cell 2009
17
Notch signalling in solid tumours: a little bit of everything but not all the time.
Prathibha Ranganathan, Kelly L Weaver, Anthony J Capobianco. Nat Rev Cancer 2011
Prathibha Ranganathan, Kelly L Weaver, Anthony J Capobianco. Nat Rev Cancer 2011
16
The Varied Roles of Notch in Cancer.
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
15
Therapeutic antibody targeting of individual Notch receptors.
Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway,[...]. Nature 2010
Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway,[...]. Nature 2010
15
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
13
Therapeutic modulation of Notch signalling--are we there yet?
Emma R Andersson, Urban Lendahl. Nat Rev Drug Discov 2014
Emma R Andersson, Urban Lendahl. Nat Rev Drug Discov 2014
12
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update.
Naoko Takebe, Lucio Miele, Pamela Jo Harris, Woondong Jeong, Hideaki Bando, Michael Kahn, Sherry X Yang, S Percy Ivy. Nat Rev Clin Oncol 2015
Naoko Takebe, Lucio Miele, Pamela Jo Harris, Woondong Jeong, Hideaki Bando, Michael Kahn, Sherry X Yang, S Percy Ivy. Nat Rev Clin Oncol 2015
12
Notch signaling: cell fate control and signal integration in development.
S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
11
Aberrant activation of notch signaling in human breast cancer.
Spyros Stylianou, Rob B Clarke, Keith Brennan. Cancer Res 2006
Spyros Stylianou, Rob B Clarke, Keith Brennan. Cancer Res 2006
11
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival.
Michael Reedijk, Silvia Odorcic, Lynn Chang, Hui Zhang, Naomi Miller, David R McCready, Gina Lockwood, Sean E Egan. Cancer Res 2005
Michael Reedijk, Silvia Odorcic, Lynn Chang, Hui Zhang, Naomi Miller, David R McCready, Gina Lockwood, Sean E Egan. Cancer Res 2005
11
Notch Signaling in Development, Tissue Homeostasis, and Disease.
Chris Siebel, Urban Lendahl. Physiol Rev 2017
Chris Siebel, Urban Lendahl. Physiol Rev 2017
10
Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors.
Anthony W Tolcher, Wells A Messersmith, Stanislaw M Mikulski, Kyriakos P Papadopoulos, Eunice L Kwak, Darlene G Gibbon, Amita Patnaik, Gerald S Falchook, Arvind Dasari, Geoffrey I Shapiro,[...]. J Clin Oncol 2012
Anthony W Tolcher, Wells A Messersmith, Stanislaw M Mikulski, Kyriakos P Papadopoulos, Eunice L Kwak, Darlene G Gibbon, Amita Patnaik, Gerald S Falchook, Arvind Dasari, Geoffrey I Shapiro,[...]. J Clin Oncol 2012
9
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells.
Nilay Sethi, Xudong Dai, Christopher G Winter, Yibin Kang. Cancer Cell 2011
Nilay Sethi, Xudong Dai, Christopher G Winter, Yibin Kang. Cancer Cell 2011
9
Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy.
Shannon M McAuliffe, Stefanie L Morgan, Gregory A Wyant, Lieu T Tran, Katherine W Muto, Yu Sarah Chen, Kenneth T Chin, Justin C Partridge, Barish B Poole, Kuang-Hung Cheng,[...]. Proc Natl Acad Sci U S A 2012
Shannon M McAuliffe, Stefanie L Morgan, Gregory A Wyant, Lieu T Tran, Katherine W Muto, Yu Sarah Chen, Kenneth T Chin, Justin C Partridge, Barish B Poole, Kuang-Hung Cheng,[...]. Proc Natl Acad Sci U S A 2012
8
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H van Es, Marielle E van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J Winton, Freddy Radtke,[...]. Nature 2005
Johan H van Es, Marielle E van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J Winton, Freddy Radtke,[...]. Nature 2005
8
Notch signaling: an emerging therapeutic target for cancer treatment.
Xun Yuan, Hua Wu, Hanxiao Xu, Huihua Xiong, Qian Chu, Shiying Yu, Gen Sheng Wu, Kongming Wu. Cancer Lett 2015
Xun Yuan, Hua Wu, Hanxiao Xu, Huihua Xiong, Qian Chu, Shiying Yu, Gen Sheng Wu, Kongming Wu. Cancer Lett 2015
8
Direct inhibition of the NOTCH transcription factor complex.
Raymond E Moellering, Melanie Cornejo, Tina N Davis, Cristina Del Bianco, Jon C Aster, Stephen C Blacklow, Andrew L Kung, D Gary Gilliland, Gregory L Verdine, James E Bradner. Nature 2009
Raymond E Moellering, Melanie Cornejo, Tina N Davis, Cristina Del Bianco, Jon C Aster, Stephen C Blacklow, Andrew L Kung, D Gary Gilliland, Gregory L Verdine, James E Bradner. Nature 2009
8
Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
Bruno M Simões, Ciara S O'Brien, Rachel Eyre, Andreia Silva, Ling Yu, Aida Sarmiento-Castro, Denis G Alférez, Kath Spence, Angélica Santiago-Gómez, Francesca Chemi,[...]. Cell Rep 2015
Bruno M Simões, Ciara S O'Brien, Rachel Eyre, Andreia Silva, Ling Yu, Aida Sarmiento-Castro, Denis G Alférez, Kath Spence, Angélica Santiago-Gómez, Francesca Chemi,[...]. Cell Rep 2015
8
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
L W Ellisen, J Bird, D C West, A L Soreng, T C Reynolds, S D Smith, J Sklar. Cell 1991
L W Ellisen, J Bird, D C West, A L Soreng, T C Reynolds, S D Smith, J Sklar. Cell 1991
8
Notch signaling: simplicity in design, versatility in function.
Emma R Andersson, Rickard Sandberg, Urban Lendahl. Development 2011
Emma R Andersson, Rickard Sandberg, Urban Lendahl. Development 2011
7
A phase II study of RO4929097 in metastatic colorectal cancer.
Jonathan R Strosberg, Timothy Yeatman, Jill Weber, Domenico Coppola, Michael J Schell, Gang Han, Khaldoun Almhanna, Richard Kim, Tiffany Valone, Helen Jump,[...]. Eur J Cancer 2012
Jonathan R Strosberg, Timothy Yeatman, Jill Weber, Domenico Coppola, Michael J Schell, Gang Han, Khaldoun Almhanna, Richard Kim, Tiffany Valone, Helen Jump,[...]. Eur J Cancer 2012
7
Hypoxia requires notch signaling to maintain the undifferentiated cell state.
Maria V Gustafsson, Xiaowei Zheng, Teresa Pereira, Katarina Gradin, Shaobo Jin, Johan Lundkvist, Jorge L Ruas, Lorenz Poellinger, Urban Lendahl, Maria Bondesson. Dev Cell 2005
Maria V Gustafsson, Xiaowei Zheng, Teresa Pereira, Katarina Gradin, Shaobo Jin, Johan Lundkvist, Jorge L Ruas, Lorenz Poellinger, Urban Lendahl, Maria Bondesson. Dev Cell 2005
7
Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.
Ian Krop, Tim Demuth, Tina Guthrie, Patrick Y Wen, Warren P Mason, Prakash Chinnaiyan, Nicholas Butowski, Morris D Groves, Santosh Kesari, Steven J Freedman,[...]. J Clin Oncol 2012
Ian Krop, Tim Demuth, Tina Guthrie, Patrick Y Wen, Warren P Mason, Prakash Chinnaiyan, Nicholas Butowski, Morris D Groves, Santosh Kesari, Steven J Freedman,[...]. J Clin Oncol 2012
7
Gamma secretase inhibitors of Notch signaling.
Roma Olsauskas-Kuprys, Andrei Zlobin, Clodia Osipo. Onco Targets Ther 2013
Roma Olsauskas-Kuprys, Andrei Zlobin, Clodia Osipo. Onco Targets Ther 2013
7
A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.
Wells A Messersmith, Geoffrey I Shapiro, James M Cleary, Antonio Jimeno, Arvind Dasari, Bo Huang, M Naveed Shaik, Rossano Cesari, Xianxian Zheng, Jennifer M Reynolds,[...]. Clin Cancer Res 2015
Wells A Messersmith, Geoffrey I Shapiro, James M Cleary, Antonio Jimeno, Arvind Dasari, Bo Huang, M Naveed Shaik, Rossano Cesari, Xianxian Zheng, Jennifer M Reynolds,[...]. Clin Cancer Res 2015
7
A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors.
Elena Gabriela Chiorean, Patricia LoRusso, Robert Matthew Strother, Jennifer R Diamond, Anne Younger, Wells A Messersmith, Lieve Adriaens, Liming Liu, Richard J Kao, Albert Thomas DiCioccio,[...]. Clin Cancer Res 2015
Elena Gabriela Chiorean, Patricia LoRusso, Robert Matthew Strother, Jennifer R Diamond, Anne Younger, Wells A Messersmith, Lieve Adriaens, Liming Liu, Richard J Kao, Albert Thomas DiCioccio,[...]. Clin Cancer Res 2015
8
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.
Irene Noguera-Troise, Christopher Daly, Nicholas J Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W Gale, Hsin Chieh Lin, George D Yancopoulos, Gavin Thurston. Nature 2006
Irene Noguera-Troise, Christopher Daly, Nicholas J Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W Gale, Hsin Chieh Lin, George D Yancopoulos, Gavin Thurston. Nature 2006
7
Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cancer.
Mohammed Tanjimur Rahman, Kentaro Nakayama, Munmun Rahman, Hiroshi Katagiri, Atsuko Katagiri, Tomoka Ishibashi, Masako Ishikawa, Kouji Iida, Satoru Nakayama, Yoshiro Otsuki,[...]. Am J Clin Pathol 2012
Mohammed Tanjimur Rahman, Kentaro Nakayama, Munmun Rahman, Hiroshi Katagiri, Atsuko Katagiri, Tomoka Ishibashi, Masako Ishikawa, Kouji Iida, Satoru Nakayama, Yoshiro Otsuki,[...]. Am J Clin Pathol 2012
12
6
Notch signaling in human development and disease.
Andrea L Penton, Laura D Leonard, Nancy B Spinner. Semin Cell Dev Biol 2012
Andrea L Penton, Laura D Leonard, Nancy B Spinner. Semin Cell Dev Biol 2012
6
6
Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses.
Diana J Azzam, Dekuang Zhao, Jun Sun, Andy J Minn, Prathibha Ranganathan, Katherine Drews-Elger, Xiaoqing Han, Manuel Picon-Ruiz, Candace A Gilbert, Seth A Wander,[...]. EMBO Mol Med 2013
Diana J Azzam, Dekuang Zhao, Jun Sun, Andy J Minn, Prathibha Ranganathan, Katherine Drews-Elger, Xiaoqing Han, Manuel Picon-Ruiz, Candace A Gilbert, Seth A Wander,[...]. EMBO Mol Med 2013
11
A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.
Ahmet Acar, Bruno M Simões, Robert B Clarke, Keith Brennan. Stem Cells Int 2016
Ahmet Acar, Bruno M Simões, Robert B Clarke, Keith Brennan. Stem Cells Int 2016
15
Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).
Shivaani Kummar, Geraldine O'Sullivan Coyne, Khanh T Do, Baris Turkbey, Paul S Meltzer, Eric Polley, Peter L Choyke, Robert Meehan, Rasa Vilimas, Yvonne Horneffer,[...]. J Clin Oncol 2017
Shivaani Kummar, Geraldine O'Sullivan Coyne, Khanh T Do, Baris Turkbey, Paul S Meltzer, Eric Polley, Peter L Choyke, Robert Meehan, Rasa Vilimas, Yvonne Horneffer,[...]. J Clin Oncol 2017
7
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways.
Mirjam C Boelens, Tony J Wu, Barzin Y Nabet, Bihui Xu, Yu Qiu, Taewon Yoon, Diana J Azzam, Christina Twyman-Saint Victor, Brianne Z Wiemann, Hemant Ishwaran,[...]. Cell 2014
Mirjam C Boelens, Tony J Wu, Barzin Y Nabet, Bihui Xu, Yu Qiu, Taewon Yoon, Diana J Azzam, Christina Twyman-Saint Victor, Brianne Z Wiemann, Hemant Ishwaran,[...]. Cell 2014
6
Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.
Hannah Harrison, Gillian Farnie, Sacha J Howell, Rebecca E Rock, Spyros Stylianou, Keith R Brennan, Nigel J Bundred, Robert B Clarke. Cancer Res 2010
Hannah Harrison, Gillian Farnie, Sacha J Howell, Rebecca E Rock, Spyros Stylianou, Keith R Brennan, Nigel J Bundred, Robert B Clarke. Cancer Res 2010
6
PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitor.
Kai Wang, Qin Zhang, Danan Li, Keith Ching, Cathy Zhang, Xianxian Zheng, Mark Ozeck, Stephanie Shi, Xiaorong Li, Hui Wang,[...]. Clin Cancer Res 2015
Kai Wang, Qin Zhang, Danan Li, Keith Ching, Cathy Zhang, Xianxian Zheng, Mark Ozeck, Stephanie Shi, Xiaorong Li, Hui Wang,[...]. Clin Cancer Res 2015
6
A monoclonal antibody against human Notch1 ligand-binding domain depletes subpopulation of putative breast cancer stem-like cells.
Ankur Sharma, Anurag N Paranjape, Annapoorni Rangarajan, Rajan R Dighe. Mol Cancer Ther 2012
Ankur Sharma, Anurag N Paranjape, Annapoorni Rangarajan, Rajan R Dighe. Mol Cancer Ther 2012
8
NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype.
Mizuki Yamamoto, Yuu Taguchi, Taku Ito-Kureha, Kentaro Semba, Noritaka Yamaguchi, Jun-ichiro Inoue. Nat Commun 2013
Mizuki Yamamoto, Yuu Taguchi, Taku Ito-Kureha, Kentaro Semba, Noritaka Yamaguchi, Jun-ichiro Inoue. Nat Commun 2013
6
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Mats Hellström, Li-Kun Phng, Jennifer J Hofmann, Elisabet Wallgard, Leigh Coultas, Per Lindblom, Jackelyn Alva, Ann-Katrin Nilsson, Linda Karlsson, Nicholas Gaiano,[...]. Nature 2007
Mats Hellström, Li-Kun Phng, Jennifer J Hofmann, Elisabet Wallgard, Leigh Coultas, Per Lindblom, Jackelyn Alva, Ann-Katrin Nilsson, Linda Karlsson, Nicholas Gaiano,[...]. Nature 2007
6
Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.
Pasquale Sansone, Claudio Ceccarelli, Marjan Berishaj, Qing Chang, Vinagolu K Rajasekhar, Fabiana Perna, Robert L Bowman, Michele Vidone, Laura Daly, Jennifer Nnoli,[...]. Nat Commun 2016
Pasquale Sansone, Claudio Ceccarelli, Marjan Berishaj, Qing Chang, Vinagolu K Rajasekhar, Fabiana Perna, Robert L Bowman, Michele Vidone, Laura Daly, Jennifer Nnoli,[...]. Nat Commun 2016
6
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
Jennifer O'Neil, Jonathan Grim, Peter Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James Hardwick, Markus Welcker, Jules P Meijerink, Rob Pieters,[...]. J Exp Med 2007
Jennifer O'Neil, Jonathan Grim, Peter Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James Hardwick, Markus Welcker, Jules P Meijerink, Rob Pieters,[...]. J Exp Med 2007
6
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Teresa Palomero, Wei Keat Lim, Duncan T Odom, Maria Luisa Sulis, Pedro J Real, Adam Margolin, Kelly C Barnes, Jennifer O'Neil, Donna Neuberg, Andrew P Weng,[...]. Proc Natl Acad Sci U S A 2006
Teresa Palomero, Wei Keat Lim, Duncan T Odom, Maria Luisa Sulis, Pedro J Real, Adam Margolin, Kelly C Barnes, Jennifer O'Neil, Donna Neuberg, Andrew P Weng,[...]. Proc Natl Acad Sci U S A 2006
6
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.
Xose S Puente, Magda Pinyol, Víctor Quesada, Laura Conde, Gonzalo R Ordóñez, Neus Villamor, Georgia Escaramis, Pedro Jares, Sílvia Beà, Marcos González-Díaz,[...]. Nature 2011
Xose S Puente, Magda Pinyol, Víctor Quesada, Laura Conde, Gonzalo R Ordóñez, Neus Villamor, Georgia Escaramis, Pedro Jares, Sílvia Beà, Marcos González-Díaz,[...]. Nature 2011
6
The role of Notch and gamma-secretase inhibition in an ovarian cancer model.
Monjri M Shah, Marielba Zerlin, Blake Y Li, Thomas J Herzog, Jan K Kitajewski, Jason D Wright. Anticancer Res 2013
Monjri M Shah, Marielba Zerlin, Blake Y Li, Thomas J Herzog, Jan K Kitajewski, Jason D Wright. Anticancer Res 2013
26
Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study.
Charles M Rudin, M Catherine Pietanza, Todd M Bauer, Neal Ready, Daniel Morgensztern, Bonnie S Glisson, Lauren A Byers, Melissa L Johnson, Howard A Burris, Francisco Robert,[...]. Lancet Oncol 2017
Charles M Rudin, M Catherine Pietanza, Todd M Bauer, Neal Ready, Daniel Morgensztern, Bonnie S Glisson, Lauren A Byers, Melissa L Johnson, Howard A Burris, Francisco Robert,[...]. Lancet Oncol 2017
5
Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin.
Joon Tae Park, Xu Chen, Claes G Tropè, Ben Davidson, Ie-Ming Shih, Tian-Li Wang. Am J Pathol 2010
Joon Tae Park, Xu Chen, Claes G Tropè, Ben Davidson, Ie-Ming Shih, Tian-Li Wang. Am J Pathol 2010
5
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.