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Times Cited: 207
Times Cited: 207
Times Cited
Times Co-cited
Similarity
Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Aleksandra Trifunovic, Anna Wredenberg, Maria Falkenberg, Johannes N Spelbrink, Anja T Rovio, Carl E Bruder, Mohammad Bohlooly-Y, Sebastian Gidlöf, Anders Oldfors, Rolf Wibom,[...]. Nature 2004
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Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations.
Leslie S Itsara, Scott R Kennedy, Edward J Fox, Selina Yu, Joshua J Hewitt, Monica Sanchez-Contreras, Fernando Cardozo-Pelaez, Leo J Pallanck. PLoS Genet 2014
Leslie S Itsara, Scott R Kennedy, Edward J Fox, Selina Yu, Joshua J Hewitt, Monica Sanchez-Contreras, Fernando Cardozo-Pelaez, Leo J Pallanck. PLoS Genet 2014
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The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.
James B Stewart, Patrick F Chinnery. Nat Rev Genet 2015
James B Stewart, Patrick F Chinnery. Nat Rev Genet 2015
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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
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Sequence and organization of the human mitochondrial genome.
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Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.
Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli Papaemmanuil, Gunes Gundem, Adam Shlien,[...]. Elife 2014
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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease.
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Mitochondrial point mutations do not limit the natural lifespan of mice.
Marc Vermulst, Jason H Bielas, Gregory C Kujoth, Warren C Ladiges, Peter S Rabinovitch, Tomas A Prolla, Lawrence A Loeb. Nat Genet 2007
Marc Vermulst, Jason H Bielas, Gregory C Kujoth, Warren C Ladiges, Peter S Rabinovitch, Tomas A Prolla, Lawrence A Loeb. Nat Genet 2007
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Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice.
Johanna H K Kauppila, Nina A Bonekamp, Arnaud Mourier, Marita A Isokallio, Alexandra Just, Timo E S Kauppila, James B Stewart, Nils-Göran Larsson. Nucleic Acids Res 2018
Johanna H K Kauppila, Nina A Bonekamp, Arnaud Mourier, Marita A Isokallio, Alexandra Just, Timo E S Kauppila, James B Stewart, Nils-Göran Larsson. Nucleic Acids Res 2018
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Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors.
Weiming Zheng, Konstantin Khrapko, Hilary A Coller, William G Thilly, William C Copeland. Mutat Res 2006
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Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.
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Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.
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Detection of ultra-rare mutations by next-generation sequencing.
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Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers.
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Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.
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Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations.
Mingkun Li, Roland Schröder, Shengyu Ni, Burkhard Madea, Mark Stoneking. Proc Natl Acad Sci U S A 2015
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Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.
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Mitochondrial DNA mutations in human disease.
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Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.
Jesse J Salk, Michael W Schmitt, Lawrence A Loeb. Nat Rev Genet 2018
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11
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.
Marc Vermulst, Jonathan Wanagat, Gregory C Kujoth, Jason H Bielas, Peter S Rabinovitch, Tomas A Prolla, Lawrence A Loeb. Nat Genet 2008
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Somatic mitochondrial DNA mutations in mammalian aging.
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Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage.
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Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid.
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11
Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.
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The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
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Detecting ultralow-frequency mutations by Duplex Sequencing.
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10
A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations.
Weiwei Fan, Katrina G Waymire, Navneet Narula, Peng Li, Christophe Rocher, Pinar E Coskun, Mani A Vannan, Jagat Narula, Grant R Macgregor, Douglas C Wallace. Science 2008
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Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases.
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Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.
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mtDNA Variation and Analysis Using Mitomap and Mitomaster.
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The mitochondrial DNA genetic bottleneck: inheritance and beyond.
Haixin Zhang, Stephen P Burr, Patrick F Chinnery. Essays Biochem 2018
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Minimizing the damage: repair pathways keep mitochondrial DNA intact.
Lawrence Kazak, Aurelio Reyes, Ian J Holt. Nat Rev Mol Cell Biol 2012
Lawrence Kazak, Aurelio Reyes, Ian J Holt. Nat Rev Mol Cell Biol 2012
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The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit.
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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease.
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Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals.
Kaixiong Ye, Jian Lu, Fei Ma, Alon Keinan, Zhenglong Gu. Proc Natl Acad Sci U S A 2014
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Recurrent tissue-specific mtDNA mutations are common in humans.
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Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.
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Somatic mtDNA mutation spectra in the aging human putamen.
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MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James B Stewart, Carlos T Moraes. Nat Med 2018
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Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
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9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.